Although speculations related to using tailored DNA / RNA sequences to cure genetic disorders were made as early as the 1960s, the first reported use of a gene therapy was in 1990, to treat adenosine deaminase (ADA) deficiency related severe combined immunodeficiency (SCID). Briefly, a replication defective retrovirus was used to transfect autologous T-cells with a functional copy of the ADA gene, which restored normal immune function. The success of the aforementioned regimen spurred several similar attempts over the following years. However, it was the human genome project (1990-2003) that evidently ushered in the era of personalized medicine, turning the tide of treatment for several rare genetic conditions, which were previously considered undruggable. Since then, several gene-targeted therapies have been developed and launched; popular examples include ABECMA™ (Celgene, approved by the US FDA in 2021), BREYANZI (Juno Therapeutics, approved by the US FDA in 2021), SKYSONA™ (bluebird bio, approved by the EC in 2021), TECARTUS™ (Kite Pharma, approved by the US FDA in 2020), and ZOLGENSMA® (Novartis Gene Therapies, approved by the US FDA in 2019). In addition, there are over 1,700 product candidates under development, and close to 40 in the mid to late stages of development (phase II and above), which are anticipated to soon (two to three years) enter the market. Considering the target specificity of such products, many experts believe that this particular segment of modern advanced therapy medicinal products (ATMPs) truly offers the promise of lasting disease remission.
Although the COVID-19 pandemic limited certain aspects of the wider cell and gene therapies segment of the biopharmaceutical industry, it created significant future opportunities. From the financial perspective, the domain reported strong positive growth, primarily driven by drugs such as ZOLGENSMA®, which reported close to 50% year-on-year growth in 2021. In addition, some innovators, leveraging proprietary technologies, launched COVID-19 directed R&D programs, while others took the opportunity to reposition existing assets in the same direction; either way, industry stakeholders were able to tap into the vast infectious diseases market. Taking into consideration both historical and recent developments, and modern technological advances, it is evident that this upcoming industry segment is at an inflection point. With the rapidly growing success of genetic medicine prompting more innovators to enter the market, the focus is now on building better and more efficacious assets, based on next generation biotechnology platforms. This is likely to pave the way for a much broader wave of new biological interventions. It is, therefore, important to identify key pockets of innovation and areas of improvement, in order to truly innovate whilst maintaining a competitive edge. This report summarizes some of the key R&D trends related to gene therapies and affiliated vectors. It also provides a perspective on the pace and focus of innovation in this field, briefly describing the future of gene therapies as mainstream healthcare solutions.
The “Gene Therapies & Associated Vectors: Intellectual Property Landscape” report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents) describing gene therapies and affiliated vector constructs. The insights generated in this report have been presented across two deliverables, namely a MS Excel sheet and a MS PowerPoint deck, summarizing the ongoing activity in this domain. Key inclusions are briefly described below:
An in-depth review of the various patents and affiliated IP documents that have been published related to the diverse technologies, methods, and compositions associated with the use of genomic data and synthetic DNA / RNA constructs, for therapeutic purposes. It features insights on both historical and recent trends in R&D within this niche.
An examination of IP literature, shortlisting key words and phrases that have been used to describe gene therapies and associated vector constructs. The analysis includes information on the historical use of the aforementioned terms across different types of IP filings, key affiliated terms (which can be used to further identify similar innovations), and other related trends.
A competitive benchmarking and valuation analysis of the IP documents published in this field of innovation, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in regional GDP).
A systematic approach to identify relevant areas of innovation by analyzing published IP documents, defining the uniqueness of patented / patent pending innovations, understanding the scope of patentability in this domain, and pinpointing jurisdictions where new and / or modified claims may be filed without infringing on existing IP.
A detailed summary of the patent applications that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis segregates the intellectual capital in terms of area of innovation and intended applications, thereby, offering the means to understand key areas of research and identify innovation-specific IP filing trends.
An elaborate summary of the granted patents across different jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted patents into relevant categories to help develop a more detailed perspective on the diverse types of innovations in this domain and their intended applications, and the feasibility for innovators to enter into promising product markets.
An insightful analysis of the various CPC codes used in published IP literature and their affiliated families, in order to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic system of classifying IP); the analysis also features a discussion on prevalent white spaces (based on CPC symbols) in this arena of research.
One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents in the dataset. Using a systematic segregation approach, we have analyzed trends associated with [A] the preamble, [B] type of patent (technology patent or method patent), [C] type of claim (open ended claim or closed ended claim) and [D] key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
Although the COVID-19 pandemic limited certain aspects of the wider cell and gene therapies segment of the biopharmaceutical industry, it created significant future opportunities. From the financial perspective, the domain reported strong positive growth, primarily driven by drugs such as ZOLGENSMA®, which reported close to 50% year-on-year growth in 2021. In addition, some innovators, leveraging proprietary technologies, launched COVID-19 directed R&D programs, while others took the opportunity to reposition existing assets in the same direction; either way, industry stakeholders were able to tap into the vast infectious diseases market. Taking into consideration both historical and recent developments, and modern technological advances, it is evident that this upcoming industry segment is at an inflection point. With the rapidly growing success of genetic medicine prompting more innovators to enter the market, the focus is now on building better and more efficacious assets, based on next generation biotechnology platforms. This is likely to pave the way for a much broader wave of new biological interventions. It is, therefore, important to identify key pockets of innovation and areas of improvement, in order to truly innovate whilst maintaining a competitive edge. This report summarizes some of the key R&D trends related to gene therapies and affiliated vectors. It also provides a perspective on the pace and focus of innovation in this field, briefly describing the future of gene therapies as mainstream healthcare solutions.
