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Target Analytical Report - CCKBR
Jubilant Biosys Limited, Sep 2008, Pages: 79
The cholecystokinin 2 receptor (CCKBR; CCK2R) is a member of the rhodopsin-like G protein-coupled receptor family that mediates important physiological functions by binding cholecystokinin (CCK) and gastrin peptides.
The CCK2R is present in the central nervous system, where it regulates anxiety/panic attacks, dopamine release, and nociception. In the periphery, it regulates acid, histamine, and leptin secretion as well as cell growth and differentiation.
CCKBR has been reported to be associated with various tumours. Given the clinical importance of CCK2R-mediated functions, great interest has been devoted to the identification of efficient and selective CCK2 ligands. The predominant brain cholecystokinin receptor (CCK-B/gastrin) has been implicated in mediating many of the central effects of cholecystokinin, including anxiety, panic attacks, satiety, and analgesia, suggesting it is an important pharmacologic target.
Today, the drug discovery research sector faces tremendous internal and external pressure due to the huge investments required in terms of money and time in order to produce meaningful information from the huge data sources available on a molecule. This process involves increased involvement from cross functional domains like Molecular Biology, Bioinformatics and Medicinal Chemistry, which has made the process both cumbersome and complicated.
This current report on CCKBR1 addresses the above problem as a compilation of manually curated information that is derived from the following sources:
- Public domain databases such as SwissProt, UniProt, Entrez PubMed, OMIM, etc
- In-house databases
- Curated information from journal articles and reviews
- Chemistry information from patents
- Company websites
Competitive landscape
The competitive landscape information is obtained by analysis of manually selected patents in the area of small molecules acting on the target
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