Contents:

CARDIOVASCULAR CATHETERS AND SYSTEMS A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 A. Diagnostic Catheters I-4 Angiography Catheters I-4 Electrophysiology (EP) Mapping Catheters I-4 B. Therapeutic Catheters I-4 Rapid -Exchange PTCA Balloon Catheter I-4 Over-The-Wire PTCA Balloon Catheter I-4 Electrophysiology Ablation Catheters I-5 Atherectomy Catheters I-5 Perfusion and Fixed Balloon Catheters I-5 Guide Catheters I-5 II. Executive Summary 1. Market Overview II-1 Technological Advancements to Drive Growth II-1 Worldwide Cardiovascular Catheters Market II-1 Market Trends & Issues II-2 Lack of Pharmacological Alternatives Boost Demand for Cardiovascular Catheters II-2 Energy-Based Solutions Compete with Conventional Interventional Systems II-2 Repeat Interventional Procedures Affected by the Advent of Drug-Eluting Stents II-2 RF Catheter Ablation Gains Popularity II-3 Molding Material and Technology II-3 Diagnostic Catheters - Advance from the Workhorse 8 Fr II-3 Smaller the Better II-3 PTCA Catheters - Affected by Direct Stenting II-4 Angioplasty - Under Price Pressure II-4 Restenosis - The Unsolved Problem II-4 New Pharmacological Therapies - Minimizing the Need for Interventional Procedures? II-4 2. Competitive Scenario II-6 Cardiovascular Catheters - Highly Concentrated Market II-6 Table 1: Leading Players in Global Angioplasty / Angiography Catheter Market (2004 & 2005E): Percentage Breakdown of Value Sales for Boston Scientific Johnson & Johnson, Guidant, Medtronic, and Others (includes corresponding Graph/Chart) II-6 Table 2: Leading Players in Global Guide Catheters Market (2004 & 2005): Percentage Breakdown of Value Sales for Johnson & Johnson, Boston Scientific, Guidant, Medtronic and Others (includes corresponding Graph/Chart) II-7 Table 3: Leading Players in Global Electrophysiology (EP) Catheter (Mapping and Ablation) Market (2004 & 2005): Percentage Breakdown of Value Sales for Johnson & Johnson, St. Jude Medical, Boston Scientific,C.R.Bard and Others (includes corresponding Graph/Chart) II-7 Balloon Catheters II-8 Table 4: Leading Players in Global Balloon Catheter Market (2004 & 2005): Percentage Breakdown of Value Sales for Boston Scientific, Guidant, Medtronic, Johnson & Johnson and Others (includes corresponding Graph/Chart) II-8 3. Catheterization - The Procedure II-9 Historical Perspective II-9 Cardiac Catheterization: Most Accurate of all Cardiac Diagnostic Examinations II-9 4. Product Profile II-10 Catheters II-10 Designing of Specialized Catheters II-10 Factors Determining Competitiveness II-10 Preventing Infection II-10 Catheter Related Infections II-10 Flow and Sealing Capability II-10 Safety II-11 System Suitability and Comprehensiveness II-11 Ease of Insertion II-11 Maneuverability II-11 Cardiovascular Catheters - Product Group/Segment Overview II-11 A. Diagnostic Catheters II-12 Angiography Catheters II-12 Electrophysiology (EP) Mapping Catheters II-12 Purpose II-12 Scope of Electrophysiology Studies II-13 Precaution II-13 B. Therapeutic Catheters II-13 Catheters Designed for Therapeutic Procedures II-13 Angioplasty: Where is it Used? II-13 Types of Angioplasty II-13 Percutaneous Transluminal Coronary Angioplasty or PTCA II-14 PTCA Catheters II-14 Types of Balloon Catheters II-14 Rapid -Exchange PTCA Balloon Catheter II-14 Over-The-Wire PTCA Balloon Catheter II-15 Electrophysiology Ablation Catheters II-15 Atherectomy Catheters II-16 Perfusion and Fixed Balloon Catheters II-16 Guide Catheters II-16 5. An Overview of The CVD Market II-17 Heart - Historic Facts and Figures II-17 Table 5: Number of Deaths from Circulatory Disorders Worldwide by Region (2002) (in ‘000) (includes Corresponding Graph/Chart) II-17 Interventional Cardiology II-17 PTCRA - The procedure II-18 Interventional Cardiology Market in the US & Europe - A Comparison II-18 Radiation Therapy (Brachytherapy) II-19 An