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EXECUTIVE SUMMARY OVERVIEW Wound Care Products Advanced Wound Care Products Fig.1: Percentage of the Professional Wound Care Market by Product, Complex Wounds: The Role of Advanced Wound Care Diabetic Ulcers Pressure Ulcers Venous Stasis Ulcers ADVANCED WOUND CARE MARKET COMPETITORS Select Manufacturers’ Wound Care Sales, 2003-2008 (US$ million) Companies’ Wound Care Sales Growth, 2007-2008 (US$ million unless stated) Fig.2: Advanced Wound Care Market Shares, ADVANCED WOUND CARE MARKET DYNAMICS Professional Wound Care Market by Product, 2007-2013 (US$ million) Global Wound Care Market Growth by Product, 2008-2013 (%) Regional Perspective Advanced Wound Care Market by Region, 2007-2013 (US$ million) Advanced Wound Care Market Growth by Region, 2007-2013 (%) Fig.3: Advanced Wound Care Market by Region, Changing Industry Landscape Advanced Wound Care Acquisitions, 2007-2013 ADVANCED WOUND CARE PRODUCTS & TECHNOLOGIES Fig.4: Advanced Wound Care Market by Product Type, Fig.5: Advanced Wound Care Market by Product Type, DEVICE-BASED WOUND CARE Negative Pressure Wound Therapy Fig.6: NPWT Market, 2006-2013 (US$ million) Kinetic Concepts’ V.A.C. Therapy ABThera Open Abdomen NPWT System V.A.C. Clinical Studies Future Developments and Market Expansion Smith & Nephew NPWT Systems Boehringer Technologies’ Engenex NPWT System Genadyne Biotechnologies’ A4 NPWT System Getinge’s WoundASSIST TNP System Innovative Therapeutics’ Svedman and Sved Systems Kalypto Medical’s NPD 1000 System Medela’s Invia NPWT Systems Premco Medical Systems’ Prodigy NPWT Systems Prospera’s PRO NPWT Systems Talley Group’s Venturi Systems Electrical Stimulation Biofisica’s POSiFECT Bio-Electric Stimulation Therapy Ivivi Technologies’ Targeted Pulsed Electromagnetic Field Therapy Synapse Microcurrent Vomaris’ PROCELLERA Ultrasound Arobella Medical’s Qoustic Wound Therapy System Celleration’s MIST Therapy System HeaLFUS’ CaviClean Misonix’ SonicOne Ultrasonic Wound Debridement System NanoVibronix’ PainShield Söring’s Sonoca Systems Extracorporeal Shock Wave Therapy SANUWAVE’s dermaPACE Tissue Regeneration Technologies’ DermaGold Regenesis Biomedical’s Provant Wound Therapy System SanoMed’s Photizo Light Therapy Vibrant Medical Vibration Therapy MOIST WOUND CARE PRODUCTS Fig.7: Moist Wound Care Market, 2007-2013 (US$ million) Moist Wound Care Market, 2007-2013 (US$ million) Moist Wound Care Market Growth, 2008-2013 (%) Hydrogels Key Hydrogel Products and Manufacturers New Hydrogel Technologies AGT Sciences’ Hydrogel Technology BioCure’s GelSpray First Water’s Pro-ionic Gel Dressings Nanotherapeutics NanoDOX 1% Doxycycline Monohydrate Hydrogel Oculus Innovative Sciences’ Microcyn Hydrogel ULURU’s Nanoflex Technology Hydrocolloid Dressings Key Hydrocolloid Products and Manufacturers New Hydrocolloid Technologies First Water’s Pro-ionic Hydrocolloid Dressings Alginates Key Alginate Products and Manufacturers Foam Dressings Key Foam Products and Manufacturers New Foam Technologies Coloplast’s Biatain ConvaTec’s Versiva XC Gelling Foam Dressings First Water’s Pro-ionic Foam Dressings Smith & Nephew’s Allevyn Dressings Composite Dressings Key Composite Products and Manufacturers 3M Tegaderm Matrix Dressing with PHI technology Archimed’s Oxyzyme ConvaTec’s AQUACEL Hydrofiber Dressings Derma Sciences’ XTRASORB Super Absorbent Dressing First Water’s Pro-ionic Matrix Activated Charcoal Dressings Key Charcoal Products and Manufacturers Transparent Film Dressings Key Transparent Film Products and Manufacturers New Transparent Film Technologies First Water’s Pro-ionic Film Antimicrobial Dressings Fig.8: Antimicrobial Dressings Market, 2007-2013 (US$ million) Silver Dressings Key Silver Products and Manufacturers Argentum Medical’s Silverlon AcryMed’s SilvaSorb ConvaTec’s AQUACEL Ag Medline’s Silver Antimicrobial Dressings Smith & Nephew’s Acticoat Dressings Smith & Nephew’s Algisite Ag, Allevyn Ag and Biostep Ag Systagenix Wound Management’s Silvercel and Actisorb Silver 220 URGO’s UrgoCell Silver New Silver Technologies Honey Dressings Advancis Medical’s Activon Comvita’s Medihoney Sanoskin’s SanoSkin-Melladerm Triticum’s L-Mesitran Range Other Antimicrobial Dressings Iodine-based Dressings PHMB Antimicrobial Dressings 3M’s Tegaderm CHG Derma Sciences’ Dermagran Healthpoint Hydrofera Blue Innocoll’s CollaRx Gentamicin Oculus Innovative Sciences’ Microcyn Technology Quick-Med Technologies’ NIMBUS BIOLOGICS AND PHARMACEUTICALS Fig.9: Wound Care Biologics Market, 2007-2013 (US$ million) Collagen-Based Wound Care Products Argentum Medical’s BIOPAD BioCore Medical Technologies’ Kollagen Collagen Matrix’ Matrix Collagen Dressing Covalon Technologies’ Biostep and ColActive Dr Suwelack Skin & Health Care’s Puracol Plus Eucare Pharmaceuticals Innocoll’s CollaRx Technology Lescarden’s Catrix Wound Dressing Pegasus Biologics’ Unite Biomatrix Systagenix Wound Management’s Collagen-Based Dressings Wound Management Technologies’ CellerateRx Products in Development Covalon Technologies Dr Suwelack Skin & Health Care’s SHC-Matrix Innocoll’s Collieva Ag, DermaSIL and CollaRx Lidocaine Sponge FibroGen’s Synthetic Collagen Skin Substitutes ACell/Medline’s MatriStem Extracellular Matrix Wound Sheet Advanced BioHealing’s Dermagraft Avita Medical’s ReCell Cook Biotech’s Oasis Wound Matrix Dr Suwelack Skin & Health Care’s Matriderm Fidia Advanced Biopolymers’ HYAFF Genzyme’s Epicel Cultured Epidermal Autografts Integra LifeSciences’ Collagen-Glycosaminoglycan Matrix LifeCell’s AlloDerm Medestea Internazionale’s Veloderm Mölnlycke’s Xelma Organogenesis’ Apligraf Promethean LifeSciences’ GammaGraft Tissue Genesis’ Cell Isolation System UDL Laboratories/S&N’s Biobrane LifeCell/Wright Medical Group’s Graftjacket and Osteoset York Pharma’s MySkin and CryoSkin Products in Development Forticell Bioscience’s OrCel Intercytex’ ICX-SKN Organogenesis US Armed Forces Institute of Regenerative Medicine York Pharma’s Lyphoderm Growth Factors Recombinant Growth Factors Products in Development Plasma-Derived Growth Factors Cytomedix’ AutoloGel System SafeBlood Technologies’ Autologous Platelet Grafting System Enzymatic Debriding Agents Healthpoint’s Collagenase Santyl Ointment Products in Development Maggot Enzyme-based Dressing Project Mediwound’s Debrase Gel Dressing Novel Biologic and Pharmaceutical Products in Development Agennix' Talactoferrin Biotec Pharmacon’s SBG Compound Brennen Medical’s Oat Beta-Glucan Covalon Technologies’ EPAS-1 Project Derma Sciences’ DSC HealOr’s Protein Kinase C-Based Therapeutics ImmuneRegen BioSciences’ Homspera Polyheal’s Microsphere-Based Technology RegeneRx’ RGN- RGN-137 for Pressure Ulcers RGN-137 for Venous