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Regenerative Medicine - Global Strategic Business Report Product Image

Regenerative Medicine - Global Strategic Business Report

  • ID: 338519
  • June 2014
  • Region: Global
  • 320 Pages
  • Global Industry Analysts, Inc

This report analyzes the worldwide markets for Regenerative Medicine in US$ Million. The report provides separate comprehensive analytics for the US, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets.

Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs.

The report profiles 46 companies including many key and niche players such as:

- AlloSource
- Anika Therapeutics, Inc.
- Biomet, Inc.
- Bioventus LLC
- DePuy Synthes Companies

Note: Product cover images may vary from those shown

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1. OUTLOOK
Regenerative Medicine: A Preface
An Overview of Regenerative Medicine in Bone and Joint Applications
Current and Future Analysis
Developed Markets Dominate, Developing to Drive Growth

2. REGENERATIVE MEDICINE A MACRO PERSPECTIVE

Regenerative Medicine
The Past, the Present, & the Future
Another Revolution in the Making?
Conventional Chemical Medicine Vs Regenerative Medicine
Regenerative Medicine
The Need of Modern Era
Regenerative Medicine Throws Up Several New Therapies
Current Global Market for Regenerative Medicine
Market Potential
Therapeutic Companies and Products in Regenerative Medicine
Current Status
Key Statistical Data
Table 1: Global Regenerative Medicine Industry Value by Activity/Segment (2012): Percentage Breakdown for Regenerative Therapies, Manufacturing & Services, and Tools & Non-Therapeutic Products (includes corresponding Graph/Chart)
Table2: Global Regenerative Medicines Market by Category (2012): Percentage Breakdown for Biopharmaceuticals, Cell and Tissue-Based Therapies, and Regenerative Devices & Compounds (includes corresponding Graph/Chart)
Table3: Global Market for Cell and Tissue-based Therapies (2012): Percentage Breakdown of Number of Therapies Being Tested or Sold (includes corresponding Graph/Chart)
Table4: Global Market for Cell and Tissue-based Therapies (2012): Percentage Breakdown of Number of Commercially Available Products by Application (includes corresponding Graph/Chart)
Table5: Clinical Development Pipeline of Cell and Tissue-Based Therapies by Stage (2012): Percentage Breakdown of Number of Products in Phase III or Pivotal Trials, Phase II Trials, Phase I Trials and Commercially Distributed (includes corresponding Graph/Chart)
List of Major Commercially Available Cell Therapy Products
Select Commercial Regenerative Medicine Products in the Global Market
Select Regenerative Products in Mid-to-Late-Stage Clinical Development
Growth Drivers for Regenerative Medicine
A Combination of Factors to Drive Regenerative Medicine Market
Burgeoning Global Population Offers Significant Growth Opportunities
Table 6: Top 25 Countries Worldwide in Terms of Population (2010 & 2013) (includes corresponding Graph/Chart)
Aging Global Population: Need for New Effective Treatments
Table 7: Global Population Statistics for the 65+ Age Group (2012) (includes corresponding Graph/Chart)
Table8: Over-65 Years Population as a % of Total Population (2010 & 2020P) (includes corresponding Graph/Chart)
Table9: Elderly Population (65+ Years) as a % of Total Population (2000 & 2025) (includes corresponding Graph/Chart)
Increasing Healthcare Spending in Emerging Markets: Opportunities in Store
Table 10: Healthcare Spending as % of GDP in Select Countries (2011) (includes corresponding Graph/Chart)
Scientific and Technological Advances in Associated Areas
Government Support and Increased Private Sector Participation
Investment and Funding Landscape
Major M&A Activity and Strategic Alliances in Regenerative Medicine: 2011-2013
Recent Advancements in the Science of Regenerative Medicine
Advanced Ceramics Gaining Preeminence in Regenerative Medicine Field
Table 11: Global Medical Ceramics Market (2013): Percentage Breakdown of Value Sales by Application (includes corresponding Graph/Chart)
3D Organ & Tissue Printing: Still in Early Stages
Nanotechnology in Regenerative Medicine
Advances in Nanotechnology Assist Regenerative Medicine
Issues to be Sorted Out
Need for New Scientific and Technological Standards
Standardized Guidelines
Clinical Translation
Collaboration of Multidisciplinary Skills is Essential
The Question of Apt Business Models
The Service and Product Approach
Autologous or Service Approach Preferred by European Firms
Allogenic or Product Approach
Slow to Develop
Regenerative Medicine Requires Improved Biomaterials
Assessment of Worldwide R&D Activities in the Area of Biomaterials
Investors Wary of Funding Regenerative Medicine
Regenerative Medicine Field Lags Behind due to Segregated Focus
Challenges Encountered by Regenerative Medicine
Scientific and Technological Challenges
Barriers in Sharing Intellectual Property Rights
Viable Manufacturing Technologies and Skilled Personnel Crucial
Strict Regulations Push up Operational Costs

