Biotechnological Production of Bioactive Phytochemicals of Medicinal Value: A Comprehensive Treatise covers a broad variety of methods for secondary metabolites production (both pharmaceuticals and cosmeceuticals), compiling state-of-the-art material about the current knowledge of in vitro production for a large number of bioactive phytochemicals. Plants are a source of bioactive compounds and specialty chemicals such as ginsenosides; paclitaxel, artemisinin, veregen and nutraceuticals. Biopharmaceuticals are important in human healthcare, and herbal actives are gaining importance all over the world. With natural resources dwindling, in vitro production of secondary compounds on a commercial scale is being more and more required. Besides providing an alternative technology to bypass difficulties, the plant tissue culture (used in a broad sense to include cell, tissue, and organ culture) offers many advantages. In vitro technology also facilitates novel means of conserving the genetic diversity of the germplasm of medicinal plants through cryopreservation, production of novel compounds through biotransformation, somatic hybridization, and selective gene transfer through recombinant DNA technology for enhancing metabolite production.
Table of Contents
VOLUME 1 1. Introduction 2. Accumulation of colchicine, an anti-gout molecule in callus cultures of Gloriosa superba 3. Factors affecting accumulation of plumbagin from hairy root cultures of Plumbago rosea 4. -Radiation mutagenesis and enhancement in the production of plant secondary metabolites 5. High-value secondary metabolites from in vitro cultures of St. John's Wort (Hypericum perforatum L.) 6. Phytoecdysteroids from Sesuvium sp.: production and potential applications 7. In vitro production of alkaloids from Rauwolfia serpentina 8. Potentially bioactive secondary metabolites from underutilized wild Elaeagnus plant 9. Bacosides Neurotropic Molecules production by tissue cultures 10. Tropane Alkaloids in Vitro production, current status and perspectives 11. In vitro production of Rutin 12. Anthraquinones : Production in Plant Cell Culture from medicinal plants 13. In vitro production of asiaticoside and its derivatives from Centella and Hydrocotyle. 14. Plant suspension cell cultures: A novel bioreactor platform for industrial production of pharmaceutical proteins 15. Production of secondary metabolites by Thymus genus 16. Nanoparticle mediated elicitation of plant secondary metabolites, in vitro and in-vivo 17. Biotechnological methods of accumulation and production of vanillin flavour for food and pharmaceutical importance 18. Opportunities and challenges to large-scale production of secondary metabolites in vitro 19. Piperine production from in-vitro plant tissue culture methods 20. Production of bioactive metabolites in in vitro cultures of saffron (Crocus sativus L.): a review. 21. A non-steroidal anti-inflammatory drug Boswellic acid from Boswellia serrata 22. Cardiotonic glycosides in Digitalis. Nikam TD and Nitnaware KM 23. Biosynthesis of Polyphenols and their antioxidant potential 24. In vitro production and cheminformatic analysis of the vital compound taraxerol with their active role in living systems: a comprehensive view 25: In vitro production of phytochemicals from Bacopa monnieri with their active Principles for pharmacological activities 26. Biotechnological routes to enhance the production of the anti-cancer drug Camptothecin: Current state of the art Experimental strategies to enhance in vitro production of plant secondary metabolites VOLUME 2 28. In vitro cultures of some Asclepiadaceae members: A source for the production of secondary metabolites 29. Secondary metabolites of Brassica species 30. In vitro production of therapeutic compounds from Caralluma Species 31. In vitro production of secondary metabolites in Cathranthus roseus 32. Production of secondary metabolite from Morinda citrifolia (Noni) plant by elicitation methods 33. Hepatoprotective lignan production in Phyllanthus 34. Antipsychotic and medicinally important harmala alkaloid production in tissue culture of Tribulus and Peganum 35. Phytochemical prospecting and biological evaluation of leaves, stem and root of in vitro propagation of Libidibia ferrea (Fabaceae) 36. Quality of LED light on the callogenesis and somatic embryogenesis of Libidibia ferrea (Fabaceae) as an alternative source for the production of secondary metabolites 37. Morphogenic potential of nodal segments of ironwood (Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz var. ferrea) cultivated in vitro aiming at maximizing the biotechnological production of secondary metabolites 38. Biotechnological Exploitation of Bioresource for Enhanced Production of Paclitaxel 39. In vitro production, medical applications and antimicrobial activity of 1,8 cineole. 1-Evrim 40: Rhinacanthins: Sources, Properties and Biotechnological Production 41: Stevia rebaudiana - A comprehensive review on in vitro culture studies for phytochemical production 42: In vitro propagation of medicinal plants of Ethiopia 44. In vitro production of Bioactive phytochemicals in Datura metel 45 Phytochemical Constituents and Pharmacological Activities of Dioscorea bulbifera: An endangered medicinal plant in Africa 46. Production of anti-cancerous bioactive compounds using hairy root cultures of Catharanthus roseus (L.) G.Don 47. In vitro Production of bio active phytochemicals of medicinal value of some medicinal plants in Sri Lanka 48. In vitro production of anthocyanins 49. Adoption of biotechnologies for Withania somnifera for sustainable utilization 50. Application of different tissue culture techniques for in vitro production of gymnemic acid: factors, approaches, and challenges to achieving higher yield 51. In vitro Production of bio active phytochemicals of medicinal value of medicinal plants in Sri Lanka: Aloe vera (Aloaceae), Munronia pinnata (Meliaceae), Zingiber officinale (Zingiberaceae), Curcuma longa (Zingiberaceae), Gyrinops walla (Thymelaeaceae) 52. Piperine production in vitro and elcitation from Piper species 53. In vitro cultures and production of bioactive compounds of black cumin Nigella sativa L 54. In vitro studies and hairy root development with reference to secondary metabolite production in a rare and threatened medicinal species Solanum erianthum D.Don
