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Advances in Biotechnology for Chemical Manufacture - Part 2
Frost & Sullivan, Dec 2003


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Blockbuster Biopharmaceutical Drugs Propel Growth of Pharma Majors

Exciting and innovative developments in biotechnology have opened a plethora of opportunities for the pharmaceuticals industry in the form of biopharmaceutical drugs. More than 20 percent of new medicines launched in 2003 were produced using biotechnology, and nearly 80 percent of those under development either use biotechnology or are derived from it. Many pharmaceutical companies have stepped up their biotech-oriented initiatives to develop blockbuster drugs that are likely to elevate them as global leaders in the world biopharmaceuticals market with an estimated worth of nearly $30 billion in 2003. Additionally, joint efforts between biotech and chemical companies are also underway to develop advanced biotech process platforms that will eliminate traditional processes involved in chemical synthesis while enabling cost-effective production of ascorbic acid (vitamin C) from glucose.

This research showcases some of the exhilarating developments in the manufacture of biotech-based chemicals besides providing wide-ranging information on patents, drug and vaccine approvals, and registered biopesticides. The principal focus of the research is confined to application of biotechnology in the health sciences industry: antibiotics, vitamins and biopharmaceuticals, biopolymers, biocatalysts, and biotech pest control.

Focus on Sustainable and Profitable Bioprocessing Govern Polymers Production

Researchers across the world are currently focusing on production of biopolymers - particularly biodegradable plastics - through cost-effective industrial bioprocessing. Another top priority is safe and sustainable development that involves shifting the procurement of carbon - the key source for manufacturing polymers - from petroleum to renewable energy sources such as corn and biomass. Companies are expediting these initiatives by reinvesting more than 50 percent of their revenues in R&D so that it could eventually result in expanding the market horizons of biopolymers, comments the analyst.

Recently, Cargill Dow LLC, a U.S. based company, has successfully commissioned a world-class manufacturing facility with more than 300-million-pound capacity for polyactic acid (PLA) polymer production from corn that is likely to enable a 50 percent savings in fossil fuel usage. This, along with a few other award-winning biotech-based processes, in 2003 might just be the preamble for the upcoming commercial success in the polymer market that is worth a whopping $30 billion in the United States alone.

Biopesticides - the Best Way to Eradicate Pests

The global market for insect-control products is estimated at $12 billion annually. Among the products, biopesticides are unquestionably taking giant strides as the most effective method to counter pests. Microbial pesticides such as Bacilluis thuringiensis (Bt) - a naturally occurring soil bacterium producing proteins that are active against certain insects - are directly applied to targets susceptible to insect species. They are also incorporated into the plants through genetic modifications. Many other biopesticides, mostly based on a subspecies and strains of Bt, are also proliferating in the market.

Although primarily meant for agricultural applications, the market turf for pesticides is growing rapidly, comments the analyst. The emphasis from regulatory agencies to reduce the use of chemical pesticides is likley to widen the market reach of biopesticides. Besides biopesticides, bioprocesses are likely to be used extensively in many industries, says the analyst. The mere fact that 99 percent of uncultured microbial species in the environment have not been catalogued is a signpost for the endless opportunities for application of biotechnology.





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