China Pharma Outsourcing Market By 2015

JZMed Inc, January 2009, Pages: 225

It has been widely accepted that China is now the primary choice of outsourcing destination for drug companies around the world. In the past eight years Chinese pharmaceutical outsourcing industry has grown in an average annual rate of 48%. Starting with chemistry service only, a complete industrial structure with all service elements now starts shaping. The industry’s growth is also accelerated by the influx of a large number of multinational service providers whose entrance greatly up-lifted the service capability of this Chinese industry. In addition, increasing numbers of traditional Chinese pharmaceutical companies and R&D-oriented Chinese biotechnology companies also join in the service. At present, about 250 professional service providers, 50 multinational service providers, 150 traditional Chinese pharmaceutical companies and 20 Chinese biotechnology companies have formed a joint force in today’s China pharma outsourcing industry. Together, they are serving an ever enlarging body of outsourcing companies from all over the world. The industry has thus realized the service revenue of more than $1.4 B.

Nearly a decade development has significantly uplifted the industry and competition as well. How this Chinese industry would likely develop in the future has become a common concern to many professionals in all related industries. The current financial crisis also puts the future development of this industry into an uncertain path.

Would you like to know how the financial crisis affects this Chinese industry in both near term and long term? What will the industry look like in five to ten years? What are the driving forces that keep this industry still fast growing? Will China still have cost effective advantage in five to ten years? How does labor cost likely grow in next few years? How to compare it with that in other countries?

“China Pharma Outsourcing Market By 2105” is designed to address these issues and to answer these questions. It is by far the most comprehensive report about Chinese pharma outsourcing industry and market. It investigated in depth the development pattern of service capability and market size of this Chinese industry and first time displayed to the world a complete picture of China pharma outsourcing industry. In addition, with in-depth analysis of more than 50 case studies, the report also first time revealed how drug companies around the world conduct outsourcing in China and what outsourcing models are popularly pursued. More importantly, the report examined in depth both the drivers and resistors of future development of this Chinese industry. It is also the first time that a clear picture of future growth and development of this Chinese industry is depicted.

The report is a must-read book to all professionals in the industries of pharmaceutical, biotechnology, financial investment and outsourcing service that are interested in pharma outsourcing in China. It is also a valuable reference book to drug regulatory agencies and other government agencies involved in strategic planning of development of pharmaceutical industry in their own countries.

Main Features of the Report

- The report started with examining in depth the current market size, industry structural composition and service capability in each sector of this Chinese industry. A clear and complete picture of current development state of China pharma outsourcing industry is thus first time displayed to the world.

- The report then studied in detail how China’s labor cost, one of the key attractions to all outsourcing companies, climbed in past few years. Based on this development trend, it is also the first time that the report provided a clear picture of how China’s cost effective advantage would likely develop in following 5-7 years and how this development could be compared with the same criteria in other countries during the same time period. It therefore gives a clear idea why it is still cost effective to conduct outsourcing in China in next few years and by when China’s this advantage would likely completely disappear.

- The report also examined in-depth more than 50 outsourcing case studies. It illustrated in detail how drug companies from all over the world, large, small and even startup, are conducting outsourcing in China. It is thus also the first time that the report revealed the most popular China outsourcing models pursued by all sized drug companies.

- The report analyzed in depth how pharma/biotech companies, large or small, will cope with the financial crisis. Based on the analysis, the report first time pointed out how China outsourcing in general and each service sector in specific would likely be affected.

- The report further analyzed in depth all drivers and resistors for future development of this Chinese industry. The report discovered that there are three outsourcing waves that will successively drive the growth of this Chinese industry. Based on these analysis results, the report also first time depicted a clear picture of future growth and development in both short term and long term of this Chinese industry.

- The report contains the most complete data in numerous aspects about China and the Chinese industries of pharmaceutical, biotechnology and outsourcing. In addition, it also contains in-depth analysis on the quality of Chinese technical workforce in pharmaceutical industry.

- What is more useful to all companies is that the report contains the most complete, up-to-date information of both service capability and contact information of 46 best Chinese professional service providers, 50 China-based multinational service providers, 22 best traditional Chinese pharmaceutical companies and 15 R&D-focused Chinese biotech companies that are involved in outsourcing service.

Your Questions Are Answered

The report addressed each of the following questions most concerned by professionals in a variety of industries:

- What is the current market size of the China pharma outsourcing industry? What is the market size of each service sector?

- What is the best outsourcing model at present? Who are in China? What outsourcing activities are most drug companies conducting in China?