Authors
Anabela Romano Professor, Department of Biotechnology, MED-Mediterranean Institute for Agriculture, Environment and Development, Universidade do Algarve, Portugal. Professor Anabela Romano is the leader of the Plant Biotechnology Lab since 1995, the year she joined the faculty at the University of Algarve, is the Director of the Department of Biological Sciences and Bioengineering at the Faculty of Science and Technology of the University of Algarve and director of the MED/Ualg - Mediterranean Institute for Agriculture, Environment and Development, and was previously Vice-Rector of the University of Algarve. Her current research focuses on the use of biotechnological approaches toward the propagation, conservation, and sustainable use of plant genetic resources and on the biological and chemical characterization of natural compounds. She is actively engaged in training graduate students and postdoctoral fellows (supervised 122 students) and teaches graduate and undergraduate-level courses in Plant Biotechnology, Genetic Engineering and Biotechnology, Natural Product Biotechnology, Medicinal Plants, and Phytotherapy, among others. She is the principal investigator of several research projects and evaluator of national and international research projects and grants. She has published 227 original papers, book chapters, and books, and has been invited to present lectures at specialized national and international congresses and other scientific meetings. She is currently an associate editor of the South African Journal of Botany (Elsevier). P. B. Kavi Kishor Vignan's Foundation for Science, Technology and Research, India. Professor P.B.Kavi Kishor joined the Department of Genetics in the year 1981 and initiated the work on Plant Biotechnology. Worked at the Biotechnology Center, Ohio State University, Columbus, Ohio, USA (1992-1994) under the Rockefeller Foundation program. Visiting Professor at the Emory University, Atlanta, Georgia, USA; Visiting Professor at the Linkoping University, Linkoping, Sweden; and a Visiting Scientist at the Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany. Published 286 papers including book chapters, edited/written seven books. Supervised 51 Ph.D.s as guide/co-guide. He has one patent to his credit. Penna Suprasanna Professor, Homi Bhabha National Institute, Mumbai & Former-Head of the Nuclear Agriculture and Biotechnology Division in the Bhabha Atomic Research Centre, India. Professor Suprasanna Penna has worked as Head of Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, and currently is a professor at the Homi Bhabha National Institute, Mumbai. He made significant contributions to plant science covering plant biotechnology, mutation breeding, stress tolerance and novel biopolymer. His work on technology development for radiation depolymerized oligo-chitosan has been successfully used in enhancing plant productivity in crop plants and vegetables. He has also contributed to molecular understanding of plant abiotic stress tolerance in crop plants and salinity-adaptive mechanisms in halophytes. He is on the editorial board of several national and international journals and published over 300 publications and has edited several books on salinity tolerance, genome editing and plant-metal interactions. T. Pullaiah Department of Botany, Sri Krishnadevaraya University, Anantapur, India. Professor T. Pullaiah is a former Professor at the Department of Botany at Sri Krishnadevaraya University in Andhra Pradesh, India, where he has taught for more than 35 years. He was President of Indian Botanical Society (2014), President of the Indian Association for Angiosperm Taxonomy (2013). He was awarded the Panchanan Maheshwari Gold Medal, the Prof. P.C.Trivedi Medal, the Dr. G. Panigrahi Memorial Lecture award of the Indian Botanical Society and Prof. Y.D. Tyagi Gold Medal of the Indian Association for Angiosperm Taxonomy. Under his guidance 54 students obtained their doctoral degrees. He has authored 52 books, edited 23 books and published over 330 research papers, including reviews and book chapters. He was also a member of Species Survival Commission of the International Union for Conservation of Nature (IUCN). Professor Pullaiah received his PhD from Andhra University, India, attended Moscow State University, Russia, and worked as Post-Doctoral Fellow A. Ranga Rao Department of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh, India. Dr Ranga Rao has carried out Postdoctoral Research work in Arizona State University, Arizona (USA). Dr. Ranga Rao has been working as Associate Professor and Senior Scientist in Department of Biotechnology, Vignan's Foundation Science, Technology and Research University (Deemed to be University), India. He has 18 years of research experience. Previously Dr. Rang Rao worked as Visiting Senior Research Fellow, Visiting Assistant Dr. Ranga Rao published more than 50 papers in peer reviewed international and national journals, edited several books and has presented over 60 conferences/symposia/seminar in international conferences. and Global Biomass Production.He was selected for Junior Scientist of the Year Award (2015) by National Environmental Science Academy, New Delhi, India; honored TWAS-Young Affiliate (2014) by Regional Office of East South-East Asia and the Pacific Chinese Academy of Sciences (CAS), China; received Young Scientist Award (2014) at the World Food Congress by International Union of Food Science and Technology (IUFoST), Canada; Carl Storm International Diversity Fellowship Award (2010) by Gordon Research Conferences, USA.
He is an associate fellow of Andhra Pradesh Akademi of Sciences (2019) Government of Andhra Pradesh, India and also fellow of the Society of Applied Biotechnology (2013), India.
He has received research grants and travel grant fellowship as both international and national awards, under Young Scientist schemes. He is also serving as editorial board member and reviewer for reputed international and national journals.
