Contents:

Contents Preface 1 Introduction References Part I 2 Blood Components 2.1 Introduction 2.2 Short History 2.3 Blood Components 2.3.1 Blood cells 2.3.2 Blood plasma 2.3.3 The blood group system References Data Sheet 3 Blood Plasma Proteins 3.1 Introduction 3.2 Short History 3.3 Classification of Blood Plasma Proteins References Part II 4 Domains, Motifs and Repeats 4.1 Introduction 4.2 The Epidermal Growth Factor (EGF)-Like Domain 4.3 The Kringle Domain 4.4 The g-Carboxyglutamic Acid-Rich (Gla) Domain 4.5 The PAN/Apple Domain 4.6 The Sushi/CCP/SCR Domain 4.7 The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains 4.8 The Coagulation Factors 5/8 Type C Domain (FA58C) 4.9 The Thrombospondin Type I Repeat (TSP1) 4.10 The VWFA, VWFC and VWFD Domains 4.11 The Cystatin-Like Domain 4.12 The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains 4.13 The C-Terminal Cystine Knot (CTCK) Structure 4.14 The Anaphylatoxin Domain 4.15 The CUB Domain 4.16 The NTR Domain 4.17 The C-Type Lectin (CTL) Domain 4.18 The Ig-Like Domain References 5 Protein Families 5.1 Introduction 5.2 Serine Proteases: The Trypsin Family 5.3 Serine Protease Inhibitors (Serpins) 5.4 The a2-Macroglobulin Family 5.5 The Serum Albumin Family 5.6 The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature 5.7 The Kazal Serine Protease Inhibitors Family Signature 5.8 The Multicopper Oxidase Family 5.9 The Lipocalin Family 5.10 The Globin Family 5.11 The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Secretin/Vasoactive Intestinal Peptide (VIP) Family 5.12 The Glycoprotein Hormone Family 5.13 Membrane Attack Complex Components/Perforin Signature (The Complement C6/C7/C8/C9 Family) 5.14 The Lipase Family 5.15 Hormone Families and Signatures 5.15.1 The erythropoietin/thrombopoietin signature 5.15.2 The corticotropin-releasing factor family 5.15.3 The gonadotropin-releasing hormone signature 5.15.4 The calcitonin/CGRP/IAPP family 5.15.5 The gastrin/cholecystokinin family 5.15.6 The insulin family 5.16 Growth Factor Families 5.16.1 The platelet-derived growth factor family 5.16.2 The transforming growth factor-b family 5.17 Cytokine Families 5.17.1 The tumor necrosis factor family 5.17.2 The interferon a, b and d family 5.18 Interleukin Families and Signatures 5.18.1 The interleukin-1 signature 5.18.2 The interleukin-2 signature 5.18.3 The interleukin-4/-13 signature 5.18.4 The interleukin-6/granulocyte colony-stimulating factor/myelomonocytic growth factor family 5.18.5 The interleukin-7 and -9 signature 5.18.6 Interleukin-10 family 5.19 The Small Cytokine (Intercrine/Chemokine) Family and Signature References 6 Posttranslational Modifications 6.1 Introduction 6.2 Databases for Posttranslational Modifications (PTMs) 6.3 Disulfide Bridges 6.4 Glycosylation 6.5 Phosphorylation 6.5.1 Ser/Thr phosphorylation sites 6.5.2 Tyr phosphorylation site 6.6 Hydroxylation 6.6.1 Aspartic acid and asparagine hydroxylation site 6.7 Sulfation 6.8 Acylation and Alkylation 6.9 Amidation 6.10 Carboxylation 6.11 Crosslinks 6.11.1 The isoglutamyl cysteine thioester bond 6.11.2 The isopeptide bond References Part III 7 Blood Coagulation and Fibrinolysis 7.1 Introduction 7.1.1 Definition of haemostasis 7.2 Primary Haemostasis 7.3 The Coagulation Cascade 7.4 The Fibrinolytic System 7.5 The Regulation of Blood Coagulation and Fibrinolysis 7.6 The Kinin and Angiotensin/Renin Systems References Data Sheets 8 The Complement System 8.1 Introduction 8.1.1 Nomenclature 8.2 The Classical Pathway 8.2.1 The anaphylatoxins C3a, C4a and C5a 8.3 The