- Whether my company should have a China strategy? What strategies should I have?

- How does the current financial crisis affect China’s pharma outsourcing industry? What is the near term and long term effects of the crisis on the growth of this Chinese industry? Which service sector(s) would be hit harder than others? How to compare the effect of the crisis on this Chinese industry with the same industry in other countries?

- Why does China still have advantages in outsourcing over other countries? Will China still have cost effective advantage in five to ten years? How does labor cost likely grow in next few years? How to compare it with that in other countries?

- What is the current structure of each service sector of the industry? What is the current service capability of each sector? What are current issues the industry needs to resolve?

- What are the drivers that will drive future growth of this Chinese industry? Which service sector has been growing fastest so far? Which sector will have most future growth potential?

- What will the industry look like in five to ten years? What about the market size by then? How will the service capability of this industry develop in the future?

- How will global pharma outsourcing industry develop in the future? What roles will this Chinese industry play?

Benefits the Report Will Bring You

- The report makes you quickly understand the current development state of China pharma outsourcing industry including its current market size and its position in world pharma outsourcing industry.

- The report helps you gain a clear picture of whether, why and how this Chinese industry will further develop in the future.

- The report makes you quickly gain detailed insights of why all types of drug companies go to China for outsourcing and what outsourcing models most suitable to your company.

- The report helps you figure out whether your company should have a China strategy incorporated into your company’s long term development goals.

- The report gives you a detailed picture of what service is currently available in China and their capability level. It helps you decide whether it is the right time to outsource your specific projects to China.

- The report further helps you figure out which China-based service provider most fits your outsourcing criteria and how to approach them.

- The report also provides you with a detailed analysis of how labor cost would likely develop in China. It greatly helps you decide why you should take China’s this advantage as early as possible if cost effectiveness is one of your main concerns.

- The report helps you gain a complete insight into the development state of global pharmaceutical outsourcing industry.

Scope of the Report

About Author

Executive Summary

China’s advantages in pharma outsourcing
Current market size, service capability and existing issues
From popular outsourcing models to future development trend: A series of case studies
Impact of financial crisis: Market development forecasts for 2009 and
Future development: Years beyond

Chapter 1: China’s Advantages in Pharma Outsourcing

Summary
1.1 Rich natural resources
1.1.1 Abundant, readily available natural resources
1. Rich natural products
2. A large, drug-naïve patient pool
3. Abundant animal species
1.2.2 Large, well-trained workforce
1.2 Advantage of low cost labor
1.3 Attraction of potentially world largest pharmaceutical market
1.4 A complete industrial structure with all service elements starts emerging
1.4.1 Rapid emerging of professional CROs and CMOs founded by Returnees
1.4.2 Increasing numbers of traditional Chinese pharma and R&D oriented biotech companies join in outsourcing service
1.4.3 Influx of a large number of multinational service provider (MNCROs/MNCMOs)
1.5 Well developed business infrastructure
1.5.1 Well funded and equipped industrial/technology parks
1.5.2 R&D centers spreading all over the country
1.5.3 Well developed transportation system
1.5.4 Abundant supporting services
1. Convenient logistics services
2. Financial service
3. Lounging

Chapter 2. Current Market Size, Service Capability and Existing Issues

Summary
2.1 Introduction
2.2 Current market size
2.2.1 Entire industry market size
2.2.2 Current market size of each service sector
1. Value chain of drug discovery, development and manufacturing process
2. Market size of target identification and validation
3. Market size of lead discovery and optimization
4. Market size of preclinical research
5. Market size of clinical research
6. Current market size of contract manufacturing
7. Market distribution of each service sector
2.3 Current service capabilities
2.3.1 Current service capability in early stage drug discovery
1. Target identification and validation
2. Focused compound libraries
3. Lead discovery and optimization
2.3.2 Current service capability in preclinical research
1. In vitro/in vivo pharmacological property study
2. In vitro/in vivo ADME/Tox study
3. In vivo drug efficacy determination
2.3.3 Current service capability in late stage development
1. Service capability in clinical research
2. Logistics services for clinical trials
2.3.4 Current service capability in contract manufacturing
1. Service capability in process R&D and scale-up synthesis
2. Service capability in API production to support drug development and commercialization
2.4 Industry boosted by the participation of Chinese pharma and biotech companies
2.4.1 Outsourcing service provided by traditional Chinese pharmaceutical companies
2.4.2 Outsourcing service provided by fast growing, R&D-oriented Chinese biotech companies
2.5 Existing Issues
2.5.1 IP protection
2.5.2 Limited service capability
2.5.3 Limited skills in drug R&D
2.5.4 Majority players still small
2.5.5 Regulation in clinical trial and drug approval

