Orthopedic Prosthetics - Global Strategic Business Report

This report analyzes the worldwide markets for Orthopedic Prosthetics in US$ Million by the following Product Segments: Hip Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder Prosthesis, & Other Secondary Joint Prosthesis). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets.

The report profiles 65 companies including many key and niche players such as AAP Implantate AG, Aesculap Implant Systems, Inc., Biomet, Inc., Corin Group PLC, DePuy Orthopedics, Inc., MatOrtho™ Ltd., DJO Surgical, Exactech, Inc., Smith & Nephew Plc, Stryker Corporation, Tornier, Wright Medical Group, Inc., and Zimmer Holdings Inc.

Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

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ORTHOPEDIC PROSTHETICS

A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Hip Prosthesis I-3
Knee Prosthesis I-4
Secondary Joint Prosthesis I-4

II. Executive Summary

1. GLOBAL MARKET OVERVIEW AND ANALYSIS II-1
Orthopedic Implants - Witnessing Steady Growth II-1
Global Hip & Knee Implants Market II-1
Hip Implants Market - Present Scenario II-2
Countering Recession II-2
Technological Advancements Fuel Growth II-2
Focus on Bone Conservation II-2
Major Growth Drivers for the Industry II-2
Aging Population Drives Demand II-2
Growing Obese Population Drives Demand for Joint Replacement
Surgeries II-3
Rising Life Expectancy & Active Lifestyle Drive Demand for
Joint Replacement Procedures II-3
Cost Containment Issues II-3
Developing Markets Hold Enormous Growth Potential II-4
Revision Procedures Buoy Growth II-4
Minimally Invasive Surgery - Attracts Attention II-4
Demand for Premium Implants Continues II-4
Growing Demand for Total Hip Replacement in Young People II-4
Hip Resurfacing Replacement for Younger Generation II-5
Table 1: Leading Manufacturers in the Global Hip Resurfacing
Market (2008 & 2009): Percentage Share Breakdown of Value
Sales for Smith and Nephew, Stryker, Wright Medical and
DePuy (Johnson and Johnson) (includes corresponding
Graph/Chart) II-6
Gender-Specific Orthopedic Devices Gain Momentum II-6

2. COMPETITIVE SCENARIO II-7
Mergers and Acquisitions Timeline in the Worldwide Orthopedic
Prosthetics Industry: 2003-2009 II-7
Table 2: Leading Players in the Global Reconstructive/
Orthopedic Implant Market (2010): Percentage Share Breakdown
of Value Sales for Zimmer, J&J/DePuy, Stryker, Biomet, Smith
& Nephew, and Others (includes corresponding Graph/Chart) II-8

Table 3: Leading Manufacturers in the Global Hip Implant
(Reconstructive) Market (2011): Percentage Share Breakdown of
Unit Sales for Zimmer, DePuy, Stryker, Biomet and Others
(includes corresponding Graph/Chart) II-8

Table 4: Leading Manufacturers in the Global Knee Implant
(Reconstructive) Market (2010): Percentage Share Breakdown of
Value Sales for Zimmer, DePuy, Stryker, Biomet, Smith &
Nephew, Wright Medical, Exactech and Others (includes
corresponding Graph/Chart) II-8

Table 5: Leading Manufacturers in the Global Spinal Implant
(Reconstructive) Market (2010): Percentage Share Breakdown of
Value Sales for Zimmer, Stryker, JNJ DePuy, Biomet, Smith &
Nephew, Wright Medical, Exactech and Others (includes
corresponding Graph/Chart) II-9

Table 6: Leading Manufacturers in the Global Hip and Knee
Implants Market (2010): Percentage Share Breakdown of Value
Sales for Zimmer, DePuy, Stryker, Biomet, Smith & Nephew, and
Others (includes corresponding Graph/Chart) II-9

Table 7: Leading Players in the Global Extremities Market
(2010): Percentage Share Breakdown of Value Sales for DePuy,
Tornier, Zimmer, Wright Medical, Biomet, and Others (includes
corresponding Graph/Chart) II-10

Table 8: Leading Players in the Global Trauma &
Craniomaxillofacial Market (2010): Percentage Share Breakdown
of Value Sales for Synthes, Stryker, Smith & Nephew, JNJ
DePuy, Zimmer, Biomet and Others (includes corresponding
Graph/Chart) II-10

Table 9: Leading Players in the Global Orthobiologics Market
(2010): Percentage Share Breakdown of Value Sales for
Medtronic, Synthes, JNJ DePuy, Osteotech, Smith & Nephew,
Stryker and Others (includes corresponding Graph/Chart) II-10