Scope of the Report
The “Gene Therapies & Associated Vectors: Intellectual Property Landscape” report features an extensive study of some of the key historical and contemporary intellectual property (IP) documents (featuring granted patents, patent applications and other documents) describing gene therapies and affiliated vector constructs. The insights generated in this report have been presented across two deliverables, namely a MS Excel sheet and a MS PowerPoint deck, summarizing the ongoing activity in this domain. Key inclusions are briefly described below:
Overall Intellectual Property Landscape
An in-depth review of the various patents and affiliated IP documents that have been published related to the diverse technologies, methods, and compositions associated with the use of genomic data and synthetic DNA / RNA constructs, for therapeutic purposes. It features insights on both historical and recent trends in R&D within this niche.
Popular / Relevant Prior Art Search Expressions
An examination of IP literature, shortlisting key words and phrases that have been used to describe gene therapies and associated vector constructs. The analysis includes information on the historical use of the aforementioned terms across different types of IP filings, key affiliated terms (which can be used to further identify similar innovations), and other related trends.
Patent Valuation Analysis
A competitive benchmarking and valuation analysis of the IP documents published in this field of innovation, taking into consideration important parameters, such as type of IP document, year of application, time to expiry, number of citations and jurisdiction (factoring in regional GDP).
Patentability and Freedom to Operate
A systematic approach to identify relevant areas of innovation by analyzing published IP documents, defining the uniqueness of patented / patent pending innovations, understanding the scope of patentability in this domain, and pinpointing jurisdictions where new and / or modified claims may be filed without infringing on existing IP.
Analysis of Patent Applications
A detailed summary of the patent applications that were filed across different jurisdictions and their relative value in the IP ecosystem. The analysis segregates the intellectual capital in terms of area of innovation and intended applications, thereby, offering the means to understand key areas of research and identify innovation-specific IP filing trends.
Analysis of Granted Patents
An elaborate summary of the granted patents across different jurisdictions and their relative value in the IP ecosystem. The analysis also features a meaningful classification system, segregating granted patents into relevant categories to help develop a more detailed perspective on the diverse types of innovations in this domain and their intended applications, and the feasibility for innovators to enter into promising product markets.
Pockets of Innovation and White Spaces
An insightful analysis of the various CPC codes used in published IP literature and their affiliated families, in order to identify historical and existing pockets of innovation (based on the functional area / industry described by the elaborate and systematic system of classifying IP); the analysis also features a discussion on prevalent white spaces (based on CPC symbols) in this arena of research.
Claims Analysis
One of the objectives of the report was to analyze and summarize key inferences from the independent claims mentioned in granted, active patents in the dataset. Using a systematic segregation approach, we have analyzed trends associated with [A] the preamble, [B] type of patent (technology patent or method patent), [C] type of claim (open ended claim or closed ended claim) and [D] key elements of a claim (individual aspects of an innovation that are covered in a singular claim).
Table of Contents
Excel Deliverable1. Research Notes
2. Summary Dashboard
A. Overall Intellectual Property Landscape
B Key Prior Art Search Expressions
C. Key Trends related to Patent Applications (featuring Patentability & Freedom to Operate)
D. Key Trends related to Granted Patents (featuring Patentability & Freedom to Operate)
E. Claims Analysis
F. Key CPC Symbols
G. Key Applicants
3. Overall Intellectual Property Landscape Dataset
4. Prior Art Search Expressions (Keyword Analysis)
5. Patent Applications Dataset
6. Granted Patents Dataset
7. Claims Analysis
8. Key Applicants Analysis
9. CPC Analysis
10. Appendix I: Pivot Tables
11. Appendix II: Country / Geography Codes
12. Appendix III: Innovation Categories
PowerPoint Deliverable
1. Context
2. Project Approach
3. Project Objectives
4. Executive Summary
5. Gene Therapies and Associated Vectors
5.1. Overview
5.2. Need for Targeted Therapies (Expert Opinion)
5.3. Gene Therapy Development Timeline
5.4. Early Gene Therapies
5.5. Modern Gene Therapies
5.6. Current Focus of Innovation & Key Application Areas
5.7. Key Advantages and Limitations
6. Overall Intellectual Property Landscape
6.1. Overview
6.2. Analysis of Published IP Documents
6.3. Insights from Patent Applications
6.4. Insights from Granted Patents
7. Key Prior Art Search Expressions
7.1. Overview
7.2. Analysis of Prior Art Search Expressions
8. Intellectual Property Valuation Analysis
8.1. Valuation Overview
