Thalassemia, An Issue of Hematology/Oncology Clinics of North America. The Clinics: Internal Medicine Volume 37-2

Table of Contents

Introduction to the Thalassemia Syndromes: Molecular Medicine's Index Case
The Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation Perspective
Molecular Basis and Genetic Modifiers of Thalassemia
Fetal Hemoglobin Regulation in Beta-Thalassemia
Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia
The Clinical Phenotypes of Alpha Thalassemia
Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability
Pathogenic Mechanisms in Thalassemia II: Iron Overload
Clinical Complications and Their Management
Clinical Challenges with Iron Chelation in Beta Thalassemia
Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia
Hematopoietic Stem Cell Transplantation in Thalassemia
Gene Therapy and Gene Editing for b-Thalassemia
Emerging Therapies in b-Thalassemia

Authors

Edward J. BenzJr Professor, Pediatrics, Richard and Susan Smith Professor, Medicine, Professor, Genetics,Harvard Medical School ,President and CEO, Emeritus, Office of the President, Dana-Farber Cancer Institute. Vijay G. Sankaran Jan Ellen Paradise, M.D. Associate Professor of Pediatrics, Harvard Medical School Lodish Family Chair, Division of Hematology/Oncology, Boston Children's Hospital Robertson Investigator, New York Stem Cell , Foundation, Principal Faculty, Harvard Stem Cell Institute, Attending Physician, Dana Farber/Boston Children's Cancer and Blood Disorders Center, Associate Member, Broad Institute of MIT and Harvard.