Table 10: Leading Players in Worldwide Hip Implants Market
(2008 & 2012): Percentage Breakdown of Dollar Sales by
Company for Zimmer, J&J DePuy, Stryker, Smith & Nephew,
Biomet, Wright Medical and Others (includes corresponding
Graph/Chart) II-11

Table 11: Leading Players in Worldwide Knee Implants Market
(2008 & 2012): Percentage Breakdown of Dollar Sales by
Company for Zimmer, J&J DePuy, Stryker, Biomet, Smith &
Nephew, Wright Medical and Others (includes corresponding
Graph/Chart) II-12

Table 12: Leading Players in Worldwide Spinal Implants Market
(2008 & 2012): Percentage Breakdown of Dollar Sales by
Company for Medtronic/Kyphon, J&J DePuy, Synthes, Stryker,
Nuvasive, Zimmer, Biomet and Others (includes corresponding
Graph/Chart) II-13

Table 13: Leading Players in the World Fracture Repair Market
(2010): Percentage Share Breakdown of Value Sales for
Synthes, Stryker, Smith & Nephew, Zimmer, DePuy, Biomet,
Acumed, Orthofix and Others (includes corresponding
Graph/Chart) II-13
Peer Group Analysis II-14
Zimmer Holdings, Inc. (USA) II-14
DePuy, Inc. (USA) II-14
Stryker Corp. (USA) II-15
Biomet, Inc. (USA) II-15
Smith & Nephew, Inc. (USA) II-16

3. FOREWORD TO THE ORTHOPEDIC INDUSTRY II-17
Mergers and Acquisitions in the Worldwide Orthopedics
Industry: 2005-2010 II-17
Orthopedic Orthotics & Prosthetics II-18
Table 14: Global Orthopedic Market (2010): Percentage
Breakdown of Dollar Sales for Hips and Knees, Spinal Devices,
Trauma and Craniomaxillofacial, Operating Room Equipment,
Orthobiologics, Arthroscopy, and Others (includes
corresponding Graph/Chart) II-19

4. ORTHOPEDIC PROSTHETICS - PRODUCT OVERVIEW II-20
Hip Prosthesis II-20
Total Hip Replacement II-20
Conditions Requiring Total Hip Replacement II-20
Materials Used... II-21
Cemented Hip Implants II-21
Cementless Hip Implants II-21
Complications Following THR II-21
Partial Hip Replacement II-21
Revision Hip Procedures II-22
Types of Hip Implants II-22
Ceramic-on-Ceramic II-22
Metal-on-Metal II-23
Highly Cross-Linked Polyethylene II-23
Ceramic-on-Polyethylene II-23
Metal-on-Polyethylene II-23
Product Portfolio of Major Players in the Hip Implants Market II-23
Knee Prosthesis II-24
Functional Aspects of the Knee II-24
Implant Design II-24
Femoral Component II-24
Tibial Component II-25
Patellar Component II-25
Unicondylar Knee Replacements II-25
Fixed and Mobile Bearing Knees II-25
Mobile Bearing Total Knee Replacement Prosthesis II-26
Revision Surgeries II-26
Secondary Joint Prosthesis II-26
Shoulder Prosthesis II-26
Ankle Prosthesis II-26
Elbow Prosthesis II-27
Finger Prosthesis II-27

5. PRODUCT TRENDS II-28
Alternate-Bearing Materials in the Hip Implants Market II-28
Diamond-on-Diamond Technology II-28
Cementless Procedures Gain Ground II-28
Trabecular Metal Technology II-29
Surface Modification Technology II-29
Novel Minimally Invasive Approaches II-29
Zimmer Launches Quad-Sparing Total Knee Replacement II-29
Zimmer Introduces New Minimally Invasive Anterolateral Hip
Replacement Procedure II-30
DePuy Introduces New Mini-Incision Technique in Hip Replacement II-30

6. MAJOR PROSTHESIS TECHNOLOGIES - AN OVERVIEW II-31
Artificial Disc Technology II-31
Artificial Total Disc II-32
Allografts II-33
Osteoinductive Agents/Bone Graft Factors II-34
The Hip Hinge Technology II-34
Resorbables II-34
Cell Therapy - Chondrocyte Transplantation II-34

7. TECHNOLOGICAL DEVELOPMENTS II-35
First Commercially Available Human Shoulder Arthroplasty
Prosthesis Developed II-35
Human Implantation of Shoulder Arthroplasty Prosthesis II-35
Artificial Intelligent Prosthesis Developed for Above-Knee
Amputees II-35
New Radial Head Prosthesis Developed II-36
Innovative Joint Prosthesis Developed II-36
US-Based Inventor Designs New Knee Prosthesis II-36
US Inventors Develop New Modular Prosthetic Knee System II-36
Californian Inventor Develops Orthopedic Implant Surface
Configuration II-37
Indiana Inventor Designs New Prosthetic Implant II-37
New Orthopedic Implant Application Method Developed II-37
US-Based Inventors Develops Stem Extension for Leg and Knee
Implants II-37
US-Based Inventor Develops New Prosthesis Hip Implant II-37

