Contents:

CLINICAL CHEMISTRY ANALYZERS AND REAGENTS A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability And Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-2 Product Definitions And Scope Of Study I-3 Clinical Chemistry Analyzers I-3 Large Volume Clinical Chemistry Analyzers I-3 Medium Sized Clinical Chemistry Analyzers I-3 Small Sized Clinical Chemistry Analyzers I-4 Reagents I-4 Metabolite Chemistry Reagents I-4 Enzyme Chemistry Reagents I-4 Electrolyte Chemistry Reagents I-4 II. 1. Market Analysis II-1 Current and Future Analysis II-1 Asia-Pacific Projected to Register Impressive Growth Rate II-1 Global Clinical Chemistry Analyzers Market II-1 Global Reagents Market II-1 2. Trends II-2 Analyzers and Sensors Transform Clinical Diagnostics II-2 Clinical Laboratory Automation-Order of the Day II-2 Mass Spectrometry A New Dimension in Clinical Diagnostics II-2 Nanotechnology Shapes the Future of Clinical Labs II-3 Northward Bound of Point-of-Care Testing II-3 Integrated Systems Cannibalize Single Unit Sales II-3 3. Diagnostic Industry Overview II-4 Exhibiting Rapid Change II-4 IVD Industry An Overview II-4 Table 1: IVD Market Worldwide: Percentage Share Breakdown by Segment in terms of Volume or Number of Tests (includes corresponding Graph/Chart) II-4 Leading Players II-5 Table 2: Leading Players in the Global IVD Market (2004): Percentage Share Breakdown by Value sales for Roche Diagnostics, Abbott, J&J/Ortho Clinical Diagnostics, Bayer, Beckman Coulter, and Others (includes corresponding Graph/ Chart) II-5 Clinical Chemistry Testing Market II-5 Table 3: Leading Players in the Global Clinical Chemistry Testing Market for 2001 & 2005: Market Share by Value Sales for Roche, Beckman Coulter, Dade Behring, Bayer, Ortho-Clinical Diagnostics, Abbott, and Others (includes corresponding Graph/Chart) II-6 Chemical Analysis An Overview II-6 Human Anatomy is Chemistry Driven II-6 History of Chemical Analysis II-6 Chemical Tests To Determine the Concentration of Substances II-7 Table 4: Most Commonly Used Blood Tests II-7 4. Product Overview II-8 Analyzers II-8 What are Clinical Chemistry Analyzers? II-8 Large Volume Clinical Chemistry Analyzers II-8 Medium Sized Clinical Chemistry Analyzers II-8 Small Sized Clinical Chemistry Analyzers II-8 Automated Analytical Methods II-8 Automated Analyzers II-9 Continuous Flow Analysis II-9 Discrete Analysis II-9 Test Tube Analyzers: Perennial Symbol of the Chemical Laboratory II-9 Advantages and Disadvantages of Test Tube Analyzers II-10 Reagents II-10 Different Applications of Reagents II-10 Metabolite Chemistry Reagents II-10 Enzyme Chemistry Reagents II-10 Electrolyte Chemistry Reagents II-10 5. Role of Computers in Clinical Chemistry II-11 Clinical Data Interpretation Supported by Computerization II-11 Bar Coding used to Increase Accuracy and Productivity II-11 Sample and Data Collection Process II-11 Modes in Clinical Chemistry for Sample Processing II-12 Batch Processing Mode: Test Oriented II-12 Random-access Processing Mode: Patient Oriented II-12 6. Clinical Laboratory Testing Services II-14 Hospital Testing Services II-14 Commercial Laboratories II-14 Physician’s Office Laboratories II-14 7. Product Introductions II-15 Toshiba Launches Automated Clinical Chemistry Analyzer II-15 Ortho-Clinical Diagnostics Unveils New Micro Tip™ Assay II-15 Bayer HealthCare Expands Chemistry Testing Portfolio II-15 Olympus Showcases AU400 Chemistry Analyzer II-15 Dade Behring Develops Dimension VISTA II-15 Bayer Rolls Out IMS Analyzer II-16 Bayer Introduces Urinalysis System II-16 Bayer HealthCare Introduces ADVIA WorkCellTM CDX II-16 Bayer Rolls out ADVIA 1200 Analyzer II-16 Ortho Diagnostics Launches VITROS 350 Chemistry System II-16 Beckman Expands UniCel Instruments Portfolio II-16 Polymedco Launches SPOTCHEM EZ- Chemistry Analyzer II-17 Ortho-Clinical Extends Testing