Insight into Cardio Vascular Diseases II-19 Coronary Artery Disease (CAD) II-19 Definition II-19 Causes and Symptoms II-19 Major Risk Factors II-20 Non-Controllable Risk Factors II-20 Heredity II-20 Sex II-20 Age II-20 Controllable Risk Factors II-20 Treatment II-20 Angina Pectoris II-21 Arrhythmias II-21 Atrial Fibrillation - A Common Arrhythmia II-21 More in Women II-22 Stroke II-22 Congestive Heart Failure II-22 Key Terms (For Reference) II-22 Angina II-22 Aneurysms II-23 Angiography II-23 Angioplasty II-23 Aortic Valve II-23 Atherosclerosis II-23 Bradycardia II-23 Catheter II-23 Coronary Arteries II-23 Echocardiogram II-23 Electrocardiogram II-23 Electrophysiology (EP) study II-23 Pacemaker II-24 Plaque II-24 HDL Cholesterol II-24 LDL Cholesterol II-24 Stenosis II-24 Stroke II-24 Tachycardia II-24 6. Technological Developments II-25 US-Based Inventors Granted Patent for Perfusion Balloon Angioplasty Catheter II-25 California Scientists Create Intravascular Balloon Catheters for Angioplasty Procedures II-25 Minnesota Scientists Develop New Ablation Catheter II-25 American Inventor Devises Drug Delivery Balloon Catheter II-25 US-Based Inventors Create Atherectomy Catheter II-25 US-Based Inventors Develop Atherectomy Device for Treatment of Occlusions II-26 US-Based Inventor Creates New Ablation Catheter System II-26 Japanese Inventor Creates RF Thermal Balloon Catheter II-26 7. Product Innovations/Intorductions II-27 Stereotaxis Obtains FDA Approval for 8mm Magnetic Ablation Catheter II-27 ClearStream Gains FDA Approval for PTA Angioplasty Balloon Catheters II-27 AngioSculpt® Gains Japanese Approval for AngioSculpt® Catheter II-27 Cordis Introduces Fire Star Rx and Dura Star Rx Catheters II-27 Cordis Introduces AVIATOR™ Catheter II-28 FlowCardia Introduces CROSSER Catheter Product Line II-28 Medtronic’s Sprinter® Catheter Gains CE Mark Approval II-28 St. Jude Gains CE Mark & FDA Approvals for Therapy™ Cool Path™ Catheter II-28 FDA Clears Venture™ Catheter Use with Rapid Exchange Delivery Platform II-29 Eurocor Unveils DIOR Catheter in Germany II-29 FDA Approves InnerChange Micro-Introducer Catheter II-29 Stereotaxis Gains EU Approval Magnetic Irrigated Ablation Catheter II-29 Atrium Medical Obtains CE Mark for ClearWay™ RX Catheter II-29 Lumen Gains FDA Approval for Large Sized Xtract™ Catheters II-30 Opto Circuits Achieves CE Mark Approval for its Catheter II-30 FDA Approves Abiomed’s Impella 5.0 Catheter-Based Circulatory Support Systems II-30 Medical Ventures Gains CE Mark Approval for Metricath Gemini® Balloon-Catheter II-31 St. Jude Receives Regulatory Approval for its Safire Ablation & Inquiry Optima Plus Catheters II-31 Boston Scientific Introduces Sterling™ Monorail® Balloon Dilatation Catheter II-31 St. Jude Receives Approval to Market EnSite® System in Japan II-31 Merit Medical’s Impress Diagnostic Catheter Gains CE Mark & FDA Approvals II-31 Medtronic Gains FDA Approval for Export® XT spiration Catheter II-32 Medtronic Obtains CE Mark Approval to Market Melody™ and Ensemble™ System II-32 Boston Scientific Gains FDA Approval for its Rio™ Aspiration Catheter II-32 Possis Introduces AngioJet® Spiroflex®Rheolytic Thrombectomy Catheter II-32 Boston Scientific Launches Chilli II Cooled Ablation Catheter II-33 Terumo Introduces PTCA Catheter with the Smallest Diameter II-33 Japan Lifeline Introduces OTTIMO ROSSO Balloon atheter for PTCA Procedures II-33 FDA Clears St. Jude’s Therapy™ EP & IBI-1500T6 Cardiac Ablation Generator Catheters II-33 Terumo Introduces Heartrail II PTCA Guiding Catheter II-33 FDA Grants Approval to Alliance for Reprocessing AcuNav™ Ultrasound Catheter II-34 Cook Introduces New ATB® PTA Dilatation Catheter II-34 St. Jude Unveils New Venture™ Wire Control Catheter Across the United States II-34 Possis Medical Adds Two New Catheters to its AngioJet® Rheolytic™ Thrombectomy Line II-34 Cook Introduces