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Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
John Wiley and Sons Ltd, May 2008, Pages: 258
Functional genomic approaches including genome-wide expression analysis, large-scale gain and loss of function genetic studies with cDNA and RNAi libraries, chemical genomics, high throughput cell-based screens, and proteomics are just emerging to rapidly fill the gap in our knowledge of stem cell fate differentiation pathways. This will let us rationally control the phenotype, genetic constitution, behavior, and function of cells.
This book discusses these new technologies and their recent applications in various areas of stem cell biology, including:
- self-renewal
- differentiation
- reprogramming of different types of embryonic and adult stem cells
- and regeneration in model organisms.
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