8. PRODUCT INNOVATIONS/INTRODUCTIONS II-38
Exactech Obtains FDA Approval for Equinoxe Platform Fracture Stem II-38
Touch Bionics Introduces i-LIMB Hand in India II-38
FDA Grants Approval for DJO's X-alt™ Polyethylene Liner II-38
Smith & Nephew Introduce R3 Acetabular System II-39
Smith & Nephew Introduces VERILAST Knee Replacement Technology II-39
Wright Medical Expands Orthopedic Hip Offerings II-39
Zimmer Holdings Introduces Zimmer® DTO™ Implants II-39
Japan Regulatory Approves Wright's CONSERVE® Plus II-40
Smith & Nephew Rolls Out Globally JOURNEY DEUCE Knee System II-40
Wright Extends Hip Product Offerings II-40
FDA Approves Cormet™ Hip Resurfacing System of Corin II-41
Exactech Gains FDA Clearance for its Novation™ Ceramic AHS™
Hip System II-41
Biomet Rolls Out Minimally Invasive Hip Stems II-41
Wright Launches EVOLVE® PROLINE System II-41
AIC Receives CE Mark Approval for its New AIC Hip Buffer™
Polymer Implant II-42
Portland Gains FDA Approval to Market Beacon Primary Knee
System in the US II-42
Portland Develops a New Cemented Hip Replacement Product II-42
Smith and Nephew Receives FDA Clearance to Market Birmingham
Hip Brand in the US II-42
Kobayashi Rolls Out New Kiapex Hip Prosthesis System II-43
ABS Gains FDA and CE Mark Approvals for its OrthoGlide Medial
Knee Implant II-43
FDA Approves Biomet's Regenerex™ Porous Titanium Construct
Acetabular System II-43
Smith & Nephew Introduces New JOURNEY* Bi-Cruciate Stabilized
Knee System II-43
Wright Medical Unveils New CLAWT Plate for Foot & Ankle
Reconstructive Surgeries II-44
Wright Medical Introduces New PROFEMUR® RENAISSANCE™ Total Hip
System II-44
Wright Medical Group Rolls Out A-CLASS™ Polyethylene Liner for
LINEAGE® Hip Implants II-44
FDA Grants PMA Clearance for Zimmer's Trilogy AB® Ceramic-on-
Ceramic Acetabular System II-44
Zimmer Develops Implant Systems Based on Trabecular Metal
Technology II-45
FDA Clears Zimmer's Gender Solutions Artificial Knee for Women II-45
Stryker Launches Triathlon Knee System for Women II-45
DePuy Introduces ASR XL Metal-on-Metal Total Hip Replacement
Device II-45
Smith & Nephew Introduces New EMPERION* Modular Hip System II-45
FDA Clears Stryker's LFIT(TM) Anatomic Femoral Heads with X3(
R) Liners II-46
Exactech Introduces Cemented Stem for its Novation™ Hip System II-46

9. RECENT INDUSTRY ACTIVITY II-47
Zimmer to Acquire Montagne Medical Device II-47
DePuy Orthopaedics Takes Over Finsbury Orthopaedics II-47
Hanger Acquires Custom Orthopedics, Creative Orthotics and
Specific Assets II-47
Langer Changes Name to PC Group II-48
Wright Medical to Take Over INBONE Technologies II-48
Encore Medical of DJO Renamed to DJO Surgical II-48
Wright Medical Acquires Foot Surgery Division of DARCO
International II-49
Smith & Nephew Acquires Plus Orthopedics II-49
DJO Concludes Merger with ReAble Therapeutics II-49
Wright Medical Purchases Metasurg's Foot and Ankle Implants II-49
Wright Medical Buys External Fixation Product Line of R&R Medical II-49
Regeneration Technologies and Wright Medical Partner to
Develop Innovative Implants II-50
Biomet Acquired by LVB Acquisition II-50
Kensey Nash and Biomet Sign Exclusive Distribution Agreement II-50
FDA Approves Zimmer® NexGen® LPS-Flex Mobile Knee II-50
Regeneration Technologies and Zimmer Holdings Ink 10-Year
Distribution Agreement II-50
Corin and Stryker Enter into a Distribution Concord II-51
Blackstone Capital Partners Inks Definitive Agreement to
Acquire Encore II-51
Integra Takes Over KMI in a Cash Transaction II-51
MAKO Licenses New Orthopedic Implant Material Rights from UF II-51
Hanger Acquires Regional Artificial Limb & Brace Co. and
Temple Medical II-51

