Primary Mediastinal Large B-Cell Lymphoma - Pipeline Insight, 2024

This Primary Mediastinal Large B-Cell Lymphoma - Pipeline Insight, 2024,” report provides comprehensive insights about 18+ companies and 20+ pipeline drugs in Primary Mediastinal Large B-Cell Lymphoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Primary Mediastinal Large B-Cell Lymphoma Understanding

Primary Mediastinal Large B-Cell Lymphoma: Overview

Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive large B cell lymphoma originating in the mediastinum, that mainly expresses B cell surface molecules, such as CD19, CD20, CD22, and CD79a. Clinically, they are characterized by rapidly increasing anterior mediastinal masses, which can cause compression of the surrounding tissues. The diagnosis of PMBCL mainly depends on the pathological features, imaging examination and clinical features. Currently, the most commonly used therapeutic regimens are R-CHOP and R-EPOCH. Radiotherapy is beneficial in some patients, but it can also lead to long-termtoxicity.

Primary Mediastinal Large B-Cell Lymphoma - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Primary Mediastinal Large B-Cell Lymphoma pipeline landscape is provided which includes the disease overview and Primary Mediastinal Large B-Cell Lymphoma treatment guidelines. The assessment part of the report embraces, in depth Primary Mediastinal Large B-Cell Lymphoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Primary Mediastinal Large B-Cell Lymphoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Primary Mediastinal Large B-Cell Lymphoma R&D. The therapies under development are focused on novel approaches to treat/improve Primary Mediastinal Large B-Cell Lymphoma.

This segment of the Primary Mediastinal Large B-Cell Lymphoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Primary Mediastinal Large B-Cell Lymphoma Drugs
Tazemetostat: Epizyme Tazemetostat (TAZVERIK) inhibits EZH2 which allows transcription of genes involved in functions such as cell cycle control and terminal differentiation and thus TAZVERIK® action inhibits cancer cell proliferation. TAZVERIK is a methyltransferase inhibitor of EZH2 developed by Epizyme that is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain patients with epithelioid sarcoma (ES) and certain patients with follicular lymphoma (FL). It was approved under FDA accelerated approval based on overall response rate (ORR) and duration of response (DOR) in January and June 2020 for ES and FL,respectively.

Primary Mediastinal Large B-Cell Lymphoma: Therapeutic Assessment

This segment of the report provides insights about the Primary Mediastinal Large B-Cell Lymphoma drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Primary Mediastinal Large B-Cell Lymphoma

There are approx. 18+ key companies which are developing the therapies for Primary Mediastinal Large B-Cell Lymphoma. The companies which have their Primary Mediastinal Large B-Cell Lymphoma drug candidates in the most advanced stage, i.e. phase II include Epizyme.

Phases

This report covers around 20+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Primary Mediastinal Large B-Cell Lymphoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intranasal
• Intrathecal
• Intravenous
• Oral
• Oral/Intravenous
• Parenteral
• Subcutaneous
• Subcutaneous/Intramuscular
• Transdermal

Molecule Type

Products have been categorized under various Molecule types such as

• Antisense oligonucleotide
• Gene therapy
• Hormones
• Neuropeptides
• Oligonucleotides
• Small Molecule
• Triglyceride

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Primary Mediastinal Large B-Cell Lymphoma: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Primary Mediastinal Large B-Cell Lymphoma therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Primary Mediastinal Large B-Cell Lymphoma drugs.

Primary Mediastinal Large B-Cell Lymphoma Report Insights

• Primary Mediastinal Large B-Cell Lymphoma Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Primary Mediastinal Large B-Cell Lymphoma Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Primary Mediastinal Large B-Cell Lymphoma drugs?
• How many Primary Mediastinal Large B-Cell Lymphoma drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Primary Mediastinal Large B-Cell Lymphoma?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Primary Mediastinal Large B-Cell Lymphoma therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Primary Mediastinal Large B-Cell Lymphoma and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• AstraZeneca
• Epizyme
• Johnson & Johnson
• Taizhou Houde AokeBiomedical
• Curocell Inc.
• Genmab
• TCR2 Therapeutics
• TG Therapeutics, Inc.
• Juno Therapeutics

Key Products

• Acalabrutinib
• Tazemetostat
• Ibrutinib
• LP002
• CRC01
• Epcoritamab
• GEN3009
• TC-110 T Cells
• TG-1801
• JCAR017

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