3. BONE AND JOINT REGENERATIVE MEDICINE AN OVERVIEW

Bone Regenerative Medicine Presents Need for Advanced Therapies
Limitations and Drawbacks for Different Bone Grafts
Key Growth Drivers
Rising Incidences of Degenerative Intervertebral Disc Diseases
Table 12: % of Women Affected by Osteoporosis (includes corresponding Graph/Chart)
Increase in Prevalence of Arthritis and Other Orthopedic Disorders
Rise in Revision Orthopedic Surgeries
Increase in Spinal Fusions in Private Healthcare
Bone Grafts Market Maintains Positive Momentum
Applications of Bone Grafts: A Review
Spine Fusion
The Largest Bone Graft Indication
Dental Bone Grafting
A High Potential Market
Table 13: Global Dental Regeneration Market (2013E): Percentage Breakdown of Value Sales for Bone Allografts, Membranes, Tissue Regeneration (includes corresponding Graph/Chart)
What Drives Physicians’ Choice of Bone Grafts?
Patient Safety Emerges as a Top Priority
Bone Graft Substitutes (BGSs) Market: Showing Promising Potential
Commercially Available Bone Graft Substitutes
Growing Clinical Use of Bone Graft Substitutes in Surgical Procedures
Synthetic Bone Graft Substitutes to Replace Traditional Autografts and Allografts
Select Synthetic Products in Orthobiologics
Orthobiologics Gain Traction in the Bone Grafts Market
Table 14: Global Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Allograft & DBM, Blood & Marrow-based Products, Growth Factors, Hemostasis, Synthetic Bone Graft Substitutes and Viscosupplements (includes corresponding Graph/Chart)
Table15: Leading Players in the Global Orthobiologics Market (2013): Percentage Breakdown of Value Sales for Baxter, J&J/ Synthes, Medtronic, Sanofi, Stryker and Others (includes corresponding Graph/Chart)
Table16: Global Stem Cell Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Alphatec, Nuvasive and Otrhofix (includes corresponding Graph/Chart)
Increasing Visibility of Orthobiological Products to Spur Grafting Options
Autograft: Gold Standard for Bone Grafting Procedures
Allograft: Leading the Race over Autografts
Commercially Available Allograft and Xenograft Bone Products
Advanced Allografts Encroaching into the Use of Autografts in Surgical Procedures
Technological Advancements Drive the Market for Bone Grafts
Foot and Extremity Reconstruction
Promising Market for Bone Grafts
Precision Machined Allograft Gain Surgeon Preference
Unmet Clinical Needs to Foster R&D Engine
Biological Solutions in Sports Medicine
Beyond Bone Grafting
What Ails the Market?
Disease Transmission through Bone Grafts
A Major Safety Concern
Lack of Standards in Bone Graft Substitute Market
Reimbursement Issues Continue to Haunt Bone Grafts Market
Table 17: Payer Mix in Orthopedic-driven Surgeries Worldwide (2012) (includes corresponding Graph/Chart)
Regional Regulations & Religious Beliefs Hamper Bone Graft Substitutes Market
Synthetic Bone Grafts
Solution for Halal Bone Graft Implantation
Bone Glue
A Potential Threat to the Bone Graft Market
Alliances with Organ Procurement Organizations: A Shot in the Arm
Aging Baby Boomers Render a Decreased Donor Pool
Limited Availability of Donor Tissues
Intense Competition from Alternative Tissue Repair Therapies
Substitute Technologies Threaten to Replace Spinal Fusions
Bone Grafts Termed as Tissues Suffer From Inconsistent Patient Outcomes
BMPs and Other Synthetic Growth Factors
Bone Morphogenic Proteins (BMPs): Safety Concerns Led to Downfall
Bone Morphogenic Protein Products in Orthobiology
Demineralized Bone Matrices (DBMs) Market: Strong Growth but Tough Competition
Table 18: Global Demineralized Bone Matrix Market (2012): Percentage Breakdown of Value Sales for Altiva, Bacterin, Integra LifeSciences, Medtronic, Synthes/MTF and Others (includes corresponding Graph/Chart)
Commercially Available Demineralized Bone Matrix Products
Biomaterials Market
Promising Opportunities for Cost- Effective Products
Tissue Engineered Cartilage Market
An Overview
Tissue Engineered Cartilages
A Promising Solution for Cartilage Repair
Stem Cells to Support Tissue Engineering
Market Potential of Tissue Engineered Cartilage Products
Potential Applications of Tissue Engineered Cartilage Products
Commercially Available tissue engineered cartilage products
Challenges in Clinical Application of Tissue Engineered Cartilage Products
Bone Marrow Transplants (BMTs)
Market Potential for BMTs
Companies Engaged in CBSC Research for BMTs
Stem Cell Research
Not Just Another Medical Advancement
Sources of Stem Cells
Stem Cell Based Bone Grafts
Fastest Growing Bone Graft Substitute Segment
Commercially Available Cell Therapy Products for Orthopedic Applications
Regenerative Stem Cell Products for Spine and Orthopedics in Clinical Development
Progenitor Cell Therapy to Witness No Holds Barred Growth
Stem Cell Market on the Verge of Rapid Growth
Clinical Development in Adult stem cells Moves Ahead, Lurches in hESCs
Adult Stem Cell Research Eludes Ethical Dispute
Teratomas
No Longer an Impediment to Stem Cell Therapy Development
Induced Pluripotent
A Potential Competitor to hESCs?
Intricate Differences Exist between hESC and iPS Cells
Use of iPS for Regenerative Medicine
Mesenchymal Stem Cells for Regenerative Medicine
MSC based Models for Orthopedic Repair
Delivery of MSCs to Regions Requiring Therapy
MSCs in the Treatment of Osteoarthritis
MSCs in the Treatment of Rheumatoid Arthritis
Scientific and Technological Challenges in Orthopedic Regenerative Market
Bone Regeneration
Clinical Approaches in Bone Regeneration and Their Limitations