10. FOCUS ON SELECT GLOBAL PLAYERS II-52
AAP Implantate AG (Germany) II-52
Aesculap Implant Systems, Inc. (USA) II-52
Biomet, Inc. (USA) II-52
Corin Group PLC (UK) II-53
DePuy Orthopedics, Inc. (USA) II-53
MatOrtho™ Ltd. (UK) II-53
DJO Surgical (USA) II-54
Exactech, Inc. (USA) II-54
Smith & Nephew Plc (UK) II-54
Stryker Corporation (USA) II-55
Tornier (USA) II-55
Wright Medical Group, Inc. (USA) II-56
Zimmer Holdings, Inc. (USA) II-56

11. GLOBAL MARKET PERSPECTIVE II-57
Table 15: World Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) II-57

Table 16: World Historic Review for Orthopedic Prosthetics by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) II-58

Table 17: World 15-Year Perspective for Orthopedic Prosthetics
by Geographic Region - Percentage Breakdown of Dollar Sales
for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 2003, 2011 &
2017 (includes corresponding Graph/Chart) II-59

Table 18: World Recent Past, Current & Future Analysis for Hip
Prosthesis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) II-60

Table 19: World Historic Review for Hip Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) II-61

Table 20: World 15-Year Perspective for Hip Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 2003, 2011 &
2017 (includes corresponding Graph/Chart) II-62

Table 21: World Recent Past, Current & Future Analysis for
Knee Prosthesis by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) II-63

Table 22: World Historic Review for Knee Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia- Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) II-64

Table 23: World 15-Year Perspective for Knee Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 2003, 2011 &
2017 (includes corresponding Graph/Chart) II-65

Table 24: World Recent Past, Current & Future Analysis for
Secondary Joint Prosthesis by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) II-66

Table 25: World Historic Review for Secondary Joint Prosthesis
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) II-67

Table 26: World 15-Year Perspective for Secondary Joint
Prosthesis by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets for
Years 2003, 2011 & 2017 (includes corresponding Graph/Chart) II-68

Table 27: World Recent Past, Current & Future Analysis for
Secondary Joint Prosthesis by Product Segment - Shoulder and
Other Secondary Joint Prosthesis Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-69

Table 28: World Historic Review for Secondary Joint Prosthesis
by Product Segment - Shoulder and Other Secondary Joint
Prosthesis Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-70

Table 29: World 15-Year Perspective for Secondary Joint
Prosthesis for Secondary Joint Prosthesis by Product Segment -
Shoulder and Other Secondary Joint Prosthesis Markets for
Years 2003, 2011 & 2017 (includes corresponding Graph/Chart) II-71

Table 30: World Recent Past, Current & Future Analysis for
Shoulder Prosthesis by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific (excluding Japan), Latin America and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) II-72

Table 31: World Historic Review for Shoulder Prosthesis by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) II-73

Table 32: World 15-Year Perspective for Shoulder Prosthesis by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America and Rest of World Markets for Years 2003, 2011 &
2017 (includes corresponding Graph/Chart) II-74

Table 33: World Recent Past, Current & Future Analysis Other
Secondary Joint Prosthesis by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2009 through 2017
(includes corresponding Graph/Chart) II-75

Table 34: World Historic Review for Other Secondary Joint
Prosthesis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), Latin America and Rest of
World Markets Independently Analyzed with Annual Sales Figures
in US$ Million for Years 2003 through 2008 (includes
corresponding Graph/Chart) II-76

Table 35: World 15-Year Perspective for Other Secondary Joint
Prosthesis by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America and Rest of World Markets for
Years 2003, 2011 & 2017 (includes corresponding Graph/Chart) II-77

III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Issues & Trends III-1
Large-Joint Reconstructive Implants Market - An Insight III-1
Rising Demand for Hip and Knee Replacement Surgeries III-1
Advancements in Prosthetic Implants Foster Demand for Joint
Replacement Procedures III-2
Reconstructive Products - Growth Drivers III-3
Demographics III-3
Table 36: Percentage of Population by Age Group in the US
(2010) (includes corresponding Graph/Chart) III-3

