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According to the recently published report 'Gamma Secretase - Pipeline Review, H2 2020'; Gamma Secretase (EC 3.4.23.) pipeline Target constitutes close to 20 molecules. Out of which approximately 17 molecules are developed by companies and remaining by the universities/institutes.
Gamma Secretase (EC 3.4.23.) - Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. The most well-known substrate of gamma secretase is amyloid precursor protein, when cleaved by both gamma and beta secretase, produces a short 39-42 amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of the Notch protein.
The report 'Gamma Secretase - Pipeline Review, H2 2020' outlays comprehensive information on the Gamma Secretase (EC 3.4.23.) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies/Universities.
It also reviews key players involved in Gamma Secretase (EC 3.4.23.) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 3, 3, 9 and 1 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 2 molecules, respectively. Report covers products from therapy areas Central Nervous System, Oncology, Ear Nose Throat Disorders, Non Malignant Disorders, Cardiovascular and Metabolic Disorders which include indications Alzheimer's Disease, Adenoid Cystic Carcinoma (ACC), Benign Tumor, Hearing Disorders, Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Soft Tissue Sarcoma, Triple-Negative Breast Cancer (TNBC), Acute Sensorineural Hearing Loss, Bile Duct Cancer (Cholangiocarcinoma), Burkitt Lymphoma, Chronic Lymphocytic Leukemia (CLL), Colon Cancer, Congestive Heart Failure (Heart Failure), Gastrointestinal Stromal Tumor (GIST), Glioblastoma Multiforme (GBM), Leiomyosarcoma, Leukemia, Metastatic Breast Cancer, Metastatic Hepatocellular Carcinoma (HCC), Multiple Myeloma (Kahler Disease), Natural Killer Cell Lymphomas, Obesity, Solid Tumor and T-Cell Acute Lymphocytic Leukemia (T-Cell Acute Lymphoblastic Leukaemia).
Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Gamma Secretase (EC 3.4.23.)
- The report reviews Gamma Secretase (EC 3.4.23.) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Gamma Secretase (EC 3.4.23.) targeted therapeutics and enlists all their major and minor projects
- The report assesses Gamma Secretase (EC 3.4.23.) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Gamma Secretase (EC 3.4.23.) targeted therapeutics
Reasons to Buy
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Gamma Secretase (EC 3.4.23.)Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Gamma Secretase (EC 3.4.23.) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
Introduction
Gamma Secretase (EC 3.4.23.) - Therapeutics Development
Gamma Secretase (EC 3.4.23.) - Therapeutics Assessment
Gamma Secretase (EC 3.4.23.) - Companies Involved in Therapeutics Development
ACD-679 - Drug Profile
ACD-680 - Drug Profile
AL-101 - Drug Profile
AL-102 - Drug Profile
crenigacestat - Drug Profile
dibenzazepine - Drug Profile
EF-005 - Drug Profile
Gene Therapy to Activate PSEN1 for Heart Failure - Drug Profile
GSI-34 - Drug Profile
LP-226A1 - Drug Profile
LY-3056480 - Drug Profile
NGP-555 - Drug Profile
nirogacestat hydrobromide - Drug Profile
Peptides to Inhibit PSEN1 for Alzheimer’s Disease - Drug Profile
PIPE-505 - Drug Profile
RO-7185876 - Drug Profile
Small Molecules to Inhibit Beta Secretase and Gamma Secretase for Alzheimer's Disease - Drug Profile
Small Molecules to Inhibit Gamma Secretase for Hearing Loss - Drug Profile
Small Molecules to Inhibit PSEN1 for Alzheimer's Disease - Drug Profile
Small Molecules to Modulate Gamma Secretase for Alzheimer's Disease - Drug Profile
Gamma Secretase (EC 3.4.23.) - Product Development Milestones
Appendix
List of Tables
List of Figures
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Adipo Therapeutics LLC
- AlzeCure Pharma AB
- Astellas Pharma Inc
- Audion Therapeutics BV
- Ayala Pharmaceuticals Inc
- Eli Lilly and Co
- Everfront Biotech Inc
- F. Hoffmann-La Roche Ltd
- Lipopharma Therapeutics SL
- Merck & Co Inc
- NeuroGenetic Pharmaceuticals Inc
- Pharchoice Therapeutics Inc
- Pipeline Therapeutics Inc
- SpringWorks Therapeutics Inc