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Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance
John Wiley and Sons Ltd, Feb 2008, Pages: 524
This book will represent a collection of informative contributions of the most common methods used for the construction of an O-glycosidic bond. Each of the chapters will be written by experienced scientists in the area of carbohydrate chemistry, who were either original developers of a new methodology or significant contributors to the original methodology. This will thus provide an expert opinion and vision on each and every topic discussed. This book will be of unique value to everybody working in the area of carbohydrate chemistry, mainstream organic synthesis, medicinal chemistry, or natural product chemistry.
Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.
About the Author
Born in 1965, Alexei Demchenko gained his MSc in chemical engineering from Mendeleev University of Chemical Technology, Russia, in 1988, before joining the Zelinski Institute of Organic Chemistry, at the Russian Academy of Sciences, Moscow. It was here, under Professor Kochetkov, that he took his first steps in researching carbohydrate synthesis. In 1993 he was awarded a PhD for his work on the development of thiocyanate methodology for stereospecific glycosylation and, after two post-doctoral years under Kochetkov, he joined Geert-Jan Boons' group at the University of Birmingham, UK, as a BBSRC post-doctoral research fellow. In 1998 he moved with Professor Boons to the Complex Carbohydrate Research Center at the University of Georgia as a research associate, where his research focused on the synthesis of complex oligosaccharides for immunological studies and the exploration of chemical O-sialylation. In 2001 he joined the University of Missouri St. Louis as an assistant professor of chemistry and biochemistry. Professor Demchenko is a recipient of the CAREER award from the National Science Foundation, and has co-authored over 50 articles, reviews, and book chapters. His current research interests are in the field of synthetic carbohydrate chemistry.
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