4. COMPETITIVE LANDSCAPE

Bone Grafts: A Highly Fragmented Market
Bone Growth Stimulation Market
Table 19: Global Bone Growth Stimulation Market (2012): Percentage Breakdown of Value Sales for Biomet, Bioventus, DJO and Orthofix (includes corresponding Graph/Chart)

5. REGENERATIVE MEDICINE IN OTHER AREAS

Wound Healing
The Second Largest Segment
Tissue Engineered Skin Substitutes: Potential Substitutes for Skin grafts
Commercially Available Tissue Engineered Skin Substitutes
Cardiology
Promising Opportunities
Select Stem Cell Products in the Development for CV Indications
Diabetes
Highly Effective Innovative Treatments
Regenerative Medicine Products in Development Pipeline for Diabetes
Neurodegenerative Diseases
Great Potential
Body Sculpting/Cosmetics
High Potential
Platelet Rich Plasma Treatment Gains Popularity
Genetic Disorders
Osteoarthritis
Orthopedic Oncology
What’s in Store?
Regenerative Medicine to Arrest Ageing?
Thriving on an Aging World Population
Faster Healing Process
Regenerative Medicine to Overcome Donor Organs Shortage
Possible Scenarios

6. REGULATORY ENVIRONMENT

Global Regulatory Landscape
US
FDA Classification of Bone Products
Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps)
Good Tissue Practices
DBM-based Products in US
Synthetic Bone Graft Substitutes
Tissue Banking Regulation
FDA Regulations on Xenograft
EU
Japan
Regulatory Norms Governing Embryonic Stem Cell Research
Human Embryonic Stem Cell Regulation in Select Countries Worldwide
The IP Scenario in the Embryonic Stem Cells Research
Diversity in Patent Regimes Pose Tremendous Challenges
International Divide on Patenting Dents hESC Research

