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Circulating Tumor Cells and Cancer Stem Cells Technologies - Global Strategic Business Report Product Image

Circulating Tumor Cells and Cancer Stem Cells Technologies - Global Strategic Business Report

  • ID: 2832326
  • March 2014
  • Region: Global
  • 213 Pages
  • Global Industry Analysts, Inc

This report analyzes the worldwide markets for Circulating Tumor Cells and Cancer Stem Cells Technologies in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World.

Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs.

The report profiles 66 companies including many key and niche players such as:

- Alchemia Limited
- Amgen Inc.
- Exelixis, Inc.
- Formula Pharmaceuticals
- GlaxoSmithKline Plc

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1. CIRCULATING TUMOR CELLS (CTCS) GLOBAL MARKET OVERVIEW

CTC Detection
Real-Time ‘Liquid Biopsy’ Scores Over Surgical Biopsy
Challenges in CTC Diagnostics
Need for CTC Enrichment and Popular Methods
CTC Enrichment Techniques
CTC Identification
Various Approaches
CTC IDENTIFICATION APPROACHES
A List of mRNA Markers for RT-PCR-based Detection of CTCs by Tumor Type
CellSearch System™- The Only FDA Approved Automated Enrichment/Isolation Technique
Market Outlook
Rising Incidence of Cancer
An Opportunity Indicator
Table 1: World Cancer Incidence by Geographic Region and Gender (2012): Number of New Cancer Cases Reported in Thousands for Asia-Oceania, Europe, North America, Latin America & the Caribbean, and Africa (includes corresponding Graph/Chart)
Table 2: World Cancer Mortality by Geographic Region and Gender (2012): Number of Cancer-Related Deaths in Thousands for Asia-Oceania, Europe, North America, Latin America & the Caribbean, and Africa (includes corresponding Graph/Chart)
Table 3: New Cancer Cases in the World by Affected Site: 2012 (in Thousands) (includes corresponding Graph/Chart)
Table 4: Global Incidence of Common Cancers in Men (2012): Number of New Cases Reported in Thousands for Lung & Bronchus, Prostate, Colorectal and Liver Cancers (includes corresponding Graph/Chart)
Table 5: Global Incidence of Common Cancers in Women (2012): Number of New Cases Reported in Thousands for Breast, Colorectal, Lung & Bronchus and Liver Cancers (includes corresponding Graph/Chart)
Table 6: Global Cancer Mortality in Men for Select Cancers (2012): Number of Deaths in Thousands for Lung & Bronchus, Liver, Colorectal and Prostate Cancers (includes corresponding Graph/Chart)
Table 7: Global Cancer Mortality in Women for Select Cancers (2012): Number of Deaths in Thousands for Breast, Lung & Bronchus, Colorectal and Liver (includes corresponding Graph/Chart)
Cancer Prone Sites based on Age

2. MARKET TRENDS AND DRIVERS

CTCs for Personalized Cancer Treatment
Microfluidic Chip-based Technologies
A Promising Avenue for Cancer Diagnosis
CTC Microdevices Hog the Limelight
Table 8: Select CTC Microdevices and Their Characteristics
Limitations of CTC Technology for Point-of-Care Testing
CTC Technologies Offer an Edge over Imaging Tests for Breast Cancer Prognosis
Limited Biomarkers Utilized In CTC Diagnostics
A Threat to Market Growth?

3. CANCER STEM CELLS GLOBAL MARKET OVERVIEW
CSC-Focused Innovations in Cancer Therapeutics
Select Pathways or Molecular Targets for CSC Candidates
Pipeline Analysis of Select Cancer Stem Cells Therapeutics ( 2014)
Select Targeted Toxins against CSC Markers: 2013
Various Methods Used for Isolation of Cancer Stem Cells
Antibody-mediated Therapies

4. CTC AND CSC RESEARCH FINDINGS & BREAKTHROUGHS

Microfluidic Device with Micro-Hall Sensors Detect CTCs with Higher Sensitivity and Specificity
NBiomics Makes its Contribution to CTC Diagnosis
Researchers at University of Michigan Develop Revolutionary Capture CTCs Method
Dean Flow Fractionation to Overcome Limitations Associated with Conventional Biomarker Analysis
Gold Nanoparticles Help in the Detection of CTCs
Diabetes Drug Metformin May Prove Effective against Pancreatic Cancer Stem Cells
Novel Chemical Inhibitors that Target Cancer Stem Cells

