Contents:

Chapter 1: Executive Summary Scope of this Report GPCRs and Ion Channels Target Space Snapshot of the Current GPCR Space Market Drivers, Challenges, and Opportunities Affecting Ion Channels and GPCRs Ion Channels GPCRs Ranking of Important Research Topics in the GPCR Space for Pharmaceutical Industry Researchers versus Academic Researchers Chapter 2: Market Analysis of Ion Channels Scope of this Chapter Introduction Price per Data Point for the Various Ion Channel Segments Ion Channel Interrogation Capital Equipment and Consumable Budgets Market Size for Ion Channel Instrumentation: 2006, 2007, and 2008 hERG Liability Screening Market Metrics Types of Ion Channels Being Studied Ligand-Gated Ion Channels Voltage-Gated Ion Channels Fee-for-Service Business Model in the Ion Channels Space Segments in the Ion Channels Space That Offer Growth Opportunities Chapter 3: G Protein-coupled Receptors (GPCRs): Qualitative and Quantitative Market Analyses Scope of this Chapter Introduction to the Space Market Analysis: GPCR Analysis and Interrogation R&D Efforts Directed at GPCR Subclasses and The Various GPCR Interrogation/Analysis Technologies Size of GPCR Interrogation/Analysis Screening Campaigns Qualitative Impressions of the GPCR Marketplace, Trends Therein, and Open Questions Side Bar: Subclass-based GPCR Market Segmentation Chapter 4: Ion Channels: Classification & Structure Technologies for Interrogation Scope of This Chapter Chapter 5: G Protein-coupled Receptors (GPCRs): Classification & Structure Receptor-mediated Signaling Technologies for Interrogation Scope of This Chapter Chapter 6: GPCR and Ion Channel Classes: An End-user Survey of Growth Opportunities, Market Trends, and Quantitative Analyses Survey Methodology Table of Exhibits Exhibit 1.1 Number and Percentage of GPCRs and Ion Channels in the Human Genome Exhibit 1.2 Ranking of Pharma Industry Researchers versus Academic Researchers of Different Topics in the GPCR Space Exhibit 2.1 Ion Channel Interrogation Technologies and the Market Segments that they Address Exhibit 2.2 Penetrance of the Various APC Platforms in Ion Channel R&D—APC Instrument Market Share in terms of Ion Channel R&D Exhibit 2.3 Price per Data Point in the Various Ion Channel Market Segments Exhibit 2.4 Capital Equipment and Consumable Budgets for Ion Channel R&D Exhibit 2.5 Automated Patch Clamp (APC) Global Market Opportunity Exhibit 2.6 Global Market Opportunity for APC Sales Exhibit 2.7 In-house versus Outsourced hERG Liability Screening Exhibit 2.8 Market Model Describing the Market Opportunity for hERG Liability Screening Exhibit 2.9 The Various Types of Ion Channels Exhibit 2.10 Ion Channels Usage Pattern in the Marketplace Exhibit 2.11 Ranking of the Various Fee-for-service Vendors for Ion Channel Screening and Interrogation Exhibit 3.1 Growth of the GPCR Interrogation/analysis Marketplace Exhibit 3.2 Facilities conducting GPCR R&D Per Institution Exhibit 3.3 Monthly Research Spending Interrogating/Analyzing GPCRs Exhibit 3.4 Percentage of R&D Efforts Directed at Different GPCR Subclasses by the Total Respondent Pool Exhibit 3.5 Percentage of R&D Efforts Using Different GPCR Assay Methodologies by the Total Respondent Pool Exhibit 3.6 Percentage of R&D Efforts Using Different GPCR Assay Methodologies Resolved into Pharmaceutical Company and Biotechnology Company Participants—Illustrates Differences in R&D Trends in These Market Segments Exhibit 3.7 Trend: Growth or Decline of the Various GPCR Assay/Interrogation Approaches Exhibit 3.8 Market Shares: Companies Offering