Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease.
Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology.
Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource.
Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology.
Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource.
Readership
Students and professionals in the fields of biotechnology and pharmacology.Table of Contents
CHAPTER 1 MULTI-OMICS PROFILES ARE APPLICABLE TO HUMAN DISEASES AND- DRUG DEVELOPMENT
- Adriana Montserrat Espinosa-González, José del Carmen Benítez-Flores, Juan Carlos
- Gómez-Verjan, Nadia Alejandra Rivero-Segura, Ignacio Peñalosa Castro, Jose Cruz
- Rivera Cabrera and Edgar Antonio Estrella-Parra
- INTRODUCTION
- ANCESTRAL KNOWLEDGE: TRADITIONAL MEDICINE IN THE MULTIOMICS
- ERA
- GLOBALIZATION OF TRADITIONAL MEDICINE
- THE CONSTRUCTION OF NEW DRUGS BASED ON THE OMICS APPROACH
- OMICS SCIENCE IN PERSONALIZED MEDICINE: A GOLD STANDARD
- CHALLENGES IN THE DISCOVERY OF NEW DRUGS
- BIOINFORMATICS IN OMICS: AN ACCUMULATION OF EXPERIENCES IN
- SYNERGY
- CONCLUSION
- REFERENCES
- Olivia Pérez-Valera, Yuri Córdoba-Campo, Rafael Torres-Martínez, Yesica R. Cruz-
- Martínez and Israel Valencia Quiroz
- INTRODUCTION
- Review of the Different Docking Algorithms, Including their Strengths and Limitations
- INFECTIOUS DISEASES (TUBERCULOSIS)
- Case Study: Bedaquiline
- Clinical Trials and Approval
- Real-World Impact on Disease Treatment
- CANCER (RENAL CELL CARCINOMA AND HEPATOCELLULAR CARCINOMA)
- Disease Characteristics
- Molecular Targets and their Role in Disease
- Real-World Impact on Disease Treatment
- CARDIOVASCULAR DISEASES (VENOUS THROMBOEMBOLISM AND STROKE)
- Disease Characteristics
- Molecular Target and their Role in the Disease
- AUTOIMMUNE DISEASES (RHEUMATOID ARTHRITIS)
- METABOLIC DISORDERS (TYPE 2 DIABETES)
- PSYCHIATRIC DISORDERS (DEPRESSION)
- Disease Characteristics
- Molecular Targets and their Role in the Disease
- Molecular Docking Approach
- Case Study: Vortioxetine
- Drug Development Process using Molecular Docking
- Clinical Trials and Approval
- Real-World Impact on Disease Treatment
- GENETIC DISORDERS (CYSTIC FIBROSIS)
- Disease Characteristics
- Molecular Targets and their Role in the Disease
- Molecular Docking Approach
- Case Study: Lumacaftor
- Drug Development Process using Molecular Docking
- Clinical Trials and Approval
- Real-World Impact on Disease Treatment
- BONE-RELATED DISEASES (OSTEOPOROSIS)
- Case Study: Odanacatib
- EYE DISORDERS (GLAUCOMA)
- Disease Overview
- Case Study: Brimonidine
- Clinical Trials and Approval
- Real-world Impact on Disease Treatment
- CHALLENGES AND LIMITATIONS IN THE USE OF MOLECULAR DOCKING FOR
- DRUG DEVELOPMENT AND STRATEGIES TO OVERCOME THEM
- CONCLUSION
- REFERENCES
- ANTIBIOTIC RESISTANCE
- Axel R. Molina-Gallardo, Yesica R. Cruz-Martínez, Julieta Orozco-Martínez, Israel
- Valencia Quiroz and C. Tzasna Hernández-Delgado
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Antibacterial Activity in Qualitative Terms
- Antibacterial Activity in Quantitative Terms
- Antibiofilm Effects of Farnesol and Farnesene
- The Sensitizing Effect of Farnesol and Farnesene
- Bacterial Growth Curves: A Deep Dive
- Molecular Docking: A Glimpse into the Molecular World
- DISCUSSION
- The Role of Farnesene
- Farnesol's Antibacterial Potential
- Mechanisms of Resistance and Sensitization
- Synergistic Effects of Antibiotics
- Molecular Insights
- CONCLUSION
- REFERENCES
- Viridiana R. Escartín-Alpizar, Julieta Orozco-Martínez and Israel Valencia Quiroz
- INTRODUCTION
- GENERAL ADVANTAGES OF VIRUS-BASED DELIVERY SYSTEMS
- ADVANTAGES OF USING VIRAL VECTORS IN VACCINE DEVELOPMENT
- Viruses to Develop Vaccines for COVID-19
