Frontiers in Anti-Infective Drug Discovery: Volume 7

Table of Contents

Chapter 1 The Role Of The Microbiota In The Genesis Of Gastrointestinal Cancers 

• Edda Russo And Amedeo Amedei
  
• Introduction
  
• The Human Microbiota 
  
• The Gastrointestinal Microbiota 
  
• Composition And Activities 
  
• Gastro-Intestinal Colonization By The Microbiota And Selection
  
• The Human Microbiome Project 
  
• Gut Enterotypes
  
• The Role Of Microbiota In Tumor Development
  
• Proposed Models For Microbiota-Induced Carcinogenesis 
  
• Antibacterial-Specific Immune Response And Cancer Promotion 
  
• Microbiota And Gi Cancers 
  
• Gut Bacteria Dysbiosis Associated With Gi Cancer 
  
• Microbiota Involvement In Gastric And Esophageal Cancers, The Role Of Helicobacter Pylori 
  
• Microbiota Involvement In Colorectal Cancer
  
• Specific Gut Bacteria And Crc 
  
• Bacteria Metabolites And Crc 
  
• Gallbladder Cancer 
  
• Liver Cancer 
  
• Pancreatic Cancer 
  
• Beneficial Activities Of Gut Microbiota
  
• Antitumorigenic Impact Of Microbiota 
  
• Manipulating The Microbiota For Cancer Therapy 
  
• Conclusion
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgements 
  
• References 
  

Chapter 2 Towards Host Cell-Targeting Therapies To Treat Dengu Virus Infections 

• Cybele C García, Verónica M Quintana, Viviana Castilla And Elsa B Damonte
  
• Introduction 
  
• Interaction With Cell Receptors 
  
• Endocytosis And Fusion For Uncoating 
  
• Lipid Metabolism 
  
• Protein Translation 
  
• Unfolded Protein Response 
  
• Ubiquitin Proteasome Pathway 
  
• Nucleotide Metabolism 
  
• Kinases 
  
• Mitogen-Activated Protein Kinases 
  
• Erk Pathway 
  
• Jnk Pathway 
  
• P38 Pathway 
  
• Other Kinases 
  
• Src, Ab1 And Fyn Kinases 
  
• Ap2-Associated Protein Kinase 1 And Cyclin G-Associated Kinase 
  
• Phosphatidylinositol 3 Kinase/Akt Pathway 
  
• Protein Processing 
  
• Endoplasmic Reticulum A-Glucosidases 
  
• Furin 
  
• Endoplasmic Reticulum Associated Signal Peptidase 
  
• Innate Antiviral Response 
  
• Interferon Activity 
  
• Cell-Intrinsic Restriction Factors 
  
• Concluding Remarks 
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgements 
  
• References 
  

Chapter 3 Synergistic Interaction Between Plant Products And Antibiotics Against Potential Pathogenic Bacteria 

• Banasri Hazra, Sutapa Biswas Majee, Subhalakshmi Ghosh And Dhruti Avlani
  
• Introduction 
  
• Bacterial Resistance Towards Clinical Antibiotics 
  
• Background 
  
• Mechanisms And Associated Factors 
  
• Screening Strategies To Characterise Plant Products With
  
• Potential Resistance Modifying Activity 
  
• Assessment Of Synergistic Interaction Between Antibiotic And A
  
• Phytocompound Against Resistant Bacteria 
  
• Fractional Inhibitory Concentration Index (Fici) 
  
• Modulation Factor (Mf) 
  
• Isobologram 
  
• Search For Plant-Derived Secondary Metabolites With
  
• Prospective Resistance Modifying Activity 
  
• Key Early Studies Pertaining To Discovery Of Rmas From Plants 
  
• Recent Studies 
  
• Phytochemicals And Relevant Bacterial Resistance Mechanisms
  
• Efflux Pump Inhibition 
  
• Alteration Of Bacterial Cell Membrane Permeability 
  
• Protein Synthesis Inhibition 
  
• Enzymatic Inhibition 
  
• Biofilm Formation Inhibition 
  
• Additional Strategies For Screening And Development Of Plant
  
• Products As Adjuvants In Antimicrobial Therapy 
  
• In Vivo Validation 
  
• Standardisation Of Botanical Extracts 
  
• Ichip Technology 
  
• Concluding Remarks 
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgements 
  