Table 37: Population of the Elderly in the US (in
Millions): Population of 50-54, 55-59, 60-64, 65-69 and
70-74 Age Groups for 2001, 2006 and 2011includes
corresponding Graph/Chart) III-3
Innovations: Ameliorate Industry Growth III-4
Younger Patients - New Target III-4
Price/Mix Shift III-4
Medicare Reimbursement: A Macro Catalyst III-4
Knee Implants Market III-5
Knee Implant Statistics - Historic Review III-5
Table 38: Knee Implants Market in the US (2004): Percentage
Breakdown by Value Sales for Implant Type - Cemented
Femoral, Cemented Tibial, Cementless Femoral ,Cementless
Tibial and Polyethylene Liner (includes corresponding
Graph/Chart) III-5

Table 39: Knee Implant Procedures in the US: 2000- 2007 (In
Thousands) (includes corresponding Graph/Chart) III-5
Hip Implants Market III-6
New Materials Emerge as Polyethylene Alternatives III-6
Table 40: Hip Implant Procedures in the US: 2000- 2007 (In
Thousands) (includes corresponding Graph/Chart) III-6
Shift from Cemented to Press-Fit Procedures III-6
Shoulder Market III-7
Select Manufacturers in the US Upper Extremity Joint
Replacement Products Market III-7
Table 41: Leading Players in the US Shoulder Market
(2007): Percentage Share Breakdown of Value Sales for
DePuy, Biomet, Zimmer, Tornier, Stryker, Smith & Nephew,
Exactech, and Others (includes corresponding Graph/Chart) III-7
Major Players III-8
Player Statistics III-8
Table 42: Leading Players in the US Hip Implants Market
(2004 & 2005): Percentage Breakdown by Value Sales for
Zimmer, Depuy, Stryker, Biomet, Smith & Nephew, Wright
Medical and Others (includes corresponding Graph/Chart) III-8

Table 43: Leading Players in the US Knee Implants Market
(2004 & 2005): Percentage Breakdown by Value Sales for
Zimmer, Depuy, Stryker, Biomet, Smith & Nephew, Wright
Medical and Others (includes corresponding Graph/Chart) III-9
B.Market Analytics III-10
Table 44: US Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment - Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-10

Table 45: US Historic Review for Orthopedic Prosthetics by
Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-11

Table 46: US 15-Year Perspective for Orthopedic Prosthetics
by Product Segment - Percentage Breakdown of Value Sales for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets for 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-12

2. CANADA III-13
Market Analytics III-13
Table 47: Canadian Recent Past, Current & Future Analysis
for Orthopedic Prosthetics by Product Segment - Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-13

Table 48: Canadian Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-14

Table 49: Canadian 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-15

3. JAPAN III-16
A.Market Analysis III-16
Growth Boosters III-16
Driven by Innovations III-16
Aging Population Propels Sales III-16
Government Resorts to Reimbursement Cuts for Orthopedics Sector III-16
Players in Japanese Orthopedic Implants Market III-17
Table 50: Leading Players in the Japanese Knee Implants
Market (2005): Percentage Breakdown by Value Sales for
Zimmer, Stryker, DePuy- J&J, Wright Medical Group, Biomet,
Smith& Nephew and Others (includes corresponding
Graph/Chart) III-17
B.Market Analytics III-18
Table 51: Japanese Recent Past, Current & Future Analysis
for Orthopedic Prosthetics by Product Segment - Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-18

Table 52: Japanese Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-19

Table 53: Japanese 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-20

4. EUROPE III-21
A.Market Analysis III-21
Demographics Drive Growth III-21
Impact of Recession on Europe's Medical Devices Market III-21
Orthopedic and Prosthetic Devices Market III-21
Table 54: European Orthopedic Device market (2009):
Percentage Share breakdown by Segments -Joint
Reconstruction Devices, Orthopedics Braces and Supports,
Spinal Surgery, Trauma Fixation, Orthobiologics,
Orthopedic Diagnostic Devices and Orthopedic Accessories
(includes corresponding Graph/Chart) III-22
Small Joint Reconstructive Implants Market - High Growth
Prospects III-22
Hip and Knee Replacement Market III-23
Growth Drivers III-23
Increase in Elderly Population Fuels Demand for Joint
Replacement Procedures III-23
Reduced Waiting Time & Effective Clinical Outcomes Boost
Industry Prospects III-23
Revision Surgeries - A Major Growth Area III-23
Technological Advancements Ensure Higher Demand for
Replacement Procedures III-23
Market Restraints III-24
Reimbursements Scenario in Europe III-24
Competitive Scenario III-24
Table 55: Leading Players in the European Orthopedic
Devices Market (2008): Percentage Share Breakdown of Value
Sales for Stryker, Zimmer, DePuy, Biomet, Smith & Nephew,
Synthes, Corin and Others (includes corresponding
Graph/Chart) III-25

