Printer Friendly Printed from http://www.researchandmarkets.com/reports/39098 Bioinformatics: The Next Generation of Market Opportunities Description: Identification of targets for drug development and the discovery of therapeutics are being transformed by bioinformatics. D&MD's Bioinformatics Market Analysis Report assists in determining the best methods to incorporate and utilize bioinformatics to achieve and sustain a competitive advantage in this space. This Report examines the evolution of bioinformatics and the current status of the technology and its impending consequences. Bioinformatics stands at the interface of molecular biology and information sciences, where it promises to provide critical tools for managing the immense volume of biological information. Last year, the Human Genome Project unlocked the DNA code for 23 human chromosomes. Contained within are millions of potential genetic markers for the development of new drugs and other treatments for disease. Making sense of all that data is the job of bioinformatics companies and requires some advanced computing muscle to do it. The tools that comprise bioinformatics are themselves testament to the explosion of diversity that is present in the drug discovery industry. Just a few years ago, the only tractable experiments were intelligent chemical trial-and-error followed by extensive in vitro and in vivo testing. The 70's decade of analogue bashing gave way to the 80's rational drug design. The 90's revolution of biotechnology and new measurement technology has spawned new technologies and industries focused on in-silico and on-silico biology. The prospects for bioinformatics are inseparable from the prospects and market structure of biotech, so a large amount of the equity investment in biotech during 2000, totaling $31 billion, flowed into bioinformatics. Overall, it is estimated that the pharma sector spends 6% of its $9 billion annual drug discovery budget on IT. That's $500 million per year. Suppliers such as MDL, Molecular Simulations, Tripos, and Oxford Molecular have grown and generate revenues between $20 million and $70 million. Oxford Molecular predicts a total market for its services totaling $1.3 billion by 2002 with 75% accessible from their own products. Other sources suggest an even larger market, moving to $10 billion in five years. This Bioinformatics Report is the only report you need to carefully guide you through this competitive and challenging area. Unique Benefits of this Report » Up-to-date analysis of the various technologies, databases, and algorithms that are being deployed in bioinformatics today, giving insight into the current technology marketplace. - Discussion of the market environment, including future predictions of technology trends of computer languages that are being used in the genomics-driven drug discovery landscape, detailing where the industry is going. - Details of current venture capital breakout, presenting the market opportunities in bioinformatics. - Comprehensive profiling of the leading players in the bioinformatics market, presenting unbiased analysis of the competitive environment. - Analysis of the alliances and partnerships occurring to date, illustrating the successful strategies and collaborations. Contents: I Executive Summary Scope How do you define bioinformatics? Bioinformatics for everyone Bioinformatics - the next generation Bioinformatics - the customer need The third hurdle II Technology and Market Analysis in Bioinformatics Scope Introduction - Gene discovery - Internet security - Protein structure determination Background and technologies in bioinformatics - Aligning sequences - Local versus global alignments - Computing alignments - DotPlots - Dynamic programming methods - Scoring matrices - Aligning DNA sequences to protein sequences - Statistics - Multiple sequence alignments - Progressive pair-wise alignments - Profile analysis - Hidden Markov Models (HMMs) Bioinformatics databases Nucleotide databases - European Molecular Biology Laboratory (EMBL) - NCBI/GenBank Database - DNA Database of Japan (DDBJ) Protein databases - SWISSPROT - TrEMBL - Protein Information Resource (PIR) - Protein Data Bank (PDB) - PROSITE - IMGT/LIGM-DB Other major bioinformatics resources - Ensembl - Expert Protein Analysis System (ExPASy) - The Genome Database (GDB) - Human Genome Project Working Draft - The Institute for Genomic Research (TIGR) - The Jackson Laboratory (Mouse Genome Informatics) - National Center for Biotechnology Information (NCBI) - National Center for Genome Resources (NCGR) - The National Human Genome Research Institute (NHGRI) - The Sanger Center - Sequence Retrieval System (SRS) - The SNP Consortium Methodologies for searching databases - Smith & Waterman type searches - FASTA - BLAST (Basic Local Alignment Search Tool) Bioinformatics database search and retrieval system - Complete genomes Standardization of bioinformatics information - XML Development of an XML bioinformatics environment - This is a direction that the bioinformatics market is taking - Biopolymer Markup Language (BIOML) - Bioinfomatics Sequence Markup Language (BSML) - Genome Annotation Markup Elements (GAME) - Pasteur Institute Software Environment (PISE) - Microarray Markup Language (MAML) - Gene Expression Markup Language (GEML™) Sketch and current status of the bioinformatics market opportunity - The commercial outlook - The watch or the watchmaker? - The market opportunity - Carve the meat at the biological joints - The emerging market opportunity in bioinformatics - SNPs: A false peak or a fast track to success? 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