• Abbreviations 
  
• References 
  

Chapter 4 Molecular Modelling Approaches To Antibacterial Drug Design And Discovery 

• Agnieszka A Kaczor, Prasanthi Medarametla, Damian Bartuzi, Magdalena Kondej,
  
• Dariusz Matosiuk And Antti Poso
  
• Introduction 
  
• Challenges In Design And Discovery Of Antibacterial Drugs 
  
• Drug Targets For Antibiotics 
  
• Molecular Modelling Techniques For Design And Discovery Of
  
• Antibacterial Drugs 
  
• Protein 3D Structure Prediction 
  
• Comparative/Homology Modelling 
  
• Fold Recognition/Threading 
  
• Ab Initio Modelling 
  
• Protein Structure Prediction In Anti-Bacterial Drug Design 
  
• Molecular Docking 
  
• Molecular Docking As An Approach To Study Ligand-Protein Interactions 
  
• Application Of Molecular Docking In Anti-Bacterial Drug Discovery 
  
• Molecular Dynamics 
  
• Molecular Dynamics As An Approach To Study Dynamic Aspects Of Ligand-Protein
  
• Interactions 
  
• Application Of Molecular Dynamics For Antibacterial Drug Discovery 
  
• Qsar 
  
• Qsar As A Method Applied In Drug Design 
  
• Application Of Qsar For Antibacterial Drug Discovery 
  
• Pharmacophore Models 
  
• Importance Of Pharmacophore Models In Drug Design 
  
• Application Of Pharmacophore Models For Antibacterial Drug Discovery 
  
• Virtual Screening 
  
• Virtual Screening As A Method Of Searching Large Databases 
  
• Application Of Virtual Screening For Antibacterial Drug Discovery 
  
• Prediction Of Drug-Likeness And Admet Properties 
  
• Summary And Perspective 
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgements 
  
• References 
  

Chapter 5 Nucleic Acid Aptamers Against Virulence Factors Of Drug Resistant Pathogens 

• Canan Ozyurt, Ozge Ugurlu, Burhan Bora And Serap Evran
  
• Introduction 
  
• Selection Of Aptamers 
  
• Aptamers Against Toxins And Protein Virulence Factors 
  
• Aptamers Against Staphylococcal Toxins 
  
• Aptamers Against Clostridium Toxins 
  
• Aptamers Against E Coli Toxins 
  
• Aptamers Against Aspergillus And Penicillium Toxins 
  
• Aptamers Against Mycobacterium Tuberculosis Toxins 
  
• Aptamers Against Other Toxins 
  
• Aptamers Against Quorum Sensing Molecules 
  
• Modifications Of Aptamers For Improving Therapeutic Potential 
  
• 2'-F-Modified Rna Aptamers 
  
• 2'-Nh2 Modification Of Aptamers 
  
• Other Ribose Modified Aptamers 
  
• Phosphorothioate Modification 
  
• Nucleobase Modification Of Aptamers 
  
• Concluding Remarks 
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgement 
  
• References 
  

Chapter 6 Overcoming Fungal Multidrug Resistance By Natural Compounds Targeting Efflux Pumps 

• Shweta Singh, Sandeep Hans, Zeeshan Fatima
  
• And Saif Hameed
  
• Introduction 
  
• Candida Efflux Pumps 
  
• Abcs Transporter Family 
  
• Mfs Transporter Family 
  
• Natural Epi Targeting Abc Transporters 
  
• Natural Epi Targeting Mfs Transporters 
  
• Conclusion 
  
• Consent For Publication 
  
• Conflict Of Interest 
  
• Acknowledgements 
  
• References 
  

Chapter 7 The Infections And Hydrogen Sulfide 

Author

• Atta-ur-Rehman
  
• Iqbal Chaudhry