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Cardiovascular Catheters and Systems - Global Strategic Business Report

Global Industry Analysts, Inc, April 2008, Pages: 568

This report analyzes the worldwide markets for Cardiovascular Catheters and Systems in Millions of US$. The major product segments analyzed are Diagnostic Catheters (Angiography Catheters, & Electrophysiology (EP) Mapping Catheters), and Therapeutic Catheters (Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, Electrophysiology (EP) Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed-wire Catheters, & Guide Catheters). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Latin America. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 81 companies including many key and niche players worldwide such as Abbott, Boston Scientific, C.R. Bard, Inc., Cardima, Inc., CryoCath Technologies Inc., Edwards Lifesciences Corporation, EP Medsystems, Johnson & Johnson, Cordis Corporation, Biosense Webster, Medtronic, Merit Medical Systems, Inc., St. Jude Medical, Endocardial Solutions, Inc., Teleflex Medical, and Terumo Medical Corporation. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

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CARDIOVASCULAR CATHETERS AND SYSTEMS

A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
A. Diagnostic Catheters I-4
Angiography Catheters I-4
Electrophysiology (EP) Mapping Catheters I-4
B. Therapeutic Catheters I-4
Rapid -Exchange PTCA Balloon Catheter I-4
Over-The-Wire PTCA Balloon Catheter I-4
Electrophysiology Ablation Catheters I-5
Atherectomy Catheters I-5
Perfusion and Fixed Balloon Catheters I-5
Guide Catheters I-5

II. Executive Summary

1. Market Overview II-1
Technological Advancements to Drive Growth II-1
Worldwide Cardiovascular Catheters Market II-1
Market Trends & Issues II-2
Lack of Pharmacological Alternatives Boost Demand for
Cardiovascular Catheters II-2
Energy-Based Solutions Compete with Conventional
Interventional Systems II-2
Repeat Interventional Procedures Affected by the Advent of
Drug-Eluting Stents II-2
RF Catheter Ablation Gains Popularity II-3
Molding Material and Technology II-3
Diagnostic Catheters - Advance from the Workhorse 8 Fr II-3
Smaller the Better II-3
PTCA Catheters - Affected by Direct Stenting II-4
Angioplasty - Under Price Pressure II-4
Restenosis - The Unsolved Problem II-4
New Pharmacological Therapies - Minimizing the Need for
Interventional Procedures? II-4

2. Competitive Scenario II-6
Cardiovascular Catheters - Highly Concentrated Market II-6
Table 1: Leading Players in Global Angioplasty / Angiography
Catheter Market (2004 & 2005E): Percentage Breakdown of Value
Sales for Boston Scientific Johnson & Johnson, Guidant,
Medtronic, and Others (includes corresponding Graph/Chart) II-6

Table 2: Leading Players in Global Guide Catheters Market
(2004 & 2005): Percentage Breakdown of Value Sales for
Johnson & Johnson, Boston Scientific, Guidant, Medtronic and
Others (includes corresponding Graph/Chart) II-7

Table 3: Leading Players in Global Electrophysiology (EP)
Catheter (Mapping and Ablation) Market (2004 & 2005):
Percentage Breakdown of Value Sales for Johnson & Johnson,
St. Jude Medical, Boston Scientific,C.R.Bard and Others
(includes corresponding Graph/Chart) II-7
Balloon Catheters II-8
Table 4: Leading Players in Global Balloon Catheter Market
(2004 & 2005): Percentage Breakdown of Value Sales for Boston
Scientific, Guidant, Medtronic, Johnson & Johnson and Others
(includes corresponding Graph/Chart) II-8

3. Catheterization - The Procedure II-9
Historical Perspective II-9
Cardiac Catheterization: Most Accurate of all Cardiac
Diagnostic Examinations II-9

4. Product Profile II-10
Catheters II-10
Designing of Specialized Catheters II-10
Factors Determining Competitiveness II-10
Preventing Infection II-10
Catheter Related Infections II-10
Flow and Sealing Capability II-10
Safety II-11
System Suitability and Comprehensiveness II-11
Ease of Insertion II-11
Maneuverability II-11
Cardiovascular Catheters - Product Group/Segment Overview II-11
A. Diagnostic Catheters II-12
Angiography Catheters II-12
Electrophysiology (EP) Mapping Catheters II-12
Purpose II-12
Scope of Electrophysiology Studies II-13
Precaution II-13
B. Therapeutic Catheters II-13
Catheters Designed for Therapeutic Procedures II-13
Angioplasty: Where is it Used? II-13
Types of Angioplasty II-13
Percutaneous Transluminal Coronary Angioplasty or PTCA II-14
PTCA Catheters II-14
Types of Balloon Catheters II-14
Rapid -Exchange PTCA Balloon Catheter II-14
Over-The-Wire PTCA Balloon Catheter II-15
Electrophysiology Ablation Catheters II-15
Atherectomy Catheters II-16
Perfusion and Fixed Balloon Catheters II-16
Guide Catheters II-16

