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From Structure to Function: In Vivo Molecular Imaging
Decision Resources, Inc, Nov 2006, Pages: 24
Introduction
In vivo imaging enables researchers to view biological processes at the molecular level. In vivo molecular imaging techniques have important implications for drug discovery and development because they aid in validating drug targets and in studying the biodistribution, target binding, clinical effects, and toxicity of drug candidates.
Get the Answers You Need to Shape Your Strategy
The development of in vivo molecular imaging techniques has important implications for drug discovery and development. How will pharmaceutical companies use this valuable information to accelerate their drug development process? Which imaging companies are the major players in this field?
The FDA has introduced a new exploratory investigational new drug (eIND) mechanism that encourages companies to use imaging techniques during early-stage microdosing studies. How can pharmaceutical companies best capitalize on this new mechanism? Which imaging technologies are likely to see increased use as the result of eIND?
The high cost of in vivo molecular imaging poses a significant barrier to its widespread adoption.
Will pharmaceutical and biotech companies decide to invest in these technologies despite the cost or will they seek other options?
The development of combined PET-MRI instrumentation will be a major breakthrough. How close to market are these powerful new tools? What new benefits will they offer?
Scope
Factors fueling the molecular imaging market: trend toward systems biology and personalized medicine, FDA Critical Path initiative, and eINDs.
In vivo imaging technologies: computed tomography (CT), positron emission tomography (PET), single photon emission CT (SPECT), magnetic resonance imaging (MRI), functional MRI, optical imaging, and the use of model organisms.
Imaging initiatives: a review of important new imaging initiatives related to biomarkers, Alzheimer’s disease, lung cancer, and osteoarthritis.
Applications of imaging to key therapeutic areas: a discussion of applications in cancer, the brain, and central nervous system disorders.
Corporate profiles: features on key players in this growing field.
Outlook for molecular imaging: our take on how the role of molecular imaging in drug development will evolve over the next several years.
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