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High Throughput Screening: Redefining the Mission, 2nd Edition


Description: Screening of compounds has been going on for more than forty years. Advances in genomics and combinatorial chemistry during the 1990s placed large demands on HTS and spurred rapid evolution of new technologies and modalities. Although HTS has succeeded in accelerating the generation of new lead compounds, bottlenecks in the drug discovery process have now moved downstream. New challenges abound and HTS is now being called upon to contribute in areas such as early Adme and high-content cell-based analyses. This report, High Throughput Screening: Redefining the Mission, is the fully updated and expanded 2nd edition of our original HTS report. This Report traces the evolution of HTS, provides an in-depth look at its current status, examines scenarios for future development, and gives a thorough assessment of the relationship between pharmaceutical companies and suppliers. Detailed information on the size, structure, and future development of the markets for equipment, assays, consumables, and services is supplied. In addition, the Report describes the technologies behind the instruments and assays currently in use and still on the drawing board. Emphasis is placed on new and expanding roles for HTS in the rapidly evolving drug discovery and development processes. Unique Benefits of this Report Include: 1. Review of the history of HTS and its current status, giving an overview of this rapidly evolving field. 2. In-depth discussion of current products and technologies, identifying their attributes, advantages, and disadvantages. 3. Thorough examination of the nature of new instrument and assay technologies, highlighting their significance to the industry. 4. Comparison of miniaturization versus microfluidic approaches to HTS, presenting the pros and cons of these technologies. 5. Overview of the changing role of HTS in big pharma, outlining potential areas of opportunity. 6. Examination of HTS products and services, detailing the competitiveness of this environment. 7. Extensive profiles of key HTS players, highlighting industry leaders and strategy insights.


Contents: 1 Executive Summary

2 Introduction
This section provides the historical perspective leading to today's highly competitive HTS environment and reviews the goals and objectives of the report.

3 Elements of HTS Technology
HTS is a key link in the chain that comprises the new "industrialized" drug discovery paradigm. This section illustrates:
HTS in its broader pharmaceutical industry context
The nature and definition of HTS
Numerical data for HTS requirements

4 Market Factors Underlying HTS Technologies
This section of the report begins with a review of the universe of bioanalytical technologies that are relevant to HTS and traces its development. The section continues with a description of the drug discovery revolution and the role HTS plays in new drug discovery paradigms. Section 4 concludes with a discussion of the potential for HTS approaches to further improvements throughout the drug discovery process.

5 Current Approaches to HTS
This section starts with detailed descriptions and comparisons of the current assay and instrument technologies that have been applied to HTS. It then discusses miniaturization - the downsizing of HTS - and compares that to microfluidic approaches, which offer virtual homogeneous assays combined with sub-nanoliter volumes and enhanced speed. This section continues with discussions of assay technologies offering major enhancements in protocol simplicity, and concludes with a detailed consideration of enhanced information content in HTS assays.

6 Basic and Applied Research Activities
This section reviews key HTS publications and provides a detailed bibliography before going on to consider the nature of the HTS research community and its sources of funding.

7 HTS Products and Applications
This section presents descriptions of the broad array of instruments, assay kits, consumables, and services available to screeners.

8 The Business of HTS
HTS strategies of pharmaceutical and biotechnology companies are considered in this section, as are strategies of HTS platform companies, other vendors of HTS-related products, and HTS service providers. The section continues with a discussion of HTS collaborations and deals, and closes with a detailed market analysis in which relevant market parameters are discussed and quantified.

9 Company Profiles
This section provides detailed profiles of more than 20 companies.

10 The Future of HTS
Current relevant industry trends are considered in evaluting the future of HTS.


Companies Mentioned 3-Dimensional Pharmaceuticals

ACLARA BioSciences

Alexion Pharmaceuticals (Arradial)

Amersham Pharmacia Biotech

Applera Corporation

Aurora BioSciences Corporation

The Automation Partnership

Axiom Biotechnologies

Biacore

Biometric Imaging

Caliper Technologies

Cellomics

Cerep

Evotec OAI



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Please fax this form to:
(646) 607-1907 or (646) 964-6609 - From USA
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