5. An Overview of The CVD Market II-17
Heart - Historic Facts and Figures II-17
Table 5: Number of Deaths from Circulatory Disorders
Worldwide by Region (2002) (in ‘000) (includes Corresponding
Graph/Chart) II-17
Interventional Cardiology II-17
PTCRA - The procedure II-18
Interventional Cardiology Market in the US & Europe - A
Comparison II-18
Radiation Therapy (Brachytherapy) II-19
An Insight into Cardio Vascular Diseases II-19
Coronary Artery Disease (CAD) II-19
Definition II-19
Causes and Symptoms II-19
Major Risk Factors II-20
Non-Controllable Risk Factors II-20
Heredity II-20
Sex II-20
Age II-20
Controllable Risk Factors II-20
Treatment II-20
Angina Pectoris II-21
Arrhythmias II-21
Atrial Fibrillation - A Common Arrhythmia II-21
More in Women II-22
Stroke II-22
Congestive Heart Failure II-22
Key Terms (For Reference) II-22
Angina II-22
Aneurysms II-23
Angiography II-23
Angioplasty II-23
Aortic Valve II-23
Atherosclerosis II-23
Bradycardia II-23
Catheter II-23
Coronary Arteries II-23
Echocardiogram II-23
Electrocardiogram II-23
Electrophysiology (EP) study II-23
Pacemaker II-24
Plaque II-24
HDL Cholesterol II-24
LDL Cholesterol II-24
Stenosis II-24
Stroke II-24
Tachycardia II-24

6. Technological Developments II-25
US-Based Inventors Granted Patent for Perfusion Balloon
Angioplasty Catheter II-25
California Scientists Create Intravascular Balloon Catheters
for Angioplasty Procedures II-25
Minnesota Scientists Develop New Ablation Catheter II-25
American Inventor Devises Drug Delivery Balloon Catheter II-25
US-Based Inventors Create Atherectomy Catheter II-25
US-Based Inventors Develop Atherectomy Device for Treatment of
Occlusions II-26
US-Based Inventor Creates New Ablation Catheter System II-26
Japanese Inventor Creates RF Thermal Balloon Catheter II-26

7. Product Innovations/Intorductions II-27
Stereotaxis Obtains FDA Approval for 8mm Magnetic Ablation
Catheter II-27
ClearStream Gains FDA Approval for PTA Angioplasty Balloon
Catheters II-27
AngioSculpt® Gains Japanese Approval for AngioSculpt® Catheter II-27
Cordis Introduces Fire Star Rx and Dura Star Rx Catheters II-27
Cordis Introduces AVIATOR™ Catheter II-28
FlowCardia Introduces CROSSER Catheter Product Line II-28
Medtronic’s Sprinter® Catheter Gains CE Mark Approval II-28
St. Jude Gains CE Mark & FDA Approvals for Therapy™ Cool Path™
Catheter II-28
FDA Clears Venture™ Catheter Use with Rapid Exchange Delivery
Platform II-29
Eurocor Unveils DIOR Catheter in Germany II-29
FDA Approves InnerChange Micro-Introducer Catheter II-29
Stereotaxis Gains EU Approval Magnetic Irrigated Ablation
Catheter II-29
Atrium Medical Obtains CE Mark for ClearWay™ RX Catheter II-29
Lumen Gains FDA Approval for Large Sized Xtract™ Catheters II-30
Opto Circuits Achieves CE Mark Approval for its Catheter II-30
FDA Approves Abiomed’s Impella 5.0 Catheter-Based Circulatory
Support Systems II-30
Medical Ventures Gains CE Mark Approval for Metricath Gemini®
Balloon-Catheter II-31
St. Jude Receives Regulatory Approval for its Safire Ablation
& Inquiry Optima Plus Catheters II-31
Boston Scientific Introduces Sterling™ Monorail® Balloon
Dilatation Catheter II-31
St. Jude Receives Approval to Market EnSite® System in Japan II-31
Merit Medical’s Impress Diagnostic Catheter Gains CE Mark &
FDA Approvals II-31
Medtronic Gains FDA Approval for Export® XT spiration Catheter II-32
Medtronic Obtains CE Mark Approval to Market Melody™ and
Ensemble™ System II-32
Boston Scientific Gains FDA Approval for its Rio™ Aspiration
Catheter II-32
Possis Introduces AngioJet® Spiroflex®Rheolytic Thrombectomy
Catheter II-32
Boston Scientific Launches Chilli II Cooled Ablation Catheter II-33
Terumo Introduces PTCA Catheter with the Smallest Diameter II-33
Japan Lifeline Introduces OTTIMO ROSSO Balloon atheter for
PTCA Procedures II-33
FDA Clears St. Jude’s Therapy™ EP & IBI-1500T6 Cardiac
Ablation Generator Catheters II-33
Terumo Introduces Heartrail II PTCA Guiding Catheter II-33
FDA Grants Approval to Alliance for Reprocessing AcuNav™
Ultrasound Catheter II-34
Cook Introduces New ATB® PTA Dilatation Catheter II-34
St. Jude Unveils New Venture™ Wire Control Catheter Across the
United States II-34
Possis Medical Adds Two New Catheters to its AngioJet®
Rheolytic™ Thrombectomy Line II-34
Cook Introduces CODA for Endovascular Market II-34
Spectranetics Develops Laser Catheter for Peripheral Vascular
Disease II-35
Medrad Inc Introduces Avanta™ Fluid Management Injection
System and Vanguard Dx™ Angiographic Catheter II-35
Medtronic Releases Medtronic Attain Select 6238 TEL Guide
Catheter II-35
AngioScore Receives CE Mark Approval for its AngioSculpt
Scoring Balloon Catheter II-35
Spectranetics Introduces New Catheters II-36
Guidant Corporation Unveils VOYAGER™ Coronary Dilatation Catheter II-36
Medtronic Introduces Two New Catheters II-36