5. MEDICAL DIAGNOSTICS MARKET A CONCEPTUAL OVERVIEW

Clinical Diagnostics
Table 9: Leading Players in the Global In Vitro Diagnostics (IVD) Market (2013)
Market Share Breakdown by Value Sales for Roche Diagnostics, Abbott Laboratories, Siemens, J&J, Beckman Coulter, bioMerieux, and Others (includes corresponding Graph/Chart)
Table 10: Global In-Vitro Diagnostics (IVD) Market (2013): Percentage Breakdown for Value Sales by Segment for Point of Care, Immunity Tests, Clinical Chemistry, Nucleic Acid Tests, Histology/Cytology, Microbiology, Haematology and Others (includes corresponding Graph/Chart)
Molecular Diagnostics
Growth Drivers
Molecular Diagnostics for Lymphoid Malignancies
Market Trends & Issues
Global Molecular Diagnostics on a High Growth Curve
Automation Driving Global Market
Molecular Diagnostics: Marking Convergence of Numerous Technologies
Aging Population, Disease Incidence
Fundamental Drivers of Growth
Pharmaceutical Firms Carving their Niche in the Molecular Diagnostics Market
Limited Reimbursements by Third Party Payers
A Stumbling Block
Molecular Diagnostics and Intellectual Property
Business Opportunities in the Offing
Medical Training and Practice Challenges
Hurdles All the Way for Companies Eyeing Molecular Diagnostics
Integration of Molecular Diagnostics into Therapeutics
Molecular Diagnostics
Moving from Centralization to Decentralization

6. CIRCULATING TUMOR CELL (CTC) DIAGNOSTICS ENRICHMENT, IDENTIFICATION AND CHARACTERIZATION METHODS

Introduction
Enrichment
Filtration (iSET)
Density Gradient
Immuno-magnetic Cell Enrichment
Advantages of Different CTC Enrichment Procedures
AdnaTest
Identification
1. PCR-Based Analysis
Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)
RT-qPCR
2. Cytometric Methods
Fiber-Optic Array Scanning Technology (FAST)
Laser Scanning Cytometry (LSC)
Flow Cytometry
CellSearch
CTC-Chip
Enzyme-linked Epithelial Immunospot Assay (ELISPOT)
Fluorescence In Situ Hybridization (FISH)
Vita-Assay®
TelomeScan™
CytoTrack
Some Other Methods for Detection of CTCs
Characterization
Chemo-Sensitivity Testing of CTCs

7. CANCER STEM CELLS (CSCS) BIOLOGY, ISOLATION, CSC SURFACE MARKERS, AND SIGNALING PATHWAYS

Introduction
Differences between Normal Stem Cells and Cancer Stem Cells
Milestones in Stem Cell and Cancer Stem Cell Research
Origin
Hierarchical versus Stochastic Models of Tumour Cell Heterogeneity
Isolation of Cancer Stem Cells
Characteristics of Cancer Stem Cells
Resistance to Chemotherapy
Resistance to Radiation
Invasion or Metastatic Activity
CSC Markers
EpCAM (Epithelial Cell Adhesion Molecule)
CD133 (prominin 1)
ALDH
CD90 (THY1)
CD44 (PGP1)
CD24 (HSA)
Surface Markers Used for the Identification of CSCs
Cancer Stem Cell (CSC) Markers by Disease
Metastatic Cancer Stem Cells
Table 11: Cancer Stem Cells in Solid Tumors
Pathways Involved in the Maintenance of CSCs
p53 Pathway
Activation of Receptor Tyrosine Kinase Pathway
Notch Pathway
Retinoblastoma Pathway
Wnt and Sonic Hedgehog Pathways
BMI-1
Research Indicates Diabetes Drug Metformin Effective against Pancreatic Cancer Stem Cells
Research Leads to Development of Novel Chemical Inhibitors that Target Cancer Stem Cells

