Hepatology. An Evidence-Based Clinical Compendium

Table of Contents

1. Anatomy and Histopathology of the Liver
2. The Liver and Immunology
3. Bilirubin metabolism and its disorders
4. Non-invasive diagnosis of Metabolic dysfunction associated steatotic liver disease (MASLD)
5. Hematological Disorder and Liver
6. Acute Liver Failure (ALF)
7. Acute-on-Chronic Liver Failure
8. Hepatic Fibrogenesis
9. Cirrhosis, portal hypertension and pathophysiology
10. Ascites and Hepatorenal Syndrome
11. Management of Esophageal and Gastric Varices
12. Hepatic Encephalopathy
13. Jaundice/Cholestasis
14. Gallstones and Gall bladder Disorders
15. Benign Biliary Stricture: Causes and management
16. Hepatic and Biliary Cystic Lesions: Diagnosis, Management and Therapeutic Options
17. Congenital Biliary Diseases
18. Primary Biliary Cholangitis
19. Primary Sclerosing Cholangitis
20. Enterically Transmitted Viral hepatitis- Hepatitis A through E
21. Hepatitis B
22. Hepatitis C
23. The Worldwide Medical Impact of Hepatitis D Virus Infection: Focus to Central Asia
24. Hepatitis through non A-E viruses
25. HIV related Liver Diseases
26. Autoimmune hepatitis
27. Diagnosing drug induced liver injury
28. Alcohol-Associated Liver Disease
29. Iron Overload and Liver
30. Wilson Disease
31. Metabolic-dysfunction Associated Steatotic liver disease (MASLD)
32. Sarcopenia, Frailty and its Implications in Cirrhosis
33. Liver in neonate, infancy and childhood
34. Pregnancy Related Liver Disease
35. Viral Hepatitis and Pregnancy
36. Liver in Systemic Diseases, Part 1
37. Liver in Systemic Diseases, Part 2
38. Bacterial, Fungal and Parasitic infections and the Liver
39. Parasitic Diseases of the Liver and Biliary Tract
40. Benign Liver Tumors
41. Malignant Liver Tumors
42. Liver Targeted Therapies for Benign and Malignant Tumors of the Liver
43. Liver Transplantation
44. Multi-Organ Dynamics: Exploring Liver Transplantation in Combination with Other Organs
45. Surgical aspects of Liver Transplantation
46. COVID-19 and the Liver
47. Inherited and Metabolic disorders of the liver
48. Liver and Radiology
49. Gall Bladder Cancer

Authors

Sanjaya K. Satapathy Interim Chief, Division of Hepatology; Medical Director, Liver Transplantation; and Program Director, Transplant Hepatology Fellowship. Dr. Sanjaya Satapathy is a Professor of Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra University. He serves as the Interim Chief of Hepatology and Medical Director of Liver Transplantation at the Northwell Center for Liver Diseases & Transplantation, Northshore University Hospital. Dr. Satapathy is also the Program Director of Transplant Hepatology Fellowship at the Zucker School of Medicine/Northwell Health. His research focuses on NAFLD, Hepatitis C, post-transplant outcomes, NASH, sarcopenia, and hepatitis C. With over 160 peer-reviewed publications in high-impact journals, he is a recognized expert in the field. Dr. Satapathy is board certified in Internal Medicine, Gastroenterology, and Transplant Hepatology. He has received numerous accolades, including grants from NIH, and is a Fellow of various prestigious medical societies. Mamun-Al-Mahtab Chairman, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University.

Mamun Al Mahtab is a notable hepatologist, medical scientist, author, and columnist from Bangladesh. With an impressive portfolio of 290 publications in national and international peer-reviewed journals, Dr. Mahtab currently serves as the Head of the Division of Interventional Hepatology at Bangabandhu Sheikh Mujib Medical University (BSMMU). Dr. Mahtab plays a crucial role in medical research and development. He leads the clinical study of the Bangladesh-developed SARS-CoV-2 mRNA candidate, GBPD060. Additionally, he serves as the lead researcher for NASVAC's Phase I/II and III clinical studies. Notably, his discovery of NASVAC earned him the prestigious 'Premio Nacional' award from the Cuban Academy of Sciences in 2019. Apart from his research endeavors, Dr. Mahtab actively organizes awareness programs on liver diseases throughout Bangladesh. He is also credited with inventing the NASVAC drug, which aims to provide an affordable and effective solution for Hepatitis B to the masses in Bangladesh.

Shivaram Prasad Singh Professor, Department of Gastroenterology, S.C.B. Medical College.

Dr. Shivaram Prasad Singh is a highly accomplished medical professional. He graduated from Utkal University with degrees in MBBS and MD in Internal Medicine. He obtained his DM from C.M.C., Vellore at Madras University, India. Dr. Singh is a Fellow of the Society for Gastrointestinal Endoscopy of India, the American College of Gastroenterology, and the American Gastroenterological Association.

His remarkable contributions include initiating World Hepatitis B Eradication Day in India, endorsed by WHO, and serving on the World Hepatitis Alliance Public Health Panel. Dr. Singh held leadership positions in renowned organizations such as INASL and ISG. He has received prestigious awards, including the ISG S.R. Naik Memorial Award for Research Publications and the Indian Society of Gastroenterology Zydus Oration.

With over 160 publications and numerous national guideline papers, Dr. Singh is an acclaimed authority in gastrointestinal and liver diseases. He currently serves as the President-Elect of INASL.

Sheikh Mohammad Fazle Akbar Senior Researcher, Department of Gastroenterology and Metabology.

Dr. Akbar is an esteemed researcher in epidemiology, clinical studies, and immunology, focusing on chronic diseases like cancers. His molecular analysis has provided valuable insights into HBV, HCV, and HEV in Bangladesh, Nepal, Indonesia, and Japan. He developed a groundbreaking immune therapeutic drug for chronic hepatitis B and cancers, completing successful phase I/II and II clinical trials, with approvals in select countries. As a core member of the US-Japan Cooperative Medical Science Program (USJ CMSP), he contributes to global health research. Dr. Akbar has authored 150+ articles, compiled books, and holds editorial roles.