8. Recent Industry Activity II-37
Micrus Enters into Agreement with Genesis II-37
Teleflex Acquires Arrow International II-37
FoxHollow Merges with ev3 II-37
J&J Bags Marketing Rights for Topspin’s Catheter II-38
Cordis to Market ClearStream Technologies’ Catheters II-38
Relisys to Establish Catheter Production Facility in India II-38
Boston Scientific Acquires Guidant II-38
Abbott Acquires Guidant’s Vascular Business II-39
Cordis in Distribution Agreement with Brivant II-39
Cordis Enters into Definitive Agreement to Distribute
ClearStream’s PTCA Balloon Catheter II-39
St. Jude and GE Healthcare Collaborate to Develop Advanced
Technologies for Cardiac Procedures II-40
Bard Acquires Venetec International II-40
Koninklijke Philips Takes Over Witt Biomedical II-40
FoxHollow Enters into Definitive Agreement to Acquire Kerberos II-40
Biosense Recieves Expanded Indication for NAVISTAR®
THERMOCOOLÒ Catheter for Treatment of Ventricular Tachycardia II-40
Hansen Medical Completes Clinical Trial for Sensei Robotic
Catheter System II-40
Biosense and Siemens Enter into Strategic Alliance Involving
Catheters II-41
Recom Inks MOU with TZ Medical to Develop Cardiac Catheters II-41
Cordis Takes Over LuMend II-41
Hansen Medical Enters into Cross-Licensing Agreement with
Intuitive Surgical II-42
Hansen Medical Acquires Intellectual Assets of endoVia Medical II-42
Micrus Takes Over VascularFX II-42
St. Jude Medical Acquires Endocardial Solutions II-42
St. Jude Medical Acquires Velocimed II-42
FlowCardia Bags European Approval for Crosser Catheter II-43
AVI BioPharma Regains Full Control on Resten-NG Antisense Therapy II-43
Boston Scientific Acquires Precision Vascular Systems II-43
Edwards Lifesciences Acquires PVT II-43
St. Jude Medical Acquires IBI II-43
St. Jude Medical Takes Over Epicor Medical II-44
Merit Medical Systems Inks an Agreement with Novation II-44
Rochester Medical Enters into a Supply Agreement with Hollister II-44
CardioTech International Enters into a Licensing Agreement
with BAS II-44
CryoCor’s Model 1200 Cardiac Catheter Series Receives FDA
Clearance II-44
CryoCath’s Freezor MAX Catheter Device Receives FDA Clearance II-44
LubriLAST™-coated Catheters Receives MOHLW Clearance II-45
Abbott Laboratories Acquires Assets of JOMED II-45
JOMED Sells IVUS and Functional Management Business to Volcano
Therapeutics II-45
Boston Scientific in Alliance with Corautus Genetics II-45
Mogul Obtains FDA Approval for Diagnostic Catheters II-45

9. Focus on Select Global Players II-46
Abbott Laboratories (USA) II-46
Boston Scientific (USA) II-46
C.R. Bard, Inc. (USA) II-47
Cardima, Inc. (USA) II-47
CryoCath Technologies Inc. (Canada) II-47
Edwards Lifesciences Corporation (USA) II-48
EP Medsystems (USA) II-48
Johnson & Johnson (USA) II-48
Cordis Corporation (USA) II-49
Biosense Webster (USA) II-49
Medtronic (USA) II-50
Merit Medical Systems, Inc. (USA) II-50
St. Jude Medical (USA) II-51
Endocardial Solutions, Inc. (USA) II-51
Teleflex Medical (USA) II-52
Terumo Medical Corporation (Japan) II-52

