Osteosarcopenia

Table of Contents

1. Muscle and bone biology Similarities and differences 2. Mesenchymal stem cells as regulators of bone, muscle and fat formation 3. Age-related changes in muscle, fat and bone: Their impact on metabolism and function. 4. Cross-talk between muscle, fat and bone 5. Falls and fracture risk assessment The role of osteoporosis, obesity and sarcopenia. 6. Good and bad fat in osteosarcopenia 7. Glucose metabolism and osteosarcopenia 8. Diagnosis of osteosarcopenia Clinical 9. Diagnosis of osteosarcopenia Imaging 10. Genetics of osteosarcopenia 11. Non-pharmacological interventions for osteosarcopenia 12. Pharmacological treatments of osteosarcopenia 13. Social impact of osteosarcopenia 14. Models of care for falls and fracture prevention

Authors

Gustavo Duque Chair of Medicine and Director, Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, VIC, Australia. Professor Gustavo Duque is a world leader in ageing and musculoskeletal research. He is a geriatrician, clinical, and biomedical researcher with special interest in the mechanisms and treatment of osteoporosis, sarcopenia, and frailty in older persons. His initial training included Internal Medicine at Javeriana University (Colombia) and Geriatric Medicine, completed at McGill University in Montreal, Canada. He obtained his PhD at McGill with a thesis entitled "Molecular Changes of the Aging Osteoblast.� He moved to Australia to join the faculty as Associate Professor and Head of the Division of Geriatric Medicine and Director of the Musculoskeletal Ageing Research Program at Sydney Medical School Nepean. In 2015, he moved to Melbourne for a new position as Chair of Medicine and Director of the Australian Institute for Musculoskeletal Science at the University of Melbourne. His major research interests include the elucidation of the mechanisms of age-related bone loss, osteoporosis, sarcopenia and frailty. Bruce R. Troen Professor and Chief, Division of Geriatrics and Palliative Medicine; Physician-Investigator, VAWNY Healthcare System; Director, Center for Successful Aging; Director, Center of Excellence for Alzheimer's Disease; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY, USA. Bruce R. Troen, MD, is a physician-scientist formally trained in geriatrics and molecular biology. Dr. Troen is a professor and chief of the Division of Geriatrics and Palliative Medicine in the Department of Medicine within the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, a physician-investigator with the WNY VA Healthcare System, and Chief of Geriatric Services at the Erie County Medical Center. A thought leader in aging-related geroscience and molecular biology and regional leader in geriatric care, Dr. Troen founded and directs the Center of Excellence for Alzheimer's Disease of Western New York and the Center for Successful Aging at the University at Buffalo.