CODA for Endovascular Market II-34 Spectranetics Develops Laser Catheter for Peripheral Vascular Disease II-35 Medrad Inc Introduces Avanta™ Fluid Management Injection System and Vanguard Dx™ Angiographic Catheter II-35 Medtronic Releases Medtronic Attain Select 6238 TEL Guide Catheter II-35 AngioScore Receives CE Mark Approval for its AngioSculpt Scoring Balloon Catheter II-35 Spectranetics Introduces New Catheters II-36 Guidant Corporation Unveils VOYAGER™ Coronary Dilatation Catheter II-36 Medtronic Introduces Two New Catheters II-36 8. Recent Industry Activity II-37 Micrus Enters into Agreement with Genesis II-37 Teleflex Acquires Arrow International II-37 FoxHollow Merges with ev3 II-37 J&J Bags Marketing Rights for Topspin’s Catheter II-38 Cordis to Market ClearStream Technologies’ Catheters II-38 Relisys to Establish Catheter Production Facility in India II-38 Boston Scientific Acquires Guidant II-38 Abbott Acquires Guidant’s Vascular Business II-39 Cordis in Distribution Agreement with Brivant II-39 Cordis Enters into Definitive Agreement to Distribute ClearStream’s PTCA Balloon Catheter II-39 St. Jude and GE Healthcare Collaborate to Develop Advanced Technologies for Cardiac Procedures II-40 Bard Acquires Venetec International II-40 Koninklijke Philips Takes Over Witt Biomedical II-40 FoxHollow Enters into Definitive Agreement to Acquire Kerberos II-40 Biosense Recieves Expanded Indication for NAVISTAR® THERMOCOOLÒ Catheter for Treatment of Ventricular Tachycardia II-40 Hansen Medical Completes Clinical Trial for Sensei Robotic Catheter System II-40 Biosense and Siemens Enter into Strategic Alliance Involving Catheters II-41 Recom Inks MOU with TZ Medical to Develop Cardiac Catheters II-41 Cordis Takes Over LuMend II-41 Hansen Medical Enters into Cross-Licensing Agreement with Intuitive Surgical II-42 Hansen Medical Acquires Intellectual Assets of endoVia Medical II-42 Micrus Takes Over VascularFX II-42 St. Jude Medical Acquires Endocardial Solutions II-42 St. Jude Medical Acquires Velocimed II-42 FlowCardia Bags European Approval for Crosser Catheter II-43 AVI BioPharma Regains Full Control on Resten-NG Antisense Therapy II-43 Boston Scientific Acquires Precision Vascular Systems II-43 Edwards Lifesciences Acquires PVT II-43 St. Jude Medical Acquires IBI II-43 St. Jude Medical Takes Over Epicor Medical II-44 Merit Medical Systems Inks an Agreement with Novation II-44 Rochester Medical Enters into a Supply Agreement with Hollister II-44 CardioTech International Enters into a Licensing Agreement with BAS II-44 CryoCor’s Model 1200 Cardiac Catheter Series Receives FDA Clearance II-44 CryoCath’s Freezor MAX Catheter Device Receives FDA Clearance II-44 LubriLAST™-coated Catheters Receives MOHLW Clearance II-45 Abbott Laboratories Acquires Assets of JOMED II-45 JOMED Sells IVUS and Functional Management Business to Volcano Therapeutics II-45 Boston Scientific in Alliance with Corautus Genetics II-45 Mogul Obtains FDA Approval for Diagnostic Catheters II-45 9. Focus on Select Global Players II-46 Abbott Laboratories (USA) II-46 Boston Scientific (USA) II-46 C.R. Bard, Inc. (USA) II-47 Cardima, Inc. (USA) II-47 CryoCath Technologies Inc. (Canada) II-47 Edwards Lifesciences Corporation (USA) II-48 EP Medsystems (USA) II-48 Johnson & Johnson (USA) II-48 Cordis Corporation (USA) II-49 Biosense Webster (USA) II-49 Medtronic (USA) II-50 Merit Medical Systems, Inc. (USA) II-50 St. Jude Medical (USA) II-51 Endocardial Solutions, Inc. (USA) II-51 Teleflex Medical (USA) II-52 Terumo Medical Corporation (Japan) II-52 10. Global Market Perspective II-53 Table 6: World Recent Past, Current & Future Analysis for Cardiovascular Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-53 Table 7: World Long-term Projections for Cardiovascular Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-54 Table 8: World 10-Year Perspective for