Contents:

ION-SELECTIVE CLINICAL LAB ANALYZERS A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 ISE Analyzers I-3 Ion-selective Electrodes I-3 Disposable Supplies I-4 Reagents I-4 II. Executive Summary 1. General Overview II-1 Market Analytics II-1 2. Market Segments II-2 ISE Analyzers II-2 Ion-Selective Electrodes II-2 History II-2 Important Ion-Specific Electrodes II-3 Ammonia Ion-specific Electrodes II-3 Calcium Ion-Specific Electrodes II-3 Chloride Ion-specific Electrodes II-3 Magnesium Ion-Specific Electrodes II-3 Potassium Ion-Specific Electrodes II-4 Sodium Ion-specific Electrodes II-4 Application of ISEs II-4 Principle Governing ISE II-5 Ecell = Eise - Eref II-5 Methods for Measuring Ion Concentration II-5 Direct Calibration Method II-5 Standard Additions Method II-5 Titration Method II-5 Ion-Selective Membranes II-5 Glass Ion-Selective Membranes II-6 Solid Ion-Selective Membranes II-6 Gas Permeable Membranes II-6 Liquid/Polymeric Ion-Selective Membranes II-6 Replacement of ISE Membranes II-7 Approved Methods for Using ISE II-7 Electrochemical Measuring System II-7 ISEs Measurement Considerations II-7 Agitation II-8 Sample pH II-8 Response Time II-8 Establishing a Calibration Curve II-8 Rinsing II-8 Conditioning II-8 Disposable Supplies II-8 ISE Reagents II-8 Ion Exchange Ion-selective Reagents II-8 Neutral carrier ion-selective reagents II-9 Technological Developments/Breakthroughs II-9 Ion Selective Electrode for Extended Use II-9 Analytical Method Devised for Improving Detection Limits of IS Electrodes II-9 3. ISE Market Dynamics II-10 Electrolyte and Blood Gas Analyzers II-10 Emergence of Distinct Market Sectors II-10 Integration of Technologies II-10 Development of Biosensors for Common Tests II-10 Competitive Scenario II-10 4. Clinical Laboratories - Overview and Trends II-11 Hospital Laboratories II-11 Hospital Labs: Undergoing Transformation II-11 Point of Care Testing II-11 Emergence of POCT Segment II-11 Satellite Laboratories II-11 Limited Service, But Reduces Turnaround Time II-11 Costlier to Operate II-12 Alternatives to STAT Labs II-12 5. Overview of Related Technologies/Systems/Products II-13 Ion Sensitive Field Effect Transistors II-13 ISFETs - Sophisticated Ion-Sensitive Micro fabricated Devices II-13 Ion-Sensitive Electrochemical Electrodes Principle II-13 Multi-Sensor Devices and Intelligent sensors II-13 Advantages of Various Integrated Sensors II-13 Biomedical Measurement Offer Growth Potential For ISFETs II-13 ISFETs Face Competition from Optical Fiber Devices II-13 Applications of ISFETs II-14 Biosensors II-14 Engineered on Biological Material II-14 Biological Components of Biosensors II-14 Blood Gas Analyzers II-15 Blood Gases - An Insight II-15 Blood Analysis - Critical Aspect of Patient Diagnosis II-15 Use of Ion Selective Electrodes II-15 Market Trends in Blood Gas Analysis II-16 6. Recent Industry Activity II-17 IDEXX Laboratories Inks Agreement with Sysmex II-17 Beckman Coulter Takes Over Dako’s Cytometry Instrumentation Business II-17 Beckman Coulter Enters into Agreements with Amerinet II-17 Beckman Coulter Signs Agreement with Alverno Clinical Laboratories II-17 Beckman Coulter and Bio-Rad Extends Partnership Agreement II-17 Abbott Enters into Agreement with Novation II-17 Abbott Inks Contract with Premier II-18 Sysmex America Bags FDA Approval for XE-5000™ Hematology Analyzer II-18 Escalon Gains FDA Clearance to Market TRILOGY Analyzer II-18 Roche Diagnostics Unveils Cobas C 111 Chemistry Analyzer II-18 Thermo Electron Merges with Fisher Scientific to Create Thermo Fisher Scientific II-18 US FDA Approves i-STAT® BNP Cartridge from Abbott II-19 i-STAT® CHEM 8+ Cartridge Receives 510(K) Clearance from US FDA II-19 Abbott Point of Care Signs a Group Buy Agreement with Premier II-19 Abbott Point of Care Extends Contract with Novation II-20 Abbott Acquires i-STAT II-20 7. Focus on Select Players II-21 Abbott Point of Care (US) II-21 Alfa Wassermann S.p.A. (Italy) II-22 Alfa Wassermann, Inc. (USA) II-22 Beckman Coulter, Inc. (US) II-22 F. Hoffmann-La Roche Ltd Diagnostics Division (Switzerland) II-23 Microelectrodes Inc (US) II-23 Van London-pHoenix Company (USA) II-23 Thermo Fisher Scientific (USA) II-24 8. Global Market Perspective II-25 Table 1: World Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-25 Table 2: World Long-term Projections for ISE Clinical Lab Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-26 Table 3: World Historic Review for ISE Clinical Lab Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-27 Table 4: World 15-Year Perspective for ISE Clinical Lab Analyzers by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-28 