7. A PEEK INTO THE GLOBAL ORTHOPEDIC INDUSTRY

Orthopedic Industry: An Overview
Table 20: Fractures by Age Group (2012): Percentage Breakdown of Number of Fractures by Age Group (includes corresponding Graph/Chart)
Table21: Global Orthopedic Market by Segment (2013E): Percentage Breakdown of Value Sales for Extremities, Hips, Knees, Orthobiologics, Spice, Trauma and Others (includes corresponding Graph/Chart)
Medical Devices and Implants for Orthopedics
Expanding Opportunities in Hip and Knee Market
Extremity Reconstruction
A Growing Market
Is Consolidation Blowing in the Wind?
Product Mix of Reconstructive Devices Companies
Key Statistics in Global Orthopedics Industry
Table 22: Worldwide Orthopedic Market (2013E): Percentage Breakdown of Value Sales by Company for DePuy Synthes, Medtronic, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
Table23: Worldwide Market for Orthopedic Implants in Spinal Procedures (2013E): Percentage Breakdown of Value Sales by Company for J&J, Medtronic and Others (includes corresponding Graph/Chart)
Table24: Worldwide Market for Orthopedic Implants for Reconstructive Procedures (2013E): Percentage Breakdown of Value Sales by Company for Biomet, J& J, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
Table25: Worldwide Market for Orthopedic Implants for Trauma Procedures (2013E): Percentage Breakdown of Value Sales by Company for Biomet, J&J, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
Table26: Global Joint Replacement Market (2013E): Percentage Breakdown of Sales for Biomet, DePuy Synthes, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
Bone Grafts & Joint Revision Arthroplasty
Table 27: Worldwide Orthopedic Large Joint Market by Segment (2013E): Percentage Breakdown of Value Sales for Hip, Knee and Spine (includes corresponding Graph/Chart)
Table28: Worldwide Orthopedic Extremities Market by Segment (2013E): Percentage Breakdown of Value Sales for Foot/Ankle, Shoulder, Wrist/Finger and Elbow (includes corresponding Graph/Chart)

8. RESEARCH AND DEVELOPMENT

Tissue Engineers Found New Biomaterial for Stimulating Cartilage Growth
Chrysalis Develops Chrysalin® Drug for Stimulating Tissue Growth
Innovative Artificial Implants Hold Promise for Bone Injuries
Bone Marrow Grafts Exhibit Promise for Low-Back Pain Patients
Charged Nanoparticles Hold Potential to Heal Cracked Bones
Silk Scaffolds with Excellent Mechanical Properties to Facilitate Bone Formation
New Fusion Protein to Stimulate Bone Tissue Regeneration
Researchers Develop Human Heart Tissues with Autonomous Beating
Scientists at Free University of Brussels Develop Thyroid Cells of Mice
Scientists Demonstrate New Source of Skin for Reconstructive Procedures
Instron TGT Bioreactor Stimulates Cell Growth by Applying Hydrostatic Pressure
New Ways of Fixing Broken Bones
BoneCure Sleeve
Heading Towards the Human Market
Bioactive Glass
Suitable for Weight Bearing Portion
Neural Stem Cell to Restore Memory Functioning
Pancreatic Islet Cells to Control Blood Sugar in Diabetics
Therapeutic Cloning to Cure Parkinson’s

9. PRODUCT OVERVIEW

Regenerative Medicine
An Introduction
Bone Replacements/Grafting: Introduction
Bone Grafts: A Peek into their Mechanism of Action
Types of Bone Grafts
Scoring of Osteoconduction, Osteoinduction, and Osteogenesis Properties of Bone Grafts by Type
Autografts
Standard Allografts
Machined Bone Allografts
Demineralized Bone Matrix
Bone Morphogenetic Proteins (BMPs)
Basic Functions of TGF-Beta
Synthetic Bone Grafts
Collagen-based Matrices
Ceramic: A Material of Choice
Hydroxyapatite: A Major Calcium Phosphate Based Ceramic
Calcium Sulfate
Polymer Based Bone Grafts
Coral: A Valuable Synthetic Graft Material
Electrical Bone Growth Stimulators
Internal Bone Growth Stimulators
External Bone Growth Stimulators
Cell and Tissue-based Therpies
Stem Cells-Based Therapies
Bone Tissue Engineering
Hybrid Materials
Osteoinductive Materials
Immuno-modulatory Biomaterials
Advanced Hydrogels
Biodegradable Scaffolds