8.2. Analysis of Individual Value Ranks
8.2.1. Rank 1 IP Documents
8.2.2. Rank 2 IP Documents
8.2.3. Rank 3 IP Documents
8.2.4. Rank 4 IP Documents
8.2.5. Rank 5 IP Documents
8.3. Concluding Remarks
9. Analysis of Patent Applications
9.1. Overview
9.2. Relative Valuation of Patent Applications
9.3. Patentability & Freedom-to-Operate
10. Analysis of Granted Patents
10.1. Overview
10.2. Relative Valuation of Grated Patents
10.3. Patentability & Freedom-to-Operate
10.4. Analysis of Patent Claims
11. Key Applicants
11.1. Overview
11.2. Analysis of Key Applicants
11.2.1. Company A
11.2.2. Company B
11.2.3. Company C
11.2.4. Company D
11.2.5. Company E
11.2.6. Company F
11.2.7. Company G
11.2.8. Company H
11.2.9. Company I
11.2.10. Company J
12. Pockets of Innovation and White Spaces
12.1. Overview
12.2. Pockets of Innovation
12.3. White Spaces
12.4. Concluding Remarks
13. Future Outlook
13.1. Overview
13.2. Contemporary Sentiments & Expert Opinions
13.3. Key Developments since the COVID-19 Pandemic
13.4. Future Tipping Points in Gene Therapy
13.5. Anticipated Future Developments & Trends
14. Appendices
Companies Mentioned
- 20/20 GeneSystems
- Aarhus University
- Aav Gene Therapeutics
- Abbott
- Abeona Therapeutics
- Abic
- Abiomed
- Abrev Biotechnology
- Acambis
- Access Biologics
- ACGT
- Acuitas Therapeutics
- Adagene
- Adaptimmune
- Adrenas Therapeutics
- Advanced Tissue Sciences
- Advanced Vision Therapies
- Advantagene
- Advaxis
- Advec
- Adverum Biotechnologies
- Advisys
- Aegera Therapeutics
- Affymetrix
- Agency for Science and Technology Research
- Agenovir
- Agenta Biotechnologies
- Agenus
- Agouron Pharmaceuticals
- Ajou University
- Akouos
- Albert Einstein College of Medicine
- Alcon
- Aleta Biotherapeutics
- Alexion Pharma
- Alkermes
- All India Institute of Medical Sciences
- Allogene Therapeutics
- Alnylam Pharmaceuticals
- AlphaCore Pharma
- Alpharma
- AlphaVax
- Alpine Immune Sciences
- Alsatech
- Altimmune
- Altius Institute for Biomedical Sciences
- Alza
- Amaxa
- Amedeo Avogadro University of Eastern Piedmont
- American Biosciences
- American Gene Technologies International
- Amgen
- Amicus Therapeutics
- AmpliPhi Biosciences
- Amrad Operations
- Amryt Pharma
- Andaris
- AnGes
- Angiocrine Bioscience
- Angiogene Pharmaceuticals
- Ansun Biopharma
- Anthrogenesis
- AntiCancer
- Antigen Express
- Apceth Biopharma
- Apellis Pharmaceuticals
- Apoptosis Technology
- Applied Biotechnology
- Applied Genetic Technologies Corporation
- Applied Genetic Technology Corporation
- Applied Research Solutions
- Apres Therapeutics
- Araid Pharmaceuticals
- Arbor Biotechnologies
- Arcturus Therapeutics
- Arecor Therapeutics
- Ariad Pharma
- Arizeke Pharmaceuticals
- Ark Therapeutics
- Aronex Pharmaceuticals
- Artemis Pharmaceuticals
- Asklepios Biopharmaceutical (AskBio)
- Astellas Pharma
- AstraZeneca
- Asuragen
- Atara Biotherapeutics
- Auburn University
- Auckland Uniservices
- Audentes Therapeutics
- Autolus
- Auxolytic
- Avalanche Australia
- Aventis Pharma
- Avigen
- AviGenics
- Avior Bio
- AVIR Green Hills Biotechnology
- Avrobio
- AxioMx
- Axovant Sciences
- Azienda Ospedaliera Universitaria Senese (AOUS)
- Bamboo Therapeutics
- BASF
- Bavarian Nordic
- Baxalta
- Baxter International
- Bayer
- BDgene
- Beam Therapeutics
- Behringwerke
- Beijing Bio Targeting Therapeutics Technology
- Beijing Marino Biotechnology
- Beijing Meikang Geno Immune Biotechnology
- Beijing SBS Genetech
- Beijing Shuangyin Biotechnology
- Belief Biomed
- Bellicum Pharmaceuticals
- Ben-Gurion University of the Negev
- Benitec Biopharma
- Beth Israel Deaconess Medical Center
- Biocache Pharmaceuticals
- Bio-D
- Biogen
- BioInnovations
- BioMarin Pharmaceuticals
- Biomirna Holdings
- Bioneer
- Bionomics
- BioNTech Innovative Manufacturing Services
- Bioray Laboratories
- Biorchestra
- Biosense
- Biosource Genetics
- Biosource Technology
- Biosphere Medical
- BioStratum
- Biotechnology Research
- BioTransplant
- Bioverativ Therapeutics
- BioVex
- BioViva
- Bluebird Bio
- Boehringer Ingelheim
- Boehringer Mannheim
- Boston Medical Center
- Boston Scientific
- Boston University
- Brainvta Wuhan
- Brandeis University
- BresaGen
- Brigham and Women's Hospital
- British Columbia Cancer Agency
- Broad Institute
- Brown University Research Foundation
- Brunel University London
- Cafa Therapeutics
- Caladrius Biosciences
- California Institute of Technology
- Calimmune
- Calydon
- Cambridge Enterprise
- Cancer Research Technology
- Canji
- CanSino Biologics
- Cantab Biopharmaceuticals
- Capital University of Medicine
- Cardiff University
- Cardium Therapeutics
- Carestream Health
- Carina Biotech
- Carisma Therapeutics
- Carmel Haifa University Economic Corporation
- Carnegie Institute for Science
- Carnegie Venture Capital
- Carsgen Therapeutics
- Case Western Reserve University
- Catalan Institution for Research and Advanced Studies
- Catalent Pharma Solutions
- Catalyst Biosciences
- Celgene
- Cell & Brain
- Cell and Gene Therapy
- Cell Care Therapeutics
- Cell Genesys
- Cell Medica Switzerland
- Celladon
- CellCentric
- CellGenTech
- Cellinbio
- Cell-Medicine
- Celltech Therapeutics
- Cellular Biomedicine Group
- Cellular Dynamics International
- Cellular Therapeutics
- Centenary Institute for Cancer Medicine and Cell Biology
- Centre Hospitalier de l’Université Laval (CHUL) Research Centre