Capabilities For the VITROS Chemistry System II-17 Abbott Unveils Cancer Tests for ARCHITECT Analyzers II-17 Abbott Rolls Out 10 Clinical Chemistry Tests II-17 Abbott Laboratories Unveil New Assays for Therapeutic Drug Monitoring Management II-18 Roche Diagnostics Rolls Out OMNI S 1-4 Models II-18 Roche Diagnostics Launches Urine Test Strip Analyzer II-18 Applied Biosystems Group Unveils SNPlex II-18 8. Recent Industry Activity II-19 Siemens to Acquire Bayer Diagnostics II-19 FDA Grants 510(k) Clearance for iChem 100 II-19 FDA Clears cobas 6000 Analyzer Range II-19 Sysmex Signs an Agreement with Roche Diagnostics II-19 Olympus Expands Immunoessay R&D Center II-19 NSAID Panel to Support VetTest® Chemistry Analyzer II-20 Thermo and DP Enter into an Agreement for Clinical Chemistry Platform II-20 Clinical Data Inks Master Distribution Agreement with Daiichi Pure Chemicals II-20 Ortho-Clinical Diagnostics Receives FDA Clearance for Lipoprotein Assay II-21 IRIS Renews Agreement with ARKRAY II-21 Abbott Extends Assays to Diagnostic Laboratories II-21 Hemagen Receives FDA Stamp of Approval for Liquid Stable Reagents II-21 Abbott and Seradyn Obtain FDA Clearance for Hemoglobin Test for Diabetes II-21 Beckman Receives Approval for New Clinical Chemistry Analyzers II-21 Abbott Acquires I-Stat II-22 Hemagen Diagnostics Extends Supply Agreement with Roche II-22 Vital Scientific Bags FDA Clearance for V-Twin and Selectra XL II-22 Sysmex Bags Approval for Manufacturing Item 23 Clinical Chemistry Reagents II-22 Sysmex Initiates Marketing of RANREAM HCV II EX Reagent in Japan II-22 Invitrogen Bags Products and Technology Rights from Vertex II-22 diaDexus to Supply Analyte Specific Reagents to Mayo II-23 Historic Review II-23 9. Focus on Select Global Players II-27 Abbott Laboratories (US) II-27 Alfa Wassermann, Inc.(US) II-27 Bayer AG (Germany) II-28 Beckman Coulter, Inc.(US) II-28 Cholestech Corporation (US) II-29 Dade Behring (US) II-29 Hemagen Diagnostics, Inc.(US) II-29 Ortho-Clinical Diagnostics (US) II-30 Olympus (US) II-30 Roche Diagnostics (US) II-30 Sigma-Aldrich (US) II-31 Sysmex Corporation (Japan) II-31 10. Global Market Perspective II-32 Table 5: World Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-32 Table 6: World 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia -Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-32 Table 7: World Recent Past, Current & Future Analysis for Analyzers by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-33 Table 8: World 10-Year Perspective for Analyzers by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-33 Table 9: World Recent Past, Current & Future Analysis for Analyzers by Product Segment- Large Volume Clinical Chemistry Analyzers, Medium Sized Clinical Chemistry Analyzers and Small Sized Clinical Chemistry Analyzers Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-34 Table 10: World 10-Year Perspective for Analyzers by Product Segment Percentage Breakdown of Dollar Sales for Large Volume Clinical Chemistry Analyzers, Medium Sized Clinical Chemistry Analyzers and Small Sized Clinical Chemistry Analyzers Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-34 Table 11: World Recent Past, Current & Future Analysis for Large Volume Clinical Chemistry Analyzers by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-35 Table 12: World 10-Year Perspective for Large Volume Clinical Chemistry Analyzers by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-35 Table 13: World Recent Past, Current & Future Analysis for Medium Sized Clinical Chemistry Analyzers by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-36 Table 14: World 10-Year Perspective for Medium Sized Clinical Chemistry Analyzers by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-36 Table 15: World Recent Past, Current & Future Analysis for Small Sized Clinical Chemistry Analyzers