Chapter 3. From Popular Outsourcing Models To Future Development

Trend: A Series of Case Studies

Summary
3.1 Introduction
3.2 Outsourcing in China by major pharma companies: All types -----------------
3.3 Small biotech companies in China: Starting to embrace China opportunity
3.4 Outsourcing by generic drug makers: To secure supply stability by gaining ownership
3.4.1 Pure contract manufacturing outsourcing
3.4.2 Taking partial ownership
3.4.3 Complete acquisition
3.4.4 Establishing wholly owned manufacturing facilities
3.5 Multinational CROs in China: To utilize rich, low cost resources
3.5.1 Clinical research service providers
3.5.2 Preclinical research service providers
3.5.3 Diagnostics and cardiac safety testing service providers

Chapter 4. Impact of Financial Crisis: Market Development Forecasts for 2009 and 2010

Summary
4.1 Introduction
4.2 Biotech companies hit hardest by the financial crisis
4.3 How terror attack at Mumbai of India will affect China pharma outsourcing industry
4.4 Qualitative analysis of the impact
4.4.1 How major pharma and biotech companies will change their outsourcing behavior
4.4.2 How small biotech companies will change their outsourcing behavior
1. Financially troubled small biotech companies can survive by outsourcing to China
2. How small biotech companies safely operate outsourcing in China: some practical advices
4.4.3 How each service sector will be affected
1. Impact on early stage drug discovery
2. Impact on preclinical development
3. Impact on clinical development
4. Impact on contract manufacturing
4.5 Quantitative analysis and forecast of market development for and 2010
4.5.1 Forecast of overall market development
4.5.2 Market development forecast of each service sector
4.5.3 How to compare with India pharma outsourcing market

Chapter 5. Future Development: Years beyond 2010

Summary
5.1 Introduction
5.1.1 Global drug makers still need outsourcing services from China
5.1.2 Improved outsourcing environment and growing outsourcing demands by domestic companies will also drive the industry
to further grow
5.2 Drivers of the industry’s future growth
5.2.1 Advantage of still low cost labor
1. Analysis of labor increase in next seven years
(1) Salary increase caused by employee turnover will gradually fall flat
(2) China is producing more college graduates than all industries of the country can absorb
(3) Living expense throughout entire country still varies dramatically
(4) More third tier cities in inner land are being rapidly developed
2. Comparison of labor cost increase with other countries
5.2.2 Improved IP protection environment
5.2.3 Improved service capability and quality
5.2.4 Government support
5.2.5 Increasing outsourcing demands by small biotech companies pressured by financial crisis
5.2.6 More outsourcing demands by the emerging and growing domestic, R&D-oriented Chinese pharma/biotech companies
5.3 Will China follow the development model of the West or India?
5.3.1 Development pattern of Western pharma outsourcing industry
5.3.2 Development pattern of Indian outsourcing industry
5.3.3 Which development model would China follow?
5.4 Forecast of market development by 2015
5.4.1 Forecast of China pharma outsourcing market by 2015
5.4.2 Forecasts of market development of each service sector by 2015
1. Market development of outsourcing in early stage drug discovery
2. Market development of preclinical research outsourcing
3. Market development of outsourcing in clinical research
4. Market development of contract manufacturing
(1) More APIs and finished drugs will be exported to the well regulated markets
(2) More cGMP facilities compliance to the Western standards
(3) Service capability at traditional Chinese pharma companies will be greatly improved
5.5 Three outsourcing waves successively drive the future growth
5.5.1 First wave: Outsourcing by major pharma companies
5.5.2 Second wave (soon to come): Outsourcing by small biotech companies
5.5.3 Third wave (to come in near future): Outsourcing by domestic drug companies
1. More investment in R&D programs by Chinese pharma and biotech companies
2. A growing number of venture capitalists investing in R&D oriented Chinese pharma and biotech companies
3. Chinese government has pledged to increase R&D investment in its pharma industry
5.6 Forecast of Industry growth pattern
5.6.1 More competition
5.6.2 More consolidation
5.6.3 More large players resulting from alliance with MNCROs
5.6.4 More Chinese companies will use service from MNCROs
5.6.5 More Chinese CROs and CMOs will have overseas operations
5.6.6 More MNCROs/MNCMOs will greatly expand their service facilities in China
1. MNCROs/MNCMOs already in China would likely expand their facility and offer more services
2. More MNCROs will enter the Chinese market in near future
5.6.7 More Chinese CROs/CMOs will have internal drug R&D programs
5.7 Challenges to Chinese CROs and CMOs
5.7.1 Rising labor cost
5.7.2 Abiding by the international rule of game
5.7.3 Competition from CROs/CMOs in other countries