10. Global Market Perspective II-53
Table 6: World Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Geographic Region - USA, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Latin
American Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-53

Table 7: World Long-term Projections for Cardiovascular
Catheters by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-54

Table 8: World 10-Year Perspective for Cardiovascular
Catheters by Geographic Region - Percentage Breakdown of
Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Latin American Markets for Years 2003,
2008 & 2012 (includes corresponding Graph/Chart) II-55

Table 9: World Recent Past, Current & Future Analysis for
Diagnostic Catheters by Geographic Region - USA, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Latin
American Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010
(includescorresponding Graph/Chart) II-56

Table 10: World Long-term Projections for Diagnostic Catheters
by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-57

Table 11: World Recent Past, Current & Future Analysis for
Diagnostic Catheters by Product Segment - Angiography
Catheters and EP Mapping Catheters Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) II-58

Table 12: World Long-term Projections for Diagnostic Catheters
by Product Segment - Angiography Catheters & EP Mapping
Catheters Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-58

Table 13: World 10-Year Perspective for Diagnostic Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-59

Table 14: World 10-Year Perspective for DiagnosticcCatheters
by Product Segment - Percentage Breakdowncof Dollar Sales for
Angiography Catheters and EP Mapping Catheters Markets for
Years 2003, 2008 & 2012 II-59

Table 15: World Recent Past, Current & Future Analysis for
Angiography Catheters by Geographic Region - USA, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Latin
American Markets Independently Analyzedcwith Annual Sales
Figures in US$ Million forcYears 2000 through 2010 (includes
corresponding Graph/Chart) II-60

Table 16: World Long-term Projections for Angiography
Catheters by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-61

Table 17: World 10-Year Perspective for Angiography Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe,Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) II-62

Table 18: World Recent Past, Current & Future Analysis for EP
Mapping Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-63

Table 19: World Long-term Projections for EP Mapping Catheters
by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-64

Table 20: World 10-Year Perspective for EP Mapping Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-65

Table 21: World Recent Past, Current & Future Analysis for
Therapeutic Catheters by Geographic Region - USA, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Latin
American Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-66

Table 22: World Long-term Projections for Therapeutic
Catheters by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-67

Table 23: World Recent Past, Current & Future Analysis for
Therapeutic Catheters by Product Segment - Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2010 (includes corresponding Graph/Chart) II-68

Table 24: World Long-term Projections for Therapeutic
Catheters by Product Segment - Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed Balloon,
and Guide Catheters Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-68

Table 25: World 10-Year Perspective for Therapeutic Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) II-69

Table 26: World 10-Year Perspective for Therapeutic Catheters
by Product Segment - Percentage Breakdown of Dollar Sales for
Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) II-70

Table 27: World Recent Past, Current & Future Analysis for
Rapid-Exchange PTCA Balloon Catheters by Geographic Region -
USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
and Latin American Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2010
(includes corresponding Graph/Chart) II-71

Table 28: World Long-term Projections for Rapid-Exchange PTCA
Balloon Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-72

Table 29: World 10-Year Perspective for Rapid-Exchange PTCA
Balloon Catheters by Geographic Region - Percentage Breakdown
of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Latin American Markets for Years 2003,
2008 & 2012 (includes corresponding Graph/Chart) II-73

Table 30: World Recent Past, Current & Future Analysis for
Over-the-Wire PTCA Balloon Catheters by Geographic Region -
USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
and Latin American Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2010
(includes corresponding Graph/Chart) II-74

Table 31: World Long-term Projections for Over-the-Wire PTCA
Balloon Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-75

Table 32: World 10-Year Perspective for Over-the-Wire PTCA
Balloon Catheters by Geographic Region - Percentage Breakdown
of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Latin American Markets for Years 2003,
2008 & 2012 (includes corresponding Graph/Chart) II-76

Table 33: World Recent Past, Current & Future Analysis for EP
Ablation Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-77

Table 34: World Long-term Projections for EP Ablation
Catheters by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-78

Table 35: World 10-Year Perspective for EP Ablation Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-79

Table 36: World Recent Past, Current & Future Analysis for
Atherectomy Catheters by Geographic Region - USA, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Latin
American Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-80

Table 37: World Long-term Projections for Atherectomy
Catheters by Geographic Region - USA, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Latin American Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) II-81

Table 38: World 10-Year Perspective for Atherectomy Catheters
by Geographic Region - Percentage Breakdown of Dollar Sales
for USA, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Latin American Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-82

Table 39: World Recent Past, Current & Future Analysis for
Perfusion and Fixed Balloon Catheters by Geographic Region -
USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
and Latin American Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2010
(includes corresponding Graph/Chart) II-83

