Neuroblastoma. Molecular Mechanisms and Therapeutic Interventions

Table of Contents

1. Neuroblastoma pathology and classification 2. Role of genetic and epigenetic alterations in pathogenesis of neuroblastoma 3. Neuroblastoma molecular biology and promising therapeutic targets 4. The GD2-targeted immunotherapy of neuroblastoma 5. Targeting angiogenesis in neuroblastoma 6. Autophagy and novel therapeutic strategies in neuroblastoma 7. Energy metabolism and new therapeutic opportunities in neuroblastoma 8. Multimodality imaging for diagnosis of neuroblastoma 9. Immunotherapy for neuroblastoma 10. Advances in surgical treatment of neuroblastoma 11. Role of stemness factors in neuroblastoma: Neuroblastoma stem cells, tumor microenvironment, and chemoresistance 12. Current pharmacotherapy for neuroblastoma 13. Current challenges in the management of neuroblastoma 14. Novel therapeutic targets in neuroblastoma 15. Current and future strategies for treatment of relapsed neuroblastoma 16. Current evidence in favor of a tumor suppressor role of Krüppel-like factor 4 in malignant neuroblastoma 17. Modulation of expression of microRNA as a therapeutic strategy in malignant neuroblastoma

Authors

Swapan K. Ray Professor, Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA. Dr. Ray is senior faculty at the University of South Carolina School of Medicine with a deep interest in neuro-oncology. He has been working in the neuroblastoma field for more than 10 years has over 175 publications in the field and is funded by the federal, state, and private funding agencies for conducting his research. His laboratory focuses on the understanding of the cellular and molecular mechanisms of pathogenesis of malignant diseases such as glioblastoma, neuroblastoma, and Ewing's sarcoma and the development of novel therapeutic strategies for neurological disorders. He has trained many students, postdoctoral fellows, and junior faculty members as well.