 |
Printer Friendly
Printed from http://www.researchandmarkets.com/reports/687030
Brain Cancer Drug Pipeline Update 2009
|
Description: |
Despite the heavy investment made into brain cancer research, primary brain cancer, with glioblastoma multiforme being the most aggressive and most common form, remains one of the most deadly diseases in the developed world. While primary brain tumors are relatively rare, the chances of survival for patients with the disease are very low, even with the best treatment options currently available.
Datamonitor predicts that there will be around 26,000 new cases of glioblastoma multiforme diagnosed in the seven major markets (US, Japan, France, Germany, Italy, Spain and UK) in 2007. In the US alone, around 14,000 people will die from brain cancer in 2007.
There are today at least 145 therapeutics targeting brain cancer in active development, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 45 drugs. Brain Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 96 different targets. These targets are further categorized on the CD-ROM by 37 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Brain Cancer Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes 142 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 200 names
Developmental stage This Drug Pipeline Update contains 145 drugs in active development for the treatment of brain cancer:
#9 marketed drugs
#1 registered drug
#1 drug in pre-registration
#10 drugs in Phase III
#60 drugs in Phase II
#27 drugs in Phase I
#34 drugs in Preclinical
#3 drugs in other developmental stages
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included brain cancer drugs are also in development for over 120 other indications.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to more than 96 different targets, divided into 37 classifications of molecular function:
- Auxiliary transport protein activity
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Complement activity
- Cysteine-type peptidase activity
- Cytokine activity
- DNA repair protein
- DNA topoisomerase activity
- DNA-directed DNA polymerase activity
- Extracellular ligand-gated ion channel activity
- G-protein coupled receptor activity
- Growth factor activity
- Ion channel activity
- Kinase activity
- Ligand-dependent nuclear receptor activity
- Ligase activity
- Lipid kinase activity
- Lipid phosphatase activity
- Molecular function unknown
- Oxidoreductase activity
- Peptidase activity
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling protein serine/threonine kinase activity
- Receptor signaling protein tyrosine phosphatase activity
- Structural constituent of cytoskeleton
- Sugar-phosphatase activity
- Transcription factor activity
- Transcription regulator activity
- Transferase activity
- Translation regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
Identified targets are categorized into 12 different primary and alternate sub-cellular localizations:
- Cell surface
- Clathrin-coated vesicle
- Cytoplasm
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Lysosome
- Mitochondrion
- Nucleolus
- Nucleus
- Plasma membrane
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to 118 protein expression profiles of 72 drug targets in various human tissues and cancer types, cell lines and primary cells, includin up to
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta 193 Pathways
- KEGG 57 Pathways
- NetPath 17 Signaling Pathways
Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism In total there are 118 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Investigator & Partners
Presentation of principal investigator and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
- Direct links to company web pages of principal investigators
Export and sharing of information
- Found information is easily shared with others over e-mail, file export (xls) or in print
System Requirements - AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP/VISTA
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Internet access (for related internet resources) |
|
Ordering: |
Order Online - visit http://www.researchandmarkets.com/reports/687030
Order by Fax - using the order form below
Order By Post - print the order form below and send to
|
|
Research and Markets,
Guinness Centre,
Taylors Lane,
Dublin 8,
Ireland.
|
|
|
 |
Page 1 of 2
Printed 27/11/2009 12:01:10 |
|
Fax Order Form
To place an order via fax simply print this form, fill in the information below and
fax the completed form to
646-607-1907 (from USA) or +353 1 6849977 (from Rest of World). If you have any questions please email help@researchandmarkets.net
Order information
Please verify that the product information is correct and select the format you require.
|
|
|
|
Product Name: |
Brain Cancer Drug Pipeline Update 2009
|
|
Web Address: |
http://www.researchandmarkets.com/reports/687030
|
|
Office Code: |
|
OC8HJNPOUMUXU
|
Report formats
Please enter the quantity of the report format you require.
|
|
Format
|
Quantity
|
Price
|
|
CD ROM
|
|
€1,499.00 + EUR€ 50.00 Shipping/Handling *
|
* Shipping/Handling is only charged once per order.
Contact information
Please enter all the information below in BLOCK CAPITALS.
|
|
|
First Name: |
Last Name: |
|
Email Address: |
|
|
Job Title: |
|
|
Organisation: |
|
|
Address: |
|
|
City: |
|
|
Postal/Zip Code: |
|
|
Country: |
|
|
Phone Number: |
|
|
Fax Number: |
|
|
Please fax this form to:
(646) 607-1907 or (646) 964-6609 (from USA)
+353-1-481-1716 or +353-1-653-1571 (from Rest of World)
|
|
Page 2 of 2
Printed 27/11/2009 12:01:10
|
|
Payment information
Please indicate the payment method you would like to use by selecting the appropriate
box.
|
|
|
|
|
American Express
|
|
|
Diners Club
|
|
|
Master Card
|
|
|
Visa
|
|
|
|
|
|
|
Cardholder's Name: |
|
|
|
|
Cardholder's Signature: |
|
|
|
|
Expiry Date: |
/ |
|
|
|
Card Number: |
|
|
|
|
CVV Security Code: |
|
|
|
|
Issue Date: |
/ (Diners
Club only)
|
|
|
|
|
|
|
Please post the check, accompanied by this form, to:
Research and Markets,
Guinness Centre,
Taylors Lane,
Dublin 8,
Ireland.
|
|
|
|
|
|
|
Please transfer funds to:
|
|
|
Account number: |
83313083 |
|
Sort code: |
98-53-30 |
|
Swift code: |
ULSBIE2D |
|
IBAN number: |
IE78ULSB98533083313083 |
|
Bank Address: |
Ulster Bank,
27-35 Main St,
Blackrock,
Co. Dublin,
Ireland. |
|
|
|
If you have a Marketing Code please enter it below:
|
|
|
Marketing Code: |
|
|
Please note that by ordering from Research and Markets you are agreeing to our Terms and Conditions at http://www.researchandmarkets.com/info/terms.asp
|
|
Please fax this form to:
(646) 607-1907 or (646) 964-6609 (from USA)
+353-1-481-1716 or +353-1-653-1571 (from Rest of World)
|
|
|
|
|
|