- Viruses to Develop Influenza Vaccines
- Viruses to Develop Vaccines for HIV
- Viruses to Develop Vaccines for Malaria
- Ability of Virus to Stimulate a Humoral Response
- Ability of Virus to Stimulate a Cellular Immune Response
- Anticancer Drug Delivery using Viral Vectors
- Development of Personalized Vaccines for Cancer Immunotherapy
- STRATEGIES USED TO TARGET SPECIFIC CANCER CELLS
- ONCOLYTIC VIRUSES
- RISKS AND POTENTIAL COMPLICATIONS OF VIRUS-BASED DELIVERY
- SYSTEMS
- Regulatory Issues during Development and Testing of Viral Vectors for Clinical Use
- CONCLUSION
- ACKNOWLEDGEMENT
- REFERENCES
- Erick Nolasco-Ontiveros, María del Socorro Sánchez-Correa, José Guillermo Avila-
- Acevedo, Rocío Serrano-Parrales and Adriana Montserrat Espinosa-González
- INTRODUCTION
- PHOTOCHEMOPROTECTION
- PHENOLIC COMPOUNDS
- Phenolic Acids
- Caffeic Acid
- Ferulic Acid
- Gallic Acid
- Phenylpropanoids
- Rosmarinic Acid
- Stilbenes
- Resveratrol
- Piceatannol
- Pterostilbene
- Flavonoids
- Flavonols
- Catechin and Epicatechin
- Flavones
- Apigenin
- Luteolin
- Quercetin and Rutin
- Kaempferol
- Curcumin
- Isoflavonoids
- Genistein
- Equol
- Anthocyanins
- Tannins
- Ellagic Acid
- Tannic Acid
- Lignins
- CONCLUSION
- LIST OF ABBREVIATIONS
- REFERENCES
- Nallely Álvarez-Santos, Rocío Serrano-Parrales, Patricia Guevara-Fefer, Felix
- Krengel and Ana María García-Bores
- INTRODUCTION
- NATURAL PRODUCTS: EXTRACTS AND SECONDARY METABOLITES
- BIOTECHNOLOGY IN WOUND REGENERATION
- Hydrogels
- Nanotechnology
- Nanoparticles
- Nanofibrous
- Nanoemulsion
- CONCLUSION
- ACKNOWLEDGEMENT
- REFERENCES
- BACTERIA, FUNGI, AND YEASTS
- Mai M. Badr and Israel Valencia Quiroz
- INTRODUCTION
- EXPLORING THE ORIGINS AND DIVERSITY OF NATURAL ANTIBIOTICS
- Botanical Origins: Natural Antimicrobial Substances
- The Utilization of Herbs and Spices for Antimicrobial Applications
- Harnessing the Antibacterial Potentials of Fruits and Vegetables
- Antimicrobial Properties in Seeds and Foliage
- Antimicrobial Substances Sourced from Animals
- ANTIMICROBIAL COMPOUNDS ORIGINATING FROM MICROORGANISMS
- Categorizing Natural Compounds with Antimicrobial Properties
- Understanding the Mechanisms of Action of Natural Antibacterial Agents
- Influential Factors in the Antibacterial Activity of Natural Products
- Methods of Extracting Natural Antibacterial Compounds
- Increasing Resistance to Natural Products
- PUBLIC PERCEPTION AND CONCERNS REGARDING ADVERSE EFFECTS OF
- NATURAL ANTIMICROBIALS
- CONCLUSION
- REFERENCES
- IN CURBING DISEASES
- Ana K. Villagómez-Guzmán and Israel Valencia Quiroz
- INTRODUCTION
- CVD: THE LEADING CAUSE OF DEATH WORLDWIDE
- CANCER: ONE OF THE MOST COMMON AND DEVASTATING DISEASES
- DIABETES: ONE OF THE MOST PREVALENT AND DEADLY HUMAN DISEASES
- HIV: ONE OF THE MOST PREVALENT AND DEADLY HUMAN DISEASES
- COVID-19: ONE OF THE DEADLIEST HUMAN INFECTIOUS DISEASES
- NEXT-GENERATION NANOMEDICINES AND COMBINATION THERAPIES:
- BRIDGING THE GAP IN GLOBAL HEALTH EQUITY
- Alzheimer's Disease and Dementia: Rising Global Prevalence and Innovative Genome
- Editing Approaches
- Advanced Therapy Medicinal Products: Harnessing Gene Therapy for Disease Treatment 173
- Immunotherapy: A Paradigm Shift in Cancer Treatment
- Precision Medicine: The Future of Individualized Treatment Strategies
- Harnessing Biotechnology in the Battle Against Infectious Diseases
- Utilizing Biotechnology in the Development of Treatments for Chronic Diseases Such as
- Cancer
- Leveraging Biotechnology in the Development of Treatments for Diabetes Mellitus
- NAVIGATING CHALLENGES OF BIOTECHNOLOGY IN DRUG DEVELOPMENT:
- COST, ACCESS, AND ETHICAL CONCERNS
Author
- Israel Valencia Quiroz
