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Advances in Tissue Engineering and Organ Regeneration - Technical Insights Report

  • ID: 2707490
  • Report
  • August 2013
  • 47 Pages
  • Frost & Sullivan
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State-of-the-Art Technology for Artificial Organ Implant
Tissue engineering, which is now being categorized as a form of regenerative medicine, can be defined as biomedical engineering to reconstruct, repair, and improve biological tissues. Research efforts in tissue engineering have been ongoing and it is emerging as one of the key areas of medical research. Furthermore, there are vast developments in tissue engineering, which involve leveraging of technologies from biomaterials, molecular medicine, biochemistry, nanotechnology, genetic and biomedical engineering for regeneration and cell expansion targets to restructure and/or repair human organs.

Tissue engineering is often referred to as regenerative medicine and reparative medicine. It is an interdisciplinary field requiring the combined efforts of cell biologists, engineers, material scientists, geneticists, clinicians, mathematicians etc., towards the development of biological substitutes that restore, maintain, or improve tissue function. Currently it has emerged as a rapidly diversifying field with the potential to address the worldwide organ shortage issue and comprises of tissue regeneration and organ replacement. Cells placed on or within the tissue constructs is the most common methodology in tissue engineering. Successful cell seeding as it is known depends on the fast attachment of engineered cell to scaffolds, high cell survival and uniform cell distribution over the scaffold. The cell seeding time is dependents strongly on the scaffold material and structure. Scaffolds act as an initial biochemical substrate for the new cells to proliferate, until the cells can produce their own extra-cellular matrix (ECM).

Tissue engineering has been a field of consistent research for just more than a decade. Still considered a nascent science, research in the field has offered and continues to offer an increasing number of substitutes for applications that would enable the human body to withstand pain and injuries inflicted upon it. While in the present time, it is a task to categorize tissue engineering into their respective categories, applications so far have been developed across three fronts namely materials, biomolecules, and cells. From the materials' perspective, focus has largely been on the development of tissue scaffolds that serve as a base for the growth of the tissue. These biomaterials range from being fully bioresorbable to replaceable. At the next level lie biomolecules that are typically growth factors and proteins that tend to stimulate cell growth and division apart from the proteins that offer stability for the cellular layer over the scaffold as a result of the formation of the extracellular matrix. However, with developments in both these areas, key developments have been in cell sensitization and cellular reprogramming or dedifferentiation wherein committed cells that are destined to form a certain organ are returned to their native state. A vast degree of research has been carried out in the development of varied cell types out of which most of it has been done by means of autografts, allografts or xenografts. Yet there is a drive toward focusing on stem cell research owing to their totipotent and pluripotent abilities. As a result, most of the developments in tissue engineering have focused largely on the developments of stem cell-based developments that to a great extent have fuelled the innovations in organ regeneration.

In brief this study provides:

- A brief snapshot of the capabilities of existing technologies and standards in the tissue engineering and organ regeneration domain.
- An overview of the value chain networks existing in this domain and the assessment of the value chain networks.
- A sneak preview of the market impact of key innovations in this segment.
- A brief snapshot on the key business accelerators and challenges in the tissue engineering and organ regeneration domain.
- A brief snapshot on the demands from the end-user side.
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1. Executive Summary

2. Technology Snapshot and Trends

- Research Scope
- Research Methodology
- Key Findings

3. Technology Capability

- Technology Value Chain

4. Impact Assessment and Analysis

- Market Impact of Proprietary Technologies

5. Diffusion of Innovations and Needs Assessment

- Business Drivers
- Business Challenges
- Technology Adoption Cycle

6. Opportunity Evaluation and Roadmapping

- Demand Side Analysis
- Scenario Modeling
- Technology Roadmap
- Technology Management Strategies

7. Key Contacts and Patents

8. Decision Support Database
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