Contents:

CELL/TISSUE CULTURE SUPPLIES A GLOBAL STRATEGIC BUSINESS REPORT CONTENTS I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations I-1 Disclaimers I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Cell/Tissue Culture Media, Sera and Reagents I-3 II. Executive Summary 1. Market Dynamics II-1 Outlook II-1 Biopharmaceutical Drugs Fuel Cell Culture Market II-1 Market Scenario II-1 Industrial vs. Academic II-1 Segmental Outlook II-2 Global Market Analysis II-2 Analysis by Region II-3 Analysis by Product Segment II-3 Market Structure II-3 Leading Players II-3 Table 1: Leading Players in US Cell/Tissue Culture Market (2003, 2004, & 2005): Percentage Breakdown of Value Sales for Invitrogen, JRH Biosciences, Hyclone, Cambrex Bio Science Walkersville (Formerly BioWhittaker), Sigma-Aldrich, and Others (includes corresponding Graph/Chart) II-3 2. Trends and Issues II-4 Surging Demand for Cell Culture Products II-4 Stem Cells and Vaccines - Key Drivers II-4 Growing Acceptance for Hi-Veg Culture Media II-4 Fed-Batch Cultures - a Big Hit with Large-Scale Bioprocessors II-5 Changing Trend Towards Serum-Free Media II-5 Proteomics and Pharmacokinetics to Drive Market Growth II-5 Bioresearch and Cell Culture in Protein-Based Drug Development II-6 CHO, Hybridomas and Mabs Dominate Mammalian Cell Culture II-7 Sluggish Fetal Bovine Serum Market II-7 Cell Therapy Market Witnesses Increasing Consolidation Activity II-7 Specialty Media Growing in Demand II-7 Emerging Alternatives to Conventional Serum Supplemented Media II-8 Growth of Defined Media II-8 Regulations Prompt Change in Trends II-8 Media Optimization II-8 Cell-Line Engineering Vs. Cell Culture Media II-9 Other Trends II-9 Underlying Threat to Cell Culture Industry II-9 Manufacture-on-Demand: Gaining Momentum II-9 Move Towards Contract Manufacturing II-9 Factors Impacting Growth II-10 Business Models Driving the Need for Contract Manufacturing II-10 Trends in Contract Manufacturing II-10 Target Sectors for Contract Manufacturers II-10 3. End Use Analysis II-11 End Use Applications II-11 Cell Therapy II-11 Growing by Leaps and Bounds II-11 Cell Therapy Applications II-12 Key Factors Affecting the Cell Therapy Market II-12 Future Trends II-12 Related Market Sectors II-12 Progenitor Cell Therapy II-12 Table 2: US Market for Progenitor Cell Therapy in the Recent Past (2003 & 2004): Annual Sales in US$ Million for Blood Cells Skin, Bone and Cartilage and Others (includes corresponding Graph/Chart) II-13 Table 3: US Market for Progenitor Cell Therapy in the Recent Past (2003 & 2004): Percentage Breakdown by Value Sales for Blood Cells Skin, Bone and Cartilage and Others (includes corresponding Graph/Chart) II-13 Stem Cell Therapy II-13 Scope and Applications II-14 Other Related Technologies II-14 Somatic Cell Nuclear Transfer (SCNT) II-14 Tissue Engineering II-14 End Use Industries II-14 4. Cell/Tissue Culture: Physiological Overview II-15 Introduction II-15 History II-15 Plant Cell and Tissue Culture (PCTC) II-18 Cell/Tissue Culture Media, Sera and Reagents II-22 Classical Media II-22 Specialty Media II-22 Serum II-23 Fetal Bovine Serum II-23 Serum-Free Media II-23 Cell Culture Reagents II-23 Role of Tissue Culture in the Growth of Cell Types II-23 Equipment II-24 Storage and Preservation II-24 Maintenance II-24 Growth Pattern II-24 Harvesting II-25 Media and Growth Requirements II-25 Physiological Parameters II-25 Medium Requirements (Often Empirical) II-25 Feeding II-26 Safety Precautions II-26 Methods of Tissue Culture II-26 Preparation of Media II-26 Growth and Morphology II-26 Sub Culturing Adherent Cells II-27 Trypsin-EDTA II-27 EDTA Alone II-27 Thawing Frozen Cells II-27 Freezing Cells II-27 Cell Culture Contamination - A Looming Problem II-28 Classification II-28 Major Cell Culture Contaminants II-28 Chemical Contamination II-28 Types and Sources of Potential Chemical Contaminants II-28 Varied Sources of Chemical Contamination II-29 Media and Components II-29 Sera II-29 Water II-29 