Table 56: Leading Players in the European Reconstructive
Market (2008): Percentage Share Breakdown of Value Sales
for Zimmer, J&J/ DePuy, Smith & Nephew, Stryker, Biomet,
Wright Medical, and Others (includes corresponding
Graph/Chart) III-25
Trends Driving the Implants Segment III-25
Modular Systems Turn the Most Common Form of Knee Implant
in Europe III-26
B.Market Analytics III-26
Table 57: European Recent Past, Current & Future Analysis
for Orthopedic Prosthetics by Geographic Region - France,
Germany, Italy, UK, and Rest of Europe Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-26

Table 58: European Historic Review for Orthopedic
Prosthetics by Geographic Region - France, Germany, Italy,
UK and Rest of Europe Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2003 through
2008 (includes corresponding Graph/Chart) III-27

Table 59: European Recent Past, Current & Future Analysis
for Orthopedic Prosthetics by Product Segment - Hip
Prosthesis, Knee Prosthesis, and Secondary Joint Prosthesis
(Shoulder Prosthesis and Other Joint Prosthesis) Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-28

Table 60: European Historic Review for Orthopedic
Prosthetics by Product Segment - Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-29

Table 61: European 15-Year Perspective for Orthopedic
Prosthetics by Geographic Region - Percentage Breakdown of
Value Sales for France, Germany, Italy, UK, and Rest of
Europe Markets for Years 2003, 2011 & 2017 (includes
corresponding Graph/Chart) III-30

Table 62: European 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-31

4a. FRANCE III-32
A.Market Analysis III-32
Orthopedic Market III-32
Demographics Underpinning Growth III-32
Table 63: Percentage of Population by Age Group in France
(2010) (includes corresponding Graph/Chart) III-32
B.Market Analytics III-33
Table 64: French Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment - Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-33

Table 65: French Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-34

Table 66: French 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-35

4b. GERMANY III-36
A.Market Analysis III-36
Orthopedic Products III-36
Demographic Profile III-36
Table 67: Percentage of Population by Age Group in Germany
(2010) (includes corresponding Graph/Chart) III-36
B.Market Analytics III-37
Table 68: German Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment - Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-37

Table 69: German Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-38

Table 70: German 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-39

4c. ITALY III-40
A.Market Analysis III-40
Demographic Profile III-40
Table 71: Percentage of Population by Age Group in Italy
(2010) (includes corresponding Graph/Chart) III-40
B.Market Analytics III-41
Table 72: Italian Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment - Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-41

Table 73: Italian Historic Review for Orthopedic Prosthetics
by Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-42

Table 74: Italian 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-43

4d. THE UNITED KINGDOM III-44
A.Market Analysis III-44
Total Hip Replacement Statistics III-44
Shoulder & Small Joint Implants III-44
Demographic Profile III-44
Table 75: Percentage of Population by Age Group in the UK
(2010) (includes corresponding Graph/Chart) III-44
Leading Players III-44
Issues & Trends III-44
Aging Baby Boomer Generation Fuels Demand for Knee
Replacement Surgeries III-44
Trends in Primary and Revision Joint (Hip and Knee)
Replacement Procedures III-45
B.Market Analytics III-46
Table 76: UK Recent Past, Current & Future Analysis for
Orthopedic Prosthetics by Product Segment - Hip Prosthesis,
Knee Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) III-46

Table 77: UK Historic Review for Orthopedic Prosthetics by
Product Segment - Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through 2008
(includes corresponding Graph/Chart) III-47

Table 78: UK 15-Year Perspective for Orthopedic Prosthetics
by Product Segment - Percentage Breakdown of Value Sales for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets for years 2003, 2011 & 2017 (includes corresponding
Graph/Chart) III-48

4e. REST OF EUROPE III-49
A.Market Analysis III-49
Overview of Select European Markets III-49
Austria III-49
Czech Republic III-49
Competition III-49
Spain III-50
Switzerland III-50
B.Market Analytics III-51
Table 79: Rest of Europe Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) III-51

Table 80: Rest of Europe Historic Review for Orthopedic
Prosthetics by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-52

Table 81: Rest of Europe 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-53

5. ASIA-PACIFIC III-54
A.Market Analysis III-54
Factors Influencing Demand for Joint Replacement Procedures III-54
Hip Implants Market in Asia - Potential for Growth III-54
Declining Reimbursements - Means to Reduce Financial Burden III-54
Overview of Select Markets in Asia III-54
Australia III-54
China III-55
Table 82: China Orthopedics Market (2007, 2020 & 2050):
Breakdown of Prevalence for Vertebral Fractures in Women
Aged Over 50 Years (includes corresponding Graph/Chart) III-55

