The primary causes of wounds requiring skin replacement are severe burns and ulcers; materials must provide an effective temporary barrier, promote healing and minimise scarring. Massive improvements have been made to skin repair biomaterials in the last ten years with widespread adoption of new developments in the medical sector. This book provides a comprehensive review of biomaterials for treating skin loss. Chapters initially review the biomechanics and biological environment of skin. Further chapters discuss important methods and techniques for replacing and stabilising damaged skin, regulation and clinical trials. The final group of chapters discuss human origin and cultured dermal replacements and the principles of skin regeneration.