Table 40: World Long-term Projections for Perfusion and Fixed
Balloon Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-84

Table 41: World 10-Year Perspective for Perfusion and Fixed
Balloon Catheters by Geographic Region - Percentage Breakdown
of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Latin American Markets for Years 2003,
2008 & 2012 (includes corresponding Graph/Chart) II-85

Table 42: World Recent Past, Current & Future Analysis for
Guide Catheters by Geographic Region - USA, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), and Latin American
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) II-86

Table 43: World Long-term Projections for Guide Catheters by
Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Latin American Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) II-87

Table 44: World 10-Year Perspective for Guide Catheters by
Geographic Region - Percentage Breakdown of Dollar Sales for
USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
and Latin American Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) II-88

III. MARKET

1. The United States III-1
A.Market Analysis III-1
Current & Future Analysis III-1
Cardiovascular Catheters Market III-1
Competition III-1
Table 45: Leading Players in the US Cardiovascular
Catheters Market (2005): Percentage Breakdown of Value
Sales for Boston Scientific, Cordis (J&J), Guidant
Corporation, Medtronic, and Others (includes corresponding
Graph/Chart) III-2
Arrhythmia Management Products III-3
Cardiovascular Disease in the US - An Insight III-3
Table 46: Prevalence of Cardiovascular Disease in the US:
2004 (Includes Corresponding Graph/Chart) III-4
Market Trends and Issues III-4
Rising Obesity Rates & Numbers Lead to Increased Number of
Interventional Cardiac Procedures III-4
Reimbursements - A Major Issue Affecting Growth in
Cardiovascular Devices Market III-4
Need for Advanced Cardiovascular Devices at Competitive Prices III-4
Inadequate Clinical Evidence Deters Surgeons from Adopting
New Catheters III-5
Increasing Demand for Atherectomy & Thrombectomy Products III-5
Need for Improvement in Hypotube Design III-5
Reimbursement Rates in the US III-5
Table 47: Common Physician Payments for Percutaneous
Coronary Interventions III-5

Table 48: Common Outpatient Ambulatory Procedure
classifications (APCs) for Percutaneous Coronary
Interventions III-6

Table 49: Medicare Physician Professional Payment III-6
Table 50: Payment for Carotid Artery Stenting III-6
Payment for Peripheral Interventions III-6
Table 51: Hospital In-patient Payment III-6
Table 52: Hospital Outpatient - Based on APCClassification III-6
Table 53: Physician Professional Payment - Based on CPT®
Code III-7
Table 54: Peripheral Stent / Shunt Placement, Percutaneous III-7
Table 55: Catheter Placement III-7
Table 56: Diagnostic Angiography, Radiological S&I III-8
Table 57: Procedural Radiological S&I III-8
Product Launches/ Approvals/Patents III-9
Strategic Developments III-16
Key Players III-24
Abbott Laboratories III-24
Boston Scientific Corporation III-24
C.R. Bard, Inc. III-25
Cardima, Inc. III-25
Cardiofocus, Inc. III-26
Edwards Lifesciences Corporation III-26
EP Medsystems III-27
Johnson & Johnson III-27
Cordis Corporation III-27
Biosense Webster III-28
Medtronic, Inc. III-28
Merit Medical Systems, Inc. III-29
Spectranetics Corporation III-29
St. Jude Medical III-29
Endocardial Solutions, Inc. III-30
Teleflex Medical III-30
B.Market Analytics III-32
Table 58: US Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-32

Table 59: US Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-33

Table 60: US 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-34

2. Canada III-35
A.Market Analysis III-35
Current & Future Analysis III-35
Key Player III-35
CryoCath Technologies, Inc. III-35
B.Market Analytics III-36
Table 61: Canadian Recent Past, Current & Future Analysis
for Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion & Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2000
through 2010 (includes corresponding Graph/Chart) III-36

Table 62: Canadian Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon,& Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-37

Table 63: Canadian 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-38

3. Japan III-39
A.Market Analysis III-39
Current & Future Analysis III-39
PTCA Catheter Market III-39
Product Launches/Developments III-39
Key Players III-41
Japan Lifeline Co., Ltd. III-41
Terumo Medical Corporation III-41
Tokai Medical Products Co., Ltd. III-41
B.Market Analytics III-42
Table 64: Japanese Recent Past, Current & Future Analysis
for Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters,Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-42

Table 65: Japanese Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion &
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million forYears
2011 through 2015 (includes corresponding Graph/Chart) III-43

Table 66: Japanese 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography
Catheters and EP Mapping Catheters) and Therapeutic
Catheters (Rapid-Exchange PTCA Balloon Catheters,
Over-The-Wire PTCA Balloon Catheters, EP Ablation Catheters,
Atherectomy Catheters, Perfusion and Fixed Balloon, and
Guide Catheters) Markets for Years 2003, 2008 & 2012
(includes corresponding Graph/Chart) III-44