Table 83: Government Spending on Hip Fractures in China
(2007, 2020 and 2050) (includes corresponding Graph/Chart) III-56
India III-56
Regulatory Impact on Orthopedic Devices Industry III-56
India - A Favored Destination for Low-Cost Orthopedic
Surgical Procedures III-57
New Zealand III-57
Government Funding for Increasing Number of Hip and Knee
Replacement Surgeries III-57
South Korea III-57
Imports III-58
Competition III-58
Taiwan III-58
B.Market Analytics III-59
Table 84: Asia-Pacific Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) III-59

Table 85: Asia-Pacific Historic Review for Orthopedic
Prosthetics by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-60

Table 86: Asia-Pacific 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-61

6. LATIN AMERICA III-62
Market Analytics III-62
Table 87: Latin American Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) III-62

Table 88: Latin American Historic Review for Orthopedic
Prosthetics by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-63

Table 89: Latin American 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-64

7. REST OF WORLD III-65
A.Market Analysis III-65
Israel III-65
B.Market Analytics III-66
Table 90: Rest of World Recent Past, Current & Future
Analysis for Orthopedic Prosthetics by Product Segment for
Hip Prosthesis, Knee Prosthesis, and Secondary Joint
Prosthesis (Shoulder Prosthesis and Other Joint Prosthesis)
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2009 through 2017 (includes
corresponding Graph/Chart) III-66

Table 91: Rest of World Historic Review for Orthopedic
Prosthetics by Product Segment for Hip Prosthesis, Knee
Prosthesis, and Secondary Joint Prosthesis (Shoulder
Prosthesis and Other Joint Prosthesis) Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2003 through 2008 (includes corresponding Graph/Chart) III-67

Table 92: Rest of World 15-Year Perspective for Orthopedic
Prosthetics by Product Segment - Percentage Breakdown of
Value Sales for Hip Prosthesis, Knee Prosthesis, and
Secondary Joint Prosthesis (Shoulder Prosthesis and Other
Joint Prosthesis) Markets for years 2003, 2011 & 2017
(includes corresponding Graph/Chart) III-68

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 65 (including Divisions/Subsidiaries - 100)

------------------------------------------
Region/Country Players
------------------------------------------
The United States 43
Canada 4
Japan 4
Europe 40
France 6
Germany 11
The United Kingdom 8
Italy 3
Spain 2
Rest of Europe 10
Asia-Pacific (Excluding Japan) 7
Latin America 2
------------------------------------------

The economic meltdown slowed down the pace of growth in the global hip and knee implants market during 2008 and 2009. Growth was affected due to dampened procedural demand, as patients opted to delay surgery until after the recession. Long-term growth in the hip and knee replacement market is expected from the growing awareness levels about the procedure, favorable reimbursement scenario, and increasing familiarity of surgeons with the procedures. Developing nations, such as India, China and Latin American countries, offer immense growth potential for orthopedic companies owing to their steady economic growth, and the presence of large elderly population. The development of advanced prosthetic implants involving better fixation, cementless design and wear-resistant material is also enhancing growth prospects in the industry. Budgetary constraints and the increasing demand from developing countries are expected to foster the development of low cost, limited function orthopedic implants.

The United States and Europe collectively account for a major share of the global market, as stated by the new market research report on Orthopedic Prosthetics. The recession affected growth prospects in the European reconstructive (hip and knee implants) market, as patients opted to defer minor as well as major surgeries, thereby impacting revenue generation in the prosthetic devices and the overall orthopedic market. However, the industry is likely to overcome the adversities and register growth driven by developing advanced devices, such as bio-absorbable structures. The increasing desire of consumers to maintain active lifestyle is also contributing to a rise in demand for less invasive and bone preserving technologies. The under-served markets of Russia and Eastern Europe offer potential growth opportunities for companies operating in the European market.

Rapid technological advancements in the hip prosthesis market are contributing to the development of improved implant materials and devices, featuring better design and offering longer life. Minimally invasive surgical techniques are gaining popularity for performing hip replacement surgeries, thereby enabling patients to maintain active lifestyle. The growing popularity of hip arthroplasty procedures among younger patients is also enhancing prospects in the global hip implants market. Latin America is poised to witness the fastest growth in the hip prosthesis market, increasing at a compounded annual growth rate of over 8.5% over the analysis period. In the United States, sales of knee prosthesis are driven by a shift towards differentiated devices, and the growing popularity of knee replacements in younger patients.

Zimmer, DePuy, Stryker, Biomet and Smith & Nephew are the leading manufacturers in the global hip and knee implants markets. In addition to the global leaders, the hip and knee implants market also involves the participation of local manufacturers, particularly in Asian countries such as Japan, China, and Australia commanding a significant presence due to their extensive distribution networks.