Stasis Ulcers RGN-137 for Epidermolysis Bullosa (EB) TGR BioSciences’ Tissue Regeneration Technologies OTHER PRODUCTS Oxygen Dressings AcryMed’s Oxygenated Dressing Archimed’s Oxyzyme Oxygen Biotherapeutics’ Oxybiocyte Sangui BioTech’s HEMO2SPRAY Chitosan Dressings BioSyntech’s BST-DermOn HemCon Medical Technologies Sangui BioTech’s Chitoskin MANUFACTURERS THE MARKET LEADERS 3M Recent Key Events Current Alliances Becton Dickinson Kinetic Concepts Greystone Pharmaceuticals Financial Performance 3M Health Care - Operating Results, 2005-2008 (US$ million) Fig.10: 3M Health Care - Revenue by Business Unit, 2008 Fig.11: 3M Health Care - Revenue by Region, 2008 Latest Results and Outlook Coloplast Current Alliances Smith & Nephew Johnson & Johnson Financial Performance Coloplast - Operating Results, 2004-2008 (DKr million) Revenue by Product Line, 2007-2008 (DKr million) Fig.12: Coloplast: Percentage of Revenue by Product Line, 2008 Fig.13: Coloplast - Wound & Skin Care Revenue, 2003-2008 (DKr million) Latest Results Outlook ConvaTec Recent Key Events Current Alliances Boehringer Technologies HemCon Medical Technologies Financial Performance ConvaTec - Operating Results, 2006-2008 (US$ million) ConavTec - Revenue by Product Line, 2002-2007 (US$ million) ConvaTec Wound Therapeutics Sales by Region, 2003-2007 (US$ million) Unomedical’s Results Unomedical - Operating Results, 2003-2007 (DKr million) Covidien Financial Performance Covidien - Operating Results, 2004-2008 (US$ million) Fig.14: Covidien - Revenue by Division, 2008 Hartmann Group Current Alliances Indian Apollo Hospital Group and the West China Hospital Kinetic Concepts Financial Performance Hartmann - Operating Results, 2004-2008 (EUR million) Hartmann Wound Management Results, 2007-2008 (EUR million) Fig.15: Hartmann - Revenue by Division, 2008 Latest Results and Outlook Kinetic Concepts Recent Key Events Current Alliances 3M Avail Medical Products NovaBay Pharmaceuticals Hartmann Wake Forest University GPO Contracts and US Customers Litigation Smith & Nephew Medela Innovative Therapies Mölnlycke Health Care Boehringer Technologies and ConvaTec Financial Performance KCI - Operating Results, 2004-2008 (US$ million) KCI - Revenue by Product Type, 2004-2008 (US$ million) KCI - V.A.C. Revenue, 2004-2008 (US$ million) KCI - V.A.C. Revenue by Region, 2006-2008 (US$ million) Fig.16: KCI- Percentage of V.A.C. Revenue by Region, 2008 Fig.17: KCI- Percentage of V.A.C. Revenue by Type, 2008 Latest Results Outlook Medline Industries Current Alliances ACell Avery Dennison Medical AcryMed Lohmann & Rauscher Dr Suwelack Skin & Health Care GPO Contracts Mölnlycke Health Care Current Alliances University of Nottingham and AGT Sciences Litigation Kinetic Concepts Financial Performance Mölnlycke - Operating Results, 2006-2008 (EUR million) Smith & Nephew Recent Key Events Current Alliances Coloplast Apria Healthcare Group Universal Hospital Services Covalon Technologies UDL Laboratories Movianto Deutschland Lescarden/Valeant Pharmaceuticals Derma Sciences Nucryst Pharmaceuticals Litigation with Kinetic Concepts Financial Performance S&N - Operating Results, 2004-2007 (US$ million) S&N Advanced Wound Care Results, 2004-2008 (US$ million) Fig.18: S&N Advanced Wound Care Sales by Region, 2008 Latest Results Systagenix Wound Management Other Companies ACell AcryMed Financial