Cardiovascular Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-55 Table 9: World Recent Past, Current & Future Analysis for Diagnostic Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includescorresponding Graph/Chart) II-56 Table 10: World Long-term Projections for Diagnostic Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-57 Table 11: World Recent Past, Current & Future Analysis for Diagnostic Catheters by Product Segment - Angiography Catheters and EP Mapping Catheters Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-58 Table 12: World Long-term Projections for Diagnostic Catheters by Product Segment - Angiography Catheters & EP Mapping Catheters Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-58 Table 13: World 10-Year Perspective for Diagnostic Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-59 Table 14: World 10-Year Perspective for DiagnosticcCatheters by Product Segment - Percentage Breakdowncof Dollar Sales for Angiography Catheters and EP Mapping Catheters Markets for Years 2003, 2008 & 2012 II-59 Table 15: World Recent Past, Current & Future Analysis for Angiography Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzedcwith Annual Sales Figures in US$ Million forcYears 2000 through 2010 (includes corresponding Graph/Chart) II-60 Table 16: World Long-term Projections for Angiography Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-61 Table 17: World 10-Year Perspective for Angiography Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe,Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-62 Table 18: World Recent Past, Current & Future Analysis for EP Mapping Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-63 Table 19: World Long-term Projections for EP Mapping Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-64 Table 20: World 10-Year Perspective for EP Mapping Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-65 Table 21: World Recent Past, Current & Future Analysis for Therapeutic Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-66 Table 22: World Long-term Projections for Therapeutic Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-67 Table 23: World Recent Past, Current & Future Analysis for Therapeutic Catheters by Product Segment - Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-68 Table 24: World Long-term Projections for Therapeutic Catheters by Product Segment - Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-68 Table 25: World 10-Year Perspective for Therapeutic Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-69 Table 26: World 10-Year Perspective for Therapeutic Catheters by Product Segment - Percentage Breakdown of Dollar Sales for Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-70 Table 27: World Recent Past, Current & Future Analysis for Rapid-Exchange PTCA Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-71 Table 28: World Long-term Projections for Rapid-Exchange PTCA Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-72 Table 29: World 10-Year Perspective for Rapid-Exchange PTCA Balloon Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-73 Table 30: World Recent Past, Current & Future Analysis for Over-the-Wire PTCA Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-74 Table 31: World Long-term Projections for Over-the-Wire PTCA Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-75 Table 32: World 10-Year Perspective for Over-the-Wire PTCA Balloon Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-76 Table 33: World Recent Past, Current & Future Analysis for EP Ablation Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-77 Table 34: World Long-term Projections for EP Ablation Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-78 Table 35: World 10-Year Perspective for EP Ablation Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-79 Table 36: World Recent Past, Current & Future Analysis for