4. Europe III-45
A.Market Analysis III-45
Current & Future Analysis III-45
European Union Cardiovascular Diseases Fact Sheet III-45
Angioplasty Products Market III-46
Trends Observed in Various Countries III-46
Product Launches/Developments III-46
Strategic Corporate Developments III-48
B.Market Analytics III-50
Table 67: European Recent Past, Current & Future Analysis
for Cardiovascular Catheters by Geographic Region - France,
Germany, Italy, UK, and Rest of Europe Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-50

Table 68: European Long-term Projections for Cardiovascular
Catheters by Geographic Region - France, Germany, Italy,
UK, and Rest of Europe Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-50

Table 69: European Recent Past, Current & Future Analysis
for Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-51

Table 70: Canadian Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion & Fixed Balloon,
and Guide Catheters) Markets Independently Analyzed with
Annual Sales Figures in US$ Millionfor Years 2011 through
2015 (includescorresponding Graph/Chart) III-52

Table 71: European 10-Year Perspective for Cardiovascular
Catheters by Geographic Region - Percentage Breakdown of
Dollar Sales for France, Germany, Italy, UK, and Rest of
Europe Markets for Years 2003, 2008 and 2012 (includes
corresponding Graph/Chart) III-53

Table 72: European 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 and 2012 (includes
corresponding Graph/Chart) III-54

4a. France III-55
A.Market Analysis III-55
Current & Future Analysis III-55
EP Catheters Market III-55
B.Market Analytics III-56
Table 73: French Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-56

Table 74: French Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-57

Table 75: French 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-58

4b. Germany III-59
A.Market Analysis III-59
Current & Future Analysis III-59
Electrophysiology Market Overview III-59
Competitive Scenario III-59
B.Market Analytics III-60
Table 76: German Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed withAnnual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-60

Table 77: German Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-61

Table 78: German 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-62

4c. Italy III-63
A.Market Analysis III-63
Current & Future Analysis III-63
Electrophysiology Market Overview III-63
B.Market Analytics III-64
Table 79: Italian Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-64

Table 80: Italian Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-65

Table 81: Italian 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-66

4d. The United Kingdom III-67
A.Market Analysis III-67
Current & Future Analysis III-67
Healthcare Industry III-67
UK Cardiovascular Diseases Fact Sheet III-67
B.Market Analytics III-68
Table 82: UK Recent Past, Current & Future Analysis for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-68

Table 83: UK Long-term Projections for Cardiovascular
Catheters by Product Group/Segment - Diagnostic Catheters
(Angiography Catheters and EP Mapping Catheters) and
Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2011
through 2015 (includes corresponding Graph/Chart) III-69

Table 84: UK 10-Year Perspective for Cardiovascular
Catheters by Product Group/Segment - Percentage Breakdown of
Dollar Sales for Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-70

4e. Rest of Europe III-71
A.Market Analysis III-71
Current & Future Analysis III-71
Spain III-71
Electrophysiology Market III-71
Outlook III-71
B.Market Analytics III-72
Table 85: Rest of Europe Recent Past, Current & Future
Analysis for Cardiovascular Catheters by Product Group/
Segment - Diagnostic Catheters (Angiography Catheters and EP
Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-72

Table 86: Rest of Europe Long-term Projections for
Cardiovascular Catheters by Product Group/ Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for
Years 2011 through 2015 (includes corresponding
Graph/Chart) III-73

Table 87: Rest of Europe 10-Year Perspective for
Cardiovascular Catheters by Product Group/ Segment -
Percentage Breakdown of Dollar Sales for Diagnostic
Catheters (Angiography Catheters and EP Mapping Catheters)
and Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets for Years 2003,
2008 and 2012(includes corresponding Graph/Chart) III-74

5. Asia-Pacific III-75
A.Market Analysis III-75
Current & Future Analysis III-75
Increasing Rate of Western Diseases III-75
Focus on Select Markets III-75
Australia III-75
China III-76
Treatment Providers and Hospitals Overview III-76
India III-76
Market Overview III-76
Strategic Corporate Developments III-77
B.Market Analytics III-78
Table 88: Asia-Pacific Recent Past, Current & Future
Analysis for Cardiovascular Catheters by Product
Group/Segment - Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) and Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters, Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion & Fixed Balloon, and Guide Catheters)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-78

Table 89: Asia-Pacific Long-term Projections for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon,and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includescorresponding Graph/Chart) III-79

Table 90: Asia-Pacific 10-Year Perspective for
Cardiovascular Catheters by Product Group/Segment -
Percentage Breakdown of Dollar Sales for Diagnostic
Catheters (Angiography Catheters and EP Mapping Catheters)
and Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters) Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-80

