Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.
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Table of Contents
Section 1: Kidney Development and Regeneration1. Nephrogenesis in Health and Disease
Adrian S. Woolf and Sophie L. Ashley
2. Renal organogenesis in the lymph node microenvironment
Maria Giovanna Francipane
3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology
Oren Pleniceanu Benjamin Dekel
4. Nephrogenesis in malnutrition
Brian B. Ratliff, May M. Rabadi, and Selin Celikoyar
Section 2: Modulators of Regeneration
5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease
Ross Doyle and Catherine Godson
6. T-cell in kidney injury and regeneration
Li Li, Dylan Baer, and Mark D. Okusa
7. Monocytes and dendritic cells in?injury and regeneration
Elise N. Erman, Meryl C. Nath, Matthew D. Cheung, Anupam Agarwal, and James F. George
8. Mast cells in kidney regeneration
Eric Douglas, Nicholas Charles, and Ulrich Blank
Section 3: Stem Cells in Regenerative Processes
9.Regeneration and replacement of endothelial cells and renal vascular repair
David?P. Basile and Mervin C. Yoder
10. Stem cells in regenerative processes: Induced pluripotent stem cells
Kenji Osafune
11. Nephroprotective effect of urine-derived stem cells for renal injury
Yuanyuan Zhange and Anthony Atala
12. Amniotic stem cells and their exosomes
Jing Ji and Li Yang
13. Regenerative potential of stem-cell-derived extracellular vesicles
Hoon Young Choi and Hyeong Cheon Park
14. Stem cell?therapies in diabetes
Sevim Kahraman, Danielle Diegisser, and Ercument Dirice
Section 4: Causes of Regenerative Failure
15. Progression of kidney disease as a maladaptive response to injury
Xuezhu Li, Fend Ding, Kyung Lee, and John Cijiang He
16. Molecular mechanisms of cellular senescence
Jamil Nehme, Marta Varela-Eirin, and Marco Demaria
17. Characteristics of senescent cells
Roland Schmitt and Anette Melk
18. Stress-induced senescence of tubular cells
David P. Baird, David A. Ferenbach, and Joseph V. Bonventre
19. Stress-induced senescence as a forme fruste of chronic?kidney disease- A case for failed regeneration
Michael S. Goligorsky
20. Premature vascular aging and?senescence in chronic kidney disease
Thomas Ebert and Peter Stenvinkel
21. Injury and regeneration in renal aging
Janka Babickova, Hai-Chun Yang, and Agnes B. Fogo
22. Gender-dependent mechanisms of injury and repair
Joel Neugarten and Ladan Golestaneh
Section 5: Kidney Engineering
23. Glomerular stem cells
Laura Lasagni, Benedetta Mazzinghi, and Paola Romagnani
24. Reconstitution of the kidney glomerular capillary wall
Titilola D. Kalejaiye, Jordan A. Holmes, Rohan Bhattacharya, and Samira Musah
25. Microfluidic modeling of glomerulus and tubular appartus
Gretchen J. Mahler and Stephanie Zhang
26. Matrix scaffolds in kidney engineering
Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando
Section 6: Emerging Clinical Aspects of Regenerative Therapy
27. Reprogramming toward kidney regeneration: New technologies and future promises
Yun Xia and Juan Carlos Izpisua Belmonte
28. Therapy cell reconditioning
Michael S. Goligorsky
29. Senomorphic, senolytic, and rejuvenation therapies
Xiang Yang Zhu and Lilach O. Lerman
30. Natural products in regeneration Rachel B. Wilson, Jason?J.?Lee, Geoffrey Pickering, and Nica M.?Borradaile?
31. Nanotargeting to the kidney
Ryan M. Williams, Chintan Kapadia, Edgar A. Jaimes, and Daniel A. Heller
32. Small molecules in regeneration
Amanda E. Crunk, Aneta Przepiorski, and Neil Hukriede
33. Systems biology in diagnosis and reamtnet of kidney disease
Jennifer Schaub and Matthias Kretzler
34. Overview of ethical concerns raised by kidney organoids
Paola Nicolas and Ira Bedzow
35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies
Joshua Hunsberger and Sita Somara
