Summary:

Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 100 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 240 names Developmental stage This Drug Pipeline Update contains more than 120 drugs in active development for the treatment of brain cancer: 10 marketed drugs 9 drugs in Phase III 49 drugs in Phase II 23 drugs in Phase I 30 drugs in Preclinical Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included 120+ drugs are also in development for over 100 other indications. Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to 77 different targets, divided into 29classifications of molecular function: - Auxiliary transport protein activity - Catalytic activity - Cell adhesion molecule activity - Cysteine-type peptidase activity - Cytokine activity - DNA repair protein - DNA topoisomerase activity - DNA-directed DNA polymerase activity - Extracellular ligand-gated ion channel activity - G-protein coupled receptor activity - Growth factor activity - Kinase activity - Ligand-dependent nuclear receptor activity - Lipid kinase activity - Lipid phosphatase activity - Peptidase activity - Protein serine/threonine kinase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor signaling protein serine/threonine kinase activity - Receptor signaling protein tyrosine phosphatase activity - Structural constituent of cytoskeleton - T cell receptor activity - Transcription factor activity - Transcription regulator activity - Transferase activity - Translation regulator activity - Transmembrane receptor activity - Transmembrane receptor protein tyrosine kinase activity Identified targets are categorized into 11 different primary and alternate localizations: - Clathrin-coated vesicle - Cytoplasm - Cytosol - Endoplasmic reticulum - Endosome - Extracellular - Mitochondrion - Nucleolus - Nucleus - Plasma membrane - Secreted Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application. Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 35 drug targets in various human tissues, cell lines and primary cells, including up to: - 48 different normal tissue types - 20 different types of cancer - 47 cell lines - 12 samples of primary blood cells Targeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and no less than 17 are currently being pursued in brain cancer drug development: - Alpha6 Beta4 Integrin Signaling Pathway - Androgen Receptor Signaling Pathway - B Cell Receptor Signaling Pathway - EGFR1 Signaling Pathway - IL-1 Signaling Pathway - IL-2 Signaling Pathway - IL-3 Signaling Pathway - IL-4 Signaling Pathway - IL-5 Signaling Pathway - IL-6 Signaling Pathway - IL-9 Signaling Pathway - Kit Receptor Signaling Pathway - Notch Signaling Pathway - T Cell Receptor Signaling Pathway - TGF-beta Receptor Signaling Pathway - TNF-alpha Signaling Pathway - Wnt Signaling Pathway Note: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application. Mechanism In total there are at least 90 different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms (if any) Principal Investigator & Partners Presentation of principal investigator and partners (if any) Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Signaling Pathways Described target(s) is/are matched for the involvement in 20 major signaling pathways. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs - Drug status - Clinical Trial Status - Principle Investigator - Partners - Indication - Developmental Stage - Compound Type - Mechanism - Target - Molecular Function of Target - Target Localization - Targeted Signaling Pathways - Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Target data is linked directly to Human Protein Atlas - Direct links to company web pages of principal investigators Export and sharing of information - Found information is easily shared with others over e-mail, file export (xls) or in print System Requirements - AMD-Athlon/Pentium II PC - Windows 98/NT4/2000/ME/XP - 8x-speed CD Rom drive - SVGA 16 bit display. (32 bit recommended) - 32 MB of available RAM (128 MB recommended) - Internet access (for related internet resources)