- Ceregene
- CERo Therapeutics
- CG Oncology
- Chameleon Biosciences
- Chan Zuckerberg Biohub
- Chemokine Therapeutics
- Chengdu Youwa Biotechnology
- Children's Healthcare of Atlanta
- Children's National Hospital
- China Agricultural University
- China Medical University
- China Pharmaceutical University
- Chiron
- CHO Pharma
- ChromaXome
- Chromos Molecular Systems
- CHS Pharma
- Chugai Pharmaceutical
- Chungbuk National University
- Chungnam National University
- Ciba-Geigy
- Circuit Therapeutics
- Citagenix
- Claude Bernard University Lyon 1
- Clear Solutions Biotech
- Clearside Biomedical
- CLS Therapeutics
- CMIC Holdings
- CNIC - Spanish National Center for Cardiovascular Research
- Cobra Biologics
- CODA Biotherapeutics
- Codexis
- Codiak Biosciences
- Cogent Biosciences
- Cogent Neuroscience
- Coley Pharmaceutical Group
- Coley Pharmaceuticals
- Collaborative Lab
- Collateral Therapeutics
- College of Medicine Pochon Cha University Industry -Academic Cooperation Foundation
- Columbia University
- Combined Therapeutics
- Copernicus Therapeutics
- Corestem
- Coretecs
- Corixa
- Cornell Research Foundation
- Cornell University
- Côte d'Azur University
- Council of the Queensland Institute of Medical Research
- Creighton University
- CRISPR Therapeutics
- Crusade Laboratories
- CSL Behring
- CSL Gene Therapy
- Cue Biopharma
- Curamys
- CureVac
- Curocell
- Cyto Pulse Sciences
- Cytogen
- Cytoimmune Therapeutics
- Cytos Biotechnology
- CytoTherapeutics
- CytRx
- Daegu Institute of Science and Technology
- Daiichi Asubio Pharma
- Daiichi Sankyo
- Dalian Minzu University
- Dana Farber Cancer Institute
- Dankook University
- DaRen
- Darwin Molecular
- Decibel Therapeutics
- Defyrus
- DeNovix
- Dept Of Biotechnology
- Diadexus
- Digital Gene Technologies
- Discovery Genomics
- Distributed Bio
- DNA Twopointo
- DNA2.0
- DNAVEC Research
- DRK-Blutspendedienst Baden-Württemberg-Hessen gemeinnützige
- Duke University
- Dyax
- East China Normal University
- East China University of Science and Technology
- EdiGene
- Editas Medicine
- Edwards Lifesciences
- Egen
- Eiger Biopharmaceuticals
- Eisai
- Elan Pharmaceuticals
- Elbio
- Elim Biopharmaceuticals
- Elixirgen Therapeutics
- Emerald Gene Systems
- Emory University
- Enanta Pharmaceuticals
- Encoded Therapeutics
- Encodegen
- Endocyte
- Endorecherche
- enGene
- Engeneic Molecular Delivery
- EnhancedBio
- Enzo Therapeutics
- Enzon Pharmaceuticals
- Eötvös Loránd University
- Epeius Biotechnologies
- Erasmus University Medical Center
- Erytech Pharma
- Esteve Pharmaceuticals
- Ethicon
- Etubics
- Evolva
- Evotech Biosystems
- Evox Therapeutics
- Excision BioTherapeutics
- Exemplar
- Exhaura
- Exonics Therapeutics
- Exuma Biotech
- Factor Bioscience
- Falcon Therapeutics
- Fantasia Biopharma Zhejiang
- Fate Therapeutics
- Feldan Therapeutics
- Finnish Immunotechnology
- FinVector
- Five Prime Therapeutics
- Flagship Pioneering Innovations
- FloDesign Sonics
- Florida Atlantic University
- Fondazione Cariplo
- Forhumantech
- Forschungszentrum Jülich
- Fortgen Tech
- Fortis Therapeutics
- Fortunebio
- Freeline Therapeutics
- Friedrich Miescher Institute of Biomedical Research
- Friedrich–Alexander University Erlangen–Nürnberg
- Fujifilm Cellular Dynamics
- Fulcrum Therapeutics
- Fundação Edson Queiroz - Universidade de Fortaleza
- Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol (IGTP)
- Fundación para la Investigación Biomédica del Hospital Infantil Universitario Niño Jesús
- Fuso Pharmaceutical
- Fziomed
- G&P Bioscience
- Gachon University
- Ganymed Pharmaceuticals
- Garelag
- Gavish-Galilee Bio Applications
- GC Pharma
- GE Healthcare Dharmacon
- GE Healthcare Systems
- Geistlich Holding
- Gemini Therapeutics
- Genascence
- Gencia
- Gene Bridges
- Gene Logic
- Gene Medicine
- Gene Therapy Research Institution
- GeneArt
- Genelux
- Genemedicine
- Genena
- Genentech
- GeneProTech
- Generoath
- GeneSense Technologies
- Genethon
- Genetic Diagnostics and Therapy 21
- Genetix Pharmaceuticals
- Geneuin Technology
- Genizon Biosciences
- Genotherapeutics
- Genovo
- GenScript Biotech
- GenStar Therapeutics
- GenVec
- Genzyme
- Georg-August-University of Goettingen
- Georgetown University
- GeoVax
- Geron
- Ghent University
- Gilead Sciences
- Glaxo Smith Kline (GSK)
- Global BioTherapeutics
- GlobeImmune
- Goleini
- GPC Biotech
- Gracell Biotechnologies
- Gradalis
- Greatbatch Medical
- Greffex
- Gritstone Bio
- Grünenthal
- Guangdong Tcrcure Biopharma Technology
- Guangdong Xiangxue Life Sciences
- Guangzhou Heershi Pharma Development
- Guangzhou Huazhen Pharmaceutical
- Guangzhou N Biomed
- Guangzhou Virotech Pharmaceutical
- Gustave Roussy
- Gwangju Institute of Science and Technology
- Gyeongsang National University
- Gyroscope Therapeutics
- Haldane Research
- Hanall Pharmaceuticals
- HanX Biopharmaceuticals
- Hanyang University
- Hav Vaccines
- Health and Social Care Research & Development
- Health Protection Agency
- Health Research
- Heart Biosystems
- Helixmith
- Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
- Hepatix
- HepaVec
- Hera Testing Laboratories
- Hisamitsu Pharmaceutical
- Hoechst
- Homology Medicines
- Hookipa Biotech
- Horizon Discovery
- Hormos Medical
- HSC Research and Development
- HSF Pharmaceuticals
- Human Genome Sciences