Global Industry Analysts ©

- AAP Implantate AG (Germany)
- Active Implants Corporation (USA)
- Advanced Bio-Surfaces, Inc. (USA)
- Advanced Surgical Design & Manufacture Ltd. (Australia)
- Amann's Orthopedic and Prosthetics, Inc. (USA)
- Apothecaries Sundries Mfg., Co. (India)
- Ascension Orthopedics (USA)
- B. Braun Melsungen AG (Germany)
- Aesculap AG & Co., KG. (Germany)
- Aesculap, Inc. (USA)
- Aesculap Implant Systems, Inc. (USA)
- Ballert Orthopedic (USA)
- Baumer SA (Brazil)
- Beznoska Sro (Czech Republic)
- Biomet, Inc. (USA)
- Biomet A/S (Denmark)
- Biomet Europe (The Netherlands)
- Biomet Spain Orthopaedics SL (Spain)
- Biopro, Inc. (USA)
- Biotek - Chetan Meditech Pvt., Ltd. (India)
- Brandes & Diesing (Germany)
- Centri (Sweden)
- Consensus Orthopedics, Inc. (USA)
- Corin Group PLC (UK)
- Corin USA (USA)
- Darco International, Inc. (USA)
- DePuy Orthopaedics, Inc. (USA)
- DePuy International Ltd. (UK)
- DePuy Orthopadie GmbH (Germany)
- MatOrtho® Ltd. (UK)
- DJO, Inc. (USA)
- DJO Surgical (USA)
- Erothitan Titanium Implants (Germany)
- Exactech, Inc. (USA)
- Hanger Orthopedic Group, Inc. (USA)
- Hosmer Dorrance Corporation (USA)
- Hospital Equipment Mfg., Co. (India)
- Implants Industrie (France)
- IMPOL Instrumental E Implantes Ltda (Brazil)
- Integra LifeSciences Holdings Corporation (USA)
- Integra Lifesciences Corporation (USA)
- Japan Medical Dynamic Marketing, Inc. (Japan)
- Ortho Development Corporation (USA)
- Joint Replacement Instrumentation Ltd. (UK)
- Kensey Nash Corporation (USA)
- Kobayashi Pharmaceutical Co., Ltd. (Japan)
- Liberating Technologies, Inc. (USA)
- Lima Group (Italy)
- Linkbio Corporation (USA)
- MAKO Surgical Corporation (USA)
- Mathys Ltd. Bettlach (Switzerland)
- Medtronic Sofamor Danek, Inc. (USA)
- Metasurg (USA)
- Motion Control, Inc. (USA)
- OHST Medizintechnik AG (Germany)
- Ossur HF (Iceland)
- Ossur North America (USA)
- Otto Bock Health Care, Inc. (USA)
- PLD Corporation Ltd. (Australia)
- Proteor Handicap Technologie (France)
- Rotec Medizintechnik GmbH (Germany)
- RTI Biologics, Inc. (USA)
- Societe D' Etudes Recherches Et Fabrications (SERF) (France)
- Smith & Nephew PLC (UK)
- Smith & Nephew Orthopaedics Ltd. (UK)
- Smith & Nephew, Inc. (USA)
- Smith & Nephew, Inc. Orthopaedic Div. (Canada)
- Smith & Nephew Ltd. (Hong Kong)
- Smith & Nephew Srl (Italy)
- Smith & Nephew Orthopaedics Schweiz AG (Switzerland)
- Smith & Nephew Orthopaedics (USA)
- Stelkast, Inc. (USA)
- Stryker Corporation (USA)
- Stryker Orthopaedics (USA)
- Stryker Canada (Canada)
- Stryker Singapore Pte., Ltd. (Singapore)
- Summit Medical Ltd. (UK)
- Surgival (Spain)
- Symmetry Medical, Inc. (USA)
- Synthes, Inc. (Switzerland)
- Teknimed SA (France)
- TMJ Concepts (USA)
- TMJ Medical (USA)
- Tornier, Inc. (USA)
- Tornier SA (France)
- Trulife USA (USA)
- Waldemar Link GmbH & Co., KG. (Germany)
- Wright Medical Technology, Inc. (USA)
- Wright Medical Belgium NV (Belgium)
- Wright Medical Deutschland GmbH (Germany)
- Wright Medical Italy Srl (Italy)
- Wright Cremascoli OrthoTechnique (France)
- Wright Medical Japan KK (Japan)
- Wright Medical Technology Canada Ltd. (Canada)
- Zimmer, Inc. (USA)
- Zimmer of Canada Ltd. (Canada)
- Zimmer Chirurgie GmbH (Germany)
- Zimmer KK (Japan)
- Zimmer Ltd. (UK)
- Zimmer Netherlands BV (The Netherlands)