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Bioinformatics Markets


Description: The life science informatics marketplace--known as bioinformatics--is set to expand as high-tech companies infiltrate this arena and biopharmaceutical companies incorporate key informatic solutions into their business strategies. It is believed that many of the segments of bioinformatics described in this report offer an unusual opportunity for accelerated expansion within the coming years. This study is arranged to provide an overview of bioinformatics market segments and offer evidence that these segments are poised for significant future growth. Each segment is accompanied by analysis and forecasts by product type and application.

This analysis surveys the bioinformatics market and the latest information regarding emerging new products and industry trends. The study will quantify and qualify the bioinformatics market segments as an area of research, product development and investment. Forecasts of the bioinformatics market and an analysis of products in the worldwide information-processing market will provide a basis for understanding the significance of past developments and future possibilities within this market category.

The main objectives of this analysis are as follows:

- Identify viable technology drivers through a comprehensive look at various platform technologies for segments of the bioinformatics market.

- Impart a complete understanding of the chief bioinformatics tools and their predictive, screening, prognostic, monitoring, pharmacogenomic and product value, from basic principles to application.

- Distinguish feasible market opportunities via identifying high-growth applications in different bioinformatics areas, with a focus on the biggest and fastest expanding markets for diagnosis and treatment of diseases.

- Focus on global industry development through an in-depth analysis of the major world markets for bioinformatics, including forecasts for growth.

- Present market figures regarding the current value of the bioinformatics market, projections and growth rates. The source of this information is the most current data derived from the global diagnostic industry.



Contents: 1. Overview 7
1.1 Statement of Report 7
1.2 Objectives of this Report 7
1.3 Scope of this Report 9
1.4 Methodology 9

2. Introduction 10
2.1 Global Bioinformatics Products Industry 10
2.2 Computers and Biology 11
2.2.1 Bioinformatics and the Internet 13
2.3 Company Evaluation Overview 13
2.4 Market Outlook 14
2.4.1 Competitive Structure 14
2.5 Applications of Bioinformatics 15
2.5.1 Healthcare 15
2.5.2.1 Allocation of R&D 17
2.5.2.2 Traditional Drug Discovery Process 19
2.5.2.3 Drug Discovery and Informatics 20
2.5.2.4 Collaborative Agreements 20
2.6 The Human Genome Project (HGP) 21
2.6.1 Goals of the Human Genome Project 21
2.6.2 Benefits of the Human Genome Project 22
2.7 Barriers to Entry 23
2.8 Proteomics and Databases 24
2.8.1 Protein Database Standards 26
2.8.2 Future Trends 26

3. The U.S. Bioinformatics Market 28
3.1 Overview 28
3.2 Market Revenue and Growth Forecasts 30
3.3 Market Drivers 30

4. Genomics 32
4.1 The Biotechnology Industry 32
4.2 The Development of a Genomics Market 34
4.2.1 Market Drivers 34
4.2.2 Market Restraints 34
4.2.3 Market Size and Growth Projections 35
4.2.4 The U.S. Genomics Market 35
4.3 Biochips and Microarrays 35
4.3.1 Key Challenges 37
4.3.2 Freeware 37
4.3.3 New Tools 38
4.4 Bioinformatics 41
4.5 Disease Targets 42
4.6 Functional Genomics 42
4.7 Gene Sequencing 45
4.8 Gene Sequence Variation Detection 45
4.9 Comparative Genomics 46
4.10 Genome Database Arrays 46
4.11 High-throughput Genomics 48
4.11.1 High-throughput Technology 48
4.11.2 Lab on a Chip 49
4.12 Pharmacogenomics 50
4.13 Probe Arrays 52
4.13.1 Gene Expression Monitoring Arrays 52
4.14 DNA Analysis Arrays 54
4.15 Proteomics 55
4.16 Sequencing 56
4.17 Single Nucleotide Polymorphisms (SNPs) 56
4.18 Structural Genomics 58
4.19 Photolithography 58
4.20 Instrumentation 59