by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-37 Table 16: World 10-Year Perspective for Small Sized Clinical Chemistry Analyzers by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-37 Table 17: World Recent Past, Current & Future Analysis for Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-38 Table 18: World 10-Year Perspective for Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-38 Table 19: World Recent Past, Current & Future Analysis for Reagents by Product Segment- Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-39 Table 20: World 10-Year Perspective for Reagents by Product Segment Percentage Breakdown of Dollar Sales for Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-39 Table 21: World Recent Past, Current & Future Analysis for Metabolite Chemistry Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-40 Table 22: World 10-Year Perspective for Metabolite Chemistry Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-40 Table 23: World Recent Past, Current & Future Analysis for Enzyme Chemistry Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-41 Table 24: World 10-Year Perspective for Enzyme Chemistry Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia- Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-41 Table 25: World Recent Past, Current & Future Analysis for Electrolyte Chemistry Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-42 Table 26: World 10-Year Perspective for Electrolyte Chemistry Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-42 Table 27: World Recent Past, Current & Future Analysis for Other Chemistry Reagents by Geographic Region- US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 II-43 Table 28: World 10-Year Perspective for Other Chemistry Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-43 III. MARKET 1. The United States III-1 A.Market Analysis III-1 Current and Future Analysis III-1 Ageing Population Creates More Opportunities III-1 Trends in the Clinical Chemistry Analyzers Market III-1 US Clinical Laboratory Analyzer Market III-1 Table 29: Leading Players in the US Clinical Chemistry Analyzers Market (2003-2005): Percentage Share Breakdown by Value Sales (*) for Beckman Coulter, Roche, Olympus, Ortho Clinical Diagnostics, Dade Behring, Bayer, Abbott, and Others (includes corresponding Graph/Chart) III-2 Table 30: Leading Players in the US Clinical Chemistry Reagents Market (2003-2005): Percentage Share Breakdown by Value Sales (*) for Beckman Coulter, Roche, Ortho Clinical Diagnostics, Dade Behring, and Others (includes corresponding Graph/Chart) III-3 CLIA- Regulatory Framework of Diagnostic Testing III-3 Product Introductions/Launches III-3 Strategic Corporate Developments III-8 Focus on Select US Players III-14 Abbott Laboratories III-14 Alfa Wassermann, Inc III-15 Beckman Coulter, Inc. III-15 Cholestech Corporation III-16 Dade Behring III-16 Hemagen Diagnostics, Inc. III-16 Olympus America III-17 Ortho-Clinical Diagnostics III-17 Roche Diagnostics III-17 Sigma-Aldrich III-18 Third Wave Molecular Diagnostics III-18 B.Market Analytics III-19 Table 31: US Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-19 Table 32: US 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-20 2. Canada III-21 A.Market Analysis III-21 Current and Future Analysis III-21 An Overview of the Medical Equipment Market III-21 Focus on Key Canadian Player III-21 Roche Diagnostics Canada III-21 B.Market Analytics III-22 Table 33: Canadian Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-22 Table 34: Canadian 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-23 3. Japan III-24 A.Market Analysis III-24 Current and Future Analysis III-24 Strategic Corporate Developments III-24 Product Introductions/Launches III-26 Focus on Key Japanese Player III-26 Sysmex Corporation III-26 B.Market Analytics III-27 Table 35: Japanese Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-27 Table 36: Japanese 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-28 4. Europe III-29 A.Market Analysis III-29 Current and Future Analysis III-29 B. Market Analysis III-30 Table 37: European Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Geographic Region- France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-30 Table 38: European 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Geographic Region- Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-30 Table 39: European Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-31 Table 40: European 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-32 4a. France III-33 A.Market Analysis III-33 Current and Future Analysis III-33 French Laboratory Equipment Market III-33 B.Market Analytics III-34 Table 41: French Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-34 Table 42: French 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-35 4b. Germany III-36 A.Market Analysis III-36 Current and Future Analysis III-36 Bayer AG A Key Player III-36 Strategic Corporate Developments III-37 B.Market Analytics III-38 Table 43: German Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-38 Table 44: German 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-39 4c. Italy III-40 A. Market Analytics III-40 Current and Future Analysis III-40 Italian Laboratory Instruments Market III-40 B.Market Analytics III-41 Table 45: Italian Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-41 Table 46: Italian 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents ( Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-42 4d. The United Kingdom III-43 A.Market Analysis III-43 Current and Future Analysis III-43 UK Instrumentation Market III-43 B.Market Analytics III-44 Table 47: UK Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-44 Table 48: UK 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-45 4e. Rest of Europe III-46 A. Market Analytics III-46 Current and Future Analysis III-46 B.Market Analytics III-47 Table 49: Rest of Europe Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-47 Table 50: Rest of Europe 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents ( Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-48 5. Asia-Pacific III-49 A. Market Analytics III-49 Current and Future Analysis III-49 Health-Care Industry in Asia-Pacific III-49 Key Asia-Pacific Markets III-50 Singapore III-50 Taiwan III-50 B.Market Analytics III-51 Table 51: Asia-Pacific Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-51 Table 52: Asia-Pacific 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-52 6. Latin America III-53 A. Market Analytics III-53 Current and Future Analysis III-53 Mexico III-53 B.Market Analytics III-54 Table 53: Latin American Recent Past, Current & Future Analysis for Clinical Chemistry Analyzers and Reagents by Product Segment- Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents (Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-54 Table 54: Latin American 10-Year Perspective for Clinical Chemistry Analyzers and Reagents by Product Segment - Percentage Breakdown of Dollar Sales for Analyzers (Large Volume Clinical Chemistry, Medium Sized Clinical Chemistry, and Small Sized Clinical Chemistry), and Reagents ( Metabolite Chemistry Reagents, Enzyme Chemistry Reagents, Electrolyte Chemistry Reagents, and Other Chemistry Reagents) Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-55 IV. COMPETITION 1. Abaxis, Inc. (USA) IV-1 Table 55: Annual Sales Analysis: 2005-2006 (In US$ million) IV-2 Table 56: Annual Sales Analysis by Segment: 2005-2006 (In US$ million) IV-2 Table 57: Annual Sales Analysis by Product: 2005-2006 (In US$ million) IV-2 Table 58: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-2 Table 59: Annual Sales Analysis by Product: 2004-2005 (In US$ million) IV-3 2. Abbott