8. PRODUCT LAUNCHES AND INTRODUCTIONS

EU Authorisation for ANGLE’s Parsortix Cancer Diagnostic Device
ANGLE Launches Parsortix Device into the Research Market
Promab Introduces New Range of Cancer Stem Cells Solutions
Clearbridge BioMedics Unveils ClearCell® FX Cancer Cell Enrichment System
Fluxion Introduces New IsoFlux System CTC Technology
Cynvenio Launches LiquidBiopsy Lab Service
Biocept Launches OncoCEE-BR
ApoCell to Launch ApoStream

9. RECENT INDUSTRY ACTIVITY

Stem Cell Therapeutics and University of York Ink Option Agreement
Veridex Undergoes Name Change to Janssen Diagnostics
Janssen Diagnostics and Arno Therapeutics Ink Collaboration Agreement
Veridex Enters into Agreement with LabCorp
Stemline Therapeutics Obtains Orphan Drug Designation for SL-401
ANGLE Announces Test Results of Parsortix Non-Invasive Cancer Diagnostic Product
University Health Network Signs Definitive License Agreement with Stem Cell Therapeutics
Verastem Inks Agreement with LabCorp®
Verastem Receives Orphan Drug Designation for Defactinib from US FDA
Lonza Partners with Eclipse
Verastem Signs Agreement with Pfizer to Acquire Exclusive In- License Rights for VS-6063
ScreenCell Inks Global Distribution Agreement with Affymetrix
Dainippon Sumitomo Pharma to Take Over Boston Biomedical
Bionomics Takes Over Eclipse Therapeutics
BioView Signs Commercial Collaboration Agreement with ScreenCell
Coare Enters into a Services and Co-Marketing Alliance with ChemDiv
Eisai Signs Research Agreement with Verastem
Fluxion Biosciences Inks Collaboration Agreement with Rubicon Genomics
Transgenomic Enters into Partnership with MD Anderson Cancer Center
Transgenomic Collaborates with NYU Langone Medical Center
Veridex Receives China SFDA Approval for CellSearch® CTC Test for Breast Cancer
ScreenCell Signs Global Collaboration and Distribution Agreement with Transgenomic
OncoMed Pharmaceuticals Extends Collaboration with Bayer Healthcare for New Cancer Drug
Veridex Partners with Massachusetts General Hospital for CTC Technology

10. FOCUS ON SELECT MAJOR PLAYERS IN CTC DIAGNOSTICS

Adnagen GmbH (Germany)
ApoCell, Inc (US)
Biocep LTD (Israel)
Biocept, Inc. (US)
Biofluidica Microtechnologies LLC (US)
Celltrafix Inc. (US)
Clearbridge Biomedics (Singapore)
Creatv Microtech, Inc (US)
Cynvenio Biosystems, Inc. (US)
Ikonisys, Inc. (US)
IVDiagnostics, Inc. (US)
Janssen Diagnostics LLC (US)
Epic Biosciences Inc (US)
RARECELLS SAS (Italy)
SCREENCELL (France)
Stemcell Technologies, Inc. (Canada)

11. SELECT MARKET PARTICIPANTS IN THE CANCER STEM CELLS (CSCS) SPACE

Alchemia Limited (Australia)
Amgen Inc. (US)
Exelixis, Inc. (US)
Formula Pharmaceuticals (US)
GlaxoSmithKline Plc. (UK)
Geron Corp. (US)
Infinity Pharmaceuticals (US)
Kalobios Pharmaceuticals Inc. (US)
Novartis AG (Switzerland)
OncoMed Pharmaceuticals, Inc. (US)
Pfizer, Inc. (US)
Roche Diagnostics (Switzerland)
Verastem, Inc. (US)

12. GLOBAL MARKET PERSPECTIVE

Table 12: World Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 13: World Historic Review for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 14: World 15-Year Perspective for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
Percentage Breakdown of Annual Revenues for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