Performance I-Flow Operating Results by Segment, 2008 (US$ thousand) Fig.19: I-Flow - Revenue by Segment, 2008 Advanced BioHealing Advanced Medical Solutions Current Agreements Systagenix B. Braun Financial Performance AMS Advanced Wound Care Division - Operating Results, 2005-2008 (£ thousand) Fig.20: AMS - Revenue by Division, 2008 Advancis Medical Advitech Financial Performance Agennix AGT Sciences R&D Projects Diagnostic Dressings Antibacterial Dressings Maggot Enzyme-based Dressing Archimed Argentum Medical Ark Therapeutics Current Agreements Darco GmbH & Co Flen Pharma Runfold Medical Ltd Sino Tau International Company Ltd Financial Performance Ark Therapeutics - Operating Results, 2004-2008 (£ thousand) Arobella Medical Aspen Surgical Products Avita Medical Financial Performance Avita Medical/C3 - Operating Results, 2006-2008 (A$ thousand) Avita Medical/C3 - Regenerative Medicine Results, 2074-2008 (A$ thousand) Latest Results B. Braun Financial Performance B Braun - Operating Results, 2004-2008 (EUR million) Fig.21: B Braun - Revenue by Division, 2008 BioCore Medical Technologies BioCure BioElectronics Biofisica BioSyntech BioSyntech - Operating Results, 2005-2008 (C$) Biotec Pharmacon Financial Performance Biotec Pharmacon - Operating Results, 2007-2008 (NKr million) Boehringer Laboratories Brennen Medical Care-Tech Laboratories Celleration Collagen Matrix Comvita Financial Performance Comvita - Operating Results, 2003-2008 (NZ$ million) Fig.22: Comvita - Revenue by Division, 2008 Latest Results and Outlook Concept Health/Gentell Covalon Technologies Recent Key Events Financial Performance Covalon Technologies - Operating Results, 2005-2008 (C$ million) Covalon - Revenue by Product Line, 2006-2008 (C$ thousand) Latest Results Cytomedix Financial Performance Cytomedix - Operating Results, 2004-2008 (US$ thousand) DermaRite Industries Derma Sciences Recent Key Events Financial Performance Derma Sciences - Operating Results, 2005-2008 (US$ million) Derma Sciences – Wound Care Division Results, 2006-2008 (US$ million) Fig.23: Derma Sciences - Revenue by Division, 2008 Fig.24: Derma Sciences - Revenue by Region, 2008 Latest Results DeRoyal Diapulse Corporation of America Dr Suwelack Skin & Health Care Eucare Pharmaceuticals Ferris FibroGen Fidia Advanced Biopolymers First Water Forticell Bioscience Bankruptcy and Future Funding Current Alliances Lonza Walkersville ES Cell International Pte Ltd Teva Pharmaceutical Industries Genadyne Biotechnologies Genzyme Biosurgery Getinge Greystone Pharmaceuticals HealOr HeaLFUS Healthpoint Helix Biomedix HemCon Medical Technologies Recent Key Events Current Alliances IT/Sligo Sangui BioTech Nanopeutics Joint Venture ConvaTec Hollister Wound Care Hydrofera Innocoll and CollMED Laboratories Innovative Therapies Integra LifeSciences Holdings Integra LifeSciences - Operating Results, 2004-2008 (US$ million) Intercytex US Armed Forces Institute of Regenerative Medicine IR BioSciences (ImmuneRegen BioSciences) Research Alliances Financial Performance Ivivi Technologies Recent Key Events Current Wound Care Alliances RecoverCare Regency Hospital Company Indiana State University Termination of Agreement - DSI Renal ADM Tronics Unlimited Financial Performance Ivivi Technologies - Operating Results, 2006-2008 (US$ thousand) Latest Results IYIA Technologies Kalypto Medical