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Textbook of In Vivo Imaging in Vertebrates
John Wiley and Sons Ltd, June 2007, Pages: 400
Molecular imaging provides one of the fastest routes from the discovery of a biochemical activity to exploiting its physiological, pharmaceutical or therapeutical use. In vivo imaging of animal models of human diseases will contribute to the more rapid discovery, development and evaluation of new therapeutic approaches.
The ability to use non-invasive explorations of intact living organisms means that such explorations may be repeated again and again during an organism’s lifetime, building a picture of development as the organism grows. This will greatly facilitate the study of embryological and organ development.
This book describes the new non-invasive imaging modalities in a clear, easy-to-follow format. It reviews the techniques and their uses in the study of living multicellular organisms, concentrating on small animal models of human diseases. It demonstrates:
-The kind of information modern in vivo imaging techniques offer
-How they replace the more precise but destructive histological techniques
-Their main advantages:
economy of animals and longitudinal follow-up
dynamic detection of reaction to stimuli
combination of several parameters measured on the same animal/organ/localisation, simultaneously
Part 1 describes current techniques in the domain of in vivo imaging, providing specialists and laboratory scientists from all disciplines clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, kidney and others. Part 3 describes the use of imaging to monitor various types of therapy, following the reaction in an individual organism over time, e.g. after gene therapy, cell therapy or pharmacological therapy.
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