6. Latin America III-81
Market Analysis III-81
Current & Future Analysis III-82
Table 91: Latin American Recent Past, Current & Future
Analysis for Cardiovascular Catheters by Product
Group/Segment - Diagnostic Catheters (Angiography Catheters
and EP Mapping Catheters) & Therapeutic Catheters
(Rapid-Exchange PTCA Balloon Catheters,Over-The-Wire PTCA
Balloon Catheters, EP Ablation Catheters, Atherectomy
Catheters, Perfusion and Fixed Balloon, and Guide Catheters)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-82

Table 92: Latin American Long-term Projections for
Cardiovascular Catheters by Product Group/Segment -
Diagnostic Catheters (Angiography Catheters and EP Mapping
Catheters) and Therapeutic Catheters (Rapid-Exchange PTCA
Balloon Catheters, Over-The-Wire PTCA Balloon Catheters, EP
Ablation Catheters, Atherectomy Catheters, Perfusion and
Fixed Balloon, and Guide Catheters) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-83

Table 93: Latin American 10-Year Perspective for
Cardiovascular Catheters by Product Group/Segment -
Percentage Breakdown of Dollar Sales for Diagnostic
Catheters (Angiography Catheters and EP Mapping Catheters)
and Therapeutic Catheters (Rapid-Exchange PTCA Balloon
Catheters, Over-The-Wire PTCA Balloon Catheters, EP Ablation
Catheters, Atherectomy Catheters, Perfusion and Fixed
Balloon, and Guide Catheters)Markets for Years 2003, 2008 &
2012 (includes corresponding Graph/Chart) III-84