Products in the Various GPCR Interrogation/Analysis Spaces Exhibit 3.9 Summary of Market Shares across the GPCR Interrogation/Analysis Landscape Exhibit 3.10 Number of Experiments Run by Pharmaceutical Participants versus Biotechnology Participants in terms of interrogating/analyzing GPCRs Exhibit 3.11 Distribution of Experiments Run by Pharmaceutical Participants versus Biotechnology Participants in terms of Interrogating/analyzing GPCRs Exhibit 3.12 Market Size for GPCR Interrogation/Analysis in Terms of Industry Dollars and Experiments (Assays) Exhibit 3.13 Segmentation of GPCR Market Opportunity Exhibit 4.1 Classification of Ion Channels Exhibit 4.2 Voltage-gated Ion Channel: Activation States Exhibit 4.3 Ligand-gated Ion Channel: Structure and Activation States Exhibit 4.4 Calcium Channel Structure Exhibit 4.5 Schematic Representation of the HCN Channel Exhibit 4.6 6-TM Potassium Channel Structure Exhibit 4.7 Sodium Channel Structure Exhibit 4.8 Technologies for Ion Channel Interrogation I Exhibit 4.9 Technologies for Ion Channel Interrogation II Exhibit 4.10 Sequence of Methods for Studying Ion Channels Exhibit 4.11 Technologies for Ion Channel Interrogation Exhibit 4.12 Features/Advantages of the Patch Clamp Assay Exhibit 4.13 Automated Patch Clamping (APC) Products from the Various Vendors Exhibit 4.14 Fluorescence Measurement on FLIPR: An Alternate Approach for Ca2+ Channels Exhibit 4.15 Luminescence on Flash Luminometer: Another Approach for Ca2+ Channels Exhibit 4.16 Principle of Rb+ -efflux Assay: Another Ion Channel Screening Assay Exhibit 4.17 Summary of Mainstream Technologies for Ion Channel Interrogation Exhibit 4.18 Summary of Technologies for Ion Channel Interrogation Exhibit 5.1 G Protein-coupled Receptors (GPCRs) Exhibit 5.2 A VERY Wide Variety of Ligands In Vivo Use GPRCs Exhibit 5.3 GPCRs I Exhibit 5.4 GPCRs II Exhibit 5.5 GPCRs Activate a Number of Signaling Cascades In Vivo Exhibit 5.6 GPCRs Schematic of Signaling Events Exhibit 5.7 Schematic of GPCR Stimulation with Various Physiological Ligands Exhibit 5.8 Different G Proteins for Different Responses to Ligands Exhibit 5.9 Different Cell Types Elicit Different Responses upon GPCR Stimulation Exhibit 5.10 Hoe do GPCRs Select G Protein(s) by which to Signal In Vivo? Exhibit 5.11 Summary: GPCR Signaling Cascades I Exhibit 5.12 Summary: GPCR Signaling Cascades II Exhibit 5.13 Mainstream Technologies for Interrogation of GPCRs Exhibit 5.14 Ligand-binding Assays Exhibit 5.15 GTP-binding Assays Exhibit 5.16 Time-resolved Fluorescence (TR-FRET) Exhibit 5.17 Agonists and Inverse Agonists of GPCR-mediated Signaling: Useful Reagents in GPCR Assays Exhibit 5.18 Assays for Downstream Signaling Events

Summary:

This report is focused upon an analysis of the two pharmaceutically-important drug target classes—ion channels and G protein-coupled receptors (GPCRs). The following will be presented within this report: - Classification and structure of ion channels and GPCRs. - Signal transduction cascades initiated by ligand binding/stimulation of these targets. - Technologies for interrogation of these target classes, opportunities, and challenges therein. - The major products commercially available for interrogating these target classes. - Market shares of vendors in the respective spaces. - Qualitative and quantitative market analysis: market drivers, challenges, market size, growth rate, and future market opportunity. - SWOT analysis of the various companies in the two market segments. - Market size and business opportunities in the ion channel and GPCR spaces.