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DATAMONITOR HEALTHCARE CONTACT DETAILS EXECUTIVE SUMMARY Scope Datamonitor insight into the narcolepsy market Provigil has established itself as the leading drug in the narcolepsy market remarkably rapidly. This is due to its proven efficacy in treating daytime sleepiness and its improved side effect profile and reduced abuse potential compared to the older treatments. Xyrem (sodium oxybate) is expected to achieve similar success to modafinil when it is approved for treating cataplexy related to narcolepsy. Since Xyrem and modafinil will initially be indicated for different symptoms of narcolepsy, they are unlikely to be in direct competition at first. Despite the strength of Provigil and Xyrem, there are some unmet needs in the treatment of narcolepsy which may provide opportunities for new drugs to enter the market in the future. Summary Key metrics TABLE OF CONTENTS NARCOLEPSY OVERVIEW Etiology Symptomology Causes Epidemiology Prevalence Diagnosis and treatment rates Summary Diagnosis of narcolepsy Diagnostic criteria Treatment Treatment aims Treatment guidelines NARCOLEPSY MARKET ANALYSIS Narcolepsy drug profiles Provigil (modafinil) CNS stimulants Pemoline Selegiline Antidepressants US market Assumptions and sources Compliance rates Cost of treatment Market breakdown European market Assumptions and sources Compliance rates Cost of treatment Market breakdown Japanese market Assumptions and sources Compliance rates Cost of treatment Market breakdown Summary THE FUTURE DECODED Introduction Epidemiology forecasts to 2008 Prevalence Treated population Pipeline analysis Xyrem (sodium oxybate) CEE 03-310 SWOT analysis Provigil Xyrem CNS stimulants Antidepressants Market drivers US forecasts to 2008 Market in 2004 Market in 2008 Summary European forecasts to 2008 Market in 2004 Market in 2008 Summary Japanese forecasts to 2008 Market in 2004 Market in 2008 Summary Summary APPENDIX Datamonitor's Central Nervous System Business Unit Table of tables Etiology Epidemiology Diagnosis, treatment and compliance Clinical trial data R&D research methodology Introduction Hypothesis formulation Hypothesis testing Data verification and quality control Pricing data Introduction Source prices Ex-manufacturer, wholesaler and retail prices Data validation and margin calculation Quality control Patent data