- Humanigen
- Humanzyme
- Hunan University of Chinese Medicine
- Hyal Pharmaceutical
- Hybrid Biosystems
- Ich Productions
- Icon Genetics
- ID Pharma
- Idera Pharmaceuticals
- Imagine Institue of Genetic Diseases Necker Sick Children Foundation
- ImaRx Pharmaceutical
- ImClone Systems
- Immatics Us
- Immetas Therapeutics
- Immune Design
- ImmunityBio
- Immunoclin
- ImmunoGen
- Immunomedics
- Immusoft
- Immusol
- Immvira
- Imperial College Innovations
- Inari Agriculture
- Incell: Innovative Life Science Solutions
- Indiana University
- Indoor Biotechnologies
- Ingenium Pharmaceuticals
- INmune Bio
- Innopeutics
- InnoTherapy
- Innovative Cellular Therapeutics
- Innovir Laboratories
- Inovio Pharmaceuticals
- Inozyme Pharma
- Inscripta
- InsideOutBio
- InSite Vision
- Institut National de La Rech Agronomique (INRA)
- Institute Neue Mat Gemein
- Institute of Cytosignal Research
- Institute of Oncology Ljubljana
- Intellia Therapeutics
- International healthcare center, Seoul National University Hospital
- Intima Bioscience
- Intracell Therapeutics
- Intradigm
- Intrexon
- Introgen Research Institute
- Introgen Therapeutics
- Intronn
- Invitrogen
- Ionis Pharmaceuticals
- IRCCS Ca 'Granda Foundation Maggiore Policlinico Hospital
- Island Pharmaceuticals
- Isogenis
- IVexSol
- Janssen Biotech
- Janssen Pharmaceuticals
- Japan Research and Development
- Japan Science & Technology Agency
- Japan Tissue Engineering
- Japan Weight Management
- Japanese Foundation For Cancer Research
- Jenapharm
- Jichi Medical University
- Johnson & Johnson
- Joslin Diabetes Center
- Juno Therapeutics
- Junten Bio
- Juventas Therapeutics
- Kagoshima University
- Kang Stem Biotech
- Kanglin Biotechnology Hangzhou
- KAUST: King Abdullah University of Science and Technology
- Keio University
- Kennedy Krieger Institute
- Kinetic Concepts
- King & Company
- Kite Pharma
- Knoll Pharmaceuticals
- Kojima Industries
- Kolon Industries
- Kolon Life Science
- Kolon TissueGene
- Korea Advanced Institute of Science and Technology
- Korea Institute of Radiology and Medical Science
- Korea Institute of Science and Technology
- Korea Research Institute of Bioscience
- KOS Pharmaceuticals
- KTB Tumorforschungs
- KU Leuven Research & Development
- Kudos Pharmaceuticals
- Kurume University
- Kyoto University
- La Jolla Institute for Immunology
- Lacerta Therapeutics
- Lancea Therapeutics
- Large Scale Biology
- L'Association Institut de Myologie
- Laurantis Pharma
- Laval University
- Le Centre hospitalier universitaire (CHU) de Nantes
- Le Centre Hospitalier Universitaire de Toulouse
- LegoChem Biosciences
- Leiden University
- Leiden University Medical Center (LUMC)
- Leidos
- Leipzig University
- Lentigen
- Leukocare
- Levicept
- Lexicon Pharmaceuticals
- Licentia
- Life Technologies
- Lions Eye Institute
- LocanaBio
- Loeb Health Research Institute at the Ottawa Hospital
- LogicBio Therapeutics
- Lokon Pharma
- Loma Linda University
- Lonza
- Lorus Therapeutics
- Louisiana State University
- Loxegen
- Ludvig Institute of Cancer Research
- Ludwig Maximilian University of Munich
- Lung Biotechnology
- L'Université Clermont Auvergne ( UCA )
- Maastricht University
- Maavrx
- Macfarlane Burnet Institute for Medical Research and Public Health
- Macfarlane Burnet Institute for Medicine
- Macquarie University
- Magenta Therapeutics
- Magnum Therapeutics
- Mandom
- Martin Luther University of Halle-Wittenberg
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Maxygen
- McGill University
- McLean Hospital
- McMaster University
- Medgene Bioscience
- Medgenics Medical
- Medical Research Council
- MediGene
- Medimmune
- Medinet
- Medipost
- Meditech Research
- Medtronic
- MeiraGTX
- Mercator Genetics
- Merck
- Merial
- Mesoblast
- Metacine
- MGenbio
- Michigan State University (MSU)
- Micromet
- Millennium Pharmaceuticals
- MilliporeSigma
- Miltenyi Biotec
- Mindset BioPharmaceuticals
- Minerva Biotechnologies
- Minitüb Abfüll- und Labortechnik
- Miragen Therapeutics
- Mirexus Biotechnologies
- Mirus Bio
- Mitsubishi Tanabe Pharma
- Mochida Pharmaceutical
- Modalis Therapeutics
- Mologen
- Monash University Malaysia
- Monsanto Technology
- Montpellier 2 University
- Morphogenesis
- Motac Neuroscience
- MSD Animal Health
- MultiGene Biotech
- MultiVir
- MUSC Foundation for Research Development
- MyDOPA
- Myeloid Therapeutics
- Myelos
- Myriad Genetics
- Nagoya Industrial Science Research Institute
- Nanjing Legend Biotech
- Nanodoc
- NantBioscience
- Nantcell
- National Institute of Advanced Studies
- National Institute of Allergy and Infectious Disease
- National Institute of Higher Education and Research in Food, Animal Health, Agronomic and Environmental Sciences
- National Institute of Radiology
- National University Corporation Chiba University
- NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
- National University Corporation Kyushu University
- National University Corporation, Gunma University
- National University Corporation, Hokkaido University
- National Yang Ming Chiao Tung University
- Nature Technology
- Ncc Technology Ventures
- Neoclone Biotechnology
- NeoX
- Netherlands Cancer Institute
- Netherlands Institute for Neuroscience
- Neumedicines
- Neuren Pharmaceuticals
- Neurogenex
- NeuroLogix
- Neurome
- Neurona Therapeutics
- Neurophth
- Neurotech USA