List of Tables

Table 1. Comparison of China’s technical workforce with other countries
Table 2. Comparison of labor cost in various locations of the world (FTE rate)
Table 3. China pharmaceutical market: Past development history and future development forecast
Table 4. Market growth history of China pharma outsourcing industry
Table 5. Current market size of target identification and validation
Table 6. Current market size of drug discovery service
Table 7. Current market size of preclinical research
Table 8. Current market size of clinical research
Table 9. Current market size of contract manufacturing service
Table 10. Market distribution of each service sector in entire China pharma outsourcing industry (2007 and 2008)
Table 11. CROs providing target identification and validation service
Table 12. CROs/CMOs providing focused compound libraries
Table 13. CROs providing lead discovery and optimization service
Table 14. CROs providing preclinical research service
Table 15. CROs providing clinical research service
Table 16. CROs providing regulatory service
Table 17. CROs/CMOs providing contract manufacturing service (including chemical process R&D)
Table 18. CROs/CMOs possessing FDA or EMEA certified cGMP production facility
Table 19. Chinese pharma companies involved in contract manufacturing service
Table 20. Major Chinese biotech companies and their capabilities
Table 21. Classification and definition of contract pharmaceutical research service levels and analysis of where the current service capabilities of China-based CROs/CMOs stand
Table 22. Comparison of a typical CRO in China, India and a Western country
Table 23. Market development forecast of China pharma outsourcing industry (2009 and 2010)
Table 24. Market development forecast of each service sector in and 2010
Table 25. Growth prediction of China’s CRO and CMO market in and 2010
Table 26. Comparison of market value between China and India in and 2010
Table 27. Forecast of labor cost climbing in China pharma outsourcing industry (FTE rate)
Table 28. Comparison of labor cost increase in countries around the world in next seven years (FTE rate)
Table 29. Comparison of cost saving (%) between China and other countries in 2010 and 2015
Table 30. Development history of WuXi PharmaTech and forecast of its future development
Table 31. Market growth forecast of China pharma outsourcing industry after 2010
Table 32. Market growth forecast of early stage drug discovery service after 2010
Table 33. Market growth forecast of preclinical research service after 2010
Table 34. Market growth forecast of clinical development service after 2010
Table 35. Market growth forecast of contract manufacturing service after 2010
Table 36. Foreign VCs having invested in Chinese pharma/biotech companies
Table 37. China-based CROs/CMOs with headquarters/offices in the West
Table 38. China-based CROs/CMOs founded by Western entrepreneurs

List of Figures

Figure 1. Development of Chinese pharmaceutical market: Past and future
Figure 2. Development of each drug market section
Figure 3. Chinese pharmaceutical market composition of 2008
Figure 4. Distributions of Chinese CROs/CMOs in each technical area
Figure 5. Profile of Suzhou Biobay
Figure 6. An overview of current situation of China pharma outsourcing industry
Figure 7. Market development of China pharma outsourcing industry
Figure 8. Value chain of drug discovery, development and manufacturing
Figure 9. 2008 Market share of each service sector
Figure 10. An overall picture of outsourcing activities in China
Figure 11. Summary of latest restructuring activities taken by biotech industry
Figure 12. Biotech industry under financial crisis
Figure 13. How outsourcing to China will be affected by financial crisis
Figure 14. Market value of each service sector in 2009 and 2010
Figure 15. China’s CRO and CMO market value in 2009 and 2010
Figure 16. Comparison of pharma outsourcing market size between China and India
Figure 17. Climbing of labor cost in China pharma outsourcing industry (between 2008 and 2015)
Figure 18. Comparison of labor cost increase in China with other countries (from 2008 to 2015)
Figure 19. Cost saving comparison (%) between China and other countries (in 2010 and 2015)
Figure 20. WuXi PharmaTech’s staff growth history and forecast
Figure 21. WuXi PharmaTech’s revenue growth history and forecast
Figure 22. Market development forecast of China pharma outsourcing industry after 2010
Figure 23. Market development forecast of early stage drug discovery service after 2010
Figure 24. Market development forecast of preclinical development service after 2010
Figure 25. Market development forecast of clinical development service after 2010
Figure 26. Market growth of China’s contract manufacturing service after 2010