Kikgel Kuros Laboratoires Brothier Lescarden Lescarden - Operating Results, 2004-2008 (US$ thousand) Lohmann & Rauscher Medela Medestea Internazionale MediWound Milliken Chemical Misonix Nanotherapeutics NanoVibronix Noble Biomaterials Nucryst Pharmaceuticals Alliance with Smith & Nephew Financial Performance Nucryst Pharmaceuticals - Operating Results, 2004-2008 (US$ million) Latest Results Oculus Innovative Sciences Financial Performance Oculus - Operating Results, 2004-2008 (US$ thousand) Oculus - Product Sales by Region, 2007-2008 (US$ thousand) Latest Results and Outlook Organogenesis Armed Forces Institute of Regenerative Medicine Oxygen Biotherapeutics Pegasus Biologics Polyheal Premco Medical Systems Promethean LifeSciences Prospera Quick-Med Technologies Licensing and Development Agreements Financial Performance Quick-Med Technologies - Operating Results, 2004-2008 (US$ thousand) Latest Results RegeneRx Biopharmaceuticals Financial Performance RegeneRx - Operating Results, 2004-2008 (US$ million) Latest Results Regenesis Biomedical SafeBlood Technologies Sangui BioTech International Financial Performance Sangui BioTech - Operating Results, 2004-2008 (US$ thousand) SanoMed Manufacturing SANUWAVE Söring Southwest Technologies Synapse Microcurrent Talley Group TGR BioSciences Tissue Genesis Tissue Regeneration Technologies Triticum UDL Laboratories ULURU York Pharma Acquisition Agreement Financial Performance ULURU - Operating Results, 2006-2008 (US$ million) Latest Results URGO Current Alliances Advitech Financial Performance URGO - Operating Results, 2005-2008 (US$ million) Vibrant Medical Vomaris Wound Management Technologies Financial Performance Wound Management Technologies - Operating Results, 2004-2008 (US$ thousand) Latest Results York Pharma ZooBiotic APPENDICES: APPENDIX 1 - LIST OF ABBREVIATIONS APPENDIX 2 - REPORT METHODOLOGY Secondary Sources Primary Sources Market forecasts

Companies Mentioned

Just Some of the 115 Companies Profiled: - 3M - Coloplast - ConvaTec - Covidien - Hartmann Group - Kinetic Concepts - Medline Industries - Mölnlycke Health Care - Smith & Nephew - Systagenix Wound Management - ACell - Advitech - Agennix - AGT Sciences - Archimed - Argentum Medical - Aspen Surgical Products - Avita Medical - B. Braun - BioElectronics - Biotec Pharmacon - Boehringer Laboratories - Care-Tech Laboratories - Celleration - Collagen Matrix - Comvita - Cytomedix - DermaRite Industries - DeRoyal - Dr Suwelack Skin & Health Care - Ferris - FibroGen - Fidia Advanced Biopolymers - First Water - Forticell Bioscience - Genadyne Biotechnologies - Genzyme Biosurgery - Getinge - Healthpoint - HemCon Medical Technologies - Hollister Wound Care - Hydrofera - Innocoll and CollMED Laboratories - Innovative Therapies - Integra LifeSciences Holdings - Intercytex - Ivivi Technologies - IYIA Technologies - Kalypto Medical - Kikgel - Medestea Internazionale - MediWound - Nucryst Pharmaceuticals - Oculus Innovative Sciences - Organogenesis - Oxygen Biotherapeutics - Pegasus Biologics - Polyheal - Premco Medical Systems - Quick-Med Technologies - RegeneRx Biopharmaceuticals - Regenesis Biomedical - SanoMed Manufacturing - SANUWAVE - Söring - Southwest Technologies - TGR BioSciences - Tissue Genesis - Tissue Regeneration Technologies - ULURU - URGO - Vibrant Medical - Vomaris - York Pharma - ZooBiotic