Alternative Pathway 8.4 The Terminal Components of the Complement System 8.5 Components of Complement Activation 8.6 Regulation of the Complement System References Data Sheets 9 The Immune System 9.1 Introduction 9.2 Immunoglobulins 9.3 Antibody Diversity 9.4 Major Histocompatibility Complex (MHC) Proteins 9.5 Innate Immune System 9.6 Other Proteins References Data Sheets 10 Enzymes 10.1 Introduction 10.2 EC 1: Oxidoreductases 10.2.1 EC 1.11: peroxidases 10.3 EC 2: Transferases 10.3.1 EC 2.3: acyltransferases 10.3.2 EC 2.6: transfer of nitrogenous group 10.3.3 EC 2.7: transfer of phosphorous-containing groups 10.4 EC 3: Hydrolases 10.4.1 EC 3.1: esterases (ester bond) 10.4.2 EC 3.2: glycosylases (sugars) 10.4.3 EC 3.4: peptidases (peptide bonds) EC 3.4.17: metallocarboxypeptidases EC 3.4.21: serine endopeptidases (serine proteases) EC 3.4.22: cysteine endopeptidases (cysteine proteases) EC 3.4.23: aspartic endopeptidases (aspartic proteases) 10.5 EC 5: Isomerases 10.5.1 EC 5.3: oxidoreductases (intramolecular) References Data Sheets 11 Inhibitors 11.1 Introduction 11.2 Serine Protease Inhibitors (Serpins) 11.2.1 Introduction 11.2.2 Structural properties 11.2.3 Inhibitory reaction 11.3 Blood Coagulation and Fibrinolysis 11.3.1 Blood coagulation 11.3.2 Fibrinolysis 11.4 The Complement System 11.5 General Inhibitors 11.6 Other Serpins 11.7 Other Inhibitors References Data Sheets 12 Lipoproteins 12.1 Introduction 12.2 Enzymes in Lipoprotein Metabolism 12.3 Apolipoproteins 12.4 LDL and VLDL Receptors 12.5 Serum Amyloid A Proteins References Data Sheets 13 Hormones 13.1 Introduction 13.2 Pancreatic Hormones 13.3 Gastrointestinal Hormones 13.4 Calcium-Related Hormones 13.5 Hormone-Releasing Factors, Their Trophic Hormones and Related Hormones 13.6 Vasopressin and Oxytocin 13.7 Natural Opioid Peptides 13.8 Vasoactive Peptides 13.9 Erythropoietin and Thrombopoietin 13.10 Others 13.10.1 Adiponectin 13.10.2 Islet amyloid polypeptide References Data Sheets 14 Cytokines and Growth Factors 14.1 Introduction 14.2 Interleukin Families 14.2.1 Interleukin-1 family 14.2.2 Interleukin-2 family 14.2.3 Interleukin-3 family 14.2.4 Interleukin-4/interleukin-13 family 14.2.5 Interleukin-5 family 14.2.6 Interleukin-6 family 14.2.7 Interleukin-7/interleukin-9 family 14.2.8 Interleukin-10 family 14.2.9 Interleukin-15 family 14.2.10 Granulocyte–macrophage colony-stimulating factor family 14.3 Tumour Necrosis Factor Family 14.4 The Interferon Family 14.4.1 The interferon a/b family 14.4.2 The interferon g family 14.5 Chemokines 14.5.1 The intercrine a/chemokine CxC family 14.5.2 The intercrine b/chemokine CC family 14.6 The Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family 14.7 Transforming Growth Factor-b Family 14.8 Miscellaneous 14.8.1 The nerve growth factor-b family 14.8.2 Epidermal growth factor 14.8.3 Insulin-like growth factor binding proteins References Data Sheets 15 Transport and Storage 15.1 Introduction 15.2 The Serum Albumin Family 15.3 The Globin Family 15.3.1 Haptoglobin 15.4 Iron Transport and Storage 15.4.1 Iron oxidation: ceruloplasmin 15.4.2 Iron transport proteins: transferrins 15.4.3 Iron storage 15.4.4 Heme transport and iron recovery: hemopexin 15.5 Transport of Hormones, Steroids and Vitamins 15.5.1 Hormone transport proteins 15.5.2 Steroid transport proteins 15.5.3 Vitamin A transport protein 15.6 Other Transport Proteins in Plasma 15.6.1 Selenoproteins References Data Sheets 16 Additional Proteins 16.1 Introduction 16.2 Additional Blood Plasma Proteins Data Sheets Appendix Glossary Index