• 1-800-526-8630U.S. (TOLL FREE)
  • 1-917-300-0470EAST COAST U.S.
  • +353-1-416-8900REST OF WORLD
Antibody Technologies and Attrition Rates – an industry analysis 2013 Product Image

Antibody Technologies and Attrition Rates – an industry analysis 2013

  • ID: 2508118
  • March 2013
  • 607 Pages
  • La Merie Publishing

The report “Antibody Technologies and Attrition Rates – an industry analysis 2013” is based on the identification of the antibody generation technologies of 504 naked antibodies in clinical or market stages. Information was retrieved from scientific and corporate publications as well as from patent and legal literature. The report provides descriptive statistics of the 504 naked antibodies and their status during the study period of January 1, 2013 to February 28, 2013. The antibodies are categorized as active during the study period or discontinued during or before the study period. Attrition rates were calculated across a number of variables.

Descriptive statistics of the 504 naked antibodies include the following variables:

- Unique antibody identifiers (drug codes; generic name; brand name)
- Antibody format (full length, Fab, scFv, VH/VL, nanobody, bispecific, cocktail/polyclonal)
- In vitro antibody generation technologies (display technologies from CAT, Dyax, Morphosys, BioInvent, Domantis, Genentech, others)
- In vivo antibody generation technologies (chimeric, primatized, nanobodies, deimmunized, human engineered, humaneered, humanized, READ MORE >

Table of Contents

1 Executive Summary and Discussion

2 Introduction

3 Methodology

4 Results
4.1 Use of antibody technologies
4.2 Attrition rates
4.3 Reasons for failure
4.4 Antibody generation technologies and targets
4.5 Antibody technologies and antibody formats
4.6 Parental animal species of in vivo generated antibodies
4.7 Immunoglobulin class and isotype vs. antibody technology
4.8 Antibody technology and therapeutic areas
4.9 Attrition rates of antibodies in therapeutic areas
4.10 Benchmark analysis: big pharma and biotech antibody technology preferences and attrition rates

5 Tables
Table 1 Overall attrition rate of in vitro generated antibodies
Table 2 Overall attrition rate of in vivo generated antibodies
Table 3 Highest phase of active antibodies generated by in vitro technologies
Table 4 Highest phase of active antibodies generated by in vivo technologies
Table 5 Year of antibody failure for in vitro generated antibodies
Table 6 Year of antibody failure for in vivo generated antibodies
Table 7 Attrition rate of in vitro generated antibodies in the period 2006-2013
Table 8 Attrition rate of in vivo generated antibodies in the period 2006-2013
Table 9 Highest phase of failed antibodies generated by in vitro technologies
Table 10 Highest phase of failed antibodies generated by in vivo technologies
Tables 11 Reasons for failure of antibodies generated by in vitro technologies
Tables 12 Reasons for failure of antibodies generated by in vivo technologies
Table 13 Reasons for failure of humanized antibodies per phase
Tables 14 Targets of failed in vitro generated antibodies per technology
Tables 15 Targets vs. in vitro and in vivo antibody generation technologies
Tables 16 Transgenic mouse antibodies and targets
Table 17 Antibody technologies and antibody formats
Table 18 Parental animal species of in vivo generated antibodies
Table 19 Immunoglobulin class and isotype vs antibody technology
Table 20 In vitro antibody technology and therapeutic areas
Table 21 In vivo antibody technology and therapeutic areas
Table 22 Failed antibodies from in vitro technologies vs therapeutic areas
Table 23 Failed antibodies from in vivo technologies vs therapeutic areas
Table 24 Roche (Genentech(Chugai) use of antibody technologies vs attrition rates
Table 25 AstraZeneca (MedImmune/CAT) use of antibody technologies vs attrition rates
Table 26 Amgen use of antibody technologies vs attrition rates
Table 27 Lilly (ImClone) use of antibody technologies vs attrition rates
Table 28 Pfizer (Wyeth) use of antibody technologies vs attrition rates
Table 29 Novartis use of antibody technologies vs attrition rates
Table 30 GlaxoSmithKline (HGS) use of antibody technologies vs attrition rates
Table 31 Sanofi (Genzyme) use of antibody technologies vs attrition rates
Table 32 Bristol-Myers Squibb (Medarex) use of antibody technologies vs attrition rates
Table 33 Biogen Idec use of antibody technologies vs attrition rates
Table 34 Janssen (Centocor/J&J) use of antibody technologies vs attrition rates
Table 35 AbbVie (Abbott) use of antibody technologies vs attrition rates
Table 36 Kyowa Hakko Kirin Pharma use of antibody technologies vs attrition rates
Table 37 Merck (Schering-Plough) use of antibody technologies vs attrition rates
Table 38 UCB (Celltech) use of antibody technologies vs attrition rates
Table 39 Eisai (Morphotek) use of antibody technologies vs attrition rates
Table 40 Novo Nordisk use of antibody technologies vs attrition rates
Table 41 Ranking list of Big Pharma & Biotech companies and overall antibody attrition rates
Table 42 Ranking list of Big Pharma & Biotech companies and in vitro antibody attrition rates
Table 43 Ranking list of Big Pharma & Biotech companies and in vivo antibody attrition rates
Table 44 Ranking list of Big Pharma & Biotech companies and in vivo antibody preference rate
Table 45 Big Pharma & Biotech companies and preferred in vivo antibody technologies: humanization vs. transgenic mice
6 Addendum: Antibody Data Sheets

Note: Product cover images may vary from those shown

ALSO AVAILABLE

RELATED PRODUCTS

Our Clients

Our clients' logos