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New Options for Treating Neurological Disease: Stem Cell Therapy


Description: Stem cell therapy development is challenged by controversy, intellectual property issues, and a high failure rate. Despite these challenges, stem cell therapy presents some of the most promising options for hard-to-treat and highly degenerative neurological diseases.

Get the Answers You Need to Shape Your Strategy
Stem cell therapy holds vast potential for treating degeneration or injury in areas of the body that are incapable of autonomous healing, such as the central nervous system (CNS). How can stem cells boost healing in the CNS? What are the limitations of these therapies in the CNS? What scientific and regulatory roadblocks exist for developing stem cell therapies for the CNS?

Several manufacturers are investigating stem cell therapies to treat neurological disease. What are the different approaches for developing these therapies? What value do different stem cell therapies offer, and what challenges do they face? How might these agents impact the different disease markets?

Stem cell therapies may represent the first true disease-modifying therapies for multiple neurological diseases, but their success will depend on many factors, including ethics, clinical trial design, and safety concerns. How are ethics affecting stem cell design? What can we expect from future stem cell clinical trials? Which stem cell therapies are likely to offer the best safety profiles?

Scope
Stem cell introduction: stages of stem cell differentiation, comparison of stem cell types, history of stem cell development.
Value of stem cells for neurological diseases: benefi ts and limitations of stem cells and their therapeutic value for multiple neurological indications, including Alzheimer’s disease and Parkinson’s disease.
Emerging stem cell therapies for neurological uses: discussion of multiple companies’ initiatives into developing neurological stem cell therapies.
Outlook: hurdles for stem cell therapy development, discussion of which stem cell therapies are more likely to succeed.


Contents: Contents
Executive Summary 3
Strategic Considerations 3
Stakeholder Implications 3

Introduction 4
Overview of Stem Cell Development 4
History of Stem Cell Research 6

Potential of Stem Cell Therapies in Neurological Disease 9
Stroke 9
Alzheimer’s Disease 12
Parkinson’s Disease 13
Spinal Cord Injury 14
Multiple Sclerosis 16
Huntington’s Disease 17
Amyotrophic Lateral Sclerosis 17
Lysosomal Storage Diseases 18

Leading Companies in Stem Cell Therapeutics for Neurological Disease 19
StemCells 19
Geron 19
ReNeuron Group 20
Stem Cell Therapeutics 21
Athersys 21
BrainStorm Cell Therapeutics 21
Advanced Cell Technology 22
Saneron CCel 22

Outlook 22

Tables
1. Types of Stem Cells 5
2. Neurological Disorders That May Benefit from Stem Cell Therapy 10
3. Key Research Studies on Stem Cells in Stroke 11
4. Key Research Studies on Stem Cells in Alzheimer’s Disease 12
5. Key Research Studies on Stem Cells in Parkinson’s Disease 14
6. Key Research Studies on Stem Cells in Spinal Cord Injury 15
7. Companies Developing Stem Cell Therapies

Figures
1. Stem Cell Differentiation 6
2. Important Events in the History of Stem Cell Research 7
3. Government Policies Regarding Stem Cell Research 8


Companies Mentioned Advanced Cell Technology Athersys Berlex Boehringer Ingelheim BrainStorm Cell Therapeutics Ferrer Internacional Genentech Geron Kyowa Hakko Mitsubishi Pharma ReNeuron Group Saneron CCel Sanofi -Aventis Schering Stem Cell Therapeutics StemCells Titan Pharmaceuticals


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