This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.
The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively.
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.
The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively.
- Use of preclinical and early clinical data for accelerating antimicrobial drug development
- Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs
- Scope and limitations on the potent antimicrobial activities of hydrazone derivatives
- Current scenario of anti-leishmanial drugs and treatment
- Dengue hemorrhagic fever: the potential repurposing drugs
Table of Contents
Chapter 1 Overview of Cancer-Associated Thrombosis
- Introduction
- Epidemiology
- Prognosis and Impact of VTE in Cancer Patients
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Pathophysiology and Risk Factors for Cancer-Associated
- Thrombosis
- Pathophysiology
- Risk Factors
- Tumor Related Factors
- Treatment-Related Factors
- Surgery
- Hospitalization
- Chemotherapy, Hormonal Therapy, and Radiotherapy
- Supportive Therapy
- Patient-Related Factors
- Biomarkers
- Risk Models
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 Impact of Venous Thromboembolism on Cancer Survival
- Background
- Incidence
- Mortality
- Vte Recurrence
- Effect of Anticoagulation in Cancer
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Occult Cancer Workup in Idiopathic Venous
- Thromboembolism
- Introduction
- Prajwal Dhakal and Nishraj Basnet
- Fawzi Abu Rous, Layan a Elkhatib and Prajwal Dhakal
- Manoj Rai
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Chemotherapy Induced Thrombosis
- Introduction
- Pathophysiology
- Prophylaxis During Chemotherapy
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Catheter-Related Thrombosis in Cancer
- Introduction
- Epidemiology and Risk Factors
- Pathophysiology and Types of CRT
- Pericatheter Sheath or Fibrin Sleeve
- Intraluminal Clot
- Mural Thrombus
- Other Causes
- Clinical Presentation
- Diagnosis
- Treatment
- Removal of Catheter
- Systemic Anticoagulation
- Other Options
- Prevention of Crt in Cancer Patients
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Management of Cancer-Associated Thrombosis
- Introduction
- Initial Treatment
- Anticoagulants
- Low Molecular Weight Heparin
- Factor XA Inhibitors
- Unfractionated Heparin
- Warfarin
- Long Term Management
- Role of Direct Oral Anticoagulants
- Financial Aspects of Choosing Anticoagulation
- Mechanical Devices
- Inferior Vena Cava Filters
- Impact on Survival with Anti-Thrombotic Therapy
- Manoj Rai and Nishraj Basnet
- Prajwal Dhakal
- Lilit Karapetyan, Calvin Abro, Seda Grigoryan and Prajwal Dhakal
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 8 Special Cases in Cancer-Associated Thrombosis
- Introduction
- VTE and Thrombocytopenia
- Recurrent VTE
- VTE in Renal Impairment
- Incidental VTE in Cancer
- Myeloproliferative Disorders and VTE
- Bone Marrow Transplantation and VTE
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 9 Antitumor Effects of Heparin
- Introduction
- Types of Heparin
- Unfractionated Heparin
- Low-Molecular-Weight Heparin
- Butanoylated Heparin
- Effects of Heparin on Tumor
- Anti-Angiogenesis Effects
- Antiproliferative Effects
- Effects on Immune System
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 10 VTE Prophylaxis
- Introduction
- Risk Stratification
- Inpatient Vte Prophylaxis
- Outpatient Vte Prophylaxis
- Perioperative Vte Prophylaxis
- Society Guidelines
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Omar Albanyan and Ikponmwosa Enofe
- Samanjit Kandola and Manoj Rai
- Fawzi Abu Rous, Manoj Rai, Osama Mosalem, Layan El-Khatib, Calvin Abro And
- Abdullah Al-Abcha
- Subject Index
Author
- Atta-ur-Rahman
- M. Iqbal Chaudhary
