Explains the building blocks of the immune system - cells, organs, and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.
Features a reorganized format that presents immunology in the order in which is typically taught and learned, better integrating basic and clinical immunology.
Provides Critical Thinking boxes, chapter-opening summaries, and case-based and USMLE-style questions that provide effective review and quick practice for exams - plus more learning opportunities online, including USMLE-style questions and clinical cases.
Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.
Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.
Table of Contents
SECTION 1 The Immune System and Innate Immunity
1 Introduction to the Immune System
2 Cells, Tissues and Organs of the Immune System
3 Mechanisms of Innate Immunity
4 Complement
5 Mononuclear Phagocytes in Immune Defence
SECTION 2 Adaptive Immune Responses
6 T-Cell Receptors and Major Histocompatibility Complex Molecules
7 Antigen Presentation
8 Cell-Mediated Cytotoxicity
9 B-Cell Development and the Antibody Response
10 Antibodies
11 Immunological Tolerance
12 Regulation of the Immune Response
13 Immune Responses in Tissues
SECTION 3 Defence Against Infectious Agents
14 Immunity to Viruses
15 Immunity to Bacteria and Fungi
16 Immunity to Protozoa and Worms
17 Vaccination
SECTION 4 Immunodeficiency
18 Primary Immunodeficiencies
19 AIDS, Secondary Immunodeficiency and Immunosuppression
SECTION 5 Immune Responses Against Tissues
20 Autoimmunity and Autoimmune Disease
21 Transplantation and Rejection
22 Immunity to Cancers
SECTION 6 Hypersensitivity
23 Immediate Hypersensitivity (Type I)
24 Hypersensitivity (Type II)
25 Hypersensitivity (Type III)
26 Hypersensitivity (Type IV)