- Neutrolis
- New York Blood Center (NYBC)
- New York University
- Newcastle University
- NewLink Genetics
- NewSouth Innovations
- NGM Biopharmaceuticals
- NightstaRX
- Nordic Nanovector
- Northeast Ohio Medical University
- Northern Therapeutics
- NorthShore University HealthSystem
- Northwestern University
- Norwegian University of Science and Technology
- Nouscom
- Novartis
- Novogene
- Novopyxis
- NTF Therapeutics
- NTNU Technology Transfer
- NxGen Medicine
- NYU Grossman School of Medicine
- Obsidian Therapeutics
- Octane Biotech
- Ocugen
- Ohio University
- Oisin Biotechnologies
- Okairos
- Old Dominion University
- Ology Bioservices
- Omega Therapeutics
- OmniSpirant Therapeutics
- Oncolytics Biotech
- Onconetics Pharmaceuticals
- Oncormed
- Oncorus
- OncoSec Medical
- ONL Therapeutics
- Onyx Pharma
- Optigen Patents
- Orchard Therapeutics
- Oregon Health & Science University
- Orgenesis
- Ortho Pharma
- Orthobio Therapeutics
- Osaka University
- Oslo University Hospital
- Otonomy
- Otsuka Pharmaceuticals
- Ottawa Hospital Research Institute
- Ovid Therapeutics
- Oxford University Innovation
- OxfordBiomedica
- Oxgene
- Oxxon Therapeutics
- Oxyrane
- Pact Pharma
- Paris Descartes University
- Paris Diderot University
- Paris-Saclay University
- Paris-Sud University
- Paros Bio
- Parvogen International
- Paul Sabatier University
- Peking University
- PeptiMed
- Pfizer
- Pharchoice Therapeutics
- Pharis Biotec
- Pharmaceutical Patent Attorneys
- Pharmacia & Upjohn
- PharmaSpec
- Pharmexa
- Pherin Pharmaceuticals
- Phi Biomed
- Pierre and Marie Curie University
- Pillargo
- PlasmidFactory
- Pohang University of Science and Technology (POSTECH)
- PolyMASC Pharmaceuticals
- Poseida Therapeutics
- PowderJect Pharmaceuticals
- PPL Therapeutics
- Precigen
- Precision Biosciences
- Precision Bioservices
- Precision Nanosystems
- Prevail Therapeutics
- Primmune Therapeutics
- Princeton University
- Prizm Pharma
- ProBioGen
- ProCell Therapeutics
- Profectus Biosciences
- Prostemics
- Provention Bio
- PsiOxus Therapeutics
- PTC Therapeutics
- Purdue Research Foundation
- Puridify
- Qiagen
- Quadrant Healthcare
- Quark Pharmaceuticals
- Quarrymen & Co
- Queen Mary University of London
- Queen's University at Kingston
- Quell Therapeutics
- Quethera
- Quuensland Institute of Medical Research
- Radboud University Nijmegen
- Ramot at Tel Aviv University
- ReflectionBio
- Regeneron
- Regenxbio
- ReNeuron
- Renishaw
- Renovo
- Repair Biotechnologies
- Repligen
- Rescue Hearing
- Research Corporation Technologies
- Resverlogix
- Reyon Pharmaceutical
- RheoGene
- Ribo Life Science
- Ribozyme Pharmaceuticals
- Richland Bio Medical
- Riken
- Roche
- Rocket Pharmaceuticals
- RootPath Genomics
- Rowan University
- Rubicon Labs
- RUBITEC Gesellschaft für Innovation und Technologie der Ruhr-Universität Bochum
- Rubius Therapeutics
- Rudacure
- Ruijin Hospital Affiliated To Shanghai Jiaotong University
- Ruprecht-Karls-Universität Heidelberg
- Rush University Medical Center
- Rutgers New Jersey Medical School
- Rutgers, the State University of New Jersey
- Safescience
- Saint Louis University (SLU)
- Saint-Gobain Performance Plastics
- Salk Institue for Biological Studies
- Salus University
- Samsung Life Public Welfare Foundation
- Samyang
- Samyang Genex
- Sana Biotechnology
- Sandoz
- Sangamo Therapeutics
- Sanofi Pasteur
- Sarepta Therapeutics
- Sbarro Health Research Organistaion
- Schepens Eye Research Institute
- Schering
- Schering-Plough
- Scholar Rock
- Selecta Biosciences
- Selective Genetics
- Sementis
- Senti Biosciences
- Seoul National University R&DB Foundation
- Seoul National University R&DB Research Foundation
- Serenity Bioworks
- Shanghai Cell Therapy Group
- Shanghai Innostellar Biotherapeutics
- Shanghai Jiao Tong University
- ShanghaiTech University
- Shape Therapeutics
- Shenzhen Mindray Bio-Medical Electronics
- Sichuan University
- SiDanSai Biotechnology
- Sigilon Therapeutics
- Sirion Biotech
- Sirnaomics
- SIT Biotech
- SIT-Soft Intelligent Therapeutics
- Snipr Biome
- Soft Gene
- Solid Biosciences
- Solvo Biotechnology
- Somatix Therapy
- Somatogen
- Soochow University
- Sorbonne University
- Southeast University
- Spark Therapeutics
- Spiber
- SpyBiotech
- St. Jude Children's Research Hospital
- St. Vincent's Hospital Sydney
- Stabilitech Biopharma
- Staidson Beijing Biopharmaceuticals
- Stanford University
- Stem Cell Australia
- Stemline Therapeutics
- Stemron
- Stichting Katholieke Universiteit (SKU)
- Stoke Therapeutics
- Stressgen Biotechnologies
- StrideBio
- Strike Bio
- Stryker
- Sumitomo Dainippon Pharma
- Supratek Pharma
- SwanBio Therapeutics
- Switch Biotech
- Sygnis Bioscience
- Symbigene
- Synageva
- Synedgen
- Synergen Bio
- SynerGene Therapeutics
- SynGenix
- Syno Minicircle Biotechnology
- Synpromics
- Synthego
- SYStemix
- Takara Bio
- Takeda
- Tallinn University of Technology
- Tanox
- Targetech
- TCR2 Therapeutics
- TCRCure Biopharma
- Technion Research & Development
- Techno Network Shikoku
- Teikyo University
- Tel Hashomer Medical Research Infrastructure & Services
- Temple University
- Tenaya Therapeutics
- TET Systems
- TG Therapeutics
- The Abigail Wexner Research Institute at Nationwide Children's Hospital
- The Aeras Global TB Vaccine Foundation
- The Albert Ludwig University of Freiburg