IV. COMPETITIVE LANDSCAPE

- Abbott Laboratories (USA)
- Abiomed, Inc (USA)
- Angioscore, Inc (USA)
- Argon Medical Devices, Inc (USA)
- Arrow International, Inc (USA)
- Arrow Medical Products Ltd (Canada)
- Arrow Japan Ltd (Japan)
- Arrow Africa (Pty) Ltd (South Africa)
- Arrow Deutschland GmbH (Germany)
- Arrow France SA (France)
- Arrow Hellas AEE (Greece)
- Arrow Holland Medical Products BV (The Netherlands)
- Arrow Iberia SA (Spain)
- Arrow India (India)
- Arrow Internacional De Mexico SA De CV (Mexico)
- Arrow International CR AS (Czech Republic)
- Arrow International Europe (Belgium)
- Arrow Slovensko Piestany Sro (Slovakia)
- Arthesys (France)
- Ascent Healthcare Solutions, Inc (USA)
- B Braun Melsungen AG (Germany)
- B Braun Medical, Inc (USA)
- B Braun Medical - Cardiovascular Division (USA)
- B Braun Medical Industries Sdn Bhd (Malaysia)
- Baylis Medical Co, Inc (Canada)
- Becton, Dickinson And Company (USA)
- Biocardia, Inc (USA)
- Biosensors International Pte, Ltd (Singapore)
- Biotronik GmbH & Co (Germany)
- Biotronik, Inc (USA)
- Biotronik UK Ltd (UK)
- Boston Scientific Corporation (USA)
- Guidant Corporation (USA)
- Boston Scientific Ltd (Canada)
- Boston Scientific Ltd (UK)
- Boston Scientific (Middle East) (Lebanon)
- Boston Scientific (Portugal)
- Boston Scientific AG (Switzerland)
- Boston Scientific Asia Pacific Pte, Limited (Republic Of Singapore)
- Boston Scientific BV (The Netherlands)
- Boston Scientific Ceska Republika Sro (Czech Republic)
- Boston Scientific Chile Ltda (Chile)
- Boston Scientific Colombia Ltda (Colombia)
- Boston Scientific De Mexico SA De CV (Mexico)
- Boston Scientific Do Brazil Ltda (Brazil)
- Boston Scientific Ges mbH (Austria)
- Boston Scientific Hong Kong Ltd (Hong Kong)
- Boston Scientific Iberica SA (Spain)
- Boston Scientific International (France)
- Boston Scientific Galway (Ireland)
- Boston Scientific Japan KK (Japan)
- Boston Scientific Korea Co, Ltd (Korea)
- Boston Scientific Magyarorszag KFT (Hungary)
- Boston Scientific Medizintechnik GmbH (Germany)
- Boston Scientific Nordic A/B (Sweden)
- Boston Scientific Polska SP (Poland)
- Boston Scientific (Australia)
- Boston Scientific SpA (Italy)
- Boston Scientific Tip Gerecleri Ltd Sti (Turkey)
- Brivant Ltd (Ireland)
- C R Bard, Inc (USA)
- California Medical Laboratories, Inc (USA)
- CardiacAssist, Inc (USA)
- Cardima, Inc (USA)
- CardioFocus, Inc (USA)
- CardioGenesis Corporation (USA)
- CardioOptics, Inc (USA)
- CardioTech International, Inc (USA)
- Cardiovascular Instrument Corporation (USA)
- Catheffects LLC (USA)
- Catheter Research, Inc (USA)
- Clinical Instruments International, Inc (USA)
- Cobe Cardiovascular, Inc (USA)
- Columbus Instruments (USA)
- Cook Group, Inc (USA)
- Cook Vascular, Inc (USA)
- Cook (UK) Ltd (UK)
- William Cook Europe (Denmark)
- Corne SA de CV (Mexico)
- Cryocath Technologies, Inc (Canada)
- CryoCor, Inc (USA)
- Datascope Corporation (USA)
- Dispomedica GmbH (Germany)
- Dr Osypka GmbH (Germany)
- Edwards Lifesciences Corporation (USA)
- Edwards Lifesciences Canada, Inc (Canada)
- Edwards LifeSciences (Japan)
- Edwards Lifesciences India Pvt, Ltd (India)
- Edwards Lifesciences Ltd (UK)
- Edwards Lifesciences Macchi Ltd (Brazil)
- Edwards Lifesciences SA (Switzerland)
- Endologix, Inc (USA)
- EP MedSystems, Inc (USA)
- EP MedSystems Europe Ltd (UK)
- EP MedSystems France Sarl (France)
- EV, Inc (USA)
- E-Z-EM, Inc (USA)
- AngioDynamics, Inc (USA)
- Flash Laboratories SA (Luxembourg)
- FlowCardia, Inc (USA)
- FoxHollow Technologies, Inc (USA)
- GE Healthcare (USA)
- Goodman Co, Ltd (Japan)
- Hansen Medical, Inc (USA)
- IntraLuminal Therapeutics, Inc (USA)
- Irvine Biomedical, Inc (USA)
- Japan Lifeline Co, Ltd (Japan)
- Johnson & Johnson (USA)
- Biosense Webster, Inc (USA)
- Biosense Webster Europe (Belgium)
- Biosense Webster (Israel) Ltd (Israel)
- Cordis Corporation (USA)
- Cordis Europa NV (The Netherlands)
- Kimberly-Clark Corporation (USA)
- Koninklijke Royal Philips Electronics NV (The Netherlands)
- Medical Ventures Corporation (Canada)
- Medrad, Inc (USA)
- Medtronic, Inc (USA)
- Merit Medical Systems, Inc (USA)
- Micrus Endovascular (USA)
- Millar Instruments, Inc (USA)
- NMT Medical, Inc (USA)
- Opto Circuits India Limited (India)
- Eurocor GmbH (Germany)
- OrbusNeich (Hong Kong)
- Pathway Medical Technologies, Inc (USA)
- Possis Medical, Inc (USA)
- Siemens Medical Solutions (USA)
- Signalife, Inc (USA)
- Sorin Biomedica Cardio SpA (Italy)
- ELA Medical Srl (Italy)
- ELA Medical, Inc (USA)
- ELA Medical (Portugal)
- ELA Medical Benelux SA (Belgium)
- ELA Medical BV A Sorin Group Co (The Netherlands)
- ELA Medical GmbH (Germany)
- ELA Medical Izasa (Spain)
- ELA Medical Japan Co, Ltd (Japan)
- ELA Medical Nordic A Sorin Group Co (Denmark)
- ELA Medical SA (Switzerland)
- ELA Medical SA (France)
- ELA Medical UK Ltd (UK)
- Spectranetics Corporation, The (USA)
- St Jude Medical, Inc (USA)
- St Jude Medical - Cardiac Rhythm Management Division (USA)
- Daig Corp Div St Jude Medical, Inc (USA)
- Getz Bros Co, Ltd (Japan)
- St Jude Medical (Belgium)
- Teleflex Medical Group (USA)
- Terumo Medical Corporation (USA)
- Terumo Cardiovascular Systems Corporation (USA)
- Tokai Medical Products, Inc (Japan)
- Toray Industries, Inc (Japan)
- Toray Industries America, Inc (USA)
- Toray Industries (HK) Ltd (Hong Kong)
- Toray Industries (Singapore) Pte, Limited (Republic of Singapore)
- Toray Industries, Inc (China)
- Toray Industries, Inc (UK)
- Toray Industries, Inc (Seoul) (Korea)
- TZ Medical, Inc (USA)
- Unomedical A/S (Denmark)
- UreSil LLC (USA)
- Vascor Medical Corporation (USA)
- Vascular Solutions, Inc (USA)
- Volcano Corporation (USA)
- Xtrak Medical, Inc (USA)
- Zeon Medical, Inc (Japan)

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