Storage Vessels II-30 Fluorescent Lights II-30 Endotoxins II-30 Incubators II-30 Biological Contamination II-31 Varied Sources of Biological Contamination II-31 Mycoplasmas II-31 Airborne Particles and Aerosols II-32 Cross Contamination by Other Cell Cultures II-32 Consequences/Problems of Contamination II-32 Controlling Cell Culture Contamination II-33 Measures Aimed at Reducing Contamination Problems II-33 5. Regulatory Environment II-34 6. Product Introductions/Innovations II-35 Millipore Releases New Primary Human Epithelial Cell Cultures II-35 Millipore Expands Stem Cell Tested Initiative II-35 BD Biosciences Debuts BD FACSAria™ II System to Sort Cells II-35 Invitrogen Introduces Specific SFM for the Mesenchymal Stem Cells II-36 StemCell Launches Cryopreservation Medium Free from Serum II-36 Invitrogen Unveils SequalPrep™ System II-36 Invitrogen Introduces Animal Source-Free Substrate II-36 Invitrogen Introduces GIBCO® FoamAway™ Reagent II-36 Genetix Develops New CytoGenetix Reagents and Kits II-37 Thermo Fisher Launches NUNC In Vitro PDL Coated PETG Roller Bottles II-37 Thermo Fisher Scientific Introduces HyClone AdvanceSTEM™ Cell Culture Product Line II-37 Thermo Fisher Scientific Introduces New Medium to Culture PER.C6 Cell Line II-38 Genetix Expands CloneMedia Semi-Solid Media Products II-38 Invitrogen Launches STEMPRO® EZPassage™ Tool II-38 Sigma-Aldrich Introduces GenomePlex Tissue WGA Kit II-38 Thermo Fisher Scientific Introduces Two New Versatile Media for HEK 293 Cell Line II-39 SAFC Biosciences Launches LONG®R3IGF-I in Liquid Form II-39 Invitrogen and Novocell Introduce Media for hESC Growth II-39 Invitrogen Releases New Culture System II-39 Invitrogen Introduces New Line of Engineered Stem Cells II-40 BD Biosciences Partners with StemCell Technologies II-40 Millipore Launches MEL Cell Lines II-40 Irvine Scientific Expands Industrial Cell Culture Product Line II-40 Biovest International Introduces Automated Cell Culture Device II-41 BD Biosciences Introduces BD FACSDiva™ 6.0 Software II-41 Millipore Unveils Nylon Net Steriflip® Filter Unit II-41 Lonza Expands Product-Portfolio with Serum Free Media II-41 MediCult Unveils Flexible Culture Systems, BlastAssist® and EmbryoAssist™ II-42 Millipore Introduces New Medium for Human Embryonic Stem Cell Research II-42 Invitrogen Launches CytoGenie™ Cytometry Software Tool II-42 Novozymes Releases New Cell Culture Components II-42 The Automation Partnership Launches Advanced Plating Module II-42 Nikon Unveils BioStation CT II-43 Corning Launches Innovative Cell Culture Solutions II-43 GroPep Introduces New Assay Kit for Cell Culture Business II-43 HyClone Introduces HyQ®CDM4MAb™ for Hybridoma Cell Lines II-43 INTEGRA Biosciences Adds Alarm Interface to CELLROLL and CELLSPIN Systems II-44 Nikon Launches New Imaging and Tracking Systems for Cell Culture II-44 Genetix Develops Cell Dispenser II-44 SAFC Biosciences Introduces LONGTMR3IGF-I for Industrial Cell Culture II-44 Biocrystal Presents Opticell II-44 TAP Unveils CompacT SelecT™ II-45 New Brunswick Scientific Augments New Products to Cell Culture Systems II-45 Cell Culture Technologies Develops Fortified Production Media II-45 HyClone Unveils New Microcarrier Product Line - HyQ®Spheres™ II-45 Celliance Brings Out LucraTone(TM) Peptones II-45 Millipore Offers More Products for Cell Culture Assays II-45 FibraStage™ Cell Culture System for Higher Yields II-46 Acolyte to Incorporate AK Rapid® technology BacLite RapiTECT™ Range II-46 Ventria Bioscience Unveiled Lacromin™ for Cell Culture Media II-46 Vivascience Launches Vivadish II-46 Celliance Corporation Unveils Hybri-CYTE(TM) II-46 7. Recent Industry Activity II-47 Invitrogen Establishes Dedicated Business Unit for Cell Therapy II-47 Invitrogen Signs Deal to Acquire CellzDirect II-47 Invitrogen Renews Agreement with Luminex Corporation II-47 BioTime Establishes Tissue Culture Facility II-47 International Stem Cell Signs Agreement with ATCC II-48 Millipore Signs Agreement with Solabia