List of Case Studies

Case study 1. Company profile of India’s Dr. Reddy’s Laboratories
Case study 2. Company profile of China’s Harbin Pharmaceutical Group
Case study 3. Pfizer in China ??Initially falling behind others but becoming more aggressive now
Case study 4. Sanofi Aventis (SA) in China ? Focusing on research
Case study 5. GlaxoSmithKline (GSK) in China ? Determined to turn “Made in China” to “Discovered in China”
Case study 6. Johnson & Johnson (J&J) in China ??Focusing on outsourcing
Case study 7. Roche in China ? Considering China as an important market for its future development
Case study 8. Novartis in China ? Having a long term plan to tap Chinese drug market
Case study 9. AstraZeneca (AZ) in China: Most active among all major pharma companies in China
Case study 10. Eli Lilly in China ??Taking different approaches than all other peer competitors
Case study 11. Wyeth in China ? Focusing on China’s nutri-ceutics market
Case study 12. Bayer in China ? Focusing on manufacturing and marketing drug products in China
Case study 13. LEAD Therapeutics with ShangPharma ? A risk-sharing model with Chinese CRO investing in client company
Case study 14. Curis with ChemPartner ? To stretch the dollar value of cash reserve by allocating part of drug R&D program to China
Case study 15. ChinaBio Therapeutics ? To leverage the full potential of China’s cost-effectiveness by operating entire drug R&D program in China
Case study 16. Ascenta Therapeutics in China ? Strategically positioning
Case study 17. GNI with Shanghai Genomics ? From partnership to acquisition
Case study 18. Bicoll in China ? From a technology developer to becoming a contract research service provider
Case study 19. Boehringer Ingelheim in China
Case study 20. Krka Pharmaceuticals and Menovo Pharmaceuticals ? Krka owning 7.5% stake in Menovo
Case study 21. Oxea with Chengxing Group ??Forming a JV
Case study 22. Hovione acquired 75% stake of Hisyn Pharmaceutical Co.
Case study 23. Actavis acquired 90% stake of Zhejiang Chiral Medicine Chemicals
Case study 24. Degussa in China
Case study 25. Lonza in China
Case study 26. Covance in China - Recently established a central lab in Shanghai
Case study 27. PPD in China
Case study 28. Quintiles Transnational in China
Case study 29. MDS Pharma Services in China ? Recently established a central Lab in Beijing
Case study 30. Charles River Laboratories in China: Acquired BioExplorer
Case study 31. MPI Research in China ??Forming a JV with Medicilon
Case study 32. Bridge Pharmaceuticals in China ? Established wholly owned animal testing facility in Beijing
Case study 33. Biomagnetics Diagnostics in China
Case study 34. Cordium Links in China ? Forming a JV for cardiac safety testing
Case study 35. AstraZeneca contracting out IP sensitive drug research to Chinese CRO
Case study 36. Promega Corporation outsourced IP sensitive research to China
Case study 37. Novartis is conducting first-class drug research in China
Case study 38. Chinese pharma companies following the international rules
Case study 39. Merger between two Chinese CROs
Case study 40. Development history of a typical Chinese CRO to demonstrate the development pattern of China pharma outsourcing industry
Case study 41. A foreign CRO’s development history to illustrate the possible Future development pattern of China’s outsourcing industry
Case study 42. Compound libraries enriched with protein kinase inhibitors
Case study 43. Fast growing Zhejiang Hisun Pharmaceutical Co. Ltd.
Case study 44. Fast rising Zhejiang Huahai Pharmaceutical Co. Ltd.
Case study 45. More China-based CROs/CMOs are preparing for cGMP certification by the FDA and/or the EMEA
Case study 46. Alliance between two China-based CROs
Case study 47. Alliance between a Chinese CRO and two foreign CROs
Case study 48. Alliance of 33 China-based CROs
Case study 49. Fast growing Shanghai Medicilon by partnering with MPI Research
Case study 50. Chinese CRO utilizing multinational CRO’s technologies
Case study 51. Global Research Services expanding in China
Case study 52. Latest entrance by Drug Information Association (DIA)

Company Index

Professional Chinese CROs and CMOs
Traditional Chinese pharmaceutical companies involved in outsourcing service
Chinese biotech companies involved in outsourcing service
Multinational service providers having service facilities in China
Chinese research institutions collaborating with Western pharma companies
Foreign drug companies outsourcing in China

Appendix

Appendix I. Research methodology
Appendix II. About JZMed, Inc.

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