Contents:

Section 1. Analysis and Interpretation of Survey Results Executive Overview Biodefense Research Profile - Research Objectives - Enabling Technologies - Research Obstacles - Laboratory Budgets Supplier Opportunities - Growth Segments - Leading Suppliers - Technology Needs - New Market Penetration Conclusion Section 2. Study Methodology and Demographics - Questionnaire Overview - Questionnaire Design - Analytical Techniques - Demographics - Questionnaire Section 3. Presentation of Survey Data Biodefense Background - Currently conduct biodefense research - Change that will allow you to begin conducting biodefense research - Percentage of lab’s research devoted to biodefense - Diseases and potential bioterror agents studied - Biosafety level used in research - General application area for research - Specific focus of biodefense research - Stage of biodefense research - Company that first comes to mind when thinking of products used in biodefense research Techniques and Technologies - General approaches used in biodefense research - Types of techniques used in biodefense research - Eukaryotic culture techniques used - RNA-based gene expression techniques used - Genome analysis techniques used - Imaging techniques used - Prokaryotic culture techniques used - Protein analysis techniques used Life Science Suppliers - Suppliers used whose products are not specifically designed for biodefense applications - Ease of adapting life science products NOT specifically designed for biodefense applications - Suppliers used whose products are specifically designated for biodefense applications Unmet Needs - Areas in which life science suppliers can best support the efforts of scientists conducting biodefense research in detection - Areas in which life science suppliers can best support the efforts of scientists conducting biodefense research in prevention - Areas in which life science suppliers can best support the efforts of scientists conducting biodefense research in treatment - Procedure for which it would be most advantageous to use a commercially available kit or reagent specific to the-biological agent studied - Expectations and product performance advantages of agent-specific kit or reagent - Area in which technological improvements would best help in conducting biodefense research Resources and Support - Funding sources for biodefense research - Estimated lab operational budget for biodefense research - Expected change in lab’s operational budget for biodefense - Breakdown of biodefense budget - Total number of researchers in the lab Challenges and Trends - Types of problems typically experienced in conducting research on infectious agents or toxins - Area that should be a priority for biodefense research supported by the NIH - Research approach that will become increasingly important in enabling breakthroughs in biodefense research Demographics Section 4. Appendices - Insights and Perspectives - Cross-Tabulations of Survey Data

Methodology

Methodology 529 scientists completed a 35-question survey conducted between September 14 and 27, 2006. The electronic questionnaire was fielded to registered members of The Science Advisory Board, an online community of more than 31,000 scientists, physicians and healthcare professionals from around the world. The Science Advisory Board is divided into two panels (Research and Clinical) and “convenes” regularly via the World Wide Web (www.scienceboard.net) to voice their opinions on a wide variety of issues relating to biomedical research and clinical technologies. These experts—representing all aspects of the life sciences and medicine—have agreed to make themselves available to participate in our online research activities. The Science Advisory Board members who participated in this study were drawn from the Board’s Research Panel. In Question 1, respondents were asked to indicate whether they currently conduct biodefense research, plan to in the future, or do not plan to at all. Respondents who did not plan to ever conduct biodefense research were directed out of the survey. Question 2 was only answered by respondents who plan to conduct biodefense research in the future. Questions 3, 18, 19, 20, 29, 30 and 32 were only answered by respondents who currently conduct biodefense research. Demographics Market Segment Respondents=529 Academic 231 44% Pharmaceutical/Biotechnology 98 19% Hospital or University Medical Center 75 14% Government 53 10% Private Research 20 4% Contract Research 18 3% Medical Device/Diagnostics 13 2% Healthcare Network/Facility 6 1% Commercial Testing Lab 4 1% Managed Care 3 1% Other 6 1% Group/Private Practice 2 <1% Job Position Respondents=529 Principal Investigator 143 27% Staff Scientist 97 18% Post Doctoral Fellow 85 16% Professor/Teacher 68 13% Lab Director/Supervisor/Coordinator 51 10% Graduate Student/Research Assistant 25 5% Other 16 3% Laboratory Technician 12 2% Department Head 10 2% Physician 6 1% Quality Assurance/Quality Control 4 1% Administrator 3 1% Production/Manufacturing 3 1% IS Manager/Specialist 2 <1% Medical Technologist 1 <1% Nurse/Nurse Practitioner 1 <1% Pharmacist 1 <1% Purchasing Agent/Buyer 1 <1%