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Drugs of Tomorrow 2001: Bacterial Infections


Description: Bacteria are small single-celled micro-organisms that vary greatly in structure and function. Bacteria have the ability to mutate quickly, due to their rapid reproducibility, forming new subtypes. A major problem caused by bacterial mutation is the development of resistance to antibiotics. The antibacterial market is mature with strong generic competition but continues to grow due to the introduction of innovative products. This report investigates the future antibacterial market. Classes included are: the penicillins, cephalosporins, fluoroquinolones, macrolides, carbapenems, aminoglycosides, tetracyclines and an ‘others’ group containing products which do not fall within these pharmacological categories.


Contents: EXECUTIVE SUMMARY


1.1 Scope


1.2 Datamonitor insight into the antibacterial market


TABLE OF CONTENTS


PATIENT POTENTIAL



Definition of Disease


Future Trends in Disease Incidence


Segmentation of Bacterial Infections


Diagnosis, treatment and compliance rates



Unmet needs in the antibacterial market


Hospital Unmet Needs


Community unmet needs


R&D APPROACH



Classification of pipeline products



Definition of current 'gold standard' /comparator therapy (s)



Clinical Trial Endpoints


End-point one - Clinical cure


End-point two - Microbiological erradication


End-point three - Duration of overall treatment


End-point four - Rate of recurrence


Clinical Trial Structure


Study size


Comparator arm


Dosage regimens


OVERVIEW OF ANTIBACTERIAL PIPELINE



Pipeline overview


Key drug delivery strategies in antibacterials



Pipeline analysis by class



Pipeline analysis by licensing opportunity


LATE STAGE DRUG ANALYSIS



Comparison of Key Antibacterials


Comparison of Unmet Need


Marketing strength



Cidecin


Ramoplanin





Dalbavancin (BI-397)


Ortivancin (LY-333328)



Ketolides Class Profile


Ketek (telithromycin)


ABT-773



Quinolone Class Analysis


Factive (gemifloxacin)


Pazucross/Pasil (pazufloxacin)



Quisnon (prulifloxacin)





Sitafloxacin (DU-6859a)


BMS-284756 (T-3811)


DW 116






Carbapenem Class Overview


Faropenem


S-4661



CS-834






Tetracyclines


Tigicycline (GAR-936)


Cephalosporins class overview


Spectracef (cefditoren)


S-1090 (cefmatilen)






Comparative analysis of pipeline by classes


INNOVATIVE EARLY STAGE COMPOUNDS SHOWING BLOCKBUSTER POTENTIAL


Preclinical pipeline






THE FUTURE DECODED



Methodology


Predicting initial market share


Forecasting future growth


Influencing factors


Major factors affecting the antibiotic market 2001-2008






Key R&D product forecasts


Ketek



ABT-773


Spectracef


Farom


Invanz


S-4661


CS-834


BMS-284756


Factive


Cidecin






Alternative scenarios


Possible/Negative influences on the antibiotic market






APPEANDIX


Datamonitor's Infectious Diseases Business Unit


Contributing experts


Table of tables


R&D research methodology


Introduction


Hypothesis formulation


Hypothesis testing


Data verification and quality control


APPENDIX II: METHODOLOGY


Forecasting methodology


Forecasting drug launches for drugs in development in the dyslipidemia area


Global highest stage of development


Reclassification of development phases


Probability of a product progressing to launch


Primary delivery classifications




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