- The American Foundation for Biological Research (AFBR)
- The Arizona Board of Regents
- The Australian National University
- The Austrian Centre of Industrial Biotechnology (ACIB)
- The Autonomous University of Barcelona
- The Autonomous University of Madrid
- The Board Of Trustees Of The Leland Stanford Junior University
- The Board of Trustees of The University of Alabama
- The Carlo Besta Neurological Institute
- The Catholic University of America
- The Catholic University Of Korea Industry-Academic Cooperation
- The Catholic University of Korea Industry-Academy Foundation
- The Center Hospitalier Universitaire de Lille
- The Centre for Genomic Regulation (CRG)
- The Centre Hospitalier Universitaire Sainte-Justine
- The Chancellor Masters & Scholars of The University of Oxford
- The Charité – Universitätsmedizin Berlin
- The CHDI Foundation
- The Children's Medical Center
- The Cleveland Clinic Foundation
- The Collaborative Group
- The Connecticut Children's Medical Center
- The Cyprus Foundation for Muscular Dystrophy Research
- The Development Research Foundation (DRF)
- The Federal University of Rio de Janeiro
- The Federal University of Rio Grande do Sul
- The Federal University of Santa Maria
- The Flanders Interuniversity Institute for Biotechnology
- The Fondazione Centro San Raffaele
- The French National Centre for Scientific Research
- The General Hospital Corporation
- The Geneva University Hospitals
- The Georg August University of Göttingen
- The Heinrich Pette Institute
- The Helmholtz Centre for Infection Research
- The Henry M. Jackson Foundation for the Advancement of Military Medicine
- The Idaho Research Foundation
- The Immune Response Corporation
- The Indiana University Foundation
- The Indiana University Research and Technology Corporation
- The Industry-University-Research Cooperation Foundation
- The Institute for Research in Biomedicine (IRB Barcelona)
- The Institute of Cancer Research
- The International Centre for Genetic Engineering and Biotechnology
- The Iowa State University Research Foundation
- The Istituto Italiano di Tecnologia (IIT)
- The J.David Gladstone Institutes
- The Jawaharlal Nehru Centre for Advanced Scientific Research
- The Johns Hopkins University
- The Julius Maximilian University of Würzburg
- The Kaohsiung Medical University
- The Korea Research Institute of Bioscience and Biotechnology
- The Kyungpook National University, Industry & Academy Collaboration Foundation
- The Leland Stanford Junior University
- The LMU Klinikum
- The Marie Curie Research Institute
- The Mayo Foundation for Medical Education and Research
- The Medical College of Wisconsin
- The Medical School at University of Michigan--Ann Arbor
- The Medical University of Graz
- The Medical University of Vienna
- The Microbial Chemistry Research Foundation (MCRF)
- The Mount Sinai Health System
- The National Institute for Biotechnology in the Negev
- The National Research Council Canada
- The National University of Ireland Galway
- The National University of Singapore
- The Nemours Foundation
- The New Hope Research Foundation
- The New York Genome Center (NYGC)
- The New York Stem Cell Foundation Research Institute
- The Novartis Institutes for BioMedical Research (NIBR)
- The Ohio State Innovation Foundation
- The Ohio State University
- The Ohio State University Research Foundation
- The Oklahoma Medical Research Foundation (OMRF)
- The Penn State Research Foundation
- The Picower Institute for Learning and Memory
- The Queen's University of Belfast
- The Regents of the University of Michigan
- The Research Foundation for the State University of New York
- The Rockefeller University
- The Rudolf Magnus Institute for Neuroscience
- The Ruhr University Bochum
- The Ruprecht Karl University of Heidelberg
- The San Diego State University Research Foundation
- The Santa Lucia Foundation
- The Sapienza University of Rome
- The Scripps Research Institute
- The Seoul National University Foundation
- The Sloan Kettering Institute
- The Sogang University Research Foundation
- The Southern Illinois University Board of Trustees
- The Sungkyunkwan University Research & Business Foundation
- The Sydney Children's Hospitals Network (Randwick and Westmead)
- The Technical University of Munich
- The Technion Research & Development Foundation
- The Texas A&M System
- The Trustees of The University of Pennsylvania
- The UAB Research Foundation
- The Université de Montréal
- The Université d'Évry Val-d'Essonne
- The Université Grenoble Alpes
- The Université libre de Bruxelles
- The University Health Network (UHN)
- The University Medical Center Hamburg-Eppendorf
- The University Medical Center Utrecht
- The University of Aberdeen
- The University of Alabama
- The University of Alberta
- The University of Amsterdam
- The University of Antwerp
- The University of Arizona
- The University of Arkansas
- The University of Barcelona
- The University of Bari Aldo Moro
- The University of Basel
- The University of Beira Interior
- The University of Bern
- The University of Birmingham
- The University of Bologna
- The University of Bristol
- The University of British Columbia
- The University of California
- The University of Canberra
- The University of Castilla–La Mancha
- The University of Chicago
- The University of Chile.