Laboratories (USA) IV-6 Table 60: First Quarter Sales Analysis: 2005-2006 (In US$ billion) IV-8 Table 61: Annual Sales Analysis: 2003-2005 (In US$ billion) IV-8 Abbott Diagnostics (USA) IV-15 Abbott Point Of Care (USA) IV-24 3. Alfa Wassermann, Inc. (USA) IV-25 4. Amresco, Inc. (USA) IV-26 5. Arkray (Japan) IV-28 6. Astoria-Pacific, Inc. (USA) IV-29 7. Axon Lab AG (Switzerland) IV-30 8. Bayer HealthCare AG (Germany) IV-31 Table 62: Annual Sales Analysis: 2004-2005 (In € million) IV-33 Table 63: Annual Sales Analysis by Segment: 2004-2005 (In € million) IV-33 Table 64: Annual Sales Analysis by Geographic Region: 2004-2005 (In € million) IV-33 9. Beckman Coulter, Inc. (USA) IV-37 Table 65: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-41 Table 66: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-41 Table 67: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-41 10. Becton, Dickinson & Company (USA) IV-46 Table 68: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million) IV-48 Table 69: Half Yearly Sales Analysis by Quarter: 2005- 2006 (H1) (In US$ million) IV-48 Table 70: Half Yearly Sales Analysis by Segment: 2005- 2006 (H1) (In US$ million) IV-48 Table 71: Annual Sales Analysis: 2004-2005 (In US$ million) IV-48 Table 72: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-48 Table 73: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-49 Table 74: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-49 BD Diagnostics (USA) IV-51 Lee Laboratories (USA) IV-54 11. Biocell Laboratories, Inc. (USA) IV-55 12. Biocode Hycel (Belgium) IV-57 13. bioMérieux SA (France) IV-60 Table 75: Nine Months Sales Analysis: 2004-2005 (Nine Months Ended, September) (In € million) IV-61 Table 76: Nine Months Sales Analysis by Segment: 2004- 2005 (Nine Months Ended, September) (In € million) IV-61 Table 77: Nine Months Sales Analysis by Geographic Region: 2004-2005 (Nine Months Ended, September) (In € million) IV-61 Table 78: Annual Sales Analysis: 2003-2004 (In € million) IV-61 Biomérieux, Inc. (USA) IV-65 Biomerieux Italia SpA (Italy) IV-68 14. Bio-Rad Laboratories, Inc. (USA) IV-69 Table 79: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-70 Table 80: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million) IV-71 Table 81: Annual Sales Analysis: 2003-2005 (In US$ million) IV-71 Table 82: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-71 Table 83: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-71 Table 84: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-72 15. Celsis International PLC (UK) IV-82 Table 85: Annual Sales Analysis: 2004-2006 (In US$ million) IV-83 16. Centronic GmbH (Germany) IV-85 17. Cholestech Corporation (USA) IV-86 Table 86: First Quarter Sales Analysis: 2006-2007 (In US$ million) IV-86 Table 87: Annual Sales Analysis: 2005-2006 (In US$ million) IV-87 18. Dade Behring, Inc. / Dade Behring Holdings, Inc. (USA) IV-88 Table 88: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million) IV-89 Table 89: Half Yearly Sales Analysis by Segment: 2005- 2006 (H1) (In US$ million) IV-89 Table 90: Half Yearly Sales Analysis by Geographic Region: 2005-2006 (H1) (In US$ million) IV-89 Table 91: Annual Sales Analysis: 2004-2005 (In US$ million) IV-90 Table 92: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-90 Table 93: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-90 Table 94: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-90 19. Daiichi Pure Chemicals Co., Ltd. (Japan) IV-94 20. Delta Biologicals Srl (Italy) IV-95 21. Diagnostic Chemicals Limited (Canada) IV-96 22. Diagnostic Systems Laboratories, Inc. (USA) IV-97 23. DiaMed AG (Switzerland) IV-99 24. Dipro Med Handels GmbH (Austria) IV-100 25. EMD Chemicals, Inc. (USA) IV-101 26. ESA Biosciences, Inc./ESA, Inc. (USA) IV-104 27. Fisher Scientific International, Inc. (USA) IV-107 Table 