5. The Bioinformatics Industry 60
5.1 Definition and Role of Bioinformatics 60
5.1.1 Bioinformatics Sector Overview 62
5.1.2 The Future Status of Bioinformatics 62
5.1.3 Barriers to Growth 62
5.2 Types of Data and Bioinformatics Applications 63
5.2.1 Validated Core Modeling Technology 64
5.2.2 Broad Applicability 64
5.2.3 Data Management Compliant with Industry Standards 64
5.2.4 Open Architecture 64
5.2.5 Ease of Use 64
5.2.6 Increased Access 64
5.3 Functions of Informatics Software 65
5.3.1 Data Management 65
5.3.2 Data Transformation 65
5.3.3 Data Collaboration 65
5.3.4 Interface for Online Data Sources 66
5.4 Target Markets for Informatics Software 66
5.5 Steps Involved in Bringing a Drug to Market 66
5.6 Costs Incurred in Developing a New Drug 67
5.7 Industry Drivers and Challenges 68
5.8 Industry Risks 69
5.9 Products of Bioinformatics 70
5.10 Bioinformatics Processes 71
5.11 Informatics Tools and Functionalities 71
5.11.1 Sequence to Structure 72
5.11.2 Lead Identification and Optimization 72
5.11.3 Development and Formulation 72
5.11.4 Improving Materials and Processes 72
5.11.5 Other Materials-based Industries 73
5.12 Role of Bioinformatics in the Biotechnology Value Chain 73
5.13 Bioinformatics Market Segments 73
5.13.1 Databases 73
5.13.2 Hardware 75
5.13.3 Software 75
5.13.4 Bioinformatics Services 76
5.14 Bioinformatics Market Size 77
5.14.1 Sales and R&D 77
5.14.2 IT Budget 78
5.14.3 Projected Bioinformatics Market Size 79
5.14.4 Bioinformatics Market Components 79
5.15 Bioinformatics Business Models 80
5.15.1 Changing Business Models 81
5.15.2 Competition for Pure Play Informatics Companies 83
5.15.3 Non-Profit Organizations 83
5.15.4 In-House Bioinformatics Solutions 83
5.15.5 Large IT Companies 83
5.16 Bioinformatics Target Disciplines 84
5.16.1 Comparative Genomics 84
5.16.2 Pharmacogenomics 84
5.16.3 Functional Genomics 85
5.16.4 Proteomics 85
5.16.5 Structural Genomics 86
5.16.6 Image Informatics 86
5.16.7 Clinical Trial Informatics 87
5.16.8 Cheminformatics 87
5.17 Bioinformatics Architecture 88
5.18 Bioinformatics Applications 89
5.18.1 Data Search Tools 89
5.18.2 Data Visualization Tools 90
5.18.3 Data Mining and Clustering 90
5.18.4 Enterprise Solutions 91
5.18.5 Data Warehousing 91
5.19 Evaluation of Bioinformatics Solutions 91
5.19.1 Requirements of Study 92
5.19.2 Shortlisting the Options 92
5.19.3 Scoring Patterns 92
5.19.4 Performance 93
5.19.5 Data Storage 94
5.19.6 Data Management in Drug Discovery 94
5.19.7 Key Issues in Bioinformatics Data Storage 94
5.20 Convergence of Industries 95
5.21 Proteins as a Driver 96
5.23 Current Bioinformatics Research 97
5.24 New Bioinformatics Modeling Algorithms 97
5.25 3D Modeling 97
5.26 Patenting Bioinformatics Algorithms 98