Atherectomy Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-80 Table 37: World Long-term Projections for Atherectomy Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-81 Table 38: World 10-Year Perspective for Atherectomy Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-82 Table 39: World Recent Past, Current & Future Analysis for Perfusion and Fixed Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-83 Table 40: World Long-term Projections for Perfusion and Fixed Balloon Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-84 Table 41: World 10-Year Perspective for Perfusion and Fixed Balloon Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-85 Table 42: World Recent Past, Current & Future Analysis for Guide Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-86 Table 43: World Long-term Projections for Guide Catheters by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-87 Table 44: World 10-Year Perspective for Guide Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Latin American Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-88 III. MARKET 1. The United States III-1 A.Market Analysis III-1 Current & Future Analysis III-1 Cardiovascular Catheters Market III-1 Competition III-1 Table 45: Leading Players in the US Cardiovascular Catheters Market (2005): Percentage Breakdown of Value Sales for Boston Scientific, Cordis (J&J), Guidant Corporation, Medtronic, and Others (includes corresponding Graph/Chart) III-2 Arrhythmia Management Products III-3 Cardiovascular Disease in the US - An Insight III-3 Table 46: Prevalence of Cardiovascular Disease in the US: 2004 (Includes Corresponding Graph/Chart) III-4 Market Trends and Issues III-4 Rising Obesity Rates & Numbers Lead to Increased Number of Interventional Cardiac Procedures III-4 Reimbursements - A Major Issue Affecting Growth in Cardiovascular Devices Market III-4 Need for Advanced Cardiovascular Devices at Competitive Prices III-4 Inadequate Clinical Evidence Deters Surgeons from Adopting New Catheters III-5 Increasing Demand for Atherectomy & Thrombectomy Products III-5 Need for Improvement in Hypotube Design III-5 Reimbursement Rates in the US III-5 Table 47: Common Physician Payments for Percutaneous Coronary Interventions III-5 Table 48: Common Outpatient Ambulatory Procedure classifications (APCs) for Percutaneous Coronary Interventions III-6 Table 49: Medicare Physician Professional Payment III-6 Table 50: Payment for Carotid Artery Stenting III-6 Payment for Peripheral Interventions III-6 Table 51: Hospital In-patient Payment III-6 Table 52: Hospital Outpatient - Based on APCClassification III-6 Table 53: Physician Professional Payment - Based on CPT® Code III-7 Table 54: Peripheral Stent / Shunt Placement, Percutaneous III-7 Table 55: Catheter Placement III-7 Table 56: Diagnostic Angiography, Radiological S&I III-8 Table 57: Procedural Radiological S&I III-8 Product Launches/ Approvals/Patents III-9 Strategic Developments III-16 Key Players III-24 Abbott Laboratories III-24 Boston Scientific Corporation III-24 C.R. Bard, Inc. III-25 Cardima, Inc. III-25 Cardiofocus, Inc. III-26 Edwards Lifesciences Corporation III-26 EP Medsystems III-27 Johnson & Johnson III-27 Cordis Corporation III-27 Biosense Webster III-28 Medtronic, Inc. III-28 Merit Medical Systems, Inc. III-29 Spectranetics Corporation III-29 St. Jude Medical III-29 Endocardial Solutions, Inc. III-30 Teleflex Medical III-30 B.Market Analytics III-32 Table 58: US Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-32 Table 59: US Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-33 Table 60: US 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-34 2. Canada III-35 A.Market Analysis III-35 Current & Future Analysis III-35 Key Player III-35 CryoCath Technologies, Inc. III-35 B.Market Analytics III-36 Table 61: Canadian Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion & Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-36 Table 62: Canadian Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon,& Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-37 Table 63: Canadian 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-38 3. Japan III-39 A.Market Analysis III-39 Current & Future Analysis III-39 PTCA Catheter Market III-39 Product Launches/Developments III-39 Key Players III-41 Japan Lifeline Co., Ltd. III-41 Terumo Medical Corporation III-41 Tokai Medical Products Co., Ltd. III-41 B.Market Analytics III-42 Table 64: Japanese Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters,Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-42 Table 65: Japanese Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion & Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million forYears 2011 through 2015 (includes corresponding Graph/Chart) III-43 Table 66: Japanese 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-44 4. Europe III-45 A.Market Analysis III-45 Current & Future Analysis III-45 European Union Cardiovascular Diseases Fact Sheet III-45 Angioplasty Products Market III-46 Trends Observed in Various Countries III-46 Product Launches/Developments III-46 Strategic Corporate Developments III-48 B.Market Analytics III-50 Table 67: European Recent Past, Current & Future Analysis for Cardiovascular Catheters by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-50 Table 68: European Long-term Projections for Cardiovascular Catheters by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-50 Table 69: European Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-51 Table 70: Canadian Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion & Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Millionfor Years 2011 through 2015 (includescorresponding Graph/Chart) III-52 Table 71: European 10-Year Perspective for Cardiovascular Catheters by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, and Rest of Europe Markets for Years 2003, 2008 and 2012 (includes corresponding Graph/Chart) III-53 Table 72: European 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 and 2012 (includes corresponding Graph/Chart) III-54 4a. France III-55 A.Market Analysis III-55 Current & Future Analysis III-55 EP Catheters Market III-55 B.Market Analytics III-56 Table 73: French Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-56 Table 74: French Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-57 Table 75: French 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-58 4b. Germany III-59 A.Market Analysis III-59 Current & Future Analysis III-59 Electrophysiology Market Overview III-59 Competitive Scenario III-59 B.Market Analytics III-60 Table 76: German Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed withAnnual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-60 Table 77: German Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-61 Table 78: German 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-62 4c. Italy III-63 A.Market Analysis III-63 Current & Future Analysis III-63 Electrophysiology Market Overview III-63 B.Market Analytics III-64 Table 79: Italian Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-64 Table 80: Italian Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-65 Table 81: Italian 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-66 4d. The United Kingdom III-67 A.Market Analysis III-67 Current & Future Analysis III-67 Healthcare Industry III-67 UK Cardiovascular Diseases Fact Sheet III-67 B.Market Analytics III-68 Table 82: UK Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-68 Table 83: UK Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-69 Table 84: UK 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-70 4e. Rest of Europe III-71 A.Market Analysis III-71 Current & Future Analysis III-71 Spain III-71 Electrophysiology Market III-71 Outlook III-71 B.Market