10. PRODUCT INNOVATIONS/INTRODUCTIONS

AlloSource Introduces AlloMend™
Orthofix Launches Trinity® ELITE™
Synergy Biomedical to Introduce Biosphere Putty
K2M Launches VENADO Bone Graft Systems
K2M Introduces Vesuvius DBM Putty
The Center for Regenerative Medicine Rolls Out Genorthix System
RTI Surgical Introduces BioReady™ DBM Putty
K2M Rolls Out VESUVIUS Osteobiologic Systems
BioHorizons Introduces MinerOss® Cancellous
Amedica Introduces Dynamic Bone
Orthogen Introduces NanoGen
SIRAKOSS Introduces MaxSi
BioMimetic Therapeutics to Launch Augmatrix™ Biocomposite Bone Graft
Orthofix International Introduces Collage™ Osteoconductive Scaffold
TGA Clears BioMimetic’s Augment® Bone Graft for Commercialization in Australia
Medtronic Launches ARTISAN™ Space Maintenance System
NovaBone Adds MacroPor-Si+ to its Portfolio
RTI Surgical Announces First Implantation of map3™
Integra Receives FDA Clearance for Accell Evo3
RTI Surgical Introduces BioAdapt™ DBM Foam
Integra Unveils Trel-Xpress™ Demineralized Bone Matrix
Keystone Dental Introduces DynaMatrix™ Plus
Wright Introduces FUSIONFLEX™ Demineralized Moldable Scaffold
Micromedics Launches OsteoXpress 15cc Bone Graft Delivery Device
Bacterin Unveils OsteoSponge®SC

11. RECENT INDUSTRY ACTIVITY

Aastrom Biosciences Acquires Cell Therapy and Regenerative Medicine Business of Sanofi
Olympus to Sell the OP-1 Plant
Wright Medical Group Divests OrthoRecon Business
RTI Biologics Acquires Pioneer Surgical Technology
Bioventus and Pfizer Enter into Agreement
AlloSource Enters into Partnership with Humacyte
Wright Medical Group Acquires BioMimetic Therapeutics
BioTime Inks Definitive Deal with Geron for Stem Cell Assets
Histogen Establishes PUR Biologics Joint Venture to Develop Biologic Products
Vitro Diagnostics to Acquire and Merge with Neuromics
Mesoblast Group Takes Over Osiris’ Culture- Expanded Mesenchymal Stem Cell Business
ThermoGenesis and TotipotentRx Enter into Definitive Merger Agreement
KCI and LifeCell Merge
Sistemic and Roslin Cells Collaborate with Scottish Development International
360ip and CCRM Join Forces
Olympus Biotech and BonAlive Enter into Multi-Year Exclusive Distribution Agreement
Mesoblast's Singapore Unit Obtains the US FDA Approval for Production of MPCs
Cellectis bioresearch Inks Collaboration Agreement with Stemgent
Bonesupport Receives CE Mark Approval for Cerament|G resorbable
Dainippon Sumitomo Pharma Establishes Regenerative and Cellular Medicine Office
StemCells Partners with R Biomedical
Essex Woodlands Launches Bioventus
J&J Takes Over Synthes
EastBridge Merges with Cellular Biomedicine
Baxter Acquires Synovis
Cytomedix Acquires Aldagen
BioMimetic Therapeutics Secures CE Mark Approval for GEM 21S® in EU
EMD Millipore Collaborates with Centre for Commercialization of Regenerative Medicine
American CryoStem Associates with Alliance for Regenerative Medicine
Stryker Acquires Orthovita
Zimmer Dental and Curasan Enter into Distribution Agreement
NuVasive Signs Licensing Agreement with AlloSource
Histogenics Takes Over ProChon Biotech

12. FOCUS ON SELECT PLAYERS

AlloSource (US)
Anika Therapeutics, Inc. (US)
Biomet, Inc. (US)
Bioventus LLC (US)
DePuy Synthes Companies (US)
DePuy Spine, Inc. (US)
Exactech, Inc. (US)
Histogenics Corp. (US)
Integra LifeSciences Holdings Corp (US)
LifeCell Corporation (US)
LifeNet Health, Inc. (US)
Medtronic, Inc. (US)
NovaBone Products LLC (US)
NuVasive, Inc. (US)
Orthofix International N.V. (Netherlands)
Osiris Therapeutics, Inc. (US)
Smith & Nephew Plc (UK)
Stryker Corporation (US)
TiGenix N.V. (Belgium)
Wright Medical Technology, Inc. (US)
BioMimetic Therapeutics LLC (US)
Zimmer Holdings, Inc. (US)

