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Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022 - Product Image

Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022

  • Published: February 2013
  • 67 pages
  • GlobalData

Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022

Summary

GlobalData has released its new PharmaPoint Drug Evaluation report, “Brivaracetam (Epilepsy) - Forecast and Market Analysis to 2022”. Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB’s Keppra and GlaxoSmithKline’s Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer’s Dilantin, Abbott’s Depakote, and Novartis’ Tegretol and Trileptal which still have significant usage due to their longevity in the market. However, the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline’s Trobalt/Potiga and Eisai’s Fycompa which both offer first-in-class mechanisms READ MORE >

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1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Catalyst
2.2 Related Reports
3 Disease Overview
3.1 Classification of Seizures
3.2 Etiology and Pathophysiology
3.2.1 Etiology
3.2.2 Pathophysiology
3.2.3 Prognosis
3.2.4 Quality of Life
4 Disease Management
4.1 Diagnosis
4.2 Treatment Guidelines
4.3 Clinical Practice
5 Competitive Assessment
5.1 Overview
5.2 Strategic Competitor Assessment
6 Opportunity and Unmet Need
6.1 Overview
6.2 Unmet Needs
6.2.1 Refractory Epilepsy
6.2.2 Safety/Side Effect Profiles
6.2.3 Curative/Disease-Modifying Agents
6.2.4 Predictive Tools and Need for More Directed Treatments
6.2.5 Improved Preclinical Models and Clinical Trial Paradigms
6.2.6 Treatment Gap
6.3 Unmet Needs Gap Analysis
6.4 Opportunities
6.4.1 Disease-Modifying Agents
6.4.2 Improved Preclinical Models and Clinical Trial Paradigms
6.4.3 Treatment Gap
7 Pipeline Assessment
7.1 Overview
7.2 Strategic Pipeline Assessment
7.3 Pipeline by Phases of Development
7.3.1 Phase III Pipeline
7.3.2 Phase III Pipeline – Reformulations/New Delivery Systems
7.3.3 Phase IIb Pipeline
7.3.4 Phase II Pipeline
7.3.5 Phase I Pipeline
7.3.6 Preclinical Pipeline
7.3.7 Discovery Pipeline
7.4 Pipeline by Mechanism of Action
7.5 Promising Drugs in Clinical Development
8 Brivaracetam
8.1 Overview
8.2 Efficacy
8.3 Safety
8.4 Dosing and Formulation
8.5 Potential Clinical Positioning
8.6 Potential Commercial Positioning
8.7 Pricing and Reimbursement
8.8 SWOT Analysis
8.9 Forecast
9 Appendix
9.1 Bibliography
9.2 Abbreviations
9.3 Methodology
9.4 Forecasting Methodology
9.4.1 Prevalent Epilepsy Patients
9.4.2 Percent Drug-Treated Patients
9.4.3 General Pricing Assumptions
9.4.4 Generic Erosion
9.4.5 Pricing of Pipeline Agents
9.5 Physicians and Specialists Included in this Study
9.6 Primary Research - Prescriber Survey
9.7 About the Authors
9.7.1 Authors
9.7.2 Global Head of Healthcare
9.8 About Us
9.9 Contact Us
9.10 Disclaimer

1.1 List of Tables
Table 1: Epilepsy Syndromes by Age at Onset (2009 ILAE Classification)
Table 2: Classification of Seizures
Table 3: Etiology of Epilepsy According to Age
Table 4: Etiology of Partial Seizures
Table 5: Etiology of Generalized Seizures
Table 6: Some of the Genes Involved in Epilepsy
Table 7: Summary of Diagnostic Tools for Epilepsy
Table 8: Treatment Guidelines for Epilepsy
Table 9: AED Options by Seizure Type
Table 10: Top Three AEDs Prescribed for Epilepsy by Market
Table 11: Types of Epilepsy Surgery
Table 12: Leading Treatments for Epilepsy, 2012
Table 13: Overall Unmet Needs – Current Level of Attainment
Table 14: Clinical Unmet Needs – Gap Analysis, 2012
Table 15: Epilepsy – Phase III Pipeline, 2012
Table 16: Epilepsy – Phase III Pipeline (Reformulations), 2012
Table 17: Epilepsy – Phase IIb Pipeline, 2012
Table 18: Epilepsy – Phase II Pipeline, 2012
Table 19: Epilepsy – Phase I Pipeline, 2012
Table 20: Epilepsy – Preclinical Pipeline, 2012
Table 21: Epilepsy - Discovery Pipeline, 2012
Table 22: Comparison of MOA of Drugs in Development for Epilepsy, 2012
Table 23: Epilepsy – Promising Drugs in Clinical Development
Table 24: Product Profile – Brivaracetam
Table 25: Brivaracetam SWOT Analysis, 2012
Table 26: Global Sales Forecasts ($m) for Brivaracetam, 2012–2022
Table 27: Physicians Surveyed, By Country

1.2 List of Figures
Figure 1: Summary of the Pathophysiology of Seizures by Net Increased Neuronal Excitation
Figure 2: Mechanisms of Action of AEDs at the Synapse
Figure 3: AED Selection Based on Comorbidity
Figure 4: Epilepsy – Pipeline by MOA, 2012
Figure 5: Competitive Assessment of Late-Stage Pipeline Agents in Epilepsy, 2012–2022

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