to Distribute Animal- Free Hydrolysates II-48 Affymetrix Acquires USB Corporation II-48 SAFC to Expand Production Capacity of Viral Product II-48 Lonza Signs Partnership Agreement with Sanofi to Produce Cell Culture Vaccine II-49 SAFC to Increase Fermentation Capabilities of High-Potency API II-49 Biogen Offers Contract to Jacobs Engineering Group II-49 New Brunswick Scientific Merges with Eppendorf Group II-49 Vitrolife Extends Agreement with Cellartis II-49 Sigma-Aldrich Inks Distribution Agreement with CellPath II-49 Lonza Acquires two Subsidiaries of Cambrex Bio-Businesses II-50 Vikdas to Build Biotechnological Laboratory II-50 Novartis to Invest in a New Cell Culture Plant in Singapore II-50 Invitrogen Signs Agreement with Biocon II-50 Lonza and Bio*One form Joint Venture for Mammalian Cell Culture Plant II-50 Thermo Fisher to Extend Manufacturing Operations II-51 BD Biosciences Announces Treyburn Expansion Plans II-51 BD Biosciences Collaborates with Roche to Advance Cell Signal Transduction Study II-51 Invitrogen and RXi Pharmaceuticals Enter into Collaboration II-51 Millipore Forms a Strategic Alliance with Novozymes II-52 Thermo Fisher Takes Over OptiCell Product Line II-52 Invitrogen Collaborates with Cytori for Research on Adipose Stem Cell II-52 Thermo Fisher Partners with Cellular Engineering for Stem Cell Research II-52 VWR Signs Agreement to Distribute Biovest’s Cell Culture Device II-53 Genentech Constructs New Cell Culture Plant II-53 Invitrogen Signs Deal with Wave Biotech to Offer Media-Filled Disposable Bioreactors II-53 MediCult Purchases Humagen Fertility II-53 Millipore Acquires Serologicals II-53 ReNeuron Inks Collaboration Agreement with CellSeed II-54 Trans Valley Launches Tissue Cultured Variety of Mushrooms II-54 HiMedia Laboratories Forges Distribution Deal with VWR International II-54 Teva Signs Collaboration Agreement with Protalix Biotherapeutics II-54 SAFC-Biosciences Forms to Support Sigma-Aldrich II-54 Invitrogen and Cellartis to Co-develop hESC Reporter Lines II-55 CELLCA and Rentschler Join Forces for Unique High-Level Expression System II-55 ArcDia Partners with Chip-Man Technologies II-55 Chugai Pharmaceutical Receives License for Cell Line from Cambrex Bio Science Walkersville, Inc. II-55 Chemicon Inks Distribution Agreement with CELLnTEC II-55 Chemicon Signs an Agreement with ReNeuron II-56 Chemicon to Market Stem Cell Products of ASCC II-56 SCS and Chemicon Introduce ESGRO Complete™ Product Range II-56 Serologicals Acquires Cytomyx Ltd II-56 Millipore to Take Over Serologicals II-56 CAT Opts SelectT™ for Higher Cell Culture Yields II-56 SAFC to Market Cell Line Engineering of ProBioGen II-57 Chemicon Licensed to Employ the RheoSwitch(R) System of RheoGene II-57 SCS and Chemicon Sign an Agreement for ES Cell Media II-57 Innovata Grants UCOE Gene Expression Technology to Celliance II-57 Chemicon and Axordia Collaborate for New Antibody Markers II-57 Genzyme Acquires Verigen AG II-57 Chemicon Acquires Specialty Media II-58 CalbaTech Pockets K-D Medical II-58 Sigma- Aldrich Acquires JRH Biosciences II-58 Invitrogen Acquires Dynal II-58 Invitrogen Takes Over Biosource International II-59 CellzDirect Takes Over HepatoTech II-59 BD Acquires Atto Biosciences II-59 Serologicals Corp Pockets AltaGen Biosciences II-59 Serologicals Purchases Upstate Group II-60 The Automation Partnership (TAP) Collaborates with MAIA SCIENTIFIC II-60 Cambrex Bio Science signs agreement with QBM Cell Science II-60 Serologicals Forms Celliance II-60 JRH Biosciences Opens cGMP Facility II-60 Vitrolife Bags Patent Approvals in the US and Europe II-61 C3 Receives Clearance from Japanese Ministry of Health II-61 Fisher Scientific Acquires Perbio Science II-61 ICN Pharmaceuticals Divests Biomedicals Division II-61 Boston Scientific Enters Into a Strategic Alliance with Osiris II-61 8. Focus on Select Major Players II-63 Affymetrix, Inc. (USA) II-63 AMRESCO Inc (USA) II-63 Analytical Biological Services (USA) II-63 BD Biosciences (USA) II-63 Cell Culture Technologies (Switzerland) II-64 Cell Essentials, Inc. (USA) II-64 Invitrogen Corporation (USA) II-64 Irvine Scientific (USA) II-65 Lonza Biologics Plc (UK) II-65 Mediatech, Inc. (USA) II-65 Millipore Corporation (USA) II-65 Medi-Cult A/S (Denmark) II-65 MP Biomedicals (USA) II-66 PerBio Science AB (Sweden) II-66 PromoCell GmbH (Germany) II-66 Sera Laboratories International (UK) II-66 Sigma-Aldrich Corporation (USA) II-67 SAFC Biosciences (USA) II-67 USB Corp (USA) II-67 Vitrolife AB (Sweden) II-67 Wisent, Inc. (Canada) II-67 9. Global Market Perspective II-68 Table 4: World Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-68 Table 5: World Long-term Projections for Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-69 Table 6: World 10-Year Perspective for Cell/Tissue Culture Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) & Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-70 Cell/Tissue Culture Supplies Market by Product Segment II-71 Table 7: World Recent Past, Current & Future Analysis for Media Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-71 Table 8: World Long-term Projections for Media Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-72 Table 9: World 10-Year Perspective for Media Cell/Tissue Culture Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) & Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-73 Table 10: World Recent Past, Current & Future Analysis for Sera Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-74 Table 11: World Long-term Projections for Sera Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-75 Table 12: World 10-Year Perspective for Sera Cell/Tissue Culture Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) & Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-76 Table 13: World Recent Past, Current & Future Analysis for Reagent Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-77 Table 14: World Long-term Projections for Reagent Cell/Tissue Culture Supplies by Geographic Region - USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Latin American Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-78 Table 15: World 10-Year Perspective for Reagent Cell/Tissue Culture Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for USA, Canada, Japan, Europe, Asia-Pacific (excluding Japan) & Latin America Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) II-79 III. MARKET 1. The United States III-1 A.Market Analysis III-1 Biotech Industry in the US III-1 Government Sponsors Development of Cell-Based III-1 Technologies for Vaccines III-1 Cell & Tissue Culture Market III-1 A Brief Insight III-1 Grade Definitions III-2 Market Trends III-2 Trend Towards Serum-Free Media III-2 Table 16: US Market for Cell Culture in the Recent Past (2004): Percentage Breakdown of Value Sales for Media, Sera and Reagents for Industrial End Use Application (includes corresponding Graph/Chart) III-3 Table 17: US Market for Cell Culture in the Recent Past (2004): Percentage Breakdown of Value Sales for Academic End Use Application for Liquid Media, Powdered Media, Fetal Bovine Serum, Serum-free and Protein-free Media, Growth Factors, Other Sera, Supplements, Antibiotics, and Other Products (includes corresponding Graph/Chart) III-3 Liquid and Powdered Media Account for Major Share III-3 Table 18: Leading Players In The Us Cell Culture Media Market (2006): Percentage Breakdown Of Volume Sales For - Hyclone, Sigma-Aldrich, Cambrex, Invitrogen, Jrh, Bd Sciences, and Others (includes corresponding Graph/Chart) III-4 Fetal Bovine Serum - Uses on a Decline III-4 Table 19: Leading Players in the US Cell Culture Serum Market (2006): Percentage Breakdown of Volume Sales for - Invitrogen, Roche, Hyclone, Serological, Sigma-Aldrich, Cambrex, and Others (includes corresponding Graph/Chart) III-4 Table 20: Leading Producers of Fetal Bovine Serum in the US in the Recent Past (2004): Percentage Breakdown of Value Sales for Life Technologies, Hyclone, and Others (includes corresponding