HIV Resistance: Impact and Evolution - Market Research Reports

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HIV Resistance: Impact and Evolution

Description:

Introduction

The issue of HIV drug resistance impacts greatly on treatment regimens for HIV and AIDS patients, therefore impacting commercially on HIV therapeutic products globally. The growth in resistance monitoring is a development that HIV pharmaceutical companies need to be aware of and initiate collaborative ventures to improve product uptake. Relevant case reports and strategic proposals are discussed.

Scope

Explanation of why HIV drug resistance emerges, how it is monitored and what its impact is from both a clinical and commercial aspect

Provides an overview of all resistance mutations for all HIV drugs on the market and these affect product lifetime and development

Detailed description of entry inhibitors and their mechanisms of action and how resistance will affect this particular class of HIV drug

Identifies specific areas on which to focus on in the field of resistance and gives strategic recommendations

Report Highlights

The issue of inconcordance of plasma and sanctuary site viral evolution is a critical one that is being overlooked in this arena. Manufacturers need to be aware of the bioavailability of their drugs at these sites, as it will affect long-term resistance, efficacy and product lifetime.

The trend towards monitoring of virus-dependant factors such as coreceptor density and alterations in envelope protein distinct from the target site is growing and needs to be monitored carefully to facilitate probability of treatment success with this particular class of HIV therapy.

Datamonitor believes that relegation of entry inhibitors to salvage therapy is a suboptimal use of this novel class of HIV therapeutic drugs.

Reasons to Purchase

Understand HIV drug resistance, the monitoring assays available and its impact on clinical and commercial success of a drug

Be aware of the current and potential HIV entry inhibitors in the market and the impact of drug resistance in this class

Gives strategic recommendations for companies to focus on to overcome HIV drug resistance-related issues

Contents:

Table of Contents

Executive Summary 4
Introduction 4
Scope and coverage of the Brief 4
Key findings about the the topic 5

Chapter 1 CLINICAL AND COMMERCIAL IMPACT OF HIV DRUG RESISTANCE 9
Background 9
Impact of HIV drug resistance on disease 13

Chapter 2 RESISTANCE PROFILES OF CURRENT ANTIRETROVIRALS 18

Chapter 3 IMPACT AND EVOLUTION OF ENTRY INHIBITORS 28
Entry inhibitors: resistance defines positioning 28

Chapter 4 FUTURE OUTLOOK 37
Understanding HIV resistance has commercial benefit 37
APPENDIX 39
Bibliography 39
Websites 42

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HIV Resistance: Impact and Evolution
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