13. GLOBAL MARKET PERSPECTIVE

Table 29: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region
US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table30: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region
US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table31: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region
Percentage Breakdown of Dollar Sales for US, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)
Regenerative Medicine Market by Segment
Table 32: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Segment
Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table33: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Segment
Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table34: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Segment
Percentage Breakdown of Dollar Sales for Bone Replacements, Bone Stimulators, and Tissue Replacements Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

A.Market Analysis
Current and Future Analysis
US to Retain Leadership Position
The Strength of US in Regenerative Medicine
A Glance
Factors Driving the US Market of Regenerative Medicine
High Potential for Regenerative Medicine in Orthopedics
Regenerative Medicine in Bone and Joint Applications
Regenerative Therapy
Best Fit for Joint Problems
Bone Grafts Market
An Insight
Bone Graft Substitutes Market: Opportunities for Growth
Aging Population: A Strong Demographic Driver
Table 35: North American Elderly Population by Age Group (1975-2050) (includes corresponding Graph/Chart)
Table 36: US Population Breakdown by Age Group (2012) (includes corresponding Graph/Chart)
Rising Incidence of Degenerative Intervertebral Disc Diseases
Back Pain
Arthritis
Table 37: % of Population Diagnosed with Arthritis by Age Group (includes corresponding Graph/Chart)
Osteoporosis
Table 38: Osteoporosis Population in the US: 2002, 2005, 2008 & 2012 (includes corresponding Graph/Chart)
Table39: Breakdown of Osteoporotic Fractures by Site in the US (includes corresponding Graph/Chart)
Rise in Revision Orthopedic Surgeries Boosts Demand
Increasing Visibility of Orthobiological Products to Spur Grafting Options
Synthetic Bone Grafts to Fan Growth
Spinal Surgery Market: Opportunity for Bone Grafts Market
Dental Bone Graft Substitutes Market: An Overview
Orthopedic Biomaterials Market
An Overview
Regulatory Challenges Limit Growth in the US Orthopedic Biomaterials Market
Orthobiologics Market
Overview
Adequate Reimbursement: An Impetus for Growth & Profitability
Table 40: Payer Mix for Spinal (Cervical) Fusion Procedures in the US (includes corresponding Graph/Chart)
Table41: Payer Mix for Spinal (Lumbar) Fusion Procedures in the US (includes corresponding Graph/Chart)
Competitive Scenario
Standard Bone Allografts
Table 42: US Market for Standard Bone Allografts (2012): Percentage Market Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart)
Machined Bone Allografts
Table 43: US Market for Machined Bone Allografts (2012): Percentage Market Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart)
Demineralized Bone Matrix (DBM)
Table 44: Leading Players in the US DBM Market (2012): Percentage Breakdown of Sales for Bacterin, Exactech, Integra, Medtronic, RTI Surgical, Stryker, Synthes/ DePuy Spine, Wright Medical and Others (includes corresponding Graph/Chart)
Synthetic Bone Graft Substitutes
Table 45: US Market for Synthetic Bone Graft Substitutes (2012): Percentage Share Breakdown of Value Sales by Company for Biomet, J&J, Stryker, Wright Medical and Others (includes corresponding Graph/Chart)
Stem Cell Market Outlook
Millions of American Patients Put their Hope in Stem Cell Research
Rapidly Ageing Population Also Spurs Demand for MSC based Therapies
Rising Governmental Investments in Stem Cell Therapies
A Growth Booster
Regenerative Medicine
Other Areas of Application
Regenerative Medicine
Face of Future Revolution in Cardiology
Regenerative Medicine in Wound Healing
The Most Widespread Application
Regenerative Medicine in Diabetes
A Number of Emerging Applications
Regenerative Medicine
A Ray of Hope for Neurodegenerative Disease Patients
CBI’s Human Tissue Products for Treating Liver Failure and Diabetes
Market for Liver and Pancreas Transplantation
Implantable Regenerative Products Take Over Sports Medicine
Challenges in the Area of Product Development
Process of Integration Continues
Scientific and Technological Challenges to be Tackled
Dominant Patents a Cause of Concern
Product Innovations/Introductions
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 46: US Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table47: US Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