6. Recent Industry Activity: Collaborations and Acquisitions 102

7. Product Development and Launches 107

8. Global Market Perspective 110

9. Corporate Profiles 112
9.1 Accelrys 112
9.2 Affymetrix, Inc. 114
9.3 Agencourt Bioscience Corporation 115
9.4 Agilent Technologies 115
9.5 AlgoNomics 116
9.6 ALLEZ Software 117
9.7 ApoCom Genomics 117
9.8 Applied Biosystems 118
9.9 Ariadne Genomics, Inc. 121
9.10 Array Genetics 121
9.11 Automated Handling Systems, Inc. 121
9.12 Avestha Gengraine Technologies Pvt. Ltd. 121
9.13 Bioalma 122
9.14 Biobase GmbH 123
9.15 BioCarta 123
9.16 Biodatabases (AMITA Corporation) 123
9.17 BioDiscovery, Inc. 124
9.18 BioInformatics, LLC 124
9.19 BioInformatics Services 125
9.20 BioInformatics Solutions, Inc. 125
9.21 Biomax Informatics AG 126
9.22 Bioreason, Inc. 126
9.23 Biosiris 126
9.24 BioSoftSolutions 126
9.25 Biotique Systems, Inc. 127
9.26 BioWisdom Ltd. 127
9.27 Bio-Xtal 128
9.28 Cambridge Antibody Technology 128
9.29 Cambridge BlueGnome (BlueGnome) 128
9.30 Capital Genomix 128
9.31 Celera Genomics 129
9.32 Cellomics, Inc. 131
9.33 Cellectis 131
9.34 CeuticalSoft 132
9.35 Chemical Computing Group 132
9.36 Cimarron Software, Inc. 133
9.37 CLONDIAG Chip Technologies 133
9.38 CodonCode Corporation 133
9.39 Cognia Corporation 133
9.40 CompuDrug 134
9.41 Compugen Ltd. 134
9.42 Corimbia 136
9.43 CSIRO Bioinformatics 136
9.44 CuraGen Corporation 136
9.45 CyberGene 138
9.46 Data Unlimited International 138
9.47 deCODE Genetics 138
9.48 Decodon GmbH 139
9.49 Deltagen, Inc. 140
9.50 Digilab BioVisioN 141
9.51 Discovery Partners International, Inc. 142
9.52 DNA Software, Inc. 144
9.53 DNAPrint Genomics, Inc. 144
9.54 DNA Star, Inc. 145
9.56 DxS Genotyping, Ltd. 146
9.57 Electric Genetics, Pvt. Ltd. 146
9.58 Entelos 147
9.59 Epigenomics, AG 147
9.60 Epitope Informatics, Ltd. 148
9.61 e-Proteomics.net 148
9.62 EraGen Biosciences 148
9.63 Essential Informatics 149
9.64 European Bioinformatics Institute (EBI) Industry Programme 149
9.65 Evolutionary BioInformatics 149
9.66 Genamics 149
9.67 Genebio 149
9.68 Gene Biotechnologies 150
9.69 GeneData, AG 150
9.70 Gene-IT 151
9.71 Gene Logic, Inc. 151
9.72 GenOdyssee, SA 154
9.73 Genolyze 155
9.74 Genomatica 155
9.75 Genomics Collaborative 155
9.76 Genomic Solutions Inc. 156
9.77 Genomining 157
9.78 Geospiza, Inc. 157
9.79 Glycominds 158
9.80 Health Discovery Corporation 158
9.81 Hitachi Corporate Technology Group 159
9.82 Improved Outcomes Software, Inc. 160
9.83 INCOGEN, Inc. 160
9.84 Incyte Corporation 160
9.85 Informagen 161
9.86 Inpharmatica 161
9.87 Insightful Corporation 162
9.88 Insilico Software 162
9.89 Insilicos 162
9.90 Intrexon Corporation 162
9.91 Invenio Biosolutions 162
9.92 Invitrogen Corporation 163
9.93 IO Informatics 164
9.94 Kshema Technologies Ltd. 165
9.95 LabBook 165
9.96 LabVantage Solutions 166
9.97 Lifespan Biosciences 166
9.98 Lion Bioscience, AG 166
9.99 MathEcology LLC 168
9.100 Matrix Science 168
9.101 Medicel, Ltd. 168
9.102 METabolic EXplorer 168
9.103 Metahelix Life Sciences 168
9.104 Metalife 169
9.105 Monogram Biosciences, Inc. 169
9.106 Neurome, Inc. 170
9.107 Nonlinear Dynamics 171
9.108 Ocimum Biosolutions 171
9.109 OmniViz, Inc. 172
9.110 Partek Inc. 172
9.111 Perlegen Inc. 173
9.112 Prokaria 174
9.113 Quantiom Bioinformatics 174
9.114 Relevant Software, Inc. 174
9.115 Rosetta Inpharmatics 174
9.116 SBI Science LLC 175
9.117 Seascape Learning 175
9.118 Spotfire, U.S. Headquarters 176
9.119 Spotfire AB, European Headquarters 176
9.120 Spotfire, Japan Headquarters 176
9.121 Strand Life Sciences Pvt. Ltd. 177
9.122 Sun Microsystems 178
9.123 Syngene 178
9.124 Tahoe Informatics 179
9.125 3rd Millennium, Inc. 179
9.126 Thomson Scientific 179
9.127 TIB MOLBIOL 179
9.128 Tripos, Inc. 180
9.129 United Bioinformatica, Inc. 180
9.130 VizXLabs 180