A.Market Analysis
US Diagnostics Market: An Overview
CTC Diagnostics in the US
Set for a Strong Growth
Cancer Incidence in the US
Table 15: New Cancer Cases in the US by Gender and Affected Site: 2012
Table 16: New Cancer Cases in Males in US by Leading Site: 2012 (includes corresponding Graph/Chart)
Table 17: New Cancer Cases in Females in US by Leading Site: 2012 (includes corresponding Graph/Chart)
Research Breakthroughs in the US CTC Market
Product Launches
Strategic Corporate Development
Select Key Players in CTC Market
Select Key Players in CSC Market
B.Market Analytics
Table 18: The US Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 19: The US Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

2. CANADA

A.Market Analysis
Cancer Incidence in Canada
Table 20: New Cancer Cases in Canada by Gender and Affected Site: 2012 (includes corresponding Graph/Chart)
Table 21: New Cancer Cases in Canada by Province: 2012 (includes corresponding Graph/Chart)
Table 22: New Cancer Cases in Canada by Age Group: 2012 (includes corresponding Graph/Chart)
Strategic Corporate Development
Stemcell Technologies, Inc.
A Key Player
B.Market Analytics
Table 23: Canadian Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 24: Canadian Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

3. JAPAN

A.Market Analysis
Strategic Corporate Development
B.Market Analytics
Table 25: Japanese Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 26: Japanese Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4. EUROPE

A.Market Analysis
Insight into Molecular Diagnostics Markets in Europe
Table 27: European IVD Market for Select Countries (2010)
Market Value in US$ Million for Spain, UK, Germany, Italy, France, Poland, Netherlands, Belgium, Denmark, Portugal, Austria, Sweden, Bulgaria and Lithuania (includes corresponding Graph/Chart)
Debt Crisis in Europe Affects Healthcare Industry
Healthcare System . in a State of Transition?
Cancer Trends
Table 28: Cancer Incidence in Europe by Site: 2012 (in Thousands) (includes corresponding Graph/Chart)
ANGLE’s Parsortix Cancer Diagnostic Device Obtains EU Approval
B.Market Analytics
Table 29: European Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 30: European Historic Review for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
Table 31: European 15-Year Perspective for Circulating Tumor Cells (CTCs) Diagnostics by Geographic Region
Percentage Breakdown of Annual Revenues for France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)
4a. FRANCE
A.Market Analysis
Screencell
A Key Player
B.Market Analytics
Table 32: French Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 33: French Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4b. GERMANY
A.Market Analysis
An Overview of Molecular Diagnostics
Key Player
B.Market Analytics
Table 34: German Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 35: German Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4c. ITALY
A.Market Analysis
Rarecells Sas
A Key Player
B.Market Analytics
Table 36: Italian Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 37: Italian Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4d. THE UNITED KINGDOM
A.Market Analysis
Product Launch
Strategic Corporate Developments
GlaxoSmithKline Plc.
A Key Company Focusing on CSC Therapeutics
B.Market Analytics
Table 38: The UK Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 39: The UK Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4e. SPAIN
Market Analysis
Table 40: Spanish Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 41: Spanish Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4f. RUSSIA
Market Analysis
Table 42: Russian Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 43: Russian Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
4g. REST OF EUROPE
A.Market Analysis
Select Players in CSC Markets
B.Market Analytics
Table 44: Rest of Europe Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 45: Rest of Europe Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

5. ASIA-PACIFIC

A.Market Analysis
Cancer Trends in Asia-Pacific
Table 46: Cancer Incidence in Asia-Oceania by Site: 2011 (in Thousands) (includes corresponding Graph/Chart)
India
China
CellSearch Obtains Approval for Metastatic Breast Cancer Detection in China
Product Launch
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 47: Asia-Pacific Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 48: Asia-Pacific Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

6. REST OF WORLD

A.Market Analysis
Key Player
B.Market Analytics
Table 49: Rest of World Recent Past, Current & Future Analysis for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2013 Through 2020 (includes corresponding Graph/Chart)
Table 50: Rest of World Historic Review for Circulating Tumor Cells (CTCs) Diagnostics Analyzed with Annual Revenue Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 66 (including Divisions/Subsidiaries 67)
The United States (46)
Canada (3)
Japan (2)
Europe (9)
France (3)
Germany (2)
The United Kingdom (1)
Rest of Europe (3)
Asia-Pacific (Excluding Japan) (4)
Middle East (3)

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