95: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million) IV-110 Table 96: Half Yearly Sales Analysis by Quarter: 2005- 2006 (H1) (In US$ million) IV-110 Table 97: Half Yearly Sales Analysis by Segment: 2005- 2006 (H1) (In US$ million) IV-111 Table 98: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-111 Table 99: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-111 Table 100: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-111 28. Hemagen Diagnostics, Inc. (USA) IV-115 Table 101: Half Yearly Sales Analysis: 2005-2006 (In US$ million) IV-115 Table 102: Half Yearly Sales Analysis by Geographic Region: 2005-2006 (In US$ million) IV-115 Table 103: Annual Sales Analysis: 2004-2005 (In US$ million) IV-116 Table 104: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-116 29. Heska Corporation (USA) IV-117 Table 105: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-117 Table 106: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million) IV-117 Table 107: Annual Sales Analysis: 2003-2005 (In US$ million) IV-118 Table 108: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-118 Table 109: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-118 30. Hitachi Science Systems Ltd. (Japan) IV-120 31. Horiba Ltd. (Japan) IV-121 Table 110: Annual Sales Analysis: 2003-2005 (In ¥ million) IV-121 32. Horizon Diagnostics, Inc. (USA) IV-124 33. Idexx Laboratories, Inc. (Japan) IV-125 Table 111: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-127 Table 112: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million) IV-127 Table 113: Annual Sales Analysis: 2004-2005 (In US$ million) IV-127 Table 114: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-127 34. Instrumentation Laboratory SpA (Italy) IV-131 Chromogenix Instrumentation Laboratory SpA (Italy) IV-132 35. Iris International, Inc. (USA) IV-133 Table 115: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-134 Table 116: First Quarter Sales Analysis by Product: 2005-2006 (In US$ million) IV-134 Table 117: Annual Sales Analysis: 2004-2005 (In US$ million) IV-134 Table 118: Annual Sales Analysis by Product: 2004-2005 (In US$ million) IV-134 36. Johnson & Johnson (USA) IV-138 Table 119: First Quarter Sales Analysis: 2005-2006 (In US$ billion) IV-139 Table 120: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ billion) IV-140 Table 121: First Quarter Sales Analysis by Geographic Region: 2005-2006 (In US$ billion) IV-140 Ortho-Clinical Diagnostics (USA) IV-146 37. Kamiya Biomedical Co. (USA) IV-149 38. Linco Research, Inc. (USA) IV-151 39. LW Scientific (USA) IV-152 40. Medical Chemical Corporation (USA) IV-153 41. Millipore Corporation (USA) IV-155 Table 122: Annual Sales Analysis: 2003-2005 (In US$ million) IV-155 Table 123: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-156 Table 124: Annual Sales Analysis by Division: 2004-2005 (In US$ million) IV-156 Table 125: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-156 42. Molecular Devices Corporation (USA) IV-162 Table 126: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-163 Table 127: Annual Sales Analysis: 2003-2005 (In US$ million) IV-163 Table 128: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-163 Table 129: Annual Sales Analysis by Product: 2004-2005 (In US$ million) IV-163 Table 130: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-164 43. Nicholas Piramal India Ltd. (India) IV-167 Table 131: Half Yearly Sales Analysis: 2005-2006 (H1) (In INR billion) IV-169 Table 132: Annual Sales Analysis: 2004-2005 (In INR billion) IV-170 44. Nova Biomedical (USA) IV-175 45. Olympus America, Inc. (USA) IV-179 46. Pointe Scientific, Inc. (USA) IV-189 47. Polestar Labs, Inc. (USA) IV-190 48. Polymedco, Inc. (USA) IV-191 49. Quantimetrix Corporation (USA) IV-192 50. Quest Diagnostics, Inc. (USA) IV-193 Table 133: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-194 Table 