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Antitumor Biologics - Strategies for Success in an Expanding Market


Description: Introduction
Biological agents are essential tools in cancer treatment, particularly as antitumor drugs.
Unsurprisingly, current R&D in this therapeutic area therefore focuses on antitumor agents, predominantly MAbs. While the market is robust—anticancer biologics garnered $9.5 billion in 2005—and expanding, the future for such high-cost drugs is fraught with competitive and financial challenges.

Get the Answers You Need to Shape Your Strategy
Monoclonal antibodies, generating $7.3 billion in sales in 2005, have been the most successful class of biological anticancer agents. What does the future hold for anticancer MAbs?
Genentech’s Herceptin (trastuzumab) recently traversed a clinical path from approval in a small percentage of breast cancer patients to broader use as an early-stage treatment. How can MAbs and other biologics expand into new indications? How can agents leverage off-label use into new approvals and thus vastly expand sales potential?
Third-party payers and patients have expressed concern over the high cost of anticancer biologics, denying off-label use or forgoing treatment altogether. What impact will reimbursement issues have on developing agents?
Emerging agents may place pricing pressures on currently marketed antitumor therapies. How can companies protect the value of current agents? What approaches will manufacturers take to ensure that new drugs will be embraced in the clinic?


Contents: Executive Summary
Strategic Considerations
Stakeholder Implications
Introduction
Existing Biologic Antitumor Agents
Monoclonal Antibodies
Rituxan
Herceptin
Avastin
Recombinant Cytokines
Targeted Cytotoxins and Radiological Agents
Emerging Antitumor Biologics
Panitumumab
Pertuzumab
Galiximab
Volociximab
Mapatumumab
CAT-3888
CDP-791
Herceptin: A Model for Expanding an Agent’s Reach
Reimbursement Concerns with Anticancer Biologics
Outlook

Tables
1. Select Antitumor Biologic Therapeutic Approaches
2. Current Antitumor Protein Drugs, 2006
3. Select Emerging Antitumor Biologic Agents, 2006
4. Early Stage Approaches to Biological Cancer Treatment
5. Critical Clinical Trial Results for Herceptin

Figures
1. Antibody Structure
2. Number of Anticancer Biologics on the Market, 1995-2006




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Please fax this form to:
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