Analytics III-72 Table 85: Rest of Europe Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/ Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-72 Table 86: Rest of Europe Long-term Projections for Cardiovascular Catheters by Product Group/ Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-73 Table 87: Rest of Europe 10-Year Perspective for Cardiovascular Catheters by Product Group/ Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 and 2012(includes corresponding Graph/Chart) III-74 5. Asia-Pacific III-75 A.Market Analysis III-75 Current & Future Analysis III-75 Increasing Rate of Western Diseases III-75 Focus on Select Markets III-75 Australia III-75 China III-76 Treatment Providers and Hospitals Overview III-76 India III-76 Market Overview III-76 Strategic Corporate Developments III-77 B.Market Analytics III-78 Table 88: Asia-Pacific Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion & Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-78 Table 89: Asia-Pacific Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon,and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includescorresponding Graph/Chart) III-79 Table 90: Asia-Pacific 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-80 6. Latin America III-81 Market Analysis III-81 Current & Future Analysis III-82 Table 91: Latin American Recent Past, Current & Future Analysis for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) & Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters,Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-82 Table 92: Latin American Long-term Projections for Cardiovascular Catheters by Product Group/Segment - Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-83 Table 93: Latin American 10-Year Perspective for Cardiovascular Catheters by Product Group/Segment - Percentage Breakdown of Dollar Sales for Diagnostic Catheters (Angiography Catheters and EP Mapping Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon, and Guide Catheters)Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-84 IV. COMPETITIVE LANDSCAPE

Companies Mentioned

- Abbott Laboratories (USA) - Abiomed, Inc (USA) - Angioscore, Inc (USA) - Argon Medical Devices, Inc (USA) - Arrow International, Inc (USA) - Arrow Medical Products Ltd (Canada) - Arrow Japan Ltd (Japan) - Arrow Africa (Pty) Ltd (South Africa) - Arrow Deutschland GmbH (Germany) - Arrow France SA (France) - Arrow Hellas AEE (Greece) - Arrow Holland Medical Products BV (The Netherlands) - Arrow Iberia SA (Spain) - Arrow India (India) - Arrow Internacional De Mexico SA De CV (Mexico) - Arrow International CR AS (Czech Republic) - Arrow International Europe (Belgium) - Arrow Slovensko Piestany Sro (Slovakia) - Arthesys (France) - Ascent Healthcare Solutions, Inc (USA) - B Braun Melsungen AG (Germany) - B Braun Medical, Inc (USA) - B Braun Medical - Cardiovascular Division (USA) - B Braun Medical Industries Sdn Bhd (Malaysia) - Baylis Medical Co, Inc (Canada) - Becton, Dickinson And Company (USA) - Biocardia, Inc (USA) - Biosensors International Pte, Ltd (Singapore) - Biotronik GmbH & Co (Germany) - Biotronik, Inc (USA) - Biotronik UK Ltd (UK) - Boston Scientific Corporation (USA) - Guidant Corporation (USA) - Boston Scientific Ltd (Canada) - Boston Scientific Ltd (UK) - Boston Scientific (Middle East) (Lebanon) - Boston Scientific (Portugal) - Boston Scientific AG (Switzerland) - Boston Scientific Asia Pacific Pte, Limited (Republic Of Singapore) - Boston Scientific BV (The Netherlands) - Boston Scientific Ceska Republika Sro (Czech Republic) - Boston Scientific Chile Ltda (Chile) - Boston Scientific Colombia Ltda (Colombia) - Boston Scientific De Mexico SA De CV (Mexico) - Boston Scientific Do Brazil Ltda (Brazil) - Boston Scientific Ges mbH (Austria) - Boston Scientific Hong Kong Ltd (Hong Kong) - Boston Scientific Iberica SA (Spain) - Boston Scientific International (France) - Boston