Graph/Chart) III-5 Bovine Serum Industry: Highly Unpredictable III-5 Suppliers Searching for New Areas III-5 Sustained Rise of Serum-Free and Protein- Free Media III-5 Rise in Cell Culture Equipment Demand Leads to Innovation III-5 End Use Analysis III-5 Table 21: US Market for Cell and Tissue Culture in the Recent Past (2004): Percentage Share by Research Application for Cellular Research, Protein Expression, Protein Production, Cell Therapy, and Cell Transplantation (includes corresponding Graph/Chart) III-6 Table 22: US Market for Cell Culture Reagents in the Recent Past (2004): Percentage Breakdown of Value Sales for End Use Applications- Academic, Industrial, and Non-Academic (includes corresponding Graph/Chart) III-6 Table 23: Leading Players in US Cell/Tissue Culture Market in the Recent Past (2003, 2004, & 2005): Percentage Breakdown of Value Sales for Invitrogen, JRH Biosciences,Hyclone, Cambrex Bio Science Walkersville (Formerly BioWhittaker), Sigma-Aldrich, and Others (includes corresponding Graph/Chart) III-7 Factors Influencing the Market for Tissue and Cell Culture Media III-7 Regulatory Controls III-7 Guidelines Governing Use of Cell/Tissue Culture Reagents III-7 MSDS and Hazardous Information III-8 Toxic Substances Control Act III-8 Imports & Exports III-8 Table 24: US Imports of Preparation Culture Media (2006 & 2007): Imports by Country for Italy, Germany, Canada, UK, France, and Others (US$ Thousand) (includes corresponding Graph/Chart) III-8 Table 25: US Exports of Preparation Culture Media (2006 & 2007): Exports by Country for Belgium, Canada, Japan, UK, Germany, Netherlands, France, and Others (US$ Million) (includes corresponding Graph/Chart) III-9 Product Launches/Developments III-9 Strategic Corporate Developments III-18 Key Players III-27 B.Market Analytics III-31 Table 26: US Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-31 Table 27: US Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-31 Table 28: US 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-32 2. Canada III-33 A.Market Analysis III-33 Current & Future Analysis III-33 Biotechnology Industry III-33 Imports & Exports III-33 Table 29: Canadian Imports of Preparation Culture Media (*) (2006 & 2007): Imports by Country for USA, UK, Germany, Italy, France, Australia, Finland, and Others (in US$ Thousand) (includes corresponding Graph/Chart) III-33 Table 30: Canadian Exports of Preparation Culture Media (*) (2006 & 2007): Exports by Country for USA, Nigeria, China, UAE, Italy, and Others (in US$ Thousand) (includes corresponding Graph/Chart) III-33 Key Player III-34 B.Market Analytics III-34 Table 31: Canadian Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-34 Table 32: Canadian Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-35 Table 33: Canadian 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-35 3. Japan III-36 A.Market Analysis III-36 Current & Future Analysis III-36 Biotechnology Industry in Japan III-36 Product Launch/Development III-36 Strategic Corporate Developments III-36 B.Market Analytics III-37 Table 34: Japanese Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-37 Table 35: Japanese Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-37 Table 36: Japanese 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-38 4. Europe III-39 A.Market Analysis III-39 Current & Future Analysis III-39 Market Overview III-39 Biotech and Life-Science Research III-39 B.Market Analytics III-40 Table 37: European Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Geographic Region - France, Germany, UK, Italy & Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-40 Table 38: European Long-term Projections for Cell/Tissue Culture Supplies by Geographic Region - France, Germany, UK, Italy and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-41 Table 39: European Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-41 Table 40: European Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-42 Table 41: European 10-Year Perspective for