- The University of Cincinnati
- The University of Coimbra
- The University of Cologne
- The University of Colorado
- The University of Connecticut
- The University of Copenhagen
- The University of Dublin
- The University of Dundee
- The University of Edinburgh
- The University of Evry - Val-d'Essonne
- The University of Ferrara
- The University of Florida
- The University of Florida Research Foundation
- The University of Geneva
- The University of Georgia
- The University of Glasgow
- The University of Granada
- The University of Guelph
- The University of Helsinki
- The University of Hong Kong
- The University of Houston
- The University of Illinois Board of Trustees
- The University of Iowa Research Foundation (UIRF)
- The University of Jaén
- The University of Kansas
- The University of Kentucky Research Foundation (UKRF)
- The University of Lausanne
- The University of Leeds
- The University of Lincoln
- The University of London
- The University of Manchester
- The University of Manitoba
- The University of Maryland
- The University of Maryland Biotechnology Institute
- The University of Massachusetts
- The University of Miami
- The University of Michigan
- The University of Milan
- The University of Milano-Bicocca
- The University of Minnesota
- The University of Missouri
- The University of Montpellier
- The University of Münster
- The University of Nantes
- The University of Natural Resources and Life Sciences
- The University of Nebraska–Lincoln
- The University of Nevada, Las Vegas
- The University of New Mexico
- The University of New South Wales
- The University of Nice Sophia Antipolis
- The University of North Carolina at Chapel Hill
- The University of Notre Dame
- The University of Nottingham
- The University of Oklahoma
- The University of Orléans
- The University of Otago
- The University of Ottawa
- The University of Padua
- The University of Paris
- The University of Pennsylvania
- The University of Pittsburgh
- The University of Plymouth
- The University of Pretoria
- The University of Putra Malaysia
- The University of Rochester
- The University of Rostock
- The University of Santiago de Compostela
- The University of Saskatchewan
- The University of Sheffield
- The University of Siena
- The University of South Alabama
- The University of South Australia
- The University of South Carolina
- The University of South Florida
- The University of Southampton
- The University of Southern California
- The University of Strasbourg
- The University of Sydney
- The University of Szeged
- The University of Tartu
- The University of Tennessee Research Foundation
- The University of Texas
- The University of Texas System Board of Regents
- The University of the Basque Country
- The University of the Mediterranean Aix-Marseille II
- The University Of Toronto Governing Council
- The University of Ulsan
- The University of Ulster
- The University of Utah
- The University of Vermont and State Agricultural College
- The University of Verona
- The University of Veterinary Medicine Vienna
- The University of Vienna
- The University of Virginia
- The University of Warwick
- The University of Washington
- The University of Western Australia
- The University of Wroclaw
- The University of Wyoming
- The University of Zurich
- The Vaud University Hospital Center (CHUV)
- The Wellcome Trust
- The Wisconsin Alumni Research Foundation
- The Yonsei University Office of Research Affair
- Theragene Biomedical Lab
- TheraPten Biosciences
- Therion Biologics
- Thomas Jefferson University
- Titan Pharmaceuticals
- TLL Temasek Life Sciences Laboratory
- Tocagen
- Tokai National Higher Education and Research System National University Corporation
- Tokyo Metropolitan Institute of Medical Science
- Tongji University
- ToolGen
- Toppan
- Toray Research Center
- Torque Therapeutics
- Transderm
- TransGenRx
- Transkaryotic Therapies
- Tranzyme
- TremRx
- TRIM-edicine
- TSI
- Tufts University
- Tuskegee University
- UCB Biopharma
- Ulsan National Institute of Science and Technology
- Ultragenyx
- UMIP The University of Manchester Intellectual Property
- Umoja Biopharma
- Unicyte
- UniQure Biopharma
- Université Lille 2 Droit et Santé
- University College London Business
- University Court of the University of Edinburgh
- University of Artois
- University of Cambridge School of Technology
- University Of Florida Research Foundation
- University of Massachusetts Medical School
- University of Patras
- University of Pittsburgh - of the Commonwealth System of Higher Education
- University of Primorska
- University of Tennessee Research Foundation
- University of Virginia Patent Foundation
- University of Western Brittany
- Utah State University
- Vacdiagn Biotechnology
- Valentis
- Vanderbilt University
- Vascular Biogenics
- Vaxart
- Vaxbio
- VaxCell
- Vecprobio
- Vectogen
- VectorLogics
- Vegenics
- Verenium
- Versailles Saint-Quentin-en-Yvelines University
- Versameb
- VersiTech
- Vertex Pharmaceuticals
- VGX Pharmaceuticals
- Viagene
- Vical
- Viela Bio
- Vir Biotechnology
- Viragen
- Virginia Commonwealth University
- Virogin Biotech
- ViroLogic
- ViroMed
- Viron Therapeutics
- Virovek
- Virus Ikagaku Kenkyusho
- VIRxSYS
- Vision 7
- Vlaams Institute for Biotechnology
- Voyager Therapeutics
- Vrije Universiteit Brussel (VUB)
- Vycellix
- Wake Forest University
- Wayne State University
- Wellstat Biologics
- Wellstat Ophthalmics
- Westlake Therapeutics
- Whitehead Institute for Biomedical Research
- William Marsh Rice University
- Wuhan Institute of Physics and Mathematics of Chineses Academy of Science
- WuXi Biologics
- Wyeth
- Xalud Therapeutics
- Xencor
- Xenetic Biosciences
- Xiamen University Malaysia
- Xiangue Life Sciences
- Xuanwu Hospital affiliated to Capital Medical University
- XyloCor Therapeutics
- Yale University
- Yang Sheng Tang Group
- Yissum Research Development Company of the Hebrew University of Jerusalem
- Yokohama City University
- Yongxin Biological Science And Technology
- Yonsei University
- Youhealth Biotech
- Zaklady Farmaceutyczne Polpharma
- Zengen
- Zensun Science & Technology
- Zentrum für Forschungsförderung in der Pädiatrie
- Zhejiang University
- Zhengzhou University
- Zycos
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