Scientific Galway (Ireland) - Boston Scientific Japan KK (Japan) - Boston Scientific Korea Co, Ltd (Korea) - Boston Scientific Magyarorszag KFT (Hungary) - Boston Scientific Medizintechnik GmbH (Germany) - Boston Scientific Nordic A/B (Sweden) - Boston Scientific Polska SP (Poland) - Boston Scientific (Australia) - Boston Scientific SpA (Italy) - Boston Scientific Tip Gerecleri Ltd Sti (Turkey) - Brivant Ltd (Ireland) - C R Bard, Inc (USA) - California Medical Laboratories, Inc (USA) - CardiacAssist, Inc (USA) - Cardima, Inc (USA) - CardioFocus, Inc (USA) - CardioGenesis Corporation (USA) - CardioOptics, Inc (USA) - CardioTech International, Inc (USA) - Cardiovascular Instrument Corporation (USA) - Catheffects LLC (USA) - Catheter Research, Inc (USA) - Clinical Instruments International, Inc (USA) - Cobe Cardiovascular, Inc (USA) - Columbus Instruments (USA) - Cook Group, Inc (USA) - Cook Vascular, Inc (USA) - Cook (UK) Ltd (UK) - William Cook Europe (Denmark) - Corne SA de CV (Mexico) - Cryocath Technologies, Inc (Canada) - CryoCor, Inc (USA) - Datascope Corporation (USA) - Dispomedica GmbH (Germany) - Dr Osypka GmbH (Germany) - Edwards Lifesciences Corporation (USA) - Edwards Lifesciences Canada, Inc (Canada) - Edwards LifeSciences (Japan) - Edwards Lifesciences India Pvt, Ltd (India) - Edwards Lifesciences Ltd (UK) - Edwards Lifesciences Macchi Ltd (Brazil) - Edwards Lifesciences SA (Switzerland) - Endologix, Inc (USA) - EP MedSystems, Inc (USA) - EP MedSystems Europe Ltd (UK) - EP MedSystems France Sarl (France) - EV, Inc (USA) - E-Z-EM, Inc (USA) - AngioDynamics, Inc (USA) - Flash Laboratories SA (Luxembourg) - FlowCardia, Inc (USA) - FoxHollow Technologies, Inc (USA) - GE Healthcare (USA) - Goodman Co, Ltd (Japan) - Hansen Medical, Inc (USA) - IntraLuminal Therapeutics, Inc (USA) - Irvine Biomedical, Inc (USA) - Japan Lifeline Co, Ltd (Japan) - Johnson & Johnson (USA) - Biosense Webster, Inc (USA) - Biosense Webster Europe (Belgium) - Biosense Webster (Israel) Ltd (Israel) - Cordis Corporation (USA) - Cordis Europa NV (The Netherlands) - Kimberly-Clark Corporation (USA) - Koninklijke Royal Philips Electronics NV (The Netherlands) - Medical Ventures Corporation (Canada) - Medrad, Inc (USA) - Medtronic, Inc (USA) - Merit Medical Systems, Inc (USA) - Micrus Endovascular (USA) - Millar Instruments, Inc (USA) - NMT Medical, Inc (USA) - Opto Circuits India Limited (India) - Eurocor GmbH (Germany) - OrbusNeich (Hong Kong) - Pathway Medical Technologies, Inc (USA) - Possis Medical, Inc (USA) - Siemens Medical Solutions (USA) - Signalife, Inc (USA) - Sorin Biomedica Cardio SpA (Italy) - ELA Medical Srl (Italy) - ELA Medical, Inc (USA) - ELA Medical (Portugal) - ELA Medical Benelux SA (Belgium) - ELA Medical BV A Sorin Group Co (The Netherlands) - ELA Medical GmbH (Germany) - ELA Medical Izasa (Spain) - ELA Medical Japan Co, Ltd (Japan) - ELA Medical Nordic A Sorin Group Co (Denmark) - ELA Medical SA (Switzerland) - ELA Medical SA (France) - ELA Medical UK Ltd (UK) - Spectranetics Corporation, The (USA) - St Jude Medical, Inc (USA) - St Jude Medical - Cardiac Rhythm Management Division (USA) - Daig Corp Div St Jude Medical, Inc (USA) - Getz Bros Co, Ltd (Japan) - St Jude Medical (Belgium) - Teleflex Medical Group (USA) - Terumo Medical Corporation (USA) - Terumo Cardiovascular Systems Corporation (USA) - Tokai Medical Products, Inc (Japan) - Toray Industries, Inc (Japan) - Toray Industries America, Inc (USA) - Toray Industries (HK) Ltd (Hong Kong) - Toray Industries (Singapore) Pte, Limited (Republic of Singapore) - Toray Industries, Inc (China) - Toray Industries, Inc (UK) - Toray Industries, Inc (Seoul) (Korea) - TZ Medical, Inc (USA) - Unomedical A/S (Denmark) - UreSil LLC (USA) - Vascor Medical Corporation (USA) - Vascular Solutions, Inc (USA) - Volcano Corporation (USA) - Xtrak Medical, Inc (USA) - Zeon Medical, Inc (Japan)