Cell/Tissue Culture Supplies by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, UK, Italy & Rest of Europe Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-42 Table 42: European 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-43 4a. France III-44 Market Analysis III-44 Current & Future Analysis III-44 Table 43: French Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-44 Table 44: French Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-45 Table 45: French 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-45 4b. Germany III-46 A.Market Analysis III-46 Current & Future Analysis III-46 Biotech Research Scenario III-46 Table 46: German Biotech Market in the Recent Past (2004): Percentage Breakdown by Application Area - Environment, Human Health Care, Chemical industry, Food, Agriculture, Energy, and Others (includes corresponding Graph/Chart) III-47 Strategic Corporate Developments III-47 Key Player III-48 B.Market Analytics III-49 Table 47: German Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-49 Table 48: German Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-49 Table 49: German 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-50 4c. The United Kingdom III-51 A.Market Analysis III-51 Current & Future Analysis III-51 Biotechnology Industry - A Brief Insight III-51 Research Entities III-51 Commercial Activities III-51 Outlook III-51 Regulatory Issues III-52 HFE Act Guidelines III-52 The Ethical Issues III-52 Table 50: Prepared Culture Media Market in the UK (2004-2006): Exports and Imports in Tons and £ Millions (includes corresponding Graph/Chart) III-53 Product Launches/Developments III-53 Strategic Corporate Developments III-54 Key Player III-55 B.Market Analytics III-56 Table 51: UK Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-56 Table 52: UK Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-56 Table 53: UK 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-57 4d. Italy III-58 Market Analysis III-58 Current & Future Analysis III-58 Table 54: Italian Recent Past, Current & Future Analysis for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-58 Table 55: Italian Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-59 Table 56: Italian 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera, and Reagents Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-59 4e. Rest of Europe III-60 A.Market Analysis III-60 Current & Future Analysis III-60 Scenario in other European Countries III-60 Product Launch/Development III-60 Strategic Corporate Developments III-61 Key Players III-62 B.Market Analytics III-64 Table 57: Rest of Europe Market for Cell/Tissue Culture Supplies - Recent Past, Current & Future Analysis by Product Segment for Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-64 Table 58: Rest of Europe Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-64 Table 59: Rest of Europe 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera and Reagent Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-65 5. Asia-Pacific III-66 A.Market Analysis III-66 Current & Future Analysis III-66 Rise of Cell Culture in Asia III-66 India III-66 Cell Culture Market Constituents III-66 China III-67 Taiwan III-67 Australia III-67 Strategic Corporate Developments III-67 B.Market Analytics III-70 Table 60: Asia-Pacific Market for Cell/Tissue Culture Supplies - Recent Past, Current & Future Analysis by Product Segment for Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-70 Table 61: Asia-Pacific Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-70 Table 62: Asia-Pacific 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera and Reagent Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-71 6. Latin America III-72 A.Market Analysis III-72 Current & Future Analysis III-72 Brazilian Biotech Industry III-72 B.Market Analytics III-72 Table 63: Latin American Market for Cell/Tissue Culture Supplies - Recent Past, Current & Future Analysis by Product Segment for Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-72 Table 64: Latin American Long-term Projections for Cell/Tissue Culture Supplies by Product Segment - Media, Sera, and Reagents Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-73 Table 65: Latin American 10-Year Perspective for Cell/Tissue Culture Supplies by Product Segment - Percentage Breakdown of Dollar Sales for Media, Sera and Reagent Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart) III-73 IV. COMPETITIVE LANDSCAPE