134: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million) IV-194 51. Research Organics, Inc. (USA) IV-196 52. Roche Diagnostics (Schweiz) AG (Switzerland) IV-198 Roche Diagnostics (Deutschland) GmbH (Germany) IV-203 Roche Diagnostics Corporation (USA) IV-204 53. Seradyn, Inc. (USA) IV-205 54. Siemens AG (Germany) IV-207 55. Sigma-Aldrich Corporation (USA) IV-223 Table 135: First Quarter Sales Analysis: 2005-2006 (In US$ million) IV-224 Table 136: Annual Sales Analysis: 2003-2005 (In US$ million) IV-224 Table 137: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-224 Table 139: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-224 Table 140: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-225 56. Solmetex, Inc. (USA) IV-230 57. Sysmex Corporation (Japan) IV-231 Sysmex Reagents America, Inc. (USA) IV-237 58. Teco Diagnostics, Inc. (USA) IV-238 59. The Binding Site Ltd. (UK) IV-239 60. Thermo Electron Corporation (USA) IV-240 Table 141: First Quarter Sales Analysis: 2005-2006 (In US$ billion) IV-241 Table 142: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ billion) IV-241 Table 143: Annual Sales Analysis: 2003-2005 (In US$ billion) IV-241 Table 144: Annual Sales Analysis by Quarter: 2004-2005 (In US$ billion) IV-242 Table 145: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion) IV-242 Table 146: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion) IV-242 61. Third Wave Technologies, Inc. (USA) IV-247 Table 147: Half Yearly Sales Analysis: 2005-2006 (In US$ million) IV-247 Table 148: Annual Sales Analysis: 2004-2005 (In US$ million) IV-247 62. Toshiba Medical Systems Corporation (Japan) IV-250 63. Vector Laboratories, Inc. (USA) IV-253 64. Vital Scientific NV (The Netherlands) IV-260

Companies Mentioned

The Companies Mentioned are as follows: Abaxis, Inc (USA) Abbott Diagnostics (USA) Abbott Laboratories (USA) Alfa Wassermann, Inc (USA) Amresco, Inc (USA) Astoria-Pacific, Inc (USA) Axon Lab AG (Switzerland) Bayer AG (Germany) Bayer HealthCare -Diagnostic Div (Canada) BD Diagnostic Systems (USA) Beckman Coulter, Inc (USA) Becton, Dickinson & Co (USA) Biocell Laboratories, Inc (USA) Biocode Hycel (Belgium) Biomerieux Italia SpA (Italy) BioMerieux SA (France) Biomerieux, Inc (USA) Bio-Rad Laboratories, Inc (USA) Celsis International PLC (UK) Centronic GmbH (Germany) Cholestech Corporation (USA) Chromogenix Instrumentation Laboratory SpA (Italy) Dade Behring, Inc (USA) Daiichi Pure Chemicals Co, Ltd (Japan) Delta Biologicals Srl (Italy) Diagnostic Chemicals Limited (Canada) Diagnostic Systems Laboratories, Inc (USA) DiaMed AG (Switzerland) Damedix Corporation (USA) Dipro Med Handels GmbH (Austria) EMD Chemicals, Inc (USA) ESA, Inc (USA) Fisher Scientific International, Inc (USA) Hemagen Diagnostics Inc (USA) Heska Corporation (USA) Horiba Ltd (Japan) Horizon Diagnostics, Inc (USA) Idexx Laboratories, Inc (USA) Immunovision, Inc (USA) Instrumentation Laboratory SpA (Italy) Ivax Diagnostics, Inc (USA) Johnson & Johnson (USA) Kamiya Biomedical Company (USA) Lee Laboratories (USA) Linco Research, Inc (USA) LW Scientific (USA) Medical Chemical Corporation (USA) Molecular Devices Corporation (USA) Nicholas Piramal India Ltd (India) Nova Biomedical (USA) Olympus America, Inc (USA) Ortho-Clinical Diagnostics (USA) Pointe Scientific, Inc (USA) Polestar Labs, Inc (USA) Quantimetrix Corporation (USA) Quest Diagnostics Incorporated (USA) Research Organics, Inc (USA) Roche Diagnostics (Deutschland) GmbH (Germany) Roche Diagnostics (Switzerland) AG (Switzerland) Roche Diagnostics Corporation (USA) Seradyn, Inc (USA) Serologicals Corporation (USA) Sigma-Aldrich Corporation (USA) Solmetex, Inc (USA) Sysmex Corporation (Japan) Sysmex Reagents America, Inc (USA) Teco Diagnostics, Inc (USA) The Binding Site Limited (UK) Thermo Electron Corporation (USA) Vector Laboratories, Inc (USA) Vital Scientific NV (The Netherlands)