The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity� of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney.
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers' 2023 PROSE Awards.
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Table of Contents
PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME:� BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization��� 1. Developmental of, and environmental impact on, endothelial cell diversity 2. Endothelial cell heterogeneity in health and disease new insights from single cell studies
SECTION 2. Vasculome's Key Building Blocks Beyond the Endothelium 3.� The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types 4. SMC contractile diversity 5. Resident vascular immune cells in health and atherosclerotic disease 6. Perivascular adipose tissue (physiology, pathology) 7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome
SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues� 8. Out to the Tissues: The Arterial Side (Arteries, Arterioles Development, Structure, Functions, Pathologies) 9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs 10. The neurovascular unit and blood-CNS barriers in health and disease 11. Lymphatic biology and medicine
PART II. INVESTIGATING THE VASCULOME:� CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS SECTION 1. Experimental and Computational Studies of the Vasculome 12. The Flow-dependent Endotheliome: Hemodynamic Forces,� Genetic Programs, and Functional Phenotypes 13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism' 14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases 15. Simulation of blood flow and oxygen transport in vascular networks 16. Clinical Investigations of vascular function
SECTION 2. Realizing the Promise of New High Content Technologies 17. Angiodiversity A tale retold by comparative transcriptomics 18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create "Angioprints� for Normal and Perturbed Angiogenic Microvascular Networks 19. Artificial Intelligence (AI) for the Vasculome
PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity 20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome 21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations 22. Sprouting Angiogenesis in Vascular and Lymphatic development
SECTION 2. Physiological and Pathological Remodeling of the Vasculome 23. Enablers and drivers of vascular remodeling 24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies 25. Lymphatic vasculature anomalies and dysfunction
PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES 26. Endothelial dysfunction: basis for many local and systemic conditions 27. The vascular phenotype in hypertension 28. Functional roles of lymphatics in health and disease 29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases 30. Peripheral arterial disease (pathophysiology, presentation, prevention/management) 31. Venous Diseases Including Thromboembolic Phenomena
PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES 32. Targeting vascular zip codes: from combinatorial selection to drug prototypes 33. Angiosome concept for vascular interventions 34. RNA therapies for cardiovascular disease 35. The Brain Vasculome: An Integrative Model for CNS Function and Disease
PART VI. Looking Forward Toward "Precision Health" for the Vasculome 36. Defining and Optimizing Vascular health 37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The "Vasculature as Common Coordinate Frame (CCF)� Concept�
Authors
Zorina S. Galis Vascular Researcher, Editor, The Vasculome. Bethesda, MD, United States. Dr. Zorina Galis has been a life-long vascular researcher, recognized thought leader, innovator, highly cited researcher, mentor, and a popular science educator. She was educated in physics, biophysics, cell biology, pathology, and vascular medicine at the University of Bucharest, Romania, the McGill School of Medicine, Montreal, Canada, and the Harvard School of Medicine, Boston, USA.A prominent feature of Dr. Galis' career has been to capitalize on her own transdisciplinary training and experience to identify and pursue major scientific and implementation challenges requiring a diversity of expertise. She has created, mentored, and led such teams, first, in academic medicine, as a tenured professor of Medicine/Cardiology and Biomedical Engineering at Emory School of Medicine and the Georgia Institute of Technology, then, as a Cardiovascular pharmaceutical industry executive at Eli Lilly and Company, and, currently, at the National Institutes of Health (NIH). Her best known research works are related to pioneering hypotheses about the molecular bases of acute cardiovascular conditions, which have led to the development of new diagnostic and therapeutic interventions (Google Scholar) https://scholar.google.com/citations?user=Qwwqn60AAAAJ&hl=en
Since joining the in 2011 as the Chief of the Vascular Biology and Hypertension Branch in the National Heart Lung and Blood Institute (NHLBI), Dr. Galis has continued to create and lead wide partnerships dedicated to enhancing fundamental vascular knowledge and its translation, including the Trans-NIH Small Blood Vessels in Health and Disease and the Trans-NIH Lymphatic Coordination Committee, and has spearheaded funding opportunities, including the NHLBI Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program and the NIH Common Fund Human BioMolecular Atlas Program (HuBMAP), both recognized with NHLBI and NIH Director Collaboration Awards. She serves on external professional advisory boards, and is a proud North American Vascular Biology Organization founding member and past Councilor.
Of note: Contributions by Zorina Galis, Ph.D, to "The Vasculome� book have been provided in a personal capacity and do not necessarily reflect the opinions or endorsement of the National Institutes of Health (NIH), Department of Human Health Services (HHS).
