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Drug Transporters and ADME: Pharmacological and Commercial Implications
Drug and Market Development Publishing, Jan 2004
Drug transporters are key factors in absorption, distribution, metabolism, and excretion (ADME) of many new medicines. ADME models are increasingly influential in determining whether a New Chemical Entity (NCE) or biopharmaceutical should advance through R&D. Over the last 15 years, a heterogeneous group of proteins, collectively known as drug transporters, emerged as critical determinants of ADME for many drugs. Understanding drug transporters is critical to the analysis of a drug's pharmacokinetics and pharmacodynamics. Integrating an analysis of drug transporters is now a core competency in ADME assessments.
The scope of this report:
This Drug Transporters and ADME Report delineates some issues facing companies attempting to integrate the role of drug transporters in pharmacokinetics and pharmacodynamic assessment. The Report highlights strengths and weakness of the current means for assessing drug transporters and those areas where more research is needed. In addition, this Report summarizes the approaches companies are taking in order to better understand the role of drug transporters in ADME and provides in-depth interviews with several world-leading experts drawn from industry and academia.
Market Opportunities:
- Create targeted drug therapies through knowledge of the pharmacogenomic outcomes.
- Improve tolerability of a drug with an increased awareness of the factors leading to drug-drug interactions and adverse events.
- Overcome issues of increasing interest to regulatory authorities, such as gender differences in outcomes and adverse events.
- Appreciate and quantify the role drug transporters play in determining elimination could aid the design of drugs with optimal pharmacokinetic characteristics.
- Improve the R&D return on investment with an understanding of how drug transporters affect ADME.
- Promote drug delivery by clearly understanding the effects of drug transporters.
Key Reasons to Buy this report:
- Realize the significance drug transporters have on ADME via a in-depth analysis of their potential impact on and technological issues with ADME assessments.
- Discover the commercial applications of drug transporters from an assessment of their promise as therapeutic targets and determinants of ADME.
- Learn about the clinical and therapeutic importance of drug transporters through an examination of several impacted diseases, including cancer, HIV, dyslipidaemia, and more.
- Understand why considering drug transporters are a core competency for all pharmaceutical and biotechnology companies in every therapeutic area.
- Look inside 9 companies offering innovative approaches to determining the role of drug transporters and ADME, including their product pipelines, financial standing, technology, research & development, alliances, etc.
- Gain reliable and thought-provoking insights into the drug transporters and ADME area through in-depth interviews with 7 world authorities from industry and academia.
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