INDEX OF FIGURES

Figure 4.1: Global Biotechnology Industry 33
Figure 5.1: Informatics Applications along the Drug-Discovery Value Chain 60
Figure 5.2: Functions of Bioinformatics Software in Research 60
Figure 5.3: Growth of GenBank, 1982-2002 61
Figure 5.4: EMBL Database Growth, 1991-2003 61
Figure 5.5: Steps Involved in Bringing a Drug to Market 67
Figure 5.6: Analysis of the Total Costs in Developing a New Drug 67
Figure 5.7: Role of Bioinformatics in the Biotechnology Value Chain 73
Figure 5.8: Worldwide Projected Pharmaceutical Sales and R&D Expenditure, 2000-2010 78
Figure 5.9: Worldwide Projected Growth in IT Budget, 2000-2010 78
Figure 5.10: Worldwide Projected Bioinformatics Market, 2000-2010 79
Figure 5.11: Worldwide Bioinformatics Market Vendor Components, 2000-2010 80
Figure 5.12: Steps of a Proteomics Experiment 86
Figure 5.13: Bioinformatics Architecture 89


INDEX OF TABLES

Table 2.1: Leading Biotechnology Companies 15
Table 2.2: Pharmaceutical R&D Expenditures by World Region, 1990-2003 17
Table 2.3: Total of Domestic U.S. R&D and R&D Abroad, Ethical Pharmaceuticals, Research-Based Pharmaceutical Companies, 1980-2003 18
Table 2.4: Global Pharmaceutical R&D Expenditures, 1993-2004 18
Table 2.5: SIB Informatics Databases 25
Table 4.1: The U.S. Biotechnology Industry Size and Revenue, 1995-2005 32
Table 4.2: Global Biotechnology Industry Major Segments 34
Table 4.3: Genomics Sector Market Size, 2001-2008 35
Table 4.4: The Biochip Array Market, 2000-2010 35
Table 4.5: Selected Competitors in the Biochip Market 36
Table 4.6: Biochip Microarray Products 36
Table 4.7: Bioinformatics Tools 41
Table 4.8: Functional Genomics Companies Building Advanced Integrated Platforms and Substantial Databases 44
Table 4.9: Companies Using New Genomic Tools 45
Table 4.10: Non-DNA Based Chip Suppliers 45
Table 4.11: Robotics or "Lab-on-a-Chip" Market Sector 46
Table 4.12: Key High-Throughput and Systemic Approaches for Genomic Analysis 48
Table 4.13: Total Biochip Market, 2002-2010 49
Table 4.14: Pharmacogenomics Segment Players 51
Table 4.15: The Worldwide Market for Pharmacogenomics, 2000-2008 51
Table 4.16: Competitors in the SNP Genotyping Segment 58
Table 4.17: Scanning and Detection Technology Suppliers 59
Table 5.1: Data Sources and Bioinformatic Investigations 63
Table 5.2: Drivers and Challenges of the Bioinformatics Industry 68
Table 5.3: Bioinformatics Activities, Sub-Activities and Key Players 77
Table 5.4: Alliances between IT/Telecom and Biotechnology Firms 95
Table 5.5: Types of Intellectual Property Protection for Bioinformatics Tools 100
Table 8.1: Bioinformatics Market Size, 2000-2010 110
Table 8.2: Cheminformatics Market Size, 2004-2010 110
Table 8.3: In-silico Informatics Market Size, 2004-2010 111
Table 8.4: Bioinformatics Hardware and Systems Market Size, 2004-2010 111




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