2. JAPAN

A.Market Analysis
Current and Future Analysis
Market Overview
The Discovery of iPS Cells Lends Traction
Drug Development
A Major Application for iPS
Use of iPS for Regenerative Medicine
Intractable and Congenital Disease Treatments
Research & Development Rife in iPS Cells Space
Japan Gears Up to Devise Standards for Regenerative Medicine Products
Japan Revises the Pharmaceutical Affairs Law
General Trends in Regenerative Medicine Industry
Research Activity in Regenerative Medicine Field
More Companies Eye the Regenerative Medicine Potential
Competition Heats up Behind Closed Doors
Japanese Firms Need to Catch Up with US and European Competitors
Science Ministry Rolls Out Regenerative Medicine Project
Regenerative Medicine Exempted from Ban on Human Cloning
Strategic Corporate Development
B.Market Analytics
Table 48: Japanese Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table49: Japanese Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

3. EUROPE

A.Market Analysis
Current and Future Analysis
Great Potential for Regenerative Medicine
Challenges Faced by European Regenerative Medicine Industry
Financial Viability
A Growing Concern in the Backdrop of Euro Crisis
Recession Drubs Orthopedic Biomaterials Market
Table 50: European Bone Graft Substitutes Market by Type (2012): Percentage Share Breakdown of Value Sales for Allograft, DBM and Synthetic (includes corresponding Graph/Chart)
Synthetic Bone Graft Market Drives the BGS Market
Bone Morphogenetic Protein (BMP) Market
Dental Biomaterials Market in Europe: An Insight
Key Statistical Data
Table 51: European Market for Standard Bone Allografts by Leading Companies/Organizations (2012): Percentage Share Breakdown of Value Sales for LifeNet Health, Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart)
Table52: European Market for Machined Bone Allografts by Leading Companies/Organizations (2012): Percentage Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart)
Table53: European Market for Demineralized Bone Matrix by Leading Companies/Organizations (2012): Percentage Market Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical, Wright Medical Technology and Others (includes corresponding Graph/Chart)
Table54: European Market for Bone Graft Substitutes by Leading Players (2012): Percentage Share Breakdown of Value Sales for Biomet, Medtronic, Stryker, Wright Medical Technology, Zimmer and Others (includes corresponding Graph/Chart)
The Need to Embrace Newer Technologies
Complex Regulatory Scenario with Multi-tier Governance System
Need for More Integration
Policies Regarding Egg Procurement Weigh Down Research Progress
Need for Harmonized Clinical Trial Regulation
International Alliances
Outsourcing Options with Developing Countries
Patenting Issues in hESC Research
Ageing Population to Drive Demand for MSC based Therapies
Table 55: Population Breakup by Age Group for Select European Countries: 2012 (as a Percentage of Total Population) (includes corresponding Graph/Chart)
Overview of Select Regional Markets
Germany
United Kingdom
Research Councils Announce Ambitious Project to Support Regenerative Medicine
Barriers to Commercialization
Product Launches
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 56: European Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table57: European Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4. ASIA-PACIFIC

A.Market Analysis
Current and Future Analysis
Dental Bone Graft Substitutes and Biomaterials Market
An Overview
Table 58: Over 65 Years Individuals as % of Total Population in Select Asian Countries (includes corresponding Graph/Chart)
Overview of Select Regional Markets
China
Substantial Government Support
Orthopedic Biomaterials Market Poised for Robust Growth
India
High Growth Opportunities
Orthopedic Biomaterials and Dental Bone Grafts Market
An Insight
Rise in Medical Tourism Drives Bone Grafts Market
Adult Stem Cells
A Highly Money-Spinning Market
South Korea
Malaysia
Singapore
Product Innovations/Introduction
Strategic Corporate Development
B.Market Analytics
Table 59: Asia-Pacific Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table60: Asia-Pacific Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

5. REST OF WORLD

A.Market Analysis
Current and Future Analysis
Overview of Select Regional Markets
Canada
A Significant Player in the Field of Regenerative Medicine
Favorable Growth Prospects in Bone Graft Substitutes Market
University of Toronto
Spearheading Regenerative Medicine Research
Latin America
Argentina
Brazil
Highly Promising but Challenges Remain
Overview of Brazilian Orthopedic Devices Market
Middle East
Israel
Stem Cell Research in Full Swing
Strategic Corporate Developments
B.Market Analytics
Table 61: Rest of World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
Table62: Rest of World Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market
Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 46 (including Divisions/Subsidiaries 51)
The United States (38)
Europe (11)
Germany (2)
The United Kingdom (2)
Rest of Europe (7)
Asia-Pacific (Excluding Japan) (1)
Africa (1)

Note: Product cover images may vary from those shown
Note: Product cover images may vary from those shown

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