Companies Mentioned

The Companies Mentioned inside the report include: Aastrom Biosciences Inc (USA) ABgene (United Kingdom) Advanced Biotechnologies, Inc (USA) American Type Culture Collection (USA) Amphioxus Cell Technologies, Inc (USA) Amresco, Inc (USA) Analytical Biological Services, Inc (USA) Barnstead International (USA) Becton, Dickinson & Company (USA) BD Biosciences (USA) Bellco Glass Inc (USA) Bibby Sterilin Limited (United Kingdom) Biochrom AG (Germany) Biocientifica SA (Argentina) Biocrystal, Ltd (USA) Biodesign Inc (USA) Biohit PLC (Finland) Biological Industries (Israel) Biomedical Technologies, Inc (USA) Bio-Rad Laboratories, Inc (USA) BioReliance Corporation (USA) BioSource Europe SA (Belgium) Biosource International, Inc (USA) Biofluids Biotage, Inc (USA) Biowest (France) Boston Scientific Corporation (USA) BrandTech Scientific, Inc (USA) CalbaTech, Inc (USA) Cambrex Bio Science Walkersville, Inc (USA) Cell Applications, Inc (USA) Cell Culture Technologies (Switzerland) Cell Essentials, Inc (USA) Cell Sciences, Inc (USA) Cellontech Co, Ltd (Korea) CellzDirect, Inc (USA) Centerchem, Inc (USA) Clinical Cell Culture Ltd (United Kingdom) Cole-Parmer Instrument Company (USA) Commonwealth Biotechnologies, Inc (USA) Conception Technologies (USA) Corning, Inc (USA) Coy Laboratory Products, Inc (USA) CSL Biosciences (Australia) Digene Corporation (USA) Don Whitley Scientific Ltd (UK) Drummond Scientific Co (USA) Eberbach Corporation (USA) Essen Instruments, Inc (USA) Fertipro NV (Belgium) Gemini Bio-Products (USA) Genzyme Corporation (USA) Globepharm Ltd (UK) Greiner Bio-One GmbH (Germany) Grupo Grifols (Spain) Harvard Bioscience, Inc (USA) Hyclone Laboratories, Inc (USA) Imgenex Corporation (USA) Instruchemie BV (Netherlands) Integra Biosciences GmbH (Germany) Invitrogen Corporation (USA) Irvine Scientific, Inc (USA) JRH Biosciences, Inc (USA) Kemp Biotechnologies (USA) Kimble/Kontes Glass, Inc (USA) Leica Microsystems, Inc (USA) Mandel Scientific Company, Inc (Canada) Mediatech, Inc (USA) Medi-Cult A/S (Denmark) Midwest Scientific (USA) Millenium Biologix Corporation (Canada) Millipore Corporation (USA) Minerva Biolabs GmbH (Germany) Molecular Research Center, Inc (USA) MP Biomedicals, Inc (USA) Nalge Nunc International, Inc (USA) New Brunswick Scientific Co, Inc (USA) Osiris Therapeutics, Inc (USA) Pall Corporation (USA) Para Scientific Co (USA) PerBio Science AB (Sweden) Plas-Labs, Inc, (USA) Pope Scientific, Inc (USA) Preiser Scientific Inc (USA) Promocell GmbH (Germany) Protide Pharmaceuticals Inc (USA) Quality Biological, Inc (USA) R&D Systems, Inc (USA) Research Organics, Inc (USA) Roche Molecular Biochemicals (USA) Sartorius BBI Systems GMBH (Germany) Sartorius BBI Systems Inc (USA) Scientific Industries, Inc (USA) Sentigen Holding Corporation (USA) Sentigen Biosciences (USA) Cell and Molecular Technologies Inc (USA) Sera Laboratories International Ltd (UK) Serologicals Corporation (USA) Celliance Corporation (USA) Chemicon International, Inc (USA) Serotec Ltd (UK) Sigma-Aldrich Corporation (USA) Sigma-Aldrich Co, Ltd (UK) Spectrocell (USA) Spectrum Laboratory Products, Inc (USA) Stratagene, Inc (USA) SurModics, Inc (USA) Techne, Inc (USA) The Binding Site Ltd (United Kingdom) Theratechnologies (Canada) Thermo Electron Corporation (USA) Thomas Scientific (USA) USA Scientific, Inc (USA) USB Corporation (USA) Vitrolife AB (Sweden) Vivascience AG (Germany) Wave Biotech LLC (USA) Whatman PLC (UK) Wheaton Science Products (USA) Wilmad-Labglass (USA) Wisent, Inc (Canada)