This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.
The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses
Among other interesting topics:
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.
The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses
Among other interesting topics:
- Eradication of Helicobacter pylori Infection with Non-Bismuth Quadruple Concomitant Therapy
- Drug Discovery Strategies Against Emerging Coronaviruses: A Global Threat
- Opportunities Offered By Fragment-Based Drug Design in Antibiotic Development
- Phage therapy as a Tool for Control of Foodborne Diseases: Advantages and Limitations
- Subtractive Genomics Approaches: Towards Anti-Bacterial Drug Discovery
- Recent Advances in the Discovery of Antimicrobials through Metagenomics
- Phyto-Nano-Antimicrobials: Synthesis, Characterization, Discovery, and Advances
- Aptamers as Anti-infective Agents
Table of Contents
Chapter 1 Eradication of Helicobacter Pylori Infection with Nonbismuth- Quadruple Concomitant Therapy
- Introduction
- Objective
- Bibliographical Searches
- Efficacy of the Concomitant Regimen
- Comparison Between Concomitant and Standard Triple Regimen
- Comparison Between Concomitant and Sequential Regimens
- Effects of Different Variables on the Efficacy of Concomitant
- Therapy
- Clarithromycin Resistance
- Nitroimidazole Resistance
- Dual Clarithromycin and Metronidazole Resistance
- Duration of Treatment
- How Could We Even Increase the Efficacy of the Concomitant
- Treatment?
- What are the Results with the Concomitant Treatment In
- Clinical Practice? the Experience of the European Registry on H.
- Pylori Management
- Conclusions
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Drug Discovery Strategies Against Emerging
- Coronaviruses: a Global Threat
- Introduction
- Biological Aspects, Signs/Symptoms and Diagnosis for Mers-Cov,
- Sars-Cov, and Sars-Cov-2
- Strategies Used for Discovering New Potential Drugs
- Natural Source
- Classical Methods Applied for Discovering New Antiviral Agents
- Virtual Screening and Computational Techniques for Designing New Antiviral Agents
- Drug Repurposing
- High-Throughput Screening (Hts) for Discovering New Antiviral Agents
- Conclusion and Future Outlook
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 Opportunities Offered by Fragment-Based Drug Design In
- Antibiotic Development
- Introduction
- Potential Advantages of Fbdd for Development of Antibiotics
- Case Studies of New Antibiotic Development Utilising Fbdd
- Case Study 1: Β-Lactamase
- Case Study 2: Bacterial Dna Gyrase/Topoisomerase Iv
- Case Study 3: Fatty Acid Synthesis (Fas) Pathways
- Biotin Carboxylase
- Ketoacyl Synthase
- Case Study 4: Mycobacterium Tuberculosis (Mtb)
- Pantothenate Synthetase (Panc)
- Mtb Transcriptional Repressor (Ethr)
- Mycocyclosin Synthase (Cyp121)
- Fructose 1,6-Bisphosphate Aldolase (Fba)
- Recent Advances in Fbdd
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Phage Therapy as a Tool for Control of Foodborne
- Diseases: Advantages and Limitations
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- q�I�h�j�u�
- Introduction
- Bacteriophage
- History
- General Phage Characteristics
- Replication Cycle
- Adsorption to the Bacterial Cell Wall
- Replication
- Release of Viral Progeny and Cell Lysis
- Other Components in the Replication Cycle
- Bacteriophage Use for Phage Therapy
- Health Applications
- Applications in the Food Industry
- Bacteriophage Preparations
- Indications and Limitations
- Bacterial Resistance
- Synergy Between Bacteriophages and the Immune System
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Introduction
- Characteristics of an Ideal Drug Target
- Significance of Drug Target Identification
- Subtractive Genomics Based Efforts for Drug Target Identification
- Approaches Used for Promising Drug Target Prediction
- Drugsol and Its Utility
- Non-Host Homologues
- Subcellular Localization
- Essentiality
- Virulence
- Annotation
- Druggability Potential Evaluation
- Analyses of Metabolic Pathways
- Our Contribution
- Sequence Acquisition
- Human Homology Filter
- Subcellular Localization
- Essentiality
- Virulence
- Annotated
- Druggability Potential Evaluation
- Analyses of Metabolic Pathways
- Physiochemical Properties
- Pros and Cons of in Silico Drug Target Mining
- Success Stories
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Recent Advances in the Discovery of Antimicrobials
- Through Metagenomics
- Introduction
- Major Modular Enzymes and Their Associated Domains
- Non-Ribosomal Peptide Synthetases (Nrps)
- Polyketide Synthases (Pks)
- Type I Pkss
- Type Ii Pkss
- Type Iii Pkss
- Other Molecules
- Exploration of New Habitats
- Extreme Environment: a Niche for Novel Strains
- Role of Metagenomics in Exploration of Uncultured Microbes
- The Workflow of the Metagenomic Approach
- Direct Metagenomic Screening Based on Function
- Sequence-Based Metagenomic Screening
- Sequence Advancement: Potential of Single-Cell Genomics and High-Throughput
- Sequencing
- Mining of Genomes: Current Scenario and Future Potential
Chapter 5 Subtractive Genomics Approaches: Towards Anti-Bacterial
- Drug Discovery
- Prediction of Biosynthetic Gene Cluster (Bgc) and Their Targeted Activation
- Genetic Manipulations of the Biosynthetic Machinery for the Discovery of New
- Antimicrobials
- Different Mechanisms of Activation of Silent Bgcs
- Antibiotic and Bioactive Compounds Discovered Through
- Metagenomic Approach
- Conclusion and Future Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Phyto-Nano-Antimicrobials: Synthesis, Character-Ization,
- Discovery, and Advances
- Introduction
- Synthesis of Nanoparticles
- Bacterial Mediated Synthesis
- Fungi Mediated Synthesis
- Plant Extract Synthesis
- Solvent for Synthesis
- Mechanism of Synthesis
- Characterization of Plant Mediated Nanoparticles Having
- Microbial Activity
- General Characterization
- Uv- Visible Spectroscopy
- X-Ray Diffraction
- Transmission Electron Microscopy
- Fourier Transformed Infrared
- Dynamic Light Scattering
- Characterization of Silver Nanoparticle (Agnps)
- A). Uv-Visible Spectrophotometer
- B). Ftir Analysis
- C). Xrd Analysis
- D). Thermogravimetric Analysis
- E). Tem Analysis
- F). Ftir Analysis
- Characterization of Gold Nanoparticles (Aunps)
- A). Uv- Vis Spectroscopy
- B). Ftir
- C). Sem
- D). X-Ray Diffraction
- Characterization of Iron Oxide Nanoparticle
- A). Uv-Visible Spectroscopy
- B). Atr Spectroscopy
- C). Ft-Ir
- D). Sem Analysis
- E). Tem Analysis
- F). X-Ray Diffraction
- Zinc Oxide Nanoparticles
- A). Uv-Visible Spectroscopy
- B). Xrd Analysis
- C). Ftir Analysis
- D). Sem
- E). Tem
- Application of Nanoparticles
- Silver Nanoparticles
- Gold Nanoparticles
- Oxide Nanoparticles
- Antibacterial Property
- Gold Nanoparticles
- Oxide Nanoparticles
- Medicinal Application
- Future Prospects and Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 8 Aptamers as Anti-Infective Agents
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- Introduction
- Aptamers
- Systemic Evolution of Ligands by Exponential Enrichment (Selex)
- Negative Selex
- Counter Selex
- Microfluidic Selex
- Capillary Electrophoresis Selex
- Cell Selex
- Aptamers Versus Antibodies
- Aptamers as Anti-Infective Agents Against Pathogenic
- Microorganisms
- Aptamers Against Pathogenic Bacteria
- Aptamers Against Viruses
- Aptamers Against Protozoan Parasites
- Future Perspectives
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Subject Index
Author
- Atta-ur-Rahman
- M. Iqbal Choudhary
