Contents:

1. PART 1 INTRODUCTION 2. PART 2 BIOMATERIALS 3. PART 3 CLINICAL APPLICATIONS PART 1 INTRODUCTION The challenges of bone repair J A Planell and M. Navarro, Institute for Bioengineering of Catalonia, Spain - Introduction. - Social impact of musculoskeletal disease. - Economic burden of musculoskeletal disease. - Social aspects of dental and maxillofacial conditions. - Some clinical challenges of bone repair. - Conclusions and future trends. - Sources of further information and advice. - References. Bone anatomy, physiology and adaptation to mechanical loading R K Fuchs and S J Warden, Indiana University and C H Turner, IUPUI, USA - Introduction. - Macroscopic bone anatomy. - Microscopic bone anatomy. - Bone physiology. - Bone adaptation to mechanical loading. - Conclusions. - References. Bone repair and regeneration N Baldini, E Cenni, G Ciapetti, D Granchi and L Savarino, Istituto Ortopedico Rizzoli, Italy - Introduction. - Bone healing. - Role of stem cells in bone repair. - Molecular events of bone repair and regeneration. - Role of growth factors in bone repair and regeneration. - References. Biomechanical aspects of bone repair D Lacroix, Institute for Bioengineering of Catalonia, Spain - Bone composition and structure. - Biomechanical properties of bone. - Bone damage and repair. - Conclusions. - References. PART 2 BIOMATERIALS Characterising and improving the properties of bone repair materials A A White and S M Best, University of Cambridge, UK - Introduction. - Mechanical properties. - Molecular and microstructural properties. - Physiological effects. - Comparing material classes. - Summary. - References. Metals as bone repair materials J L González-Carrasco, Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC) and CIBER-BBN, Spain - Introduction. - Common metallic biomaterials. - Other metallic materials. - Properties. - Trends in the development of metallic biomaterials. - Conclusions. - References. Ceramics as bone repair materials M Vallet-Regi and A J Salinas, Departamento de Química Inorgánica y Bioinorgánica (U.C.M.), Spain - Overview of ceramics in biomedical engineering. - Almost bioinert ceramics: first generation bioceramics. - Biodegradable and bioactive ceramics: second generation bioceramics. - Ceramics in bone regeneration: third generation ceramics. - Bioceramics today. - Acknowledgments. - References. Polymers for bone repair M A Mateos-Timoneda, Institute for Bioengineering of Catalonia, Spain - Introduction. - Ultra high molecular weight polyethylene (UHMWPE). - Acrylic polymers as bone cement. - Biodegradable polymers. - Conclusions. - References. Composite biomaterials for bone repair R De Santis, V Guarino and L Ambrosio, IMCB-CNR Institute for Composite and Biomedical Materials - National Research Council, Italy - Introduction. - Basic concept of composite material. - Composite biomaterials in bone repair. - Not degradable composites. - Biodegradable composites. - References. Cements as bone repair materials M P Ginebra, Technical University of Catalonia, Spain - Definition and advantages of bone cements in orthopaedic surgery. - Calcium phosphate versus acrylic bone cements: historical perspective and present applications. - Acrylic bone cements (ABCs). - Calcium phosphate bone cements (CPCs). - References. Bioactive polymer coatings to improve bone repair G Helary and V Migonney, Institut Galilée, France - Introduction: concept of biocompatibility of biomaterials for bone repair. - Bioactive materials for bone repair. - Need for bone integration and repair biomaterials. - Available and new materials. - Bioactive polymer approach. - New approach: grafting bioactive polymers onto titanium implants. - Conclusions. References. Long-term performance and failure of orthopaedic devices D Taylor, Trinity College Dublin, Ireland - Introduction. - Long-term failure modes. - Stress analysis, simulations and other design methodologies. - Case study 1: fatigue design in the artificial hip joint. - Case study 2: wear in ultra-high molecular weight polyethylene. - Conclusions and future trends. - References PART 3 CLINICAL APPLICATIONS Using bone repair materials in orthopaedic surgery A Merolli, The Catholic University in Rome and P Tranquilli-Leali, University of Sassari, Italy - Introduction. - Operative techniques. - Materials. - Devices. - Conclusions. - References. Bone tissue engineering M Santin, University of Brighton, UK - Introduction. - State of the art of biomaterials for bone tissue engineering. - Cells for bone tissue engineering. - Bioactive molecules for tissue engineering. - Scaffolds for bone repair. - Bioreactors. - Clinical applications. - Conclusions. - References. Retrieval and analysis of orthopaedic implants A Palmquist, P Thomsen and R Brånemark, Sahlgrenska Academy at University of Gothenburg, H Engqvist, Uppsala University and J Lausmaa, SP Technical Research Institute of Sweden, Sweden - Introduction. - Retrieval. - Tissue preservation. - Analysis. - Examples of results. - Acknowledgements. - References. Ethical issues in bone repair and bone tissue engineering L Trommelmans, J Selling and K. Dierickx, Katholieke Universiteit Leuven, Belgium - Introduction: the ethical analysis of bone repair. - Cells in bone tissue engineered products (BTEPs). - Clinical trials with bone tissue engineered products. - Informed consent in clinical trials. - Follow-up of trial participants. - Access to therapy. - Conclusion. - References.

Author

Professor Josep A. Planell and Professor Damien Lacroix are highly regarded for their biomedical research at Universitat Politècnica de Catalunya, Spain. Dr. Serena Best is Reader in Ceramics and Medical Materials at the University of Cambridge, UK. Dr. Antonio Merolli is Orthopaedic Surgeon at the Università Cattolica del Sacro Cuore, Rome, Italy and has worked extensively on in-vivo testing of biomaterials for bone repair.