Table 5: World Recent Past, Current & Future Analysis for ISE Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-29 Table 6: World Long-term Projections for ISE Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-30 Table 7: World Historic Review for ISE Analyzers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-31 Table 8: World 15-Year Perspective for ISE Analyzers by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-32 Table 9: World Recent Past, Current & Future Analysis for IS Electrodes by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-33 Table 10: World Long-term Projections for IS Electrodes by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-34 Table 11: World Historic Review for IS Electrodes by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-35 Table 12: World 15-Year Perspective for IS Electrodes by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-36 Table 13: World Recent Past, Current & Future Analysis for Disposable Supplies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-37 Table 14: World Long-term Projections for Disposable Supplies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-38 Table 15: World Historic Review for Disposable Supplies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-39 Table 16: World 15-Year Perspective for Disposable Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-40 Table 17: World Recent Past, Current & Future Analysis for Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-41 Table 18: World Long-term Projections for Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-42 Table 19: World Historic Review for Reagents by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-43 Table 20: World 15-Year Perspective for Reagents by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin America Markets for Years 1998, 2008 & 2012 (includes corresponding Graph/Chart) II-44 III. MARKET 1. The United States III-1 A.Market Analysis III-1 Key Trends in Health Care Industry III-1 Mounting Pressure for Cost Cutting III-1 Competition from Independent Labs III-1 Strategic Corporate Developments III-1 Select Players III-5 B.Market Analytics III-8 Table 21: US Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-8 Table 22: US Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-8 Table 23: US Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-9 Table 24: US 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-9 2. Canada III-10 Market Analysis III-10 Table 25: Canadian Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes,Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-10 Table 26: Canadian Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-11 Table 27: Canadian Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies andReagents Markets Independently Analyzed with nnual SalesFigures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart III-11 Table 28: Canadian 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-12 3. Japan III-13 Market Analysis III-13 Table 29: Japanese Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-13 Table 30: Japanese Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-14 Table 31: Japanese Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-14 Table 32: Japanese 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-15 4. Europe III-16 A.Market Analysis III-16 Regulations Governing Medical Devices Exports to EU III-16 B.Market Analytics III-17 Table 33: European Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-17 Table 34: European Long-term Projections for ISE Clinical Lab Analyzers by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-18 Table 35: European Historic Review for ISE Clinical Lab Analyzers by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-18 Table 36: European 15-Year Perspective for ISE Clinical Lab Analyzers by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, and Rest of Europe Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-19 Table 37: European Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-20 Table 38: European Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-20 Table 39: European Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-21 Table 40: European 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-21 4a. France III-22 A.Market Analysis III-22 Overview of Medical Equipment Market III-22 B.Market Analytics III-23 Table 41: French Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-23 Table 42: French Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-23 Table 43: French Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-24 Table 44: French 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-24 4b. Germany III-25 Market Analysis III-25 Table 45: German Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-25 Table 46: German Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-26 Table 47: German Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-26 Table 48: German 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-27 4c. Italy III-28 A.Market Analysis III-28 Strong Growth Despite Slack in Economy III-28 Alfa Wassermann S.p.A - A Major Player. III-28 B.Market Analytics III-29 Table 49: Italian Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-29 Table 50: Italian Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-29 Table 51: Italian Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-30 Table 52: Italian 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-30 4d. The United Kingdom III-31 Market Analysis III-31 Table 53: UK Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies & Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-31 Table 54: UK Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-32 Table 55: UK Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers,IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-32 Table 56: UK 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes,Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes correspondingGraph/Chart) III-33 4e. Rest of Europe III-34 A.Market Analysis III-34 Overview of Select Markets III-34 Belgium III-34 Medical & Diagnostic Equipment Market III-34 Denmark III-34 Healthcare Industry III-34 Regulatory Environment III-35 Poland III-35 Healthcare Industry III-35 Russia III-35 Sweden III-35 Strategic Corporate Development III-36 F. Hoffmann-La Roche Ltd Diagnostics Division (Switzerland) - A Major Player III-36 B.Market Analytics III-37 Table 57: Rest of Europe Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers byProduct Segment - ISE Analyzers, IS Electrodes,Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-37 Table 58: Rest of Europe Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-37 Table 59: Rest of Europe Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-38 Table 60: Rest of Europe 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-38 5. Asia-Pacific III-39 A.Market Analysis III-39 Overview of Select Lucrative Markets III-39 China III-39 Medical Industry: Growth Spurred by Economic Transition III-39 End-user Analysis III-40 Distribution III-40 Philippines III-40 Medical Laboratory Instruments III-40 Singapore III-40 Healthcare Industry III-40 B.Market Analytics III-41 Table 61: Asia-Pacific Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-41 Table 62: Asia-Pacific Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-41 Table 63: Asia-Pacific Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-42 Table 64: Asia-Pacific 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable 4 Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-42 6. Latin America III-43 Market Analysis III-43 Table 65: Latin America Recent Past, Current & Future Analysis for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-43 Table 66: Latin America Long-term Projections for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-44 Table 67: Latin America Historic Review for ISE Clinical Lab Analyzers by Product Segment - ISE Analyzers, IS Electrodes, Disposable Supplies and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-44 Table 68: Latin America 15-Year Perspective for ISE Clinical Lab Analyzers by Product Segment - Percentage Breakdown of Dollar Sales for ISE Analyzers, IS Electrodes, Disposable Supplies, and Reagents Markets for 1998, 2008 & 2012 (includes corresponding Graph/Chart) III-45 IV. COMPETITIVE LANDSCAPE

Companies Mentioned

- Advanced Sensor Technologies, Inc (USA) - Alfa Wassermann SpA (Italy) - Analytical Sensors and Instruments Ltd (USA) - Analyticon Instruments Corporation (USA) - Arkray, Inc (Japan) - Bacharach, Inc (USA) - Beckman Coulter, Inc (USA) - Biotecnica Instruments SpA (Italy) - Brinkmann Instruments, Inc (USA) - Careside, Inc (USA) - Chiron Corporation (USA) - Cole-Parmer Instrument Company (USA) - Consort NV (Belgium) - Fresenius AG (Germany) - Hach Company (USA) - Innovative Sensors, Inc (USA) - Jenway Ltd (UK) - Kyoto Electronics Mfg Co, Ltd (Japan) - Lamotte Co (USA) - London Scientific Limited (Canada) - Medica Corp (USA) - Metrohm AG (Switzerland) - Mettler-Toledo GmbH (Switzerland) - Microelectrodes, Inc (USA) - Nova Biomedical Corporation (USA) - Phoenix Electrode Company (USA) - Polestar Labs, Inc (USA) - Process Analyzers LLC (USA) - Roche Diagnostics (Schweiz) AG (Switzerland) - Sentron, Inc (